Details of the Drug Combination

General Information of Drug Combination (ID: DCGCCUJ)

Drug Combination Name
Caffeine Diclofenac
Indication
Disease Entry Status REF
Post-Dural Puncture Headache Phase 4 [1]
Component Drugs Caffeine   DMKBJWP Diclofenac   DMPIHLS
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Caffeine
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [2]
Back pain ME84.Z Approved [2]
Cluster headache 8A81.0 Approved [2]
Common cold CA00 Approved [2]
Dysmenorrhea GA34.3 Approved [2]
Headache 8A80-8A84 Approved [2]
Migraine disorder N.A. Approved [2]
Orthostatic hypotension BA21 Approved [3]
Pain MG30-MG3Z Approved [2]
Caffeine Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adenosine A2a receptor (ADORA2A) TTM2AOE AA2AR_HUMAN Antagonist [6]
Adenosine A1 receptor (ADORA1) TTK25J1 AA1R_HUMAN Antagonist [6]
------------------------------------------------------------------------------------
Caffeine Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [7]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [8]
RNA cytidine acetyltransferase (hALP) DEZV4AP NAT10_HUMAN Metabolism [9]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [10]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [11]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [12]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [13]
Cytochrome P450 1B1 (CYP1B1) DE9QHP6 CP1B1_HUMAN Metabolism [14]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 DME(s)
Caffeine Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases ADR [15]
Metallothionein-1A (MT1A) OTKBH52X MT1A_HUMAN Increases ADR [16]
------------------------------------------------------------------------------------
Indication(s) of Diclofenac
Disease Entry ICD 11 Status REF
Chronic renal failure GB61.Z Approved [4]
Dysmenorrhea GA34.3 Approved [4]
Knee osteoarthritis FA01 Approved [4]
Osteoarthritis FA00-FA05 Approved [5]
Pain MG30-MG3Z Approved [4]
Diclofenac Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Modulator [27]
------------------------------------------------------------------------------------
Diclofenac Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [28]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [29]
------------------------------------------------------------------------------------
Diclofenac Interacts with 14 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [30]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [31]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Metabolism [32]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Metabolism [32]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [33]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [34]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [35]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [32]
Cholesterol 24-hydroxylase (CYP46A1) DEKP5HX CP46A_HUMAN Metabolism [36]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [8]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [25]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Metabolism [25]
Cytochrome P450 102A1 (cyp102) DE4OGUF CPXB_BACMB Metabolism [37]
Cytochrome P450 105D7 (cyp105) DECV2ME CYP28_STRAW Metabolism [38]
------------------------------------------------------------------------------------
⏷ Show the Full List of 14 DME(s)
Diclofenac Interacts with 470 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [21]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [39]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Expression [39]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Hydroxylation [40]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases Hydroxylation [41]
Cholesterol 24-hydroxylase (CYP46A1) OTJ27FOX CP46A_HUMAN Increases Hydroxylation [36]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Activity [42]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Decreases Activity [43]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [43]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [43]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [43]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [43]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Activity [44]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [20]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Expression [21]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [21]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Expression [21]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [21]
Albumin (ALB) OTVMM513 ALBU_HUMAN Increases Expression [21]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [21]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Decreases Expression [21]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Increases Expression [21]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [21]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Decreases Expression [21]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Increases Expression [21]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [21]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [21]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [21]
Adenosine kinase (ADK) OTXR6VDI ADK_HUMAN Increases Expression [21]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Affects Expression [21]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [21]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [22]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Decreases Expression [22]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Decreases Expression [22]
Antiviral innate immune response receptor RIG-I (RIGI) OTFIIC43 RIGI_HUMAN Decreases Expression [22]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [22]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Decreases Expression [22]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [22]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [22]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Expression [22]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Increases Expression [22]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [22]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Decreases Expression [22]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [22]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Expression [22]
Guanylate-binding protein 1 (GBP1) OTUM7RPJ GBP1_HUMAN Decreases Expression [22]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [22]
Macrophage metalloelastase (MMP12) OT9Z7LHM MMP12_HUMAN Decreases Expression [22]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Decreases Expression [22]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [22]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [22]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [22]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Decreases Expression [22]
Signal transducer and activator of transcription 4 (STAT4) OTAK3VFR STAT4_HUMAN Decreases Expression [22]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Decreases Expression [22]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Decreases Expression [22]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Decreases Expression [22]
Olfactomedin-like protein 2B (OLFML2B) OTDNJFR4 OLM2B_HUMAN Increases Expression [22]
E3 ubiquitin-protein ligase RNF19B (RNF19B) OTYCWKBP RN19B_HUMAN Decreases Expression [22]
Probable E3 ubiquitin-protein ligase HERC6 (HERC6) OT7G9PQE HERC6_HUMAN Decreases Expression [22]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Decreases Expression [22]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) OTCA9WCM RSAD2_HUMAN Decreases Expression [22]
Interferon regulatory factor 7 (IRF7) OTC1A2PQ IRF7_HUMAN Decreases Expression [22]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Decreases Expression [22]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Increases Expression [22]
Interferon-induced helicase C domain-containing protein 1 (IFIH1) OTZA2AHA IFIH1_HUMAN Decreases Expression [22]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [22]
Large neutral amino acids transporter small subunit 2 (SLC7A8) OT8XXVO8 LAT2_HUMAN Increases Expression [22]
E3 ISG15--protein ligase HERC5 (HERC5) OTZ5PR39 HERC5_HUMAN Decreases Expression [22]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [22]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [45]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Decreases Activity [46]
Glutathione S-transferase A4 (GSTA4) OTZ1USIA GSTA4_HUMAN Decreases Activity [47]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Decreases Activity [47]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Affects Activity [47]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Decreases Activity [47]
Glutathione S-transferase Mu 2 (GSTM2) OTG4WT05 GSTM2_HUMAN Decreases Activity [47]
Glutathione S-transferase Mu 4 (GSTM4) OTOTF8DU GSTM4_HUMAN Affects Activity [47]
Glutathione S-transferase A3 (GSTA3) OTJ3REE3 GSTA3_HUMAN Decreases Activity [47]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Decreases Activity [48]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Affects Expression [24]
DNA fragmentation factor subunit alpha (DFFA) OTFPFMT8 DFFA_HUMAN Affects Expression [24]
Cell division cycle 7-related protein kinase (CDC7) OT5133XY CDC7_HUMAN Affects Expression [24]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Affects Expression [24]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) OTFBU4GD P3C2A_HUMAN Affects Expression [24]
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) OTZSUQK5 P85B_HUMAN Affects Expression [24]
Suppressor of cytokine signaling 7 (SOCS7) OT503VJG SOCS7_HUMAN Affects Expression [24]
Suppressor of cytokine signaling 6 (SOCS6) OT2O5ZBK SOCS6_HUMAN Affects Expression [24]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Affects Expression [24]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Affects Expression [24]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Affects Expression [24]
Guanine nucleotide-binding protein subunit beta-5 (GNB5) OT3ZSAXH GNB5_HUMAN Affects Expression [24]
DNA-directed RNA polymerase III subunit RPC1 (POLR3A) OT5MSK10 RPC1_HUMAN Affects Expression [24]
Ras-related protein M-Ras (MRAS) OTNCVCQW RASM_HUMAN Affects Expression [24]
Transcription regulator protein BACH1 (BACH1) OTY8004K BACH1_HUMAN Affects Expression [24]
Histone acetyltransferase type B catalytic subunit (HAT1) OT307KEN HAT1_HUMAN Affects Expression [24]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [49]
Antizyme inhibitor 1 (AZIN1) OTX5W77I AZIN1_HUMAN Affects Expression [24]
Mitogen-activated protein kinase 13 (MAPK13) OT0W9GE7 MK13_HUMAN Affects Expression [24]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Affects Expression [24]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [50]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Affects Expression [24]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) OTP45YKX P4HA2_HUMAN Increases Expression [51]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Affects Expression [24]
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Affects Expression [24]
Adenylate cyclase type 6 (ADCY6) OTFOY4WW ADCY6_HUMAN Affects Expression [24]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) OTZCRXLJ IF4G3_HUMAN Affects Expression [24]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Affects Expression [24]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Affects Expression [24]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Affects Expression [24]
Integral membrane protein 2A (ITM2A) OT590V63 ITM2A_HUMAN Increases Expression [51]
Mediator of RNA polymerase II transcription subunit 14 (MED14) OTMD20XN MED14_HUMAN Affects Expression [24]
RNA helicase aquarius (AQR) OTMNDXM1 AQR_HUMAN Affects Expression [24]
Frizzled-6 (FZD6) OTBCPII8 FZD6_HUMAN Affects Expression [24]
Adenylate cyclase type 9 (ADCY9) OT1IZT5K ADCY9_HUMAN Affects Expression [24]
DNA polymerase zeta catalytic subunit (REV3L) OT0OP8EJ REV3L_HUMAN Affects Expression [24]
DnaJ homolog subfamily A member 2 (DNAJA2) OTKF1VBT DNJA2_HUMAN Affects Expression [24]
Auxilin (DNAJC6) OT1P6ZIE AUXI_HUMAN Affects Expression [24]
Frizzled-7 (FZD7) OTTK3F6E FZD7_HUMAN Affects Expression [24]
Rho-associated protein kinase 2 (ROCK2) OTVYN14T ROCK2_HUMAN Affects Expression [24]
DnaJ homolog subfamily B member 6 (DNAJB6) OTMHIIAN DNJB6_HUMAN Affects Expression [24]
Nucleoside diphosphate phosphatase ENTPD5 (ENTPD5) OTFH05B9 ENTP5_HUMAN Affects Expression [24]
DNA polymerase theta (POLQ) OTBHK0E6 DPOLQ_HUMAN Affects Expression [24]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Affects Expression [24]
Mediator of RNA polymerase II transcription subunit 6 (MED6) OT4GF4RM MED6_HUMAN Affects Expression [24]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 8 (DNAJC8) OTBE4I4X DNJC8_HUMAN Affects Expression [24]
Serine/threonine-protein kinase D3 (PRKD3) OT987HJI KPCD3_HUMAN Affects Expression [24]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Affects Expression [24]
Epsin-2 (EPN2) OTH5BHUN EPN2_HUMAN Affects Expression [24]
Neuroendocrine secretory protein 55 (GNAS) OTMH8BKJ GNAS3_HUMAN Affects Expression [24]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Affects Expression [24]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Expression [24]
Formimidoyltransferase-cyclodeaminase (FTCD) OTX9HZT5 FTCD_HUMAN Affects Expression [24]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Affects Expression [24]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Affects Expression [24]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [52]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [53]
GTPase NRas (NRAS) OTVQ1DG3 RASN_HUMAN Affects Expression [24]
GTPase HRas (HRAS) OTWQN0DP RASH_HUMAN Affects Expression [24]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Affects Expression [24]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [49]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [54]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Affects Expression [24]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Affects Expression [55]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Affects Activity [56]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Increases Expression [49]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Affects Expression [24]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Affects Expression [24]
Argininosuccinate lyase (ASL) OTI2NGQR ARLY_HUMAN Affects Expression [24]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [52]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Increases Expression [57]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Affects Expression [24]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Affects Expression [24]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Affects Expression [24]
DNA-directed RNA polymerase III subunit RPC4 (POLR3D) OTXQTBS0 RPC4_HUMAN Affects Expression [24]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Affects Expression [24]
Insulin receptor (INSR) OTTY341H INSR_HUMAN Affects Expression [24]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Affects Expression [24]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [57]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Increases Expression [52]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Affects Expression [24]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Affects Expression [24]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Affects Expression [24]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Affects Expression [24]
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Affects Expression [24]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [58]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Affects Activity [56]
Serine/threonine-protein kinase A-Raf (ARAF) OTZJ0FNO ARAF_HUMAN Affects Expression [24]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Increases Expression [52]
Nuclear receptor subfamily 2 group F member 6 (NR2F6) OTNVO2B6 NR2F6_HUMAN Affects Expression [24]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Affects Expression [24]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [59]
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT) OT4KZ5R9 ODB2_HUMAN Affects Expression [24]
Fibroblast growth factor receptor 1 (FGFR1) OT4GLCXW FGFR1_HUMAN Affects Expression [24]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Affects Expression [60]
Bone morphogenetic protein 4 (BMP4) OTPZMDFH BMP4_HUMAN Affects Expression [24]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [23]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Affects Expression [24]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [58]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Affects Expression [24]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Decreases Expression [61]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Affects Expression [24]
POU domain, class 2, transcription factor 1 (POU2F1) OTK7ELJ0 PO2F1_HUMAN Affects Expression [24]
Serine/threonine-protein kinase B-raf (BRAF) OT7S81XQ BRAF_HUMAN Affects Expression [24]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Affects Expression [24]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [62]
Transcription factor E2-alpha (TCF3) OTW6FR32 TFE2_HUMAN Affects Expression [24]
Replication protein A 32 kDa subunit (RPA2) OTZ54WAF RFA2_HUMAN Affects Expression [24]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [63]
Carbonyl reductase 1 (CBR1) OTQ3A541 CBR1_HUMAN Affects Expression [24]
Tyrosine-protein kinase Fer (FER) OT9JR7AE FER_HUMAN Affects Expression [24]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Affects Expression [24]
Rho-related GTP-binding protein RhoQ (RHOQ) OTUBTU57 RHOQ_HUMAN Affects Expression [24]
Aspartate aminotransferase, cytoplasmic (GOT1) OTZLM5UB AATC_HUMAN Increases Secretion [64]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Affects Expression [24]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Affects Expression [24]
CTP synthase 1 (CTPS1) OTZ9J6ZG PYRG1_HUMAN Affects Expression [24]
Probable ATP-dependent RNA helicase DDX5 (DDX5) OTLS124U DDX5_HUMAN Affects Expression [24]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Affects Expression [24]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [65]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Affects Expression [24]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Increases Expression [66]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [24]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) OTSBQR6D PLCG1_HUMAN Affects Expression [24]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Affects Expression [24]
Casein kinase II subunit alpha' (CSNK2A2) OT7MA2LV CSK22_HUMAN Affects Expression [24]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [52]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) OTXF0B09 IF2B_HUMAN Affects Expression [24]
Hepatocyte nuclear factor 1-alpha (HNF1A) OT9DOUKL HNF1A_HUMAN Affects Expression [24]
Ras GTPase-activating protein 1 (RASA1) OTZJ3LP4 RASA1_HUMAN Affects Expression [24]
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Affects Expression [24]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Decreases Expression [67]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Affects Expression [24]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Increases Expression [49]
Trifunctional purine biosynthetic protein adenosine-3 (GART) OT01JWJB PUR2_HUMAN Affects Expression [24]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) OT3MPPYX ENPP1_HUMAN Affects Expression [24]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2) OTJXOUCL HEM0_HUMAN Affects Expression [24]
E3 ubiquitin-protein ligase CBL (CBL) OTTKELCU CBL_HUMAN Affects Expression [24]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Affects Expression [24]
Glycine dehydrogenase (GLDC) OTVVDNW0 GCSP_HUMAN Affects Expression [24]
Thymidylate kinase (DTYMK) OTJXYQYK KTHY_HUMAN Affects Expression [24]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [64]
COUP transcription factor 2 (NR2F2) OTJFS67N COT2_HUMAN Affects Expression [24]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Affects Expression [24]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Affects Expression [24]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Affects Expression [24]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Affects Expression [24]
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Affects Expression [24]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [58]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Affects Expression [24]
Replication protein A 70 kDa DNA-binding subunit (RPA1) OT76POLP RFA1_HUMAN Affects Expression [24]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Affects Expression [24]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [58]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Affects Expression [24]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) OTFIHQGD 2AAB_HUMAN Affects Expression [24]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Affects Expression [24]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Affects Expression [24]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Affects Expression [24]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Affects Expression [24]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Affects Expression [24]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [51]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Affects Expression [24]
Cleavage stimulation factor subunit 2 (CSTF2) OTR6G4II CSTF2_HUMAN Affects Expression [24]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) OT0THBVA DUT_HUMAN Affects Expression [24]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Affects Expression [24]
Serine hydroxymethyltransferase, cytosolic (SHMT1) OTIINA3J GLYC_HUMAN Affects Expression [24]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Affects Expression [24]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Decreases Expression [52]
Cystathionine beta-synthase (CBS) OT46FSKD CBS_HUMAN Affects Expression [24]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Affects Expression [24]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Affects Expression [24]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [24]
Choline kinase alpha (CHKA) OT7FVO3Z CHKA_HUMAN Affects Expression [24]
Activin receptor type-1B (ACVR1B) OT778HIQ ACV1B_HUMAN Affects Expression [24]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Activity [68]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Increases Expression [60]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Affects Expression [24]
Glycine--tRNA ligase (GARS1) OT5B6R9Y GARS_HUMAN Affects Expression [24]
Reduced folate transporter (SLC19A1) OTWB0BTO S19A1_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Affects Expression [24]
Protein kinase C iota type (PRKCI) OTKBAVT3 KPCI_HUMAN Affects Expression [24]
Signal transducer and activator of transcription 6 (STAT6) OTCKMP49 STAT6_HUMAN Affects Expression [24]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Affects Expression [24]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [69]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Affects Expression [24]
Tyrosine-protein kinase ABL2 (ABL2) OTS8F4GD ABL2_HUMAN Affects Expression [24]
Transcription factor GATA-4 (GATA4) OTQHWAZG GATA4_HUMAN Affects Expression [24]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Affects Expression [24]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Affects Expression [24]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX) OTWG2LAB IF1AX_HUMAN Affects Expression [24]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Affects Expression [24]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Affects Expression [24]
Serine--tRNA ligase, cytoplasmic (SARS1) OTFKXQ1O SYSC_HUMAN Affects Expression [24]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Affects Expression [24]
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) OTOODWTU GNAQ_HUMAN Affects Expression [24]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4) OTOXNDI9 GBG4_HUMAN Affects Expression [24]
Cyclin-dependent kinase 7 (CDK7) OTAO19PQ CDK7_HUMAN Affects Expression [24]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Affects Expression [24]
Cyclin-H (CCNH) OTKDU3SR CCNH_HUMAN Affects Expression [24]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Affects Expression [24]
DNA polymerase subunit gamma-1 (POLG) OTDUCT04 DPOG1_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 5 (EIF5) OT79PQUN IF5_HUMAN Affects Expression [24]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Expression [52]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Affects Expression [24]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Affects Expression [24]
Tumor protein D52 (TPD52) OTPKSK43 TPD52_HUMAN Increases Expression [67]
Eukaryotic translation initiation factor 3 subunit B (EIF3B) OTF67VPH EIF3B_HUMAN Affects Expression [24]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Activity [70]
C-terminal-binding protein 2 (CTBP2) OTGZGT87 CTBP2_HUMAN Affects Expression [24]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Affects Expression [24]
Eukaryotic initiation factor 4A-I (EIF4A1) OTMTBX6N IF4A1_HUMAN Affects Expression [24]
DNA-directed RNA polymerases I, II, and III subunit RPABC2 (POLR2F) OTF9T8I2 RPAB2_HUMAN Affects Expression [24]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Decreases Expression [51]
Ras-related protein R-Ras2 (RRAS2) OT83NCEB RRAS2_HUMAN Affects Expression [24]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) OTYFTYFR PP1B_HUMAN Affects Expression [24]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Affects Expression [24]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) OT9297OG 2ABA_HUMAN Affects Expression [24]
Small ribosomal subunit protein RACK1 (RACK1) OTZBCQ1U RACK1_HUMAN Affects Expression [24]
Actin, alpha skeletal muscle (ACTA1) OTOVGLPG ACTS_HUMAN Affects Expression [24]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Affects Expression [24]
ETS-related transcription factor Elf-3 (ELF3) OTUTLEQO ELF3_HUMAN Affects Expression [24]
Phosphatidylinositol-glycan-specific phospholipase D (GPLD1) OTUUQOVY PHLD_HUMAN Affects Expression [24]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Expression [24]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Affects Expression [24]
Cyclin-dependent kinase 5 (CDK5) OT1YAK9F CDK5_HUMAN Affects Expression [24]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Affects Expression [24]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [71]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Affects Expression [24]
Myocyte-specific enhancer factor 2A (MEF2A) OTV2SF6E MEF2A_HUMAN Affects Expression [24]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Affects Activity [72]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) OT2CF1E6 IF4G1_HUMAN Affects Expression [24]
Activin receptor type-1 (ACVR1) OT4JATFE ACVR1_HUMAN Affects Expression [24]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Affects Expression [24]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Affects Expression [24]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Affects Expression [24]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Affects Expression [24]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [52]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [73]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Affects Expression [24]
Son of sevenless homolog 2 (SOS2) OTV3XRE5 SOS2_HUMAN Affects Expression [24]
Epithelial discoidin domain-containing receptor 1 (DDR1) OTYW1SH8 DDR1_HUMAN Affects Expression [24]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Affects Expression [24]
Cleavage stimulation factor subunit 3 (CSTF3) OT1Y7B5U CSTF3_HUMAN Affects Expression [24]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [49]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) OT6T408U MP2K5_HUMAN Affects Expression [24]
Serine/threonine-protein kinase PAK 2 (PAK2) OTLUNCIH PAK2_HUMAN Affects Expression [24]
Growth factor receptor-bound protein 10 (GRB10) OTCKXGRC GRB10_HUMAN Affects Expression [24]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) OTF7CGO2 2A5G_HUMAN Affects Expression [24]
Rho-associated protein kinase 1 (ROCK1) OTSXYVW1 ROCK1_HUMAN Affects Expression [24]
Frizzled-5 (FZD5) OTXFFY56 FZD5_HUMAN Affects Expression [24]
GRB2-associated-binding protein 1 (GAB1) OTQKE6V4 GAB1_HUMAN Affects Expression [24]
Mothers against decapentaplegic homolog 4 (SMAD4) OTWQWCKG SMAD4_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Affects Expression [24]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Affects Expression [24]
Activin receptor type-2B (ACVR2B) OT209XLA AVR2B_HUMAN Affects Expression [24]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) OT5UO1FA HNRPD_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 3 subunit A (EIF3A) OTFABY9G EIF3A_HUMAN Affects Expression [24]
Rho guanine nucleotide exchange factor 7 (ARHGEF7) OT9BPJCL ARHG7_HUMAN Affects Expression [24]
ARF GTPase-activating protein GIT2 (GIT2) OTQ2EQJ1 GIT2_HUMAN Affects Expression [24]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Affects Expression [24]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Affects Expression [24]
Translation initiation factor eIF2B subunit alpha (EIF2B1) OT4NCVY1 EI2BA_HUMAN Affects Expression [24]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Affects Expression [24]
Endonuclease G, mitochondrial (ENDOG) OT5IM7B3 NUCG_HUMAN Affects Expression [24]
Guanine nucleotide-binding protein subunit alpha-13 (GNA13) OTVDL515 GNA13_HUMAN Affects Expression [24]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Decreases Activity [74]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [59]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1) OT9EROL6 HERP1_HUMAN Affects Expression [24]
Advanced glycosylation end product-specific receptor (AGER) OTPY0IH7 RAGE_HUMAN Increases Expression [57]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) OTZBCRGI 2A5A_HUMAN Affects Expression [24]
Pregnancy-specific beta-1-glycoprotein 5 (PSG5) OTHTU98X PSG5_HUMAN Increases Expression [51]
Transcription factor E2F5 (E2F5) OT1XWING E2F5_HUMAN Affects Expression [24]
Nuclear receptor subfamily 6 group A member 1 (NR6A1) OTFZOOQ9 NR6A1_HUMAN Affects Expression [24]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) OTDOTWU4 KS6A1_HUMAN Affects Expression [24]
Protein phosphatase 1 regulatory subunit 7 (PPP1R7) OTY5IE69 PP1R7_HUMAN Affects Expression [24]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Affects Expression [24]
ETS-related transcription factor Elf-2 (ELF2) OTEI347F ELF2_HUMAN Affects Expression [24]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Stability [24]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Affects Expression [24]
Dihydropyrimidinase-related protein 2 (DPYSL2) OTWNQ74H DPYL2_HUMAN Affects Expression [24]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Activity [70]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Decreases Expression [52]
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) OTM6QYNQ CPSF6_HUMAN Affects Expression [24]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [75]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Decreases Expression [67]
UMP-CMP kinase 2, mitochondrial (CMPK2) OTOG90R0 CMPK2_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 21 (DNAJC21) OT8C14QA DJC21_HUMAN Affects Expression [24]
Transcription initiation factor TFIID subunit 3 (TAF3) OTVMULE9 TAF3_HUMAN Affects Expression [24]
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD) OTJI1XF3 NAPEP_HUMAN Affects Expression [24]
General transcription factor IIH subunit 5 (GTF2H5) OTRL219S TF2H5_HUMAN Affects Expression [24]
Mediator of RNA polymerase II transcription subunit 13-like (MED13L) OTSP1W0F MD13L_HUMAN Affects Expression [24]
PTB-containing, cubilin and LRP1-interacting protein (PID1) OT5YJ7FI PCLI1_HUMAN Increases Expression [49]
Glycerate kinase (GLYCTK) OTVTBNSM GLCTK_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 10 (DNAJC10) OTD2EG0R DJC10_HUMAN Affects Expression [24]
Mitochondrial Rho GTPase 2 (RHOT2) OTV8WT2L MIRO2_HUMAN Affects Expression [24]
Fanconi anemia group M protein (FANCM) OTNJG99Z FANCM_HUMAN Affects Expression [24]
Angiogenic factor with G patch and FHA domains 1 (AGGF1) OTA7U2T8 AGGF1_HUMAN Affects Expression [24]
Fanconi anemia group B protein (FANCB) OTMZTXB5 FANCB_HUMAN Affects Expression [24]
Choline dehydrogenase, mitochondrial (CHDH) OTO2DPGL CHDH_HUMAN Affects Expression [24]
Tudor domain-containing protein 7 (TDRD7) OTK639ET TDRD7_HUMAN Affects Expression [24]
DnaJ homolog subfamily B member 14 (DNAJB14) OTAC2K95 DJB14_HUMAN Affects Expression [24]
Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4) OTSGQGT2 CR3L4_HUMAN Affects Expression [24]
Fibroblast growth factor receptor substrate 2 (FRS2) OTDMD800 FRS2_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 9 (DNAJC9) OTDBQBNZ DNJC9_HUMAN Affects Expression [24]
Histone acetyltransferase KAT6B (KAT6B) OTMUDTAH KAT6B_HUMAN Affects Expression [24]
Proteasome inhibitor PI31 subunit (PSMF1) OTX84WLQ PSMF1_HUMAN Affects Expression [24]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) OTXGJ8N1 P55G_HUMAN Affects Expression [24]
Hamartin (TSC1) OTFF4YZ7 TSC1_HUMAN Affects Expression [24]
General transcription factor IIH subunit 4 (GTF2H4) OTPD1DIU TF2H4_HUMAN Affects Expression [24]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Affects Expression [24]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Affects Expression [24]
DNA repair protein RAD50 (RAD50) OTYMU9G1 RAD50_HUMAN Affects Expression [24]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Affects Expression [24]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [55]
Protein phosphatase 1 regulatory subunit 14B (PPP1R14B) OT9PTWAX PP14B_HUMAN Affects Expression [24]
Hepatitis A virus cellular receptor 1 (HAVCR1) OT184CRZ HAVR1_HUMAN Increases Expression [60]
DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3) OT61924T DNJA3_HUMAN Affects Expression [24]
Thialysine N-epsilon-acetyltransferase (SAT2) OT28QL7H SAT2_HUMAN Affects Expression [24]
Mediator of RNA polymerase II transcription subunit 30 (MED30) OTM3INJN MED30_HUMAN Affects Expression [24]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Increases Expression [57]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) OTMV4ASV MAGI1_HUMAN Affects Expression [24]
Formin-binding protein 1 (FNBP1) OTSJ5KKA FNBP1_HUMAN Affects Expression [24]
Paired amphipathic helix protein Sin3a (SIN3A) OTM8OZWV SIN3A_HUMAN Affects Expression [24]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 3 subunit C (EIF3C) OTR8RF9X EIF3C_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 7 (DNAJC7) OTQ5AL3F DNJC7_HUMAN Affects Expression [24]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Affects Expression [24]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Affects Expression [24]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Decreases Expression [75]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [76]
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) OTN0NXX2 E2AK1_HUMAN Affects Expression [24]
Mediator of RNA polymerase II transcription subunit 10 (MED10) OTCQ3ZRR MED10_HUMAN Affects Expression [24]
Fanconi anemia group J protein (BRIP1) OT38QBD4 FANCJ_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Affects Expression [24]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [50]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [24]
Group XIIA secretory phospholipase A2 (PLA2G12A) OTHHCQ17 PG12A_HUMAN Affects Expression [24]
