General Information of This Drug (ID: DMB4OLE)

Drug Name
Propofol   DMB4OLE
Synonyms
Ampofol; Aquafol; Diisopropylphenol; Dipravan; Diprivan; Disoprivan; Disoprofol; Fresofol; Ivofol; PFL; Propofolum; Rapinovet; Recofol; Abbott Brand of Propofol; Alpha Brand of Propofol; Astra Brand of Propofol; AstraZeneca Brand of Propofol; Braun Brand of Propofol; Curamed Brand of Propofol; Diprivan Injectable emulsion; Fresenius Brand of Propofol; Fresenius Kabi Brand of Propofol; Juste Brand of Propofol; Parnell Brand of Propofol; Pisa Brand of Propofol; Propofol Abbott; Propofol Fresenius; Propofol MCT; Propofol Rovi; Propofolum [Latin]; Rovi Brand of Propofol; Schering Brand of Propofol; Zeneca Brand of Propofol; AM-149; DDS-04F; Diprivan (TN); Propofol IDD-D; Propofol-Lipuro; ZD-0859; Ghl.PD_Mitscher_leg0.558; Propofol [USAN:INN:BAN]; Propofol (JAN/USAN/INN); Propofol(2,6-Diisopropylphenol); 2, 6-Diisopropylphenol; 2,6 Diisopropylphenol; 2,6-Bis(1-methylethyl)phenol; 2,6-Bis(Isopropyl)-phenol; 2,6-DIISOPROPYLPHENOL; 2,6-Diisopropyl phenol; 2,6-Diisopropylphenol; 2,6-bis(1-methylethyl)-phenol; 2,6-di(propan-2-yl)phenol
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Leukemia N.A. Approved [2]
Traumatic brain injury NA07.Z Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [3]
Therapeutic Class
Hypnotics and Sedatives
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

60 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Atracurium + Propofol DCA20IL Atracurium Pediatric Patients [4]
Desflurane + Propofol DC5WQ65 Desflurane Obesity [5]
Esmolol + Propofol DCO9XF6 Esmolol Pain [6]
Fentanyl + Propofol DC4CHW4 Fentanyl Obesity, Morbid [7]
Fentanyl + Propofol DCUJDNK Fentanyl Ventricular Tachycardia [8]
Fentanyl + Propofol DC6Q8SQ Fentanyl Hip Fractures [9]
Fentanyl + Propofol DCA9P4G Fentanyl Urinary Bladder Neoplasms [10]
Fentanyl + Propofol DCKIRKQ Fentanyl Renal Failure [11]
Fentanyl + Propofol DCIATZ5 Fentanyl Cirrhosis [12]
Fentanyl + Propofol DCKD511 Fentanyl Traumatic Brain Injury [13]
Ketamine + Propofol DCHENMG Ketamine Trauma [14]
Ketamine + Propofol DCW7096 Ketamine Endoscopy [15]
Lidocaine + Propofol DCVBR2M Lidocaine Pain [16]
Metoclopramide + Propofol DC6B6SG Metoclopramide PREGNANCY [17]
Oxytocin + Propofol DCYF1PZ Oxytocin Postpartum Hemorrhage [18]
Pregabalin + Propofol DCHCLMZ Pregabalin Pain [19]
Propofol + Esketamine DC80MV1 Esketamine Drug Effect [20]
Propofol + Sufentanil DCC6E9S Sufentanil Hemodynamic Instability [21]
Propofol + Alfentanil DCCT8DH Alfentanil Cerebral Ischemia [22]
Propofol + Midazolam DCFKA2J Midazolam Bronchoscopy [23]
Propofol + Alfentanil DCGNM8B Alfentanil Pharmacodynamics [24]
Propofol + Midazolam DCMLHMD Midazolam Anesthesia [25]
Propofol + Meperidine DCVWGZ1 Meperidine Disorders of Gallbladder, Biliary Tract and Pancrease [26]
Propofol + Remifentanil DC0JZTT Remifentanil Lung Function [27]
Propofol + Alfentanil DC1WNDE Alfentanil Lung Disease [28]
Propofol + Midazolam DC96GPZ Midazolam Biliary Tract Diseases [29]
Propofol + Sevoflurane DCGMQ2Z Sevoflurane Cardiac On-pump Surgery [30]
Propofol + Remifentanil DCKE1SL Remifentanil Parkinson's Disease [31]
Propofol + Rocuronium DCP2SC9 Rocuronium Muscle Relaxation [32]
Propofol + Esketamine DCWGBII Esketamine Pain [33]
Propofol + Alfentanil DCWO6MQ Alfentanil Sedation [34]
Propofol + Esketamine DCZB2CW Esketamine Patients With Septic Shock Admitted to the ICU on Invasive Mechanical Ventilation [35]
Propofol + Magnesium Sulfate DCESK2S Magnesium Sulfate Conscious Sedation [36]
Fentanyl + Propofol DCSB3HE Fentanyl Breast Cancer [37]
