Details of the Drug Combinations

General Information of This Drug (ID: DMMZSXQ)

• Drug Name: Azathioprine (DMMZSXQ)
• Synonyms: Azamun; Azanin; Azasan; Azathioprin; Azathioprinum; Azathiopurine; Azatioprin; Azatioprina; Azothioprine; Ccucol; Cytostatics; Immuran; Imuran; Imurek; Imurel; Methylnitroimidazolylmercaptopurine; Muran; Azamun [Czech]; Azathioprine sodium; Azatiopr in; A 4638; BW 57322; Azamun (TN); Azasan (TN); Azathioprinum [INN-Latin]; Azatioprina [INN-Spanish]; BW 57-322; Imuran (TN); Imurel (TN); [Methyl(nitroimidazolyl)mercaptopurine]; AI-981/34845012; BW-57-322; Azathioprine (JP15/USP/INN); Azathioprine [USAN:INN:BAN:JAN]; B. W. 57-322; Thiopurine 6-(1-methyl-4-nitroimidazol-5-yl); Azasan, Imuran, Azamun, BW-57-322, NSC-39084, Azathioprine; 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine; 6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)mercaptopurine; 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine; 6-(1-Methyl-4-nitroimidazol-5-ylthio)purin; 6-(1-Methyl-4-nitroimidazol-5-ylthio)purin [Czech]; 6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine; 6-(1-Methyl-p-nitro-5-imidazolyl)thiopurine; 6-(3-Methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-7H-purine; 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine; 6-(Methyl-p-nitro-5-imidazolyl)-thiopurine; 6-(Methyl-p-nitro-5-imidazolyl)thiopurine; 6-({4-nitro-1-methyl-1H-imidazol-5-yl}sulfanyl)-7H-purine; 6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine; 6-[(1-Methyl-4-nitroimidazol-5-yl)-thio] purine; 6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-Purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-7H-purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine

Indication

Lupus nephritis; ICD 11: 4A40.0Y; Status: Approved [1]; Organ transplant rejection; ICD 11: NE84; Status: Approved [2]

• Therapeutic Class: Immunosuppressive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

14 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AS602868 + Azathioprine	DCQEMWJ	AS602868	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Azathioprine + Ruxolitinib	DCTWW3J	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[4]
Azathioprine + Fomepizole	DC1FVO6	Fomepizole	Hodgkin lymphoma (Cell Line: L-1236)	[4]
Azathioprine + Nilutamide	DC29KZC	Nilutamide	Hodgkin lymphoma (Cell Line: L-428)	[4]
Azathioprine + SNX-5422	DCJH9KS	SNX-5422	Hodgkin lymphoma (Cell Line: L-1236)	[4]
Azathioprine + Bortezomib	DCILR4V	Bortezomib	Hodgkin lymphoma (Cell Line: L-1236)	[4]
Azathioprine + Sapanisertib	DCAFDOE	Sapanisertib	Hodgkin lymphoma (Cell Line: L-1236)	[4]
GDC-0084 + Azathioprine	DCZK8AV	GDC-0084	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Pelitinib + Azathioprine	DCTN28S	Pelitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
PMID25656651-Compound-5 + Azathioprine	DC3GT63	PMID25656651-Compound-5	Hodgkin lymphoma (Cell Line: L-1236)	[3]
PMID25656651-Compound-5 + Azathioprine	DCSISMF	PMID25656651-Compound-5	Hodgkin lymphoma (Cell Line: HDLM-2)	[3]
PMID25656651-Compound-5 + Azathioprine	DCE5S7Q	PMID25656651-Compound-5	Hodgkin lymphoma (Cell Line: L-428)	[3]
Vincristine + Azathioprine	DCVT8AY	Vincristine	Hodgkin lymphoma (Cell Line: L-1236)	[4]
Withaferin A + Azathioprine	DCI55UN	Withaferin A	Hodgkin lymphoma (Cell Line: L-1236)	[3]

