Details of the Drug Combination

General Information of Drug Combination (ID: DC6PKYB)

Drug Combination Name

Framycetin Tigecycline

Indication

Disease Entry	Status	REF
Antibiotic Resistant Infection	Phase 1	[1]

Component Drugs

Framycetin DMF8DNE

Tigecycline DMLE7IO

Small molecular drug

2D MOL

3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Framycetin

Disease Entry	ICD 11	Status	REF
Acute liver failure	DB91	Approved	[2]
Alcoholic cirrhosis of liver	DB94	Approved	[2]
Bacterial infection	1A00-1C4Z	Approved	[3]
Blepharoconjunctivitis	N.A.	Approved	[4]
Corneal abrasion	NA06.4	Approved	[4]
Hepatic coma	N.A.	Approved	[4]
Hepatic encephalopathy	DB99.5	Approved	[4]
Keratitis	N.A.	Approved	[5]
Urinary tract infection	GC08	Approved	[6]
Uveitis	9A96.Z	Investigative	[4]

Framycetin Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Bacterial 16S ribosomal RNA (Bact 16S rRNA)	TT38DW5	NOUNIPROTAC	Binder	[8]
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	TTQ8KVI	F4NA87_STAAU	Binder	[9]
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Framycetin Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Aminoglycoside O-phosphotransferase (aphA6)	DEWPAJD	KKA6_ACIBA	Metabolism	[10]
Aminoglycoside N-acetyltransferase (aacC2)	DEJADS9	AAC6_ACIBA	Metabolism	[10]
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Framycetin Interacts with 3 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
T-lymphocyte activation antigen CD86 (CD86)	OTJCSBPC	CD86_HUMAN	Increases Expression	[11]
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)	OT53SIZG	NAA15_HUMAN	Increases ADR	[12]
Glial fibrillary acidic protein (GFAP)	OTQ01ZAS	GFAP_HUMAN	Increases ADR	[12]
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Indication(s) of Tigecycline

Disease Entry	ICD 11	Status	REF
Skin infection	1F28-1G0Z	Approved	[7]

Tigecycline Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	TTQ8KVI	F4NA87_STAAU	Binder	[7]
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References

1	ClinicalTrials.gov (NCT03950544) The Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 709).
3	Drug information of Framycetin, 2008. eduDrugs.
4	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
5	Bacterial isolates, antimicrobial susceptibility, and clinical characteristics of bacterial keratitis in dogs presenting to referral practice in Australia. Vet Ophthalmol. 2016 Sep;19(5):418-26.
6	Prostatectomy and infection. J Urol. 1971 Dec;106(6):910-2.
7	Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110.
8	Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26.
9	Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
10	Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.
11	A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals. Toxicology. 2009 Oct 1;264(1-2):1-9. doi: 10.1016/j.tox.2009.07.021. Epub 2009 Aug 7.
12	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.