Details of the Drug Combination

General Information of Drug Combination (ID: DCAMCIS)

Drug Combination Name
Aspirin Caffeine
Indication
Disease Entry Status REF
Migraine Disorders Phase 3 [1]
Component Drugs Aspirin   DM672AH Caffeine   DMKBJWP
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Aspirin
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [2]
Adenomatous colon polyp N.A. Approved [2]
Back pain ME84.Z Approved [2]
Common cold CA00 Approved [2]
Headache 8A80-8A84 Approved [2]
Migraine disorder N.A. Approved [2]
Myocardial infarction BA41-BA43 Approved [3]
Osteoarthritis FA00-FA05 Approved [2]
Pain MG30-MG3Z Approved [4]
Cardiovascular disease BA00-BE2Z Phase 3 [4]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2/3 [5]
Colon cancer 2B90.Z Investigative [2]
Aspirin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [20]
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [3]
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Aspirin Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [21]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [22]
Sodium-dependent phosphate transport protein 1 (SLC17A1) DT8ARWJ NPT1_HUMAN Substrate [23]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [24]
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Aspirin Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [25]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Metabolism [26]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [27]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [28]
N-acetyltransferase 2 (NAT2) DER7TA0 ARY2_HUMAN Metabolism [27]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DESD26P UD16_HUMAN Metabolism [27]
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⏷ Show the Full List of 6 DME(s)
Aspirin Interacts with 513 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Affects Response To Substance [27]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Affects Response To Substance [29]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [30]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [31]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Increases ADR [32]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Increases ADR [32]
Leukotriene C4 synthase (LTC4S) OT3XNFJZ LTC4S_HUMAN Affects Response To Substance [33]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases ADR [34]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Decreases Response To Substance [35]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [36]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Decreases Expression [37]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Increases ADR [38]
Testis-expressed basic protein 1 (TSBP1) OT5GE8IO TSBP1_HUMAN Increases ADR [39]
Thromboxane A2 receptor (TBXA2R) OT9CIHQ5 TA2R_HUMAN Decreases Response To Substance [40]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Increases ADR [39]
Collagen alpha-1(XXVI) chain (COL26A1) OTMS7RNF COQA1_HUMAN Affects Response To Substance [41]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Increases ADR [42]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases ADR [17]
Laminin subunit alpha-1 (LAMA1) OTQZMP86 LAMA1_HUMAN Increases ADR [43]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5) OTUX5TWM DRB5_HUMAN Increases ADR [39]
Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3) OTBQRU82 GAL3B_HUMAN Increases Expression [8]
Anoctamin-9 (ANO9) OTQ2UM3M ANO9_HUMAN Increases Expression [8]
PH and SEC7 domain-containing protein 1 (PSD) OTUZIXUZ PSD1_HUMAN Increases Expression [8]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) OTFBU4GD P3C2A_HUMAN Decreases Expression [8]
Protocadherin-17 (PCDH17) OTRK0M05 PCD17_HUMAN Increases Expression [8]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Increases Expression [8]
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) OT4AVU95 MYPT1_HUMAN Decreases Expression [8]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Increases Expression [8]
Origin recognition complex subunit 4 (ORC4) OT3ACTST ORC4_HUMAN Increases Expression [8]
85/88 kDa calcium-independent phospholipase A2 (PLA2G6) OT5FL0WU PLPL9_HUMAN Increases Expression [8]
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) OTSQGLSB TI17B_HUMAN Increases Expression [8]
Bromodomain-containing protein 4 (BRD4) OT2Y2TCW BRD4_HUMAN Increases Expression [8]
Astrotactin-2 (ASTN2) OTF0W2FJ ASTN2_HUMAN Increases Expression [8]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Increases Expression [8]
Sperm-associated antigen 6 (SPAG6) OTVVG3Q0 SPAG6_HUMAN Increases Expression [8]
Trafficking protein particle complex subunit 6A (TRAPPC6A) OT0ZRV5C TPC6A_HUMAN Increases Expression [8]
DNA topoisomerase 3-beta-1 (TOP3B) OTNFEUOO TOP3B_HUMAN Increases Expression [8]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [8]
Salivary acidic proline-rich phosphoprotein 1/2 (PRH1) OTQZ6HX0 PRPC_HUMAN Decreases Expression [8]
Ribonuclease pancreatic (RNASE1) OTKZ7CO9 RNAS1_HUMAN Increases Expression [8]
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Increases Expression [8]
Ras-related protein Ral-B (RALB) OTFH203X RALB_HUMAN Decreases Expression [8]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [8]
Atrial natriuretic peptide receptor 1 (NPR1) OTRWART5 ANPRA_HUMAN Decreases Expression [8]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Increases Expression [8]
