Details of the Drug Combination

General Information of Drug Combination (ID: DCAZX4O)

Drug Combination Name
Streptomycin Framycetin
Indication
Disease Entry Status REF
Patients Colonized by Klebsiella Pneumoniae. Phase 1 [1]
Component Drugs Streptomycin   DME1LQN Framycetin   DMF8DNE
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Streptomycin
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [2]
Brucellosis N.A. Approved [3]
Chancroid N.A. Approved [3]
Pulmonary tuberculosis 1B10.Z Approved [3]
Tularemia 1B94 Approved [3]
Plague N.A. Investigative [3]
Streptomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [9]
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Streptomycin Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Aminoglycoside O-phosphotransferase (aphA6) DEWPAJD KKA6_ACIBA Metabolism [10]
Aminoglycoside adenylyltransferase (aadA1a) DEYWTIQ Q6YLD2_SALER Metabolism [11]
Endoglucanase Y (EGY) DE2M583 A0A256VAC0_LACRE Metabolism [12]
Endoglucanase Y (EGY) DE2AZTG A0A256VAC0_LACRE Metabolism [12]
Phosphotransferase enzyme strA (strA) DEMVXEA Q79DN3_ERWAM Metabolism [13]
Phosphotransferase enzyme strB (strB) DEXCHR2 Q57204_ERWAM Metabolism [13]
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⏷ Show the Full List of 6 DME(s)
Indication(s) of Framycetin
Disease Entry ICD 11 Status REF
Acute liver failure DB91 Approved [4]
Alcoholic cirrhosis of liver DB94 Approved [4]
Bacterial infection 1A00-1C4Z Approved [5]
Blepharoconjunctivitis N.A. Approved [6]
Corneal abrasion NA06.4 Approved [6]
Hepatic coma N.A. Approved [6]
Hepatic encephalopathy DB99.5 Approved [6]
Keratitis N.A. Approved [7]
Urinary tract infection GC08 Approved [8]
Uveitis 9A96.Z Investigative [6]
Framycetin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial 16S ribosomal RNA (Bact 16S rRNA) TT38DW5 NOUNIPROTAC Binder [14]
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [15]
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Framycetin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Aminoglycoside O-phosphotransferase (aphA6) DEWPAJD KKA6_ACIBA Metabolism [10]
Aminoglycoside N-acetyltransferase (aacC2) DEJADS9 AAC6_ACIBA Metabolism [10]
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Framycetin Interacts with 3 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Increases Expression [16]
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) OT53SIZG NAA15_HUMAN Increases ADR [17]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Increases ADR [17]
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References

1 ClinicalTrials.gov (NCT02604849) Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin
2 Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22.
3 Streptomycin FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 709).
5 Drug information of Framycetin, 2008. eduDrugs.
6 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
7 Bacterial isolates, antimicrobial susceptibility, and clinical characteristics of bacterial keratitis in dogs presenting to referral practice in Australia. Vet Ophthalmol. 2016 Sep;19(5):418-26.
8 Prostatectomy and infection. J Urol. 1971 Dec;106(6):910-2.
9 Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
10 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.
11 Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica. J Biol Chem. 2018 Jul 20;293(29):11481-11490.
12 Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.
13 Genetic analysis of streptomycin-resistant (Sm(R)) strains of Erwinia amylovora suggests that dissemination of two genotypes is responsible for the current distribution of Sm(R) E. amylovora in Michigan. Phytopathology. 2011 Feb;101(2):182-91.
14 Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26.
15 Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
16 A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals. Toxicology. 2009 Oct 1;264(1-2):1-9. doi: 10.1016/j.tox.2009.07.021. Epub 2009 Aug 7.
17 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.