Fentanyl + Propofol DCZXTLI Fentanyl General Anaesthesia [38]
Propofol + Rocuronium DCMBZUB Rocuronium Anesthesia [39]
Succinylcholine + Propofol DCVBKZ1 Succinylcholine Stroke [40]
Desflurane + Propofol DC5F967 Desflurane Pediatric Acute Respiratory Distress Syndrome [41]
Desflurane + Propofol DCL1AGO Desflurane Anesthesia; Bariatric Surgery [42]
Epinephrine + Propofol DCCS6IS Epinephrine Hemodynamic Instability [43]
Fentanyl + Propofol DC5M9CK Fentanyl C.Surgical Procedure; Cardiac [44]
Fentanyl + Propofol DCBE5BH Fentanyl Intubation, Intratracheal [45]
Fentanyl + Propofol DCBYVR4 Fentanyl Mechanical Ventilation [46]
Fentanyl + Propofol DCCPQTH Fentanyl Opioid Use [47]
Fentanyl + Propofol DCTXB3E Fentanyl Patient Satisfaction [48]
Ketamine + Propofol DCDT501 Ketamine Retinopathy [49]
Lidocaine + Propofol DCG57SD Lidocaine Topical Anesthesia [50]
Norepinephrine + Propofol DC28T66 Norepinephrine Hemodynamic Instability [51]
Palonosetron + Propofol DCV4BOD Palonosetron PONV [52]
Pentazocine + Propofol DCMYOWJ Pentazocine Induced Abortion [53]
Pentazocine + Propofol DCL0BSB Pentazocine Induced Abortion [53]
Propofol + Rocuronium DC1WIT6 Rocuronium Anesthesia [54]
Propofol + Sevoflurane DCETHLE Sevoflurane PONV [52]
Propofol + Rocuronium DCZL14Y Rocuronium Postoperative Confusion [55]
Propofol + Remifentanil DC2405N Remifentanil Target Controlled Infusion [56]
Propofol + Etomidate DC5XG17 Etomidate Surgery [57]
Propofol + Sevoflurane DC9OP5V Sevoflurane Delirium on Emergence [58]
Propofol + Etomidate DCI164K Etomidate Target Controlled Infusion [59]
Propofol + Midazolam DCNS18O Midazolam Congenital Hydronephrosis [60]
Propofol + Sufentanil DCYUZ6V Sufentanil Postoperative; Dysfunction Following Cardiac Surgery [61]
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⏷ Show the Full List of 60 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5464).
2 Propofol FDA Label
3 Propofol and sedation in patients with coronavirus disease. Am J Emerg Med. 2020 Jun 18;S0735-6757(20)30512-X.
4 ClinicalTrials.gov (NCT04945694) Pain Management of Pecto-intercostal Fascial Block Versus Intravenous Fentanyl After Pediatric Cardiac Surgery
5 ClinicalTrials.gov (NCT03756961) Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery
6 ClinicalTrials.gov (NCT01885364) Esmolol Pretreatment on Pain During Injection of Propofol
7 ClinicalTrials.gov (NCT03009877) Preoxygenation With Optiflow?in Morbidly Obese Patients is Superior to Face Mask
8 ClinicalTrials.gov (NCT02419547) Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
9 ClinicalTrials.gov (NCT02604459) Does Optimized General Anesthesia Care Reduce Postoperative Delirium?
10 ClinicalTrials.gov (NCT02534623) Postoperative Quality of Recovery After Transurethral Resection of the Bladder
11 ClinicalTrials.gov (NCT02037802) Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery
12 ClinicalTrials.gov (NCT00906139) Propofol and Fentanyl Versus Midazolam and Fentanyl for Endoscopy Sedation in Cirrhotic Patients
13 ClinicalTrials.gov (NCT01007773) Safety of Dexmedetomidine in Severe Traumatic Brain Injury
14 ClinicalTrials.gov (NCT04291521) Prospective Study of Induction Medications Used in the Trauma RSI
15 ClinicalTrials.gov (NCT00614159) Ketamine Compared to Propofol for Pediatric GI Endoscopy
16 ClinicalTrials.gov (NCT02512783) Decreasing Propofol Injection Pain by Pre-Treatment With Lidocaine in Pediatric Procedural Sedation
17 ClinicalTrials.gov (NCT01781377) Prophylactic Subhypnotic Propofol for Nausea and Vomiting During for Cesarean Section Under Subarachnoid Anesthesia.