L-serine dehydratase/L-threonine deaminase (SDS) OT5WTJ2M SDHL_HUMAN Increases Expression [8]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Increases Expression [8]
DNA excision repair protein ERCC-5 (ERCC5) OTQAKFJM ERCC5_HUMAN Increases Expression [8]
Neuroendocrine convertase 1 (PCSK1) OTPBRJ54 NEC1_HUMAN Decreases Expression [8]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Increases Expression [8]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) OTBDF9HJ ODO2_HUMAN Decreases Expression [8]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Expression [8]
Protein phosphatase inhibitor 2 (PPP1R2) OTNLOUQR IPP2_HUMAN Decreases Expression [8]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Decreases Expression [8]
Transcription initiation factor TFIID subunit 6 (TAF6) OTY1Z9C4 TAF6_HUMAN Decreases Expression [8]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Decreases Expression [8]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Increases Expression [8]
Rho-related GTP-binding protein RhoN (RND2) OT98M6UI RND2_HUMAN Increases Expression [8]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (NDST2) OT21PY3J NDST2_HUMAN Increases Expression [8]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Decreases Expression [8]
Puromycin-sensitive aminopeptidase (NPEPPS) OTMENFXR PSA_HUMAN Decreases Expression [8]
Small ubiquitin-related modifier 3 (SUMO3) OTTUJQJ1 SUMO3_HUMAN Increases Expression [8]
Actin-related protein 3 (ACTR3) OT05LJSH ARP3_HUMAN Decreases Expression [8]
26S proteasome regulatory subunit 10B (PSMC6) OTG8997V PRS10_HUMAN Decreases Expression [8]
AP-2 complex subunit beta (AP2B1) OTL6LZJ4 AP2B1_HUMAN Decreases Expression [8]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Decreases Expression [8]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Decreases Expression [8]
Pituitary homeobox 1 (PITX1) OTA0UN4C PITX1_HUMAN Increases Expression [8]
General transcription factor II-I (GTF2I) OTUYL1TQ GTF2I_HUMAN Decreases Expression [8]
Cyclin-dependent kinase 3 (CDK3) OT2GP6RL CDK3_HUMAN Increases Expression [8]
Early growth response protein 4 (EGR4) OT4R3ECK EGR4_HUMAN Decreases Expression [8]
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) OT6OCR3H CCG1_HUMAN Decreases Expression [8]
Sodium channel subunit beta-1 (SCN1B) OTGD78J3 SCN1B_HUMAN Increases Expression [8]
V-type proton ATPase 116 kDa subunit a 3 (TCIRG1) OTU1AIEW VPP3_HUMAN Increases Expression [8]
Phosphatidylinositol-binding clathrin assembly protein (PICALM) OTQVRPMQ PICAL_HUMAN Decreases Expression [8]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) OT25JBA3 F263_HUMAN Decreases Expression [8]
TBC1 domain family member 10B (TBC1D10B) OT5MVCI5 TB10B_HUMAN Increases Expression [8]
Cyclin-J (CCNJ) OTCR4WVV CCNJ_HUMAN Increases Expression [8]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Expression [8]
DENN domain-containing protein 5A (DENND5A) OT0QNNY1 DEN5A_HUMAN Increases Expression [8]
Kinesin-like protein KIF21A (KIF21A) OT511XD9 KI21A_HUMAN Increases Expression [8]
Calcium-activated potassium channel subunit beta-4 (KCNMB4) OTYQG46B KCMB4_HUMAN Decreases Expression [8]
EF-hand calcium-binding domain-containing protein 4A (CRACR2B) OT8L843R EFC4A_HUMAN Increases Expression [8]
Tumor protein p53-inducible protein 13 (TP53I13) OTSUH9V8 P5I13_HUMAN Increases Expression [8]
Basal body-orientation factor 1 (BBOF1) OT88DXU7 BBOF1_HUMAN Increases Expression [8]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Increases Expression [8]
Transient receptor potential cation channel subfamily M member 4 (TRPM4) OT354X8E TRPM4_HUMAN Increases Expression [8]
Protocadherin Fat 3 (FAT3) OT3C6H8W FAT3_HUMAN Increases Expression [8]
Sec1 family domain-containing protein 2 (SCFD2) OTYM55ET SCFD2_HUMAN Increases Expression [8]
Calcyphosin-like protein (CAPSL) OT5RRQ8E CAPSL_HUMAN Increases Expression [8]
Selenoprotein M (SELENOM) OTJ7PORS SELM_HUMAN Increases Expression [8]
Geranylgeranyl transferase type-2 subunit alpha (RABGGTA) OTYMG99C PGTA_HUMAN Increases Expression [8]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Increases Expression [8]
Ribonuclease K6 (RNASE6) OTJIK1RY RNAS6_HUMAN Increases Expression [8]
CAP-Gly domain-containing linker protein 3 (CLIP3) OTGJEGIB CLIP3_HUMAN Increases Expression [8]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Increases Expression [8]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Increases Expression [8]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (ACAP3) OTOE9OYV ACAP3_HUMAN Increases Expression [8]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [8]
Translin-associated protein X (TSNAX) OTZ9SGWB TSNAX_HUMAN Increases Expression [8]
C-C motif chemokine 19 (CCL19) OTQ2UJMH CCL19_HUMAN Increases Expression [8]
Copine-1 (CPNE1) OTH5YKSL CPNE1_HUMAN Increases Expression [8]
Allograft inflammatory factor 1-like (AIF1L) OTDEOB80 AIF1L_HUMAN Increases Expression [8]
Glucose-6-phosphatase 3 (G6PC3) OTH7BWNL G6PC3_HUMAN Increases Expression [8]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Increases Expression [8]
Transmembrane emp24 domain-containing protein 9 (TMED9) OTYGAQS0 TMED9_HUMAN Increases Expression [8]
Intraflagellar transport protein 27 homolog (IFT27) OT3NY6O6 IFT27_HUMAN Increases Expression [8]
Cyclin-dependent kinase 19 (CDK19) OTVMM0CP CDK19_HUMAN Increases Expression [8]
E3 ubiquitin-protein ligase RNF26 (RNF26) OTPXA60S RNF26_HUMAN Increases Expression [8]
tRNA dimethylallyltransferase (TRIT1) OTCU9FS5 MOD5_HUMAN Increases Expression [8]
T-lymphocyte surface antigen Ly-9 (LY9) OT1PKGDI LY9_HUMAN Increases Expression [8]
Striatin-4 (STRN4) OTHK2ZN6 STRN4_HUMAN Increases Expression [8]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [8]
ATP-dependent RNA helicase DDX18 (DDX18) OTKB9C3S DDX18_HUMAN Decreases Expression [8]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Decreases Expression [8]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [8]
Tropomodulin-4 (TMOD4) OTXLGJ4R TMOD4_HUMAN Increases Expression [8]
SUN domain-containing protein 2 (SUN2) OT2IQJUC SUN2_HUMAN Increases Expression [8]
TNF receptor-associated factor 6 (TRAF6) OTA5GO5K TRAF6_HUMAN Increases Expression [8]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [30]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [30]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [30]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Degradation [44]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases Phosphorylation [44]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Increases Expression [36]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [36]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [36]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [36]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases Expression [36]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [36]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Decreases Expression [36]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [36]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Decreases Expression [36]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [36]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Decreases Expression [36]
Prohibitin 1 (PHB1) OTZNXYS2 PHB1_HUMAN Decreases Expression [36]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [36]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [36]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Increases Expression [36]
Small ribosomal subunit protein uS9 (RPS16) OTVGZOB5 RS16_HUMAN Increases Expression [36]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Increases Expression [36]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Increases Expression [36]
Glutathione S-transferase omega-1 (GSTO1) OTUJ93MN GSTO1_HUMAN Decreases Expression [36]
Bleomycin hydrolase (BLMH) OT2QPWQJ BLMH_HUMAN Decreases Expression [36]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Increases Expression [36]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [36]
Charged multivesicular body protein 1a (CHMP1A) OTVQ5UWX CHM1A_HUMAN Decreases Expression [36]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) OTB3BFCV HNRDL_HUMAN Decreases Expression [9]
Nucleoside diphosphate kinase 6 (NME6) OTJNKOFA NDK6_HUMAN Increases Expression [9]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Expression [9]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Decreases Expression [9]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Increases Expression [9]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [9]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [9]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [9]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Increases Expression [9]
Platelet endothelial cell adhesion molecule (PECAM1) OTXOM4D9 PECA1_HUMAN Decreases Expression [9]
Tyrosine-protein kinase Fer (FER) OT9JR7AE FER_HUMAN Decreases Expression [9]
Pulmonary surfactant-associated protein D (SFTPD) OTNKPDJC SFTPD_HUMAN Increases Expression [9]
Small ribosomal subunit protein eS19 (RPS19) OTBKGP48 RS19_HUMAN Increases Expression [9]
Cell surface glycoprotein MUC18 (MCAM) OTT8XKGE MUC18_HUMAN Increases Expression [9]
RNA-binding protein FXR2 (FXR2) OTQX7ATF FXR2_HUMAN Decreases Expression [9]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Increases Expression [9]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Increases Expression [9]
Hemoglobin subunit gamma-2 (HBG2) OT4J48JJ HBG2_HUMAN Increases Expression [9]
Butyrophilin subfamily 3 member A2 (BTN3A2) OT3DIBU3 BT3A2_HUMAN Decreases Expression [9]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Decreases Expression [9]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Increases Expression [9]
Histone deacetylase 1 (HDAC1) OTQDNOXZ HDAC1_HUMAN Increases Expression [9]
Ras GTPase-activating-like protein IQGAP2 (IQGAP2) OTX2UA7P IQGA2_HUMAN Increases Expression [9]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Decreases Expression [9]
MOB kinase activator 2 (MOB2) OTMBE0NS MOB2_HUMAN Increases Expression [9]
Centromere protein S (CENPS) OTZ4J391 CENPS_HUMAN Increases Expression [9]
LIM domain only protein 7 (LMO7) OTDLY6TC LMO7_HUMAN Increases Expression [9]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Decreases Expression [9]
N-alpha-acetyltransferase 38, NatC auxiliary subunit (NAA38) OTI8VWK3 LSMD1_HUMAN Increases Expression [9]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Decreases Expression [9]
Translocon-associated protein subunit gamma (SSR3) OTJQP0IZ SSRG_HUMAN Increases Expression [9]
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) OTYOTM2B NUBP2_HUMAN Decreases Expression [9]
Pseudouridylate synthase 1 homolog (PUS1) OTS2DQ0N PUS1_HUMAN Increases Expression [9]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [10]
Importin subunit alpha-4 (KPNA3) OTLI3TM2 IMA4_HUMAN Increases Expression [10]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [10]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [10]
E3 ubiquitin-protein ligase SIAH2 (SIAH2) OTKED2XN SIAH2_HUMAN Decreases Expression [10]
Tumor protein D54 (TPD52L2) OTTOG0NK TPD54_HUMAN Decreases Expression [10]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [10]
GDNF family receptor alpha-3 (GFRA3) OT07XAZF GFRA3_HUMAN Increases Expression [10]
Tetraspanin-3 (TSPAN3) OT7WS6ZI TSN3_HUMAN Decreases Expression [10]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Decreases Expression [10]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Increases Expression [10]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Increases Expression [10]
Gamma-aminobutyric acid receptor-associated protein (GABARAP) OTAQUX6E GBRAP_HUMAN Decreases Expression [10]
Histone acetyltransferase KAT7 (KAT7) OTUN98IC KAT7_HUMAN Decreases Expression [10]
STAM-binding protein (STAMBP) OTOT2OXM STABP_HUMAN Increases Expression [10]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Decreases Expression [10]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [10]
T-cell surface glycoprotein CD8 alpha chain (CD8A) OTDWQJXK CD8A_HUMAN Decreases Expression [10]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Decreases Expression [10]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [10]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Decreases Expression [10]
Argininosuccinate lyase (ASL) OTI2NGQR ARLY_HUMAN Decreases Expression [10]
Calpain small subunit 1 (CAPNS1) OT95EBBD CPNS1_HUMAN Decreases Expression [10]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) OTEG4KU9 RPN1_HUMAN Decreases Expression [10]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Decreases Expression [10]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [10]
Adenine phosphoribosyltransferase (APRT) OT5ZUKVF APT_HUMAN Decreases Expression [10]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Expression [10]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [10]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Expression [10]
Integrin alpha-5 (ITGA5) OT3RCI67 ITA5_HUMAN Decreases Expression [10]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Decreases Expression [10]
Furin (FURIN) OTM2665Z FURIN_HUMAN Decreases Expression [10]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [10]
Interferon regulatory factor 1 (IRF1) OT43DI6J IRF1_HUMAN Increases Expression [10]
Cation-independent mannose-6-phosphate receptor (IGF2R) OTDXPQVX MPRI_HUMAN Increases Expression [10]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Decreases Expression [10]
Hematopoietic lineage cell-specific protein (HCLS1) OTX7WGYN HCLS1_HUMAN Decreases Expression [10]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [10]
Interleukin-2 receptor subunit beta (IL2RB) OT6M0F70 IL2RB_HUMAN Increases Expression [10]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Decreases Expression [10]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Decreases Expression [10]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [10]
Calpain-2 catalytic subunit (CAPN2) OTIAPE5J CAN2_HUMAN Increases Expression [10]
Probable ATP-dependent RNA helicase DDX5 (DDX5) OTLS124U DDX5_HUMAN Increases Expression [10]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Decreases Expression [10]
E3 ubiquitin-protein ligase TRIM21 (TRIM21) OTA4UJCF RO52_HUMAN Decreases Expression [10]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Decreases Expression [10]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) OTXF0B09 IF2B_HUMAN Increases Expression [10]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [10]
fMet-Leu-Phe receptor (FPR1) OTFF9I6W FPR1_HUMAN Decreases Expression [10]
Granulysin (GNLY) OTZJKA8C GNLY_HUMAN Decreases Expression [10]
Peptidyl-prolyl cis-trans isomerase B (PPIB) OTLPH6KN PPIB_HUMAN Decreases Expression [10]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Decreases Expression [10]
T-cell differentiation antigen CD6 (CD6) OTOS044E CD6_HUMAN Decreases Expression [10]
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) OTBZBL9Y FCERG_HUMAN Decreases Expression [10]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Decreases Expression [10]
Cytokine receptor common subunit gamma (IL2RG) OTRZ3OMY IL2RG_HUMAN Decreases Expression [10]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Decreases Expression [10]
Intercellular adhesion molecule 3 (ICAM3) OTTZ5A5D ICAM3_HUMAN Decreases Expression [10]
Protein EVI2B (EVI2B) OT98X1OE EVI2B_HUMAN Increases Expression [10]
Protein DEK (DEK) OTYCJ5H6 DEK_HUMAN Increases Expression [10]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Expression [10]
F-actin-capping protein subunit alpha-2 (CAPZA2) OTHAO4V2 CAZA2_HUMAN Increases Expression [10]
Prolyl endopeptidase (PREP) OTSJZBB5 PPCE_HUMAN Decreases Expression [10]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Decreases Expression [10]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [10]
Dual specificity protein kinase CLK2 (CLK2) OT1CRSY2 CLK2_HUMAN Decreases Expression [10]
Dual specificity protein kinase CLK3 (CLK3) OT74DJ3J CLK3_HUMAN Decreases Expression [10]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Decreases Expression [10]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Decreases Expression [10]
Hepatoma-derived growth factor (HDGF) OT16PTBC HDGF_HUMAN Decreases Expression [10]
F-actin-capping protein subunit alpha-1 (CAPZA1) OTAXA66U CAZA1_HUMAN Increases Expression [10]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Decreases Expression [10]
Protein SEC13 homolog (SEC13) OTSR4WWM SEC13_HUMAN Decreases Expression [10]
cAMP-regulated phosphoprotein 19 (ARPP19) OTZS3IT6 ARP19_HUMAN Increases Expression [10]
ATP synthase subunit epsilon, mitochondrial (ATP5F1E) OTMPLAIS ATP5E_HUMAN Increases Expression [10]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Increases Expression [10]
Serine/threonine-protein phosphatase 4 catalytic subunit (PPP4C) OT4B0TNV PP4C_HUMAN Decreases Expression [10]
V-type proton ATPase subunit d 1 (ATP6V0D1) OT9GU2NW VA0D1_HUMAN Decreases Expression [10]
Protein BTG1 (BTG1) OTVJ2CDM BTG1_HUMAN Increases Expression [10]
Thymosin beta-4 (TMSB4X) OT9HPLP3 TYB4_HUMAN Increases Expression [10]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [10]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) OTIIGGZ2 RS27A_HUMAN Increases Expression [10]
Transformer-2 protein homolog beta (TRA2B) OTZYQW52 TRA2B_HUMAN Increases Expression [10]
Rho-related GTP-binding protein RhoG (RHOG) OTJ7J1WA RHOG_HUMAN Decreases Expression [10]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) OTLQN1E2 HNRPU_HUMAN Increases Expression [10]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Decreases Expression [10]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Expression [10]
Killer cell lectin-like receptor subfamily B member 1 (KLRB1) OTQ2959Y KLRB1_HUMAN Increases Expression [10]
Protein flightless-1 homolog (FLII) OT7G9JG6 FLII_HUMAN Decreases Expression [10]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) OT6T408U MP2K5_HUMAN Decreases Expression [10]
Integrin-linked protein kinase (ILK) OTYG2FD1 ILK_HUMAN Decreases Expression [10]
Peptidyl-prolyl cis-trans isomerase G (PPIG) OTZ8BTTM PPIG_HUMAN Increases Expression [10]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [10]
Flotillin-2 (FLOT2) OTZ0QR5L FLOT2_HUMAN Decreases Expression [10]
Protein tyrosine phosphatase receptor type C-associated protein (PTPRCAP) OT2YERNV PTCA_HUMAN Decreases Expression [10]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Decreases Expression [10]
Homeobox protein TGIF1 (TGIF1) OTN9VHAG TGIF1_HUMAN Decreases Expression [10]
Myeloid leukemia factor 2 (MLF2) OTU3B4WU MLF2_HUMAN Decreases Expression [10]
Hsp90 co-chaperone Cdc37 (CDC37) OTYDT4A7 CDC37_HUMAN Decreases Expression [10]
Proprotein convertase subtilisin/kexin type 7 (PCSK7) OTVR1K2Y PCSK7_HUMAN Decreases Expression [10]
Protein NKG7 (NKG7) OTXDD006 NKG7_HUMAN Decreases Expression [10]
MAP kinase-activated protein kinase 3 (MAPKAPK3) OT7IWJNI MAPK3_HUMAN Decreases Expression [10]
Guanylate kinase (GUK1) OTLI0HRU KGUA_HUMAN Decreases Expression [10]
All-trans retinoic acid-induced differentiation factor (ATRAID) OTOHZG1O ARAID_HUMAN Decreases Expression [10]
eIF5-mimic protein 2 (BZW1) OT4GUFIG 5MP2_HUMAN Increases Expression [10]
F-box only protein 11 (FBXO11) OTGWF3Q2 FBX11_HUMAN Increases Expression [10]
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2) OT1O2K47 LIRA2_HUMAN Decreases Expression [10]
Protein odd-skipped-related 1 (OSR1) OTB19LEQ OSR1_HUMAN Increases Expression [10]
Pumilio homolog 2 (PUM2) OT2H7NXV PUM2_HUMAN Increases Expression [10]
PEST proteolytic signal-containing nuclear protein (PCNP) OTJUQ122 PCNP_HUMAN Increases Expression [10]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Decreases Expression [10]
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1) OTS8G0EN BAP1_HUMAN Decreases Expression [10]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [10]
Protein TFG (TFG) OT2KJENI TFG_HUMAN Increases Expression [10]
Ninjurin-1 (NINJ1) OTLRZ1EU NINJ1_HUMAN Decreases Expression [10]
Erbin (ERBIN) OTNWTUA8 ERBIN_HUMAN Increases Expression [10]
Granulocyte colony-stimulating factor receptor (CSF3R) OTXRAY6X CSF3R_HUMAN Decreases Expression [10]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) OT8GTI1V VATO_HUMAN Decreases Expression [10]
ETS-related transcription factor Elf-4 (ELF4) OT167PR5 ELF4_HUMAN Decreases Expression [10]
Prohibitin-2 (PHB2) OTCAX3AW PHB2_HUMAN Decreases Expression [10]
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) OTJP4U7K HNRL1_HUMAN Decreases Expression [10]
Programmed cell death protein 10 (PDCD10) OTCHJTSF PDC10_HUMAN Increases Expression [10]
GTP-binding protein 2 (GTPBP2) OTOJ1KUA GTPB2_HUMAN Decreases Expression [10]
NF-kappa-B inhibitor zeta (NFKBIZ) OTU728KS IKBZ_HUMAN Increases Expression [10]
Large ribosomal subunit protein mL46 (MRPL46) OTMQ2A0Q RM46_HUMAN Increases Expression [10]
Growth hormone-inducible transmembrane protein (GHITM) OTBPNIC0 GHITM_HUMAN Increases Expression [10]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [10]
Mediator of RNA polymerase II transcription subunit 4 (MED4) OTALFN4S MED4_HUMAN Increases Expression [10]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Decreases Expression [10]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Increases Expression [10]
Phosphatidylinositol 4-kinase beta (PI4KB) OTI9UQSU PI4KB_HUMAN Decreases Expression [10]
Peflin (PEF1) OTY24CUW PEF1_HUMAN Decreases Expression [10]