17 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Azathioprine + Prednisolone	DCDS0G1	Prednisolone	Lupus Nephritis	[5]
Azathioprine + Prednisolone	DC3EEZD	Prednisolone	Lupus Nephritis	[5]
Azathioprine + Mesalazine	DCVMCOT	Mesalazine	Colitis, Ulcerative	[6]
Azathioprine + Cyclosporin A	DC462NP	Cyclosporin A	Mucopolysaccharidosis I	[7]
Azathioprine + Prednisolone	DC8HTYE	Prednisolone	Crohn's Disease	[8]
Azathioprine + Metronidazole	DCIMLYB	Metronidazole	Crohn´s Disease	[9]
Azathioprine + Prednisolone	DCOHCUE	Prednisolone	Colitis, Ulcerative	[6]
Ifosfamide + Azathioprine	DCNSXSY	Ifosfamide	Inflammatory Bowel Diseases	[10]
Methotrexate + Azathioprine	DCLPML3	Methotrexate	Inflammatory Bowel Disease	[11]
Methylprednisolone + Azathioprine	DCZ0EWR	Methylprednisolone	IgA Nephropathy	[12]
Azathioprine + Tacrolimus	DCO82YN	Tacrolimus	Uterine Factor Infertility	[13]
Dapsone + Azathioprine	DCGDKFQ	Dapsone	Primary Cutaneous Vasculitis	[14]
Methotrexate + Azathioprine	DCL4PX4	Methotrexate	Mucous Membrane Pemphigoid	[15]
Azathioprine + Rifaximin	DCUJT92	Rifaximin	Crohn Disease	[16]
Hydrocortisone + Azathioprine	DCRSBCG	Hydrocortisone	Ulcerative Colitis	[17]
Methotrexate + Azathioprine	DC08DRK	Methotrexate	Crohn's Disease	[18]
Mycophenolate mofetil + Azathioprine	DCB31CC	Mycophenolate mofetil	Carcinoma, Hepatocellular	[19]

References

• [1] Azathioprine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7120).
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [5] ClinicalTrials.gov (NCT03791827) Multicenter Registry of Pediatric Lupus Nephritis in China
• [6] ClinicalTrials.gov (NCT00984568) Conventional Step-Up Versus Infliximab Monotherapy in Patients With Ulcerative Colitis (P05553)
• [7] ClinicalTrials.gov (NCT00741338) Immune Tolerance Study With Aldurazyme (Laronidase)
• [8] ClinicalTrials.gov (NCT00796250) Efficacy of Infliximab in the Treatment of Patients Affected by Corticodependent Crohn's Disease (P02732)
• [9] ClinicalTrials.gov (NCT01564823) Adalimumab on Preventing Post-chirurgic Recurrence on Crohns Disease
• [10] ClinicalTrials.gov (NCT04761952) N-3 Polyunsaturated Fatty Acids Prevent Postoperative Recurrence of Crohn's Disease
• [11] ClinicalTrials.gov (NCT02413047) Evaluate if Response to Infliximab or Adalimumab May be Regained With an Immunomodulator
• [12] ClinicalTrials.gov (NCT01392833) Steroids and Azathioprine in Advanced IgAN
• [13] ClinicalTrials.gov (NCT05646992) Uterus Transplantation to Treat Infertility
• [14] ClinicalTrials.gov (NCT02939573) A Randomized Multicenter Study for Isolated Skin Vasculitis
• [15] ClinicalTrials.gov (NCT05263505) Baricitinib for the Treatment of Ocular Mucous Membrane Pemphigoid
• [16] ClinicalTrials.gov (NCT03185611) Effectiveness of Rifaximin Combined With Thiopurine on Preventing Postoperative Recurrence in Crohn's Disease
• [17] ClinicalTrials.gov (NCT02425852) A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis
• [18] ClinicalTrials.gov (NCT02177071) A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy
• [19] ClinicalTrials.gov (NCT02081755) Safety and Efficacy of Everolimus Treatment in Liver Transplantation for Liver Cancer