Details of the Drug Combinations

General Information of This Drug (ID: DMF8DNE)

Drug Name

Framycetin DMF8DNE

Synonyms

Neomycin; neomycin; NEOMYCIN B; Soframycin; Actiline; Mycifradin; Fradiomycin; Soframycine; Framycetinum; Framycetine; Framicetina; Neomas; Fradiomycinum; Antibiotique; Nivemycin; Actilin; Neolate; Enterfram; Myacyne; Framygen; Caswell No 595; Vonamycin powder V; Neomycin B sulfate; Neomin; Neomcin; Fradiomycin B; Neo-Rx; Neomicina [DCIT]; Framycetinum [INN-Latin]; PIMAVECORT; Neobrettin; Neo-Fradin; 119-04-0; Neomycine [INN-French]; Neomycinum [INN-Latin]; Framycetine [INN-French]; Framicetina [INN-Spanish]; USAF CB-19; Endomixin; Fraquinol; Myacine; Myciguent; NMY; Neobiotic; Neomicina; Neomycinum; Tuttomycin; VONAMYCIN; NEOMYCIN AND POLYMYXIN B SULFATES; NEOMYCIN SULFATE; Neomycin solution; Soframycin Ophthalmic; Antibiotic 10676; Antibiotic produced by Streptomyces decaris Neomycin B; Framycetin (INN); Soframycin (TN); Framycetin [INN:BAN:DCF]; Sofra-Tulle (TN); BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG; BDG-(1-4)NEB-(5-1)RIB-(3-1)NED; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside; (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol; D-Streptamine, O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-O-beta-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->4)]-2-deoxy

Indication

Disease Entry	ICD 11	Status	REF
Acute liver failure	DB91	Approved	[1]
Alcoholic cirrhosis of liver	DB94	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Blepharoconjunctivitis	N.A.	Approved	[3]
Corneal abrasion	NA06.4	Approved	[3]
Hepatic coma	N.A.	Approved	[3]
Hepatic encephalopathy	DB99.5	Approved	[3]
Keratitis	N.A.	Approved	[4]
Urinary tract infection	GC08	Approved	[5]
Uveitis	9A96.Z	Investigative	[3]
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Therapeutic Class

Antibiotics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ethanol + Framycetin	DC09AZ0	Ethanol	Colorectal Neoplasms	[6]
Framycetin + Cefazolin	DCLDLH4	Cefazolin	Colostomy	[7]
Framycetin + Rifaximin	DCSZYVH	Rifaximin	Constipation-predominant Irritable Bowel Syndrome	[8]
Framycetin + Tigecycline	DC6PKYB	Tigecycline	Antibiotic Resistant Infection	[9]
Framycetin + Metronidazole	DC068IR	Metronidazole	Colorectal Neoplasms	[6]
Streptomycin + Framycetin	DCAZX4O	Streptomycin	Patients Colonized by Klebsiella Pneumoniae.	[10]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 709).
2	Drug information of Framycetin, 2008. eduDrugs.
3	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
4	Bacterial isolates, antimicrobial susceptibility, and clinical characteristics of bacterial keratitis in dogs presenting to referral practice in Australia. Vet Ophthalmol. 2016 Sep;19(5):418-26.
5	Prostatectomy and infection. J Urol. 1971 Dec;106(6):910-2.
6	ClinicalTrials.gov (NCT03042091) Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery
7	ClinicalTrials.gov (NCT03593252) Bowel Preparation in Elective Pediatric Colorectal Surgery
8	ClinicalTrials.gov (NCT00945334) Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel Syndrome
9	ClinicalTrials.gov (NCT03950544) The Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae
10	ClinicalTrials.gov (NCT02604849) Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin