Details of the Drug Combinations

General Information of This Drug (ID: DMGDA3C)

Drug Name
cycloheximide   DMGDA3C
Synonyms naramycin A; NSC 185; FT 3422-2; NM-MCD 80
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

22 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Cycloheximide DCOFG47 (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
Artemisinin + Cycloheximide DCD9YIX Artemisinin DD2 (Cell Line: DD2) [2]
Artemisinin + Cycloheximide DCGMTL3 Artemisinin Hepatoblastoma (Cell Line: HB3) [2]
Cycloheximide + AZD8055 DCP79JG AZD8055 Ewing sarcoma (Cell Line: TC-71) [2]
Cycloheximide + Formononetin DC3AE64 Formononetin Ewing sarcoma (Cell Line: TC-71) [2]
Cycloheximide + Methylene blue DC0ZQCJ Methylene blue DD2 (Cell Line: DD2) [2]
Cycloheximide + Bardoxolone methyl DCIADTJ Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
Cycloheximide + Artemisinin DCZT489 Artemisinin DD2 (Cell Line: DD2) [2]
Cycloheximide + Piperaquine DC3D3U6 Piperaquine DD2 (Cell Line: DD2) [2]
Cycloheximide + Formononetin DC826GX Formononetin Hodgkin lymphoma (Cell Line: U-HO1) [3]
Cycloheximide + Bardoxolone methyl DCHNNT1 Bardoxolone methyl Hodgkin lymphoma (Cell Line: U-HO1) [3]
Cycloheximide + Artemisinin DCPYSX4 Artemisinin Hepatoblastoma (Cell Line: HB3) [3]
Cycloheximide + Chloroquine DCEKNRB Chloroquine Hepatoblastoma (Cell Line: HB3) [3]
Cycloheximide + Naltrexone DCFF9VM Naltrexone Hepatoblastoma (Cell Line: HB3) [3]
Cycloheximide + Piperaquine DC2F0LE Piperaquine Hepatoblastoma (Cell Line: HB3) [3]
Everolimus + Cycloheximide DCB9Y5R Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Lumefantrine + Cycloheximide DCBM8EZ Lumefantrine DD2 (Cell Line: DD2) [2]
MK-1775 + Cycloheximide DCY6ZZ4 MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + Cycloheximide DCTNGZW MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + Cycloheximide DC5VAJZ MK-2206 Hodgkin lymphoma (Cell Line: U-HO1) [2]
PD-0325901 + Cycloheximide DC9KS55 PD-0325901 Hodgkin lymphoma (Cell Line: U-HO1) [3]
Verteporfin + Cycloheximide DCB5UN4 Verteporfin Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 22 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5433).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.