Details of the Drug Combination

General Information of Drug Combination (ID: DCEKNRB)

Drug Combination Name
cycloheximide Chloroquine
Indication
Disease Entry Status REF
Hepatoblastoma Investigative [1]
Component Drugs cycloheximide   DMGDA3C Chloroquine   DMSI5CB
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL
High-throughput Screening Result Testing Cell Line: HB3
Zero Interaction Potency (ZIP) Score: 0.053
Bliss Independence Score: 0.081
Loewe Additivity Score: 0.113
LHighest Single Agent (HSA) Score: 0.124

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of cycloheximide
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [2]
cycloheximide Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [15]
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cycloheximide Interacts with 78 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [16]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [8]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Expression [8]
Transforming acidic coiled-coil-containing protein 1 (TACC1) OTGX20TE TACC1_HUMAN Increases Expression [8]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [8]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [8]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Increases Expression [8]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Increases Expression [17]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Decreases Expression [17]
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) OTWVRR35 GPAA1_HUMAN Increases Expression [17]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Expression [17]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases Expression [17]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Increases Expression [17]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [17]
Kappa-type opioid receptor (OPRK1) OTXCZF4L OPRK_HUMAN Increases Expression [17]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [17]
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) OTMGP4J7 HNRH2_HUMAN Increases Expression [17]
Single-stranded DNA-binding protein, mitochondrial (SSBP1) OTH2PZWH SSBP_HUMAN Increases Expression [17]
Mitogen-activated protein kinase 7 (MAPK7) OTF7H7L7 MK07_HUMAN Increases Expression [17]
Pappalysin-1 (PAPPA) OTTTG9PG PAPP1_HUMAN Increases Expression [17]
SERTA domain-containing protein 2 (SERTAD2) OTYIG6TP SRTD2_HUMAN Increases Expression [17]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Increases Expression [17]
5'-3' exonuclease PLD3 (PLD3) OTL07SP2 PLD3_HUMAN Increases Expression [17]
Synaptopodin (SYNPO) OTICDJAB SYNPO_HUMAN Increases Expression [17]
Transmembrane protein 263 (TMEM263) OTO1RSTS TM263_HUMAN Increases Expression [17]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1) OTGND2YZ SIA8A_HUMAN Increases Expression [17]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Increases Expression [17]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Increases Expression [17]
Solute carrier family 22 member 4 (SLC22A4) OT4LOVI9 S22A4_HUMAN Increases Expression [17]
CDC42 small effector protein 2 (CDC42SE2) OT8SG9I1 C42S2_HUMAN Increases Expression [17]
Myotubularin-related protein 7 (MTMR7) OT47NVYM MTMR7_HUMAN Increases Expression [17]
Small ribosomal subunit protein uS7m (MRPS7) OT57AX7G RT07_HUMAN Decreases Expression [17]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [18]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Decreases Expression [19]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [20]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [21]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [22]
Autophagy-related protein 13 (ATG13) OTYMHNEJ ATG13_HUMAN Decreases Expression [11]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Decreases Expression [23]
Mitochondrial uncoupling protein 4 (SLC25A27) OTSBOPGD UCP4_HUMAN Increases Expression [24]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [25]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [26]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [27]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Decreases Stability [28]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Increases Expression [29]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Decreases Expression [30]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [31]
Intestinal-type alkaline phosphatase (ALPI) OTTQ468O PPBI_HUMAN Decreases Activity [32]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [33]
E3 SUMO-protein ligase EGR2 (EGR2) OTAVQ78J EGR2_HUMAN Increases Expression [34]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [33]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Increases Expression [33]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [33]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [21]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [35]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [35]
Retinoblastoma-like protein 1 (RBL1) OTDEBFYC RBL1_HUMAN Decreases Expression [36]
Protein PML (PML) OT6SM2GD PML_HUMAN Decreases Degradation [37]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [38]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Expression [39]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [40]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Expression [41]
E3 ubiquitin-protein ligase RNF4 (RNF4) OTCMXQRE RNF4_HUMAN Decreases Expression [42]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) OTTM6KRB ADA17_HUMAN Decreases Stability [43]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Decreases Activity [44]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Affects Localization [45]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Decreases Expression [46]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [47]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Decreases Expression [48]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Decreases Activity [49]
Transcription termination factor 3, mitochondrial (MTERF3) OTVE8W7X MTEF3_HUMAN Decreases Expression [50]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Decreases Expression [51]
Repressor of RNA polymerase III transcription MAF1 homolog (MAF1) OTKB0N8Q MAF1_HUMAN Increases Degradation [52]
D-ribitol-5-phosphate cytidylyltransferase (CRPPA) OTC85K8Q ISPD_HUMAN Affects Response To Substance [14]
Rab9 effector protein with kelch motifs (RABEPK) OTCZSREH RABEK_HUMAN Affects Response To Substance [14]
Kremen protein 1 (KREMEN1) OTGJFSAC KREM1_HUMAN Affects Response To Substance [14]
Unconventional myosin-Id (MYO1D) OTP2RGPN MYO1D_HUMAN Affects Response To Substance [14]
Cation channel sperm-associated protein 4 (CATSPER4) OTXJ4E8J CTSR4_HUMAN Affects Response To Substance [14]
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⏷ Show the Full List of 78 DOT(s)
Indication(s) of Chloroquine
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [3]
Plasmodium falciparum malaria 1F40 Approved [4]
Plasmodium malariae malaria N.A. Approved [4]
Plasmodium ovale malaria N.A. Approved [4]
Systemic lupus erythematosus 4A40.0 Approved [4]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [5]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [6]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [7]
Chloroquine Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HUMAN pH-dependent viral fusion/replication (pH-DVF/R) TTD16BI N.A. Inhibitor [53]
HUMAN glycosylation of host receptor (GHR) TTZGK1R N.A. Inhibitor [53]
Duffy antigen chemokine receptor (ACKR1) TTKY2NS ACKR1_HUMAN Modulator [54]
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Chloroquine Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [55]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [56]
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Chloroquine Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [57]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Metabolism [58]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [59]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [57]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [60]
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Chloroquine Interacts with 42 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [61]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Decreases Expression [62]
Trans-Golgi network integral membrane protein 2 (TGOLN2) OTM647IV TGON2_HUMAN Affects Localization [63]
Claudin-1 (CLDN1) OT27KV99 CLD1_HUMAN Increases Expression [64]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Decreases Expression [65]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Increases Expression [65]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [66]
Apolipoprotein D (APOD) OTT77XW8 APOD_HUMAN Affects Localization [67]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [61]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [48]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [68]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [68]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [62]
Cation-dependent mannose-6-phosphate receptor (M6PR) OTFEWOSB MPRD_HUMAN Affects Localization [63]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [66]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [69]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [69]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [70]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [71]
Aquaporin-2 (AQP2) OTQLBKK6 AQP2_HUMAN Decreases Expression [72]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [73]
Coatomer subunit delta (ARCN1) OTJ96STE COPD_HUMAN Affects Localization [63]
Eotaxin (CCL11) OT3BIFPK CCL11_HUMAN Decreases Secretion [74]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Increases Expression [75]
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) OTS7YVHF GBRL2_HUMAN Increases Expression [76]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [76]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [62]
Golgin subfamily A member 2 (GOLGA2) OT5S9KYM GOGA2_HUMAN Affects Localization [63]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [77]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Phosphorylation [78]
Early endosome antigen 1 (EEA1) OTIBXC1B EEA1_HUMAN Affects Localization [63]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Increases Expression [64]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [70]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [79]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [80]
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) OTPMGIU4 MLP3A_HUMAN Increases Expression [81]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) OTMEF544 SIR3_HUMAN Increases Stability [82]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Decreases Expression [61]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Decreases Expression [61]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Decreases Expression [62]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Affects Localization [83]
Linker for activation of T-cells family member 2 (LAT2) OTWJDKIH NTAL_HUMAN Increases Response To Substance [84]
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⏷ Show the Full List of 42 DOT(s)

References

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