Details of the Drug Combination

General Information of Drug Combination (ID: DCTWW3J)

Drug Combination Name
Azathioprine Ruxolitinib
Indication
Disease Entry Status REF
Hodgkin lymphoma Investigative [1]
Component Drugs Azathioprine   DMMZSXQ Ruxolitinib   DM7Q98D
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: L-1236
Zero Interaction Potency (ZIP) Score: 9.318
Bliss Independence Score: 8.754
Loewe Additivity Score: 5.707
LHighest Single Agent (HSA) Score: 7.858

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Azathioprine
Disease Entry ICD 11 Status REF
Lupus nephritis 4A40.0Y Approved [2]
Organ transplant rejection NE84 Approved [3]
Azathioprine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Amidophosphoribosyltransferase (PPAT) TTZFTY4 PUR1_HUMAN Inhibitor [13]
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Azathioprine Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [14]
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Azathioprine Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [15]
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Metabolism [16]
Glutathione S-transferase alpha-2 (GSTA2) DEH49YS GSTA2_HUMAN Metabolism [17]
Glutathione S-transferase mu-1 (GSTM1) DEYZEJA GSTM1_HUMAN Metabolism [17]
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Azathioprine Interacts with 574 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Thiopurine S-methyltransferase (TPMT) OTFOX70W TPMT_HUMAN Increases ADR [18]
Glutathione S-transferase A2 (GSTA2) OTW7UB1H GSTA2_HUMAN Affects Response To Substance [19]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [20]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Affects Response To Substance [21]
Inosine triphosphate pyrophosphatase (ITPA) OTQ47WVR ITPA_HUMAN Affects Response To Substance [22]
Dipeptidyl peptidase 4 (DPP4) OT16MVL9 DPP4_HUMAN Decreases Expression [23]
Solute carrier family 15 member 1 (SLC15A1) OT1P16B5 S15A1_HUMAN Decreases Expression [23]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) OTPG0K7E IMDH2_HUMAN Increases Expression [24]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Increases Expression [24]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [24]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [24]
Glutathione synthetase (GSS) OTVSBEIW GSHB_HUMAN Increases Expression [24]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [10]
Phospholipid phosphatase 3 (PLPP3) OTSSF7BK PLPP3_HUMAN Decreases Expression [10]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Decreases Expression [10]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [10]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Decreases Expression [10]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Decreases Expression [10]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Decreases Expression [10]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Decreases Expression [10]
Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3) OTDA431Y ENTP3_HUMAN Increases Expression [10]
Antiviral innate immune response receptor RIG-I (RIGI) OTFIIC43 RIGI_HUMAN Decreases Expression [10]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [10]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [10]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [10]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Decreases Expression [10]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [10]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [10]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Expression [10]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Increases Expression [10]
Neuromedin-B (NMB) OT4NLN6H NMB_HUMAN Decreases Expression [10]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [10]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [10]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Decreases Expression [10]
Granulocyte colony-stimulating factor (CSF3) OT9GC6TP CSF3_HUMAN Decreases Expression [10]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [10]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Decreases Expression [10]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [10]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Increases Expression [10]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [10]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Expression [10]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Decreases Expression [10]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Decreases Expression [10]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [10]
Guanylate-binding protein 1 (GBP1) OTUM7RPJ GBP1_HUMAN Decreases Expression [10]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [10]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Increases Expression [10]
Macrophage metalloelastase (MMP12) OT9Z7LHM MMP12_HUMAN Decreases Expression [10]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Decreases Expression [10]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [10]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Increases Expression [10]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [10]
Spermine synthase (SMS) OT8JYKNH SPSY_HUMAN Decreases Expression [10]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [10]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Decreases Expression [10]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Decreases Expression [10]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [10]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) OTRZH80H TNAP2_HUMAN Decreases Expression [10]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Increases Expression [10]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Decreases Expression [10]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [10]
Probable ATP-dependent RNA helicase DDX10 (DDX10) OTH48438 DDX10_HUMAN Increases Expression [10]
Neuronal membrane glycoprotein M6-b (GPM6B) OT8Q1582 GPM6B_HUMAN Increases Expression [10]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Decreases Expression [10]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2) OTTUU92F ENPP2_HUMAN Increases Expression [10]
Nidogen-2 (NID2) OTHC33FF NID2_HUMAN Increases Expression [10]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Decreases Expression [10]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Decreases Expression [10]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Decreases Expression [10]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Increases Expression [10]
Olfactomedin-like protein 2B (OLFML2B) OTDNJFR4 OLM2B_HUMAN Increases Expression [10]
E3 ubiquitin-protein ligase RNF19B (RNF19B) OTYCWKBP RN19B_HUMAN Decreases Expression [10]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Decreases Expression [10]
Probable E3 ubiquitin-protein ligase HERC6 (HERC6) OT7G9PQE HERC6_HUMAN Decreases Expression [10]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Decreases Expression [10]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) OTCA9WCM RSAD2_HUMAN Decreases Expression [10]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Decreases Expression [10]
Interferon regulatory factor 7 (IRF7) OTC1A2PQ IRF7_HUMAN Decreases Expression [10]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Decreases Expression [10]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Increases Expression [10]
Interferon-induced helicase C domain-containing protein 1 (IFIH1) OTZA2AHA IFIH1_HUMAN Decreases Expression [10]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Increases Expression [10]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Increases Expression [10]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [10]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Increases Expression [10]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Decreases Expression [10]
Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) OT7FCZRM PP4R2_HUMAN Increases Expression [10]
E3 ISG15--protein ligase HERC5 (HERC5) OTZ5PR39 HERC5_HUMAN Decreases Expression [10]
Paired immunoglobulin-like type 2 receptor alpha (PILRA) OTBE0PLF PILRA_HUMAN Decreases Expression [10]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [10]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Decreases Expression [10]
2'-5'-oligoadenylate synthase 3 (OAS3) OT6E5FYS OAS3_HUMAN Decreases Expression [10]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Decreases Expression [11]
Odontogenic ameloblast-associated protein (ODAM) OTT666SJ ODAM_HUMAN Decreases Expression [11]
UPF0524 protein C3orf70 (C3ORF70) OTDWU4AC CC070_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Decreases Expression [11]
Cell division cycle 7-related protein kinase (CDC7) OT5133XY CDC7_HUMAN Decreases Expression [11]
Citron Rho-interacting kinase (CIT) OTOZDKPG CTRO_HUMAN Decreases Expression [11]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) OTB6YLFT ENPP3_HUMAN Decreases Expression [11]
Inositol monophosphatase 2 (IMPA2) OTNFB9YN IMPA2_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Decreases Expression [11]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [11]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [11]
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B) OT8JQ1F7 PI51B_HUMAN Decreases Expression [11]
Matrilin-3 (MATN3) OTH9H74J MATN3_HUMAN Decreases Expression [11]
Mitogen-activated protein kinase 13 (MAPK13) OT0W9GE7 MK13_HUMAN Increases Expression [11]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [11]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [11]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) OTIK337D TGFI1_HUMAN Increases Expression [11]
Protein Mis18-beta (OIP5) OTI5C2DE MS18B_HUMAN Decreases Expression [11]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [11]
Band 4.1-like protein 2 (EPB41L2) OT6UABPM E41L2_HUMAN Decreases Expression [11]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [11]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [11]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [11]
Periplakin (PPL) OTTM4WDO PEPL_HUMAN Increases Expression [11]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [11]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [11]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [11]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [11]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [11]
Geminin (GMNN) OTDYKNIY GEMI_HUMAN Decreases Expression [