Details of the Drug Combinations

General Information of This Drug (ID: DMHVJFK)

• Drug Name: Misoprostol (DMHVJFK)
• Synonyms: Cytotec; GyMiso; Isprelor; Misopess; Misoprostolum; Misotol; SC 29333; Cytotec (TN); Misoprostolum [INN-Latin]; SC-29333; XP-16J; Misoprostol (JAN/USAN/INN); Methyl (11alpha,13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate; Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate; Methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E)-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]heptanoate; (+/-)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1 methyl ester; (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester

Indication

Medical abortion; ICD 11: JA00.1Z; Status: Approved [1]; Postpartum haemorrhage; ICD 11: JA43; Status: Approved [2]

• Therapeutic Class: Abortifacient Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

12 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Atorvastatin + Misoprostol	DCLR367	Atorvastatin	Abortion Early	[3]
Isoniazid + Misoprostol	DCZE4W4	Isoniazid	IUCD Complication	[4]
Mifepristone + Misoprostol	DCPNOQK	Mifepristone	Pregnancy Termination	[5]
Misoprostol + Dinoprostone	DC0WYT9	Dinoprostone	Cervical Ripening	[6]
Misoprostol + Dinoprostone	DC4V2C6	Dinoprostone	Premature Rupture of Membranes at Term	[7]
Misoprostol + Oxytocin	DCLS851	Oxytocin	Vaginal Delivery	[8]
Letrozole + Misoprostol	DC5VRXS	Letrozole	Miscarriage	[9]
Misoprostol + Estradiol	DCND5UD	Estradiol	Miscarriage	[10]
Propranolol + Misoprostol	DC6L6QJ	Propranolol	Induction of Labor Affected Fetus / Newborn	[11]
Mifepristone + Misoprostol	DC22YJ5	Mifepristone	Medical Abortion	[12]
Tranexamic acid + Misoprostol	DCD4794	Tranexamic acid	Postpartum Hemorrhage	[13]
Ulipristal + Misoprostol	DCG9GD8	Ulipristal	Induction of Second Trimester Abortion	[14]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1936).
• [2] Misoprostol FDA Label
• [3] ClinicalTrials.gov (NCT05342974) Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy
• [4] ClinicalTrials.gov (NCT04500002) Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
• [5] ClinicalTrials.gov (NCT00680394) Comparing Two Regimens for Medical Abortion: Mifepristone+Misoprostol Versus Misoprostol Alone
• [6] ClinicalTrials.gov (NCT01620814) Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy
• [7] ClinicalTrials.gov (NCT00355303) Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
• [8] ClinicalTrials.gov (NCT04004845) Labor Protocol Study
• [9] ClinicalTrials.gov (NCT03628625) Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage
• [10] ClinicalTrials.gov (NCT03479879) Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage
• [11] ClinicalTrials.gov (NCT04533841) Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor in Primigravidas
• [12] ClinicalTrials.gov (NCT01856985) Acceptability of an Out-patient Regimen of Medical Abortion With Mifepristone and 800 Mcg Misoprostol Administered at 78-84 Days Gestation
• [13] ClinicalTrials.gov (NCT02805426) Effectiveness of Tranexamic Acid When Used as an Adjunct to Misoprostol for the Treatment of Postpartum Hemorrhage
• [14] ClinicalTrials.gov (NCT04989400) Use of Ulipristal Acetate in Induction of Second Trimester Missed Abortion