Epsin-3 (EPN3) OTNNYDT6 EPN3_HUMAN Affects Expression [24]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 5 (DNAJC5) OTCZDXAL DNJC5_HUMAN Affects Expression [24]
dCTP pyrophosphatase 1 (DCTPP1) OTP1GZYF DCTP1_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 18 (DNAJC18) OTCQNEO7 DJC18_HUMAN Affects Expression [24]
Protein argonaute-3 (AGO3) OTNQGROH AGO3_HUMAN Affects Expression [24]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) OTNA9G8V MKNK2_HUMAN Affects Expression [24]
Transcription initiation factor TFIID subunit 9B (TAF9B) OTORBI4I TAF9B_HUMAN Affects Expression [24]
Calpain-10 (CAPN10) OTS9LJW4 CAN10_HUMAN Affects Expression [24]
Protein argonaute-4 (AGO4) OTKXQD70 AGO4_HUMAN Affects Expression [24]
Frizzled-3 (FZD3) OTIWDN78 FZD3_HUMAN Affects Expression [24]
Fanconi anemia group F protein (FANCF) OT3WA9N1 FANCF_HUMAN Affects Expression [24]
Transcription factor 7-like 2 (TCF7L2) OTVWPZ8B TF7L2_HUMAN Affects Expression [24]
Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7) OT3QER33 ENTP7_HUMAN Affects Expression [24]
DNA polymerase epsilon subunit 4 (POLE4) OTCMWUT6 DPOE4_HUMAN Affects Expression [24]
Rho guanine nucleotide exchange factor 3 (ARHGEF3) OTHGNC0A ARHG3_HUMAN Affects Expression [24]
CTP synthase 2 (CTPS2) OT2X9YO1 PYRG2_HUMAN Affects Expression [24]
DNA polymerase epsilon subunit 3 (POLE3) OTOELRF6 DPOE3_HUMAN Affects Expression [24]
Mediator of RNA polymerase II transcription subunit 17 (MED17) OTEZR5GC MED17_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 11 (DNAJC11) OTYLMZWW DJC11_HUMAN Affects Expression [24]
E3 ubiquitin-protein ligase FANCL (FANCL) OTJC7QPQ FANCL_HUMAN Affects Expression [24]
Very long chain fatty acid elongase 2 (ELOVL2) OTDAF6U3 ELOV2_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Activity [24]
eIF-2-alpha kinase GCN2 (EIF2AK4) OTLE1JY8 E2AK4_HUMAN Affects Expression [24]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Affects Expression [24]
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) OT3HG324 ASH2L_HUMAN Affects Expression [24]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Affects Expression [24]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Affects Expression [24]
Mediator of RNA polymerase II transcription subunit 13 (MED13) OTP5LEJE MED13_HUMAN Affects Expression [24]
Protein TASOR (TASOR) OTEAMOON TASOR_HUMAN Affects Expression [24]
Apoptotic chromatin condensation inducer in the nucleus (ACIN1) OTK81F92 ACINU_HUMAN Affects Expression [24]
Protein argonaute-2 (AGO2) OT4JY32Q AGO2_HUMAN Affects Expression [24]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) OT4DLRYY ASAP1_HUMAN Affects Expression [24]
Frizzled-4 (FZD4) OTGLZIE0 FZD4_HUMAN Affects Expression [24]
Rho GTPase-activating protein 26 (ARHGAP26) OTNGQU7A RHG26_HUMAN Affects Expression [24]
GRB2-associated-binding protein 2 (GAB2) OTBFN705 GAB2_HUMAN Affects Expression [24]
Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4) OTJ2O8BW ENTP4_HUMAN Affects Expression [24]
DNA polymerase eta (POLH) OTN07WXU POLH_HUMAN Affects Expression [24]
Choline/ethanolamine kinase (CHKB) OTNX5LPF CHKB_HUMAN Affects Expression [24]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) OTXK0SDM 2ABG_HUMAN Affects Expression [24]
Endophilin-B1 (SH3GLB1) OTAZ5OP8 SHLB1_HUMAN Affects Expression [24]
Mediator of RNA polymerase II transcription subunit 31 (MED31) OTFVKXJE MED31_HUMAN Affects Expression [24]
DnaJ homolog subfamily C member 15 (DNAJC15) OTNDUKAA DJC15_HUMAN Affects Expression [24]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Affects Expression [24]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Affects Expression [24]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Affects Expression [24]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Response To Substance [77]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Increases Response To Substance [77]
------------------------------------------------------------------------------------
⏷ Show the Full List of 470 DOT(s)

References

1 ClinicalTrials.gov (NCT03910088) Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean
2 Caffeine FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 407).
4 Diclofenac FDA Label
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72.
7 Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat. Pharmacol Rep. 2007 May-Jun;59(3):296-305.
8 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
9 A population and family study of N-acetyltransferase using caffeine urinary metabolites. Clin Pharmacol Ther. 1993 Aug;54(2):134-41.
10 Determinants of interindividual variability and extent of CYP2D6 and CYP1A2 inhibition by paroxetine and fluvoxamine in vivo. J Clin Psychopharmacol. 1998 Jun;18(3):198-207.
11 CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling. Arch Biochem Biophys. 2007 Mar 1;459(1):59-69.
12 PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95.
13 Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline. Xenobiotica. 2013 Dec;43(12):1037-42.
14 Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Drug Metab Dispos. 1997 May;25(5):617-22.
15 Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006 Mar 8;295(10):1135-41. doi: 10.1001/jama.295.10.1135.
16 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
17 Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Biopharm Drug Dispos. 2004 Sep;25(6):243-52.
18 Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)- 5-(2-furyl)-4-oxazoleacetic acid (TA-1801A). Drug Metab Pharmacokinet. 2005 Jun;20(3):212-8. doi: 10.2133/dmpk.20.212.
19 Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform. Drug Metab Dispos. 2005 Mar;33(3):403-12.
20 Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos. 2008 May;36(5):816-23.
21 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
22 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
23 Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. Lung Cancer. 2010 May;68(2):154-60. doi: 10.1016/j.lungcan.2009.06.012. Epub 2009 Jul 23.
