General Information of This Drug (ID: DMFI8A7)

Drug Name
Tranexamic Acid   DMFI8A7
Synonyms
AMCA; AMCHA; AMH; Amikapron; Amstat; Anvitoff; Carxamin; Cyclocapron; Cyklokapron; Emorhalt; Exacyl; Frenolyse; Hexapromin; Hexatron; Mastop; Rikavarin; Spiramin; Tamcha; Tranex; Tranexamsaeure; Tranexan; Transamin; Transamlon; Trasamlon; Ugurol; Acide tranexamique; Acido tranexamico; Acidum tranexamicum; Tranexmic acid; Tranhexamic acid; Trans AMCHA; CL 65336; DV 79; DV79; KABI 2161; LT00159441; ALBB-006013; Acide tranexamique [INN-French]; Acido tranexamico [INN-Spanish]; Acidum tranexamicum [INN-Latin]; CL-65336; Cis-AMCHA; Cyklokapron (TN); DV-79; RP 18,429; Rikavarin (TN); Rikavarin-S; T-AMCHA; Tranexamic acid cis-form; Trans-Amcha; Trans-Tranexamic acid; Cis-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamic acid (JP15/USAN/INN); Tranexamic acid [USAN:INN:BAN:JAN]; Trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester; Trans-p-(Aminomethyl)cyclohexanecarboxylic; Trans-p-(Aminomethyl)cyclohexanecarboxylic acid; Cis-4-Aminomethylcyclohexane-1-carboxylic acid; Trans-1-Aminomethylcyclohexane-4-carboxylic acid; Trans-4-(Aminomethyl)cyclohexane-carboxylic acid; Trans-4-Aminomethylcyclohexane-1-carboxylic acid; Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid; Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid; Trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid; 4-(Aminomethyl)-Cyclohexanecarboxylic Acid; 4-(Aminomethyl)cyclohexanecarboxylic acid; 4-(aminomethyl)cyclohexane-1-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Excessive bleeding GA30.02 Approved [1]
Menorrhagia GA20.50 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [3]
Endometriosis GA10 Investigative [2]
Therapeutic Class
Antifibrinolytic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

49 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Tranexamic acid DCBUZ9P Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Arfolitixorin + Tranexamic acid DCCH5UE Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Brincidofovir + Tranexamic acid DC1CESG Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
BRL-15572 + Tranexamic acid DC8AP9T BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cerivastatin + Tranexamic acid DCT6706 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Dactinomycin + Tranexamic acid DCZ0BBB Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Dantrolene + Tranexamic acid DCPAEUK Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Diazoxide + Tranexamic acid DCI5COZ Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Diethylcarbamazine + Tranexamic acid DCSYXDJ Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Docetaxel + Tranexamic acid DCXLWKW Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Emetine + Tranexamic acid DC3BL9R Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Estramustine + Tranexamic acid DCCK2DZ Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Ethinyl estradiol + Tranexamic acid DCIPS6D Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
IT-141 + Tranexamic acid DCBNDI6 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Lithium Citrate + Tranexamic acid DC85NOO Lithium Citrate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mebutamate + Tranexamic acid DCNCOWU Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mefloquine + Tranexamic acid DCGVL4K Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Methotrexate + Tranexamic acid DCYI1GN Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
ML323 + Tranexamic acid DCWO5KH ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Olmesartan medoxomil + Tranexamic acid DCXMC3P Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Oxyphenbutazone + Tranexamic acid DCYC7XH Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pazopanib + Tranexamic acid DCXU4EY Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pepstatin + Tranexamic acid DCZQQB9 Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pinacidil + Tranexamic acid DCI2WWE Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
PMID28460551-Compound-2 + Tranexamic acid DCBF0ED PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Aprepitant DC25KG4 Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Gefitinib DCFUUFG Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Acetazolamide DCPU4EQ Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Kanamycin DCSYKUW Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Crotamiton DCXAKBJ Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Vinblastine DCJKK4T Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Chlorzoxazone DCHOJOO Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Fluspirilene DCCHJLO Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Allopurinol DCIZXCO Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Idarubicin DCHVTP0 Idarubicin Glioblastoma? (Cell Line: T98G) [4]
Tranexamic acid + Pramipexole DC6WECI Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Bortezomib DCZB26W Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Methylene blue DC9BE2D Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Ethinyl estradiol DC6YAV9 Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Trimethobenzamide DCYLPNQ Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Acetohexamide DC1EPRZ Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Leflunomide DCO6E5A Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Brincidofovir DCP4WMP Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Asenapine DCU6KZP Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Cerivastatin DCQJEEY Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Enoxacin DC1WZL2 Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triamterene + Tranexamic acid DCR98T6 Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Vorinostat + Tranexamic acid DCSIZSB Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Zileuton + Tranexamic acid DC2T6X7 Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
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⏷ Show the Full List of 49 DrugCom(s)
9 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Epinephrine + Tranexamic acid DCUJ71Z Epinephrine Knee Prosthesis [6]
Levonorgestrel + Tranexamic acid DCLKQLV Levonorgestrel Uterine Hemorrhage [7]
Tranexamic acid + Diltiazem DC6AX3J Diltiazem Hypotension on Induction [8]
Hydroquinone + Tranexamic acid DCIWFQL Hydroquinone Melasma [9]
Epinephrine + Tranexamic acid DC612YU Epinephrine Pain, Postoperative [10]
Tranexamic acid + Tranexamic acid DC41R78 Tranexamic acid Osteoarthritis, Knee [11]
Tranexamic acid + Hyaluronic acid DC080Q4 Hyaluronic acid Injection Site Bruising [12]
Tranexamic acid + Misoprostol DCD4794 Misoprostol Postpartum Hemorrhage [13]
Tranexamic acid + Rivaroxaban DCYXVLP Rivaroxaban Osteoarthritis, Knee [14]
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⏷ Show the Full List of 9 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6573).
2 Tranexamic acid FDA Label
3 Tranexamic Acid (TXA) and Corona Virus 2019 (COVID19) in Inpatients (TCInpatient)
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
6 ClinicalTrials.gov (NCT02319915) Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.
7 ClinicalTrials.gov (NCT01295294) Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA)
8 ClinicalTrials.gov (NCT03580590) Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
9 ClinicalTrials.gov (NCT03751163) Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma
10 ClinicalTrials.gov (NCT01964781) The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain
11 ClinicalTrials.gov (NCT02458729) The Blood Saving Effect of Tranexamic Acid in Total Knee Arthroplasty With Rivaroxaban as Thromboprophylaxis
12 ClinicalTrials.gov (NCT04373603) Use of Tranexamic Acid in Facial Fillers
13 ClinicalTrials.gov (NCT02805426) Effectiveness of Tranexamic Acid When Used as an Adjunct to Misoprostol for the Treatment of Postpartum Hemorrhage
14 ClinicalTrials.gov (NCT03328832) Combined Topical Tranexamic Acid With Floseal in Total Knee Arthroplasty