18 ClinicalTrials.gov (NCT03852797) Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium
19 ClinicalTrials.gov (NCT02668094) The Effect of Pregabalin on Pain of Propofol Injection
20 ClinicalTrials.gov (NCT05686863) Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children
21 ClinicalTrials.gov (NCT05423951) Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in OPCAB Patients
22 ClinicalTrials.gov (NCT01436799) Desflurane Versus Propofol in the Sitting Position
23 ClinicalTrials.gov (NCT03406533) Sedation Strategies for Diagnostic Bronchoscopy
24 ClinicalTrials.gov (NCT03813875) Modeling and Application of Triple Drug Response Surface Models
25 ClinicalTrials.gov (NCT02536690) Remifentanil and Midazolam on Propofol for Loss of Consciousness
26 ClinicalTrials.gov (NCT01709422) Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine.
27 ClinicalTrials.gov (NCT00706277) Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function
28 ClinicalTrials.gov (NCT02000206) Comparison of Propofol/Alfentanil With Propofol/Ketamine
29 ClinicalTrials.gov (NCT01900938) Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During ERCP
30 ClinicalTrials.gov (NCT00924222) Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass
31 ClinicalTrials.gov (NCT00615472) Intravenous Versus Inhalational Anesthesia in Parkinson's Disease
32 ClinicalTrials.gov (NCT00984633) Study of Efficacy, Pharmacokinetics, and Safety of Bolus Maintenance Doses of Org 9426 (Study P05976)(COMPLETED)
33 ClinicalTrials.gov (NCT04691076) Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy
34 ClinicalTrials.gov (NCT00997113) Stress During Deep Sedation With Propofol With and Without Alfentanil
35 ClinicalTrials.gov (NCT05551910) Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical Ventilation
36 ClinicalTrials.gov (NCT03548493) Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH
37 ClinicalTrials.gov (NCT00542542) Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery
38 ClinicalTrials.gov (NCT03669484) Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia
39 ClinicalTrials.gov (NCT00988520) Study of Efficacy, Pharmacokinetics and Safety of Continuous Intravenous Infusion of Org 9426 (Study P05977)
40 ClinicalTrials.gov (NCT02822144) General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke
41 ClinicalTrials.gov (NCT05783518) Effect of Desflurane on Pediatric Acute Respiratory Distress Syndrome After Living Donor Liver Transplant Recipients
42 ClinicalTrials.gov (NCT03099616) Automated Closed Loop Propofol Anaesthesia Versus Desflurane Inhalation Anaesthesia In Bariatric Surgery
43 ClinicalTrials.gov (NCT02464722) Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery
44 ClinicalTrials.gov (NCT02119806) Decreasing the Incidence of Delirium After Cardiac Surgery
45 ClinicalTrials.gov (NCT04872881) Comparison of Effectiveness of Different Airway Management Methods During Percutaneous Tracheostomy
46 ClinicalTrials.gov (NCT01059929) Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
47 ClinicalTrials.gov (NCT03732469) Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization
48 ClinicalTrials.gov (NCT03803449) Patient Satisfaction and Safety With Propofol Based Sedation With or Without Fentanyl for Gastrointestinal Endoscopy
49 ClinicalTrials.gov (NCT01955135) Anesthesia for Retinopathy of Prematurity
50 ClinicalTrials.gov (NCT02507440) Impact of Topical Pharyngeal Anesthetics on Discharge of the Patients When Used in Conjunction With Propofol Sedation in Routine EGD's
51 ClinicalTrials.gov (NCT03864094) Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.
52 ClinicalTrials.gov (NCT02809378) The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV
53 ClinicalTrials.gov (NCT02208596) The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial
54 ClinicalTrials.gov (NCT02709473) The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia
55 ClinicalTrials.gov (NCT02631135) Cognitive Functions After TIVA With Dexmedetomidine
56 ClinicalTrials.gov (NCT02999126) Slow Stepwise Propofol TCI Induction for Titration Anesthesia Maintenance
57 ClinicalTrials.gov (NCT03820388) Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia
58 ClinicalTrials.gov (NCT02111447) Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI
59 ClinicalTrials.gov (NCT02174120) The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries
60 ClinicalTrials.gov (NCT02013986) Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
61 ClinicalTrials.gov (NCT02756598) Stress, Anxiety and Type A Personality and Analgesics