Lysine-specific demethylase 5B (KDM5B) OT5DL94T KDM5B_HUMAN Decreases Expression [10]
Tyrosine-protein kinase BAZ1B (BAZ1B) OTD5KR2J BAZ1B_HUMAN Decreases Expression [10]
F-box/LRR-repeat protein 3 (FBXL3) OTDQ1QKV FBXL3_HUMAN Increases Expression [10]
Apoptotic chromatin condensation inducer in the nucleus (ACIN1) OTK81F92 ACINU_HUMAN Decreases Expression [10]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [10]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Increases Expression [45]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [46]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [47]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Increases Expression [48]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Increases Expression [48]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [48]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Activity [49]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Decreases Activity [49]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Decreases Activity [49]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Activity [50]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [51]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [52]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Increases Expression [52]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [52]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Activity [53]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [54]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [55]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Increases Expression [31]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Increases Expression [31]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [52]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [56]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [57]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Expression [52]
Ornithine transcarbamylase, mitochondrial (OTC) OTJ57GGA OTC_HUMAN Decreases Expression [58]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Cleavage [59]
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Activity [60]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Affects Activity [61]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [62]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [52]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Decreases Expression [63]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [54]
Fibrinogen alpha chain (FGA) OTMIHY80 FIBA_HUMAN Decreases Secretion [64]
Fibrinogen beta chain (FGB) OT6RKLI9 FIBB_HUMAN Decreases Secretion [64]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Secretion [64]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [52]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [65]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Acetylation [66]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [67]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [14]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [68]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Affects Expression [69]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [70]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [71]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [72]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Secretion [62]
Apolipoprotein(a) (LPA) OTRZLU9F APOA_HUMAN Decreases Expression [73]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Increases Expression [54]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [74]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [75]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [53]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) OTA4P0FC ACADM_HUMAN Increases Expression [76]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Activity [77]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [52]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [52]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Affects Methylation [78]
Xaa-Pro dipeptidase (PEPD) OT3LFY7S PEPD_HUMAN Increases Activity [79]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Decreases Expression [80]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Decreases Expression [81]
Sucrase-isomaltase, intestinal (SI) OTUP724T SUIS_HUMAN Increases Activity [63]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Decreases Expression [52]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Decreases Expression [82]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Decreases Activity [83]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [84]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [85]
P-selectin (SELP) OTWR90PK LYAM3_HUMAN Decreases Expression [86]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Decreases Expression [86]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [52]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Increases Expression [54]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [87]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [11]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [52]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [52]
N-formyl peptide receptor 2 (FPR2) OTEZ2THZ FPR2_HUMAN Increases Expression [88]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Decreases Expression [86]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [52]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [52]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [52]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Expression [89]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Expression [52]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Expression [89]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [86]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [52]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Expression [52]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Increases Expression [31]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Localization [84]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [90]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [51]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [52]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [52]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Decreases Expression [14]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [91]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Decreases Expression [37]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Activity [92]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [76]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [93]
C-C chemokine receptor type 3 (CCR3) OT6GBUFA CCR3_HUMAN Increases Expression [94]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Decreases Expression [11]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [95]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [91]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [96]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [85]
Dermcidin (DCD) OTV5PBGJ DCD_HUMAN Decreases Secretion [64]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [54]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [97]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Decreases Expression [52]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [52]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Increases Expression [52]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Affects Activity [98]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [99]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Increases Expression [100]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Localization [101]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Cleavage [75]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [52]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [102]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [56]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Increases Expression [51]
Peroxisomal bifunctional enzyme (EHHADH) OTBAAHL5 ECHP_HUMAN Decreases Expression [95]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [54]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Expression [76]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Expression [76]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Expression [52]
Serine/threonine-protein kinase ATR (ATR) OTH0OP1J ATR_HUMAN Decreases Expression [11]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Expression [52]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [103]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Decreases Expression [57]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [52]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Increases Expression [52]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [56]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [56]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Decreases Expression [96]
Gastrokine-1 (GKN1) OT7ZYFQ9 GKN1_HUMAN Affects Expression [104]
Mammalian ependymin-related protein 1 (EPDR1) OT5JW5RB EPDR1_HUMAN Decreases Expression [52]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [54]
Cysteinyl leukotriene receptor 1 (CYSLTR1) OT904HBN CLTR1_HUMAN Increases Expression [105]
Kinesin-like protein KIF3A (KIF3A) OTMUBSSK KIF3A_HUMAN Increases Expression [106]
Angiopoietin-related protein 3 (ANGPTL3) OTCD5Z9W ANGL3_HUMAN Decreases Expression [95]
Interleukin-1 receptor type 2 (IL1R2) OT0G7E35 IL1R2_HUMAN Affects Response To Substance [107]
Prostaglandin E2 receptor EP2 subtype (PTGER2) OT1AUZAA PE2R2_HUMAN Affects Response To Substance [108]
Voltage-dependent calcium channel gamma-6 subunit (CACNG6) OT2PC1E1 CCG6_HUMAN Affects Response To Substance [109]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Increases ADR [110]
T-box transcription factor TBX21 (TBX21) OT3UK5KE TBX21_HUMAN Affects Response To Substance [111]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Affects Response To Substance [33]
Platelet glycoprotein VI (GP6) OT4IE8DV GPVI_HUMAN Decreases Response To Substance [112]
Platelet glycoprotein Ib alpha chain (GP1BA) OT62PSOB GP1BA_HUMAN Increases Response To Substance [113]
Toll-like receptor 3 (TLR3) OT8QPYXZ TLR3_HUMAN Affects Response To Substance [114]
Indoleamine 2,3-dioxygenase 1 (IDO1) OT91DBN7 I23O1_HUMAN Affects Response To Substance [107]
Histamine N-methyltransferase (HNMT) OT9F303M HNMT_HUMAN Affects Response To Substance [33]
Pikachurin (EGFLAM) OTACZZJ0 EGFLA_HUMAN Increases ADR [43]
Regulator of G-protein signaling 7-binding protein (RGS7BP) OTAGSWMH R7BP_HUMAN Affects Response To Substance [115]
Thromboxane-A synthase (TBXAS1) OTAXZJJ4 THAS_HUMAN Affects Response To Substance [116]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Affects Response To Substance [117]
Serine/threonine-protein kinase 10 (STK10) OTC33Y2F STK10_HUMAN Affects Response To Substance [118]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Hydrolysis [119]
Prostaglandin D2 receptor 2 (PTGDR2) OTCSMVF1 PD2R2_HUMAN Affects Response To Substance [33]
Angiotensin-converting enzyme (ACE) OTDF1964 ACE_HUMAN Affects Response To Substance [120]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Affects Response To Substance [121]
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Affects Response To Substance [122]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Metabolism [123]
Bis(5'-adenosyl)-triphosphatase (FHIT) OTGWBSLA FHIT_HUMAN Increases ADR [43]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Response To Substance [112]
Adenosine receptor A3 (ADORA3) OTHO1BLK AA3R_HUMAN Affects Response To Substance [124]
Interleukin-13 (IL13) OTI4YS3Y IL13_HUMAN Affects Response To Substance [125]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Affects Response To Substance [126]
Leucine-rich melanocyte differentiation-associated protein (LRMDA) OTIPNKTU LRMDA_HUMAN Increases ADR [34]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Response To Substance [127]
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) OTIRUOHF FCERA_HUMAN Affects Response To Substance [33]
Sodium- and chloride-dependent betaine transporter (SLC6A12) OTKOR4F2 S6A12_HUMAN Affects Response To Substance [128]
High affinity immunoglobulin epsilon receptor subunit beta (MS4A2) OTMCAS2D FCERB_HUMAN Affects Response To Substance [129]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Affects Response To Substance [16]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases ADR [17]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Decreases Response To Substance [130]
Stromal membrane-associated protein 2 (SMAP2) OTPGVRKO SMAP2_HUMAN Affects Response To Substance [131]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Affects Response To Substance [132]
Prostaglandin E synthase 3 (PTGES3) OTPPQWI0 TEBP_HUMAN Increases ADR [17]
Glutamate receptor ionotropic, kainate 2 (GRIK2) OTQ41U3D GRIK2_HUMAN Increases ADR [110]
Inosine triphosphate pyrophosphatase (ITPA) OTQ47WVR ITPA_HUMAN Increases ADR [133]
Prostaglandin E2 receptor EP3 subtype (PTGER3) OTQODQUN PE2R3_HUMAN Affects Response To Substance [134]
P2Y purinoceptor 1 (P2RY1) OTR2KQ6Q P2RY1_HUMAN Decreases Response To Substance [135]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Affects Response To Substance [33]
Cysteinyl leukotriene receptor 2 (CYSLTR2) OTRNEOZ0 CLTR2_HUMAN Affects Response To Substance [33]
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33) OTRZVI77 ADA33_HUMAN Affects Response To Substance [136]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [137]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Affects Response To Substance [138]
Lymphotoxin-alpha (LTA) OTUC3S76 TNFB_HUMAN Affects Response To Substance [139]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Affects Response To Substance [126]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases ADR [140]
Antigen peptide transporter 2 (TAP2) OTWSYFI7 TAP2_HUMAN Affects Response To Substance [141]
Prostacyclin receptor (PTGIR) OTWTABYM PI2R_HUMAN Affects Response To Substance [33]
Interleukin-17A (IL17A) OTY72FT2 IL17_HUMAN Affects Response To Substance [125]
Fibrous sheath-interacting protein 1 (FSIP1) OTYLL6GM FSIP1_HUMAN Affects Response To Substance [142]
Galectin-10 (CLC) OTYMYR85 LEG10_HUMAN Affects Response To Substance [143]
Centrosomal protein of 68 kDa (CEP68) OTZDM4J1 CEP68_HUMAN Affects Response To Substance [144]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Increases ADR [145]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Affects Response To Substance [146]
------------------------------------------------------------------------------------
⏷ Show the Full List of 513 DOT(s)
Indication(s) of Caffeine
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [6]
Back pain ME84.Z Approved [6]
Cluster headache 8A81.0 Approved [6]
Common cold CA00 Approved [6]
Dysmenorrhea GA34.3 Approved [6]
Headache 8A80-8A84 Approved [6]
Migraine disorder N.A. Approved [6]
Orthostatic hypotension BA21 Approved [7]
Pain MG30-MG3Z Approved [6]
Caffeine Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adenosine A2a receptor (ADORA2A) TTM2AOE AA2AR_HUMAN Antagonist [147]
Adenosine A1 receptor (ADORA1) TTK25J1 AA1R_HUMAN Antagonist [147]
------------------------------------------------------------------------------------
Caffeine Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [148]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [149]
RNA cytidine acetyltransferase (hALP) DEZV4AP NAT10_HUMAN Metabolism [150]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [151]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [152]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [153]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [154]
Cytochrome P450 1B1 (CYP1B1) DE9QHP6 CP1B1_HUMAN Metabolism [155]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 DME(s)
Caffeine Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases ADR [156]
Metallothionein-1A (MT1A) OTKBH52X MT1A_HUMAN Increases ADR [17]
------------------------------------------------------------------------------------

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