24 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
25 Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
26 Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. J Biol Chem. 2004 Jul 2;279(27):28320-9. doi: 10.1074/jbc.M401396200. Epub 2004 Apr 26.
27 Diclofenac and NS-398, a selective cyclooxygenase-2 inhibitor, decrease agonist-induced contractions of the pig isolated ureter. Urol Res. 2000 Dec;28(6):376-82.
28 Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos. 2009 Jan;37(1):129-36.
29 Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53.
30 Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine. Drug Metab Dispos. 2000 Sep;28(9):1043-50.
31 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
32 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
33 Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92.
34 New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
35 Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem Pharmacol. 1999 Sep 1;58(5):787-96.
36 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
37 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
38 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
39 The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.
40 Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans. Mol Pharmacol. 2001 Aug;60(2):382-7. doi: 10.1124/mol.60.2.382.
41 Important amino acid residues that confer CYP2C19 selective activity to CYP2C9. J Biochem. 2008 Sep;144(3):323-33. doi: 10.1093/jb/mvn070. Epub 2008 May 28.
42 Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity: evidence for a NAD(P)H:quinone reductase-dependent mechanism. Arch Toxicol. 1995;69(10):684-9.
43 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
44 Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. J Pharmacol Exp Ther. 2005 Dec;315(3):1298-305.
45 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
46 Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis. Chem Biol Interact. 2015 Jun 5;234:105-13.
47 Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicol Lett. 2016 Jul 25;255:52-62.
48 A chemoproteomic platform to assess bioactivation potential of drugs. Chem Res Toxicol. 2017 Oct 16;30(10):1797-1803.
49 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
50 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
51 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
52 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
53 Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
54 Development of a cell-based assay system considering drug metabolism and immune- and inflammatory-related factors for the risk assessment of drug-induced liver injury. Toxicol Lett. 2014 Jul 3;228(1):13-24. doi: 10.1016/j.toxlet.2014.04.005. Epub 2014 Apr 15.
55 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
56 Endocrine disrupting activities and immunomodulatory effects in lymphoblastoid cell lines of diclofenac, 4-hydroxydiclofenac and paracetamol. Toxicol Lett. 2018 Sep 15;294:95-104. doi: 10.1016/j.toxlet.2018.05.022. Epub 2018 May 16.
57 Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
58 Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs. Drug Metab Dispos. 2014 Jan;42(1):1-8. doi: 10.1124/dmd.113.054478. Epub 2013 Oct 8.
59 Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-. Toxicol Lett. 2016 Sep 6;258:71-86. doi: 10.1016/j.toxlet.2016.06.008. Epub 2016 Jun 14.
60 Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):141-9. doi: 10.1016/j.taap.2013.03.005. Epub 2013 Mar 16.
61 Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. J Biol Chem. 2002 Oct 11;277(41):38212-21. doi: 10.1074/jbc.M205142200. Epub 2002 Jul 29.
62 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. Arch Biochem Biophys. 2009 Jul 15;487(2):139-45. doi: 10.1016/j.abb.2009.05.017. Epub 2009 Jun 6.
63 Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro. Mutat Res Genet Toxicol Environ Mutagen. 2020 Jan;849:503129. doi: 10.1016/j.mrgentox.2019.503129. Epub 2019 Dec 27.
64 Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro. Chem Biol Interact. 2023 Jan 5;369:110285. doi: 10.1016/j.cbi.2022.110285. Epub 2022 Nov 26.
65 Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol Pharmacol. 2005 Feb;67(2):356-64. doi: 10.1124/mol.104.005108. Epub 2004 Oct 27.
66 Effects of nonsteroidal anti-inflammatory drugs on interleukin-1 receptor antagonist production in cultured human peripheral blood mononuclear cells. Prostaglandins. 1997 Nov;54(5):795-804. doi: 10.1016/s0090-6980(97)00159-7.
67 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
68 Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells. J Pharmacol Exp Ther. 2002 Jul;302(1):18-25. doi: 10.1124/jpet.302.1.18.
69 Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites. Arch Toxicol. 2015 Jan;89(1):107-19. doi: 10.1007/s00204-014-1242-6. Epub 2014 Apr 26.
70 Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A. Toxicol Appl Pharmacol. 2008 Mar 15;227(3):451-61. doi: 10.1016/j.taap.2007.11.030. Epub 2007 Dec 14.
71 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
72 Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
73 Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS. Biochem Pharmacol. 2003 Dec 1;66(11):2155-67. doi: 10.1016/j.bcp.2003.08.003.
74 Regulatory effects of non-steroidal anti-inflammatory drugs on cardiac ion channels Nav1.5 and Kv11.1. Chem Biol Interact. 2021 Apr 1;338:109425. doi: 10.1016/j.cbi.2021.109425. Epub 2021 Feb 19.
75 Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin Cancer Res. 2003 Aug 1;9(8):3150-7.
76 Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Biochem Biophys Res Commun. 2004 Dec 24;325(4):1298-303. doi: 10.1016/j.bbrc.2004.10.176.
77 Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. Hepatology. 2004 May;39(5):1430-40. doi: 10.1002/hep.20205.