Details of the Drug Combinations

General Information of This Drug (ID: DMKBJWP)

• Drug Name: Caffeine (DMKBJWP)
• Synonyms: CFF; Cafamil; Cafecon; Cafeina; Cafeine; Caffedrine; Caffein; Caffeina; Caffenium; Caffine; Cafipel; Coffein; Coffeine; Coffeinum; DHCplus; Dasin; Dexitac; Diurex; Durvitan; Enerjets; Ercatab; Guaranine; Hycomine; Kofein; Koffein; Mateina; Methyltheobromide; Methyltheobromine; Miudol; Nodaca; Organex; Percutafeine; Phensal; Stim; Teina; Thein; Theine; Tirend; Vivarin; Anacin Maximum Strength; Anhydrous caffeine; Caffedrine Caplets; Caffeina [Italian]; Caffeine Pure; Caffeine solution; Coffein [German]; Coffeinum N; Coffeinum Purrum; Component of Cafergot; DHC Plus; Dexitac Stay Alert Stimulant; Eldiatric C; GlaxoSmithKline Brand of Caffeine; Hycomine Compound; Keep Alert; Kofein [Czech]; Koffein [German]; Merck dura Brand of Caffeine; Methylxanthine theophylline; Midol Maximum Strength; Monomethyl derivative of Theophylline; Natural Caffeinum; Nix Nap; No Doz; Nodoz Maximum Strength Caplets; Passauer Brand of Caffeine; Percoffedrinol N; Pierre Fabre Brand of Caffeine; Quick Pep; Republic Drug Brand of Caffeine; Seid Brand of Caffeine; Theobromine Me; Theophylline Me; C 0750; Propoxyphene Compound 65; SK 65 Compound; TNP00310; Thompson Brand 1 of Caffeine; Thompson Brand 2 of Caffeine; Alert-pep; Anhydrous caffeine (JP15); Anhydrous caffeine (TN); Berlin-Chemie Brand of Caffeine; Bristol-Myers Squibb Brand of Caffeine; Cafcit (TN); Caffeine (USP); Caffeine (natural); Caffeine [BAN:JAN]; Caffeine, Monohydrate; Caffeine, anhydrous; Caffeine, synthetic; No-Doz; Pep-Back; Propoxyphene Compound-65; Quick-Pep; Refresh'n; SK-65 Compound; Tri-Aqua; Ultra Pep-Back; Wake-Up; CU-01000012617-3; P-A-C Analgesic Tablets; Theophylline, 7-methyl; Xanthine, 1,3,7-trimethyl; 1,3,7-Trimethyl-2,6-dioxopurine; 1,3,7-Trimethylpurine-2,6-dione; 1,3,7-Trimethylxanthine; 1-3-7-TRIMETHYLXANTHINE; 1-methyltheobromine; 3,7-dihydro-1,3,7-trimethyl-1H-purine; 7-Methyltheophylline

Indication

Allergic rhinitis; ICD 11: CA08.0; Status: Approved [1]; Back pain; ICD 11: ME84.Z; Status: Approved [1]; Cluster headache; ICD 11: 8A81.0; Status: Approved [1]; Common cold; ICD 11: CA00; Status: Approved [1]; Dysmenorrhea; ICD 11: GA34.3; Status: Approved [1]; Headache; ICD 11: 8A80-8A84; Status: Approved [1]; Migraine disorder; ICD 11: N.A.; Status: Approved [1]; Orthostatic hypotension; ICD 11: BA21; Status: Approved [2]; Pain; ICD 11: MG30-MG3Z; Status: Approved [1]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Caffeine + Panobinostat	DCD76TK	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]

13 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Alprazolam + Caffeine	DC04760	Alprazolam	Psychotropic Drugs Effects	[4]
Biperiden + Caffeine	DC76NZW	Biperiden	Cocaine Dependence	[5]
Biperiden + Caffeine	DCZ0DFM	Biperiden	Cocaine Related Disorders	[6]
Caffeine + Dipyridamole	DCDONMW	Dipyridamole	Cardiovascular Disease	[7]
Caffeine + Rosuvastatin	DCU31AS	Rosuvastatin	Atherosclerosis	[8]
GDC-0152 + Caffeine	DCJN7YB	GDC-0152	Amyotrophic Lateral Sclerosis	[9]
Marinol + Caffeine	DCBWWFC	Marinol	Behavioral Pharmacology of Cannabinoids	[10]
Repaglinide + Caffeine	DC71KZN	Repaglinide	Pharmacokinetics of Repaglinide	[11]
Aspirin + Caffeine	DCAMCIS	Aspirin	Migraine Disorders	[12]
Ibuprofen + Caffeine	DCDY58I	Ibuprofen	Back Pain	[13]
Ibuprofen + Caffeine	DCHMOCH	Ibuprofen	Pain, Postoperative	[14]
Caffeine + Hydrocortisone	DCTSKEV	Hydrocortisone	Post-Dural Puncture Headache	[15]
Caffeine + Diclofenac	DCGCCUJ	Diclofenac	Post-Dural Puncture Headache	[15]

References

• [1] Caffeine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 407).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT01747590) Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T
• [5] ClinicalTrials.gov (NCT00495183) Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence
• [6] ClinicalTrials.gov (NCT00495092) Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients
• [7] ClinicalTrials.gov (NCT00430170) Does Caffeine Reduce Dipyridamole-Induced Protection Against Ischemia-Reperfusion Injury?
• [8] ClinicalTrials.gov (NCT00851175) Is Augmentation of PORH by Rosuvastatin Adenosine-receptor Mediated?
• [9] ClinicalTrials.gov (NCT02655614) A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis
• [10] ClinicalTrials.gov (NCT05478863) The Pharmacodynamics of Cannabinoid-Caffeine Combinations
• [11] ClinicalTrials.gov (NCT02128321) A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Repaglinide and Caffeine
• [12] ClinicalTrials.gov (NCT02183688) Acetylsalicylic Acid (ASA) + Paracetamol + Caffeine Combination Compared With ASA + Paracetamol as Well as ASA, Paracetamol, and Caffeine in Headache Patients
• [13] ClinicalTrials.gov (NCT03003000) Ibuprofen/Caffeine Lower Back or Neck Pain Study
• [14] ClinicalTrials.gov (NCT01929031) Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain
• [15] ClinicalTrials.gov (NCT03910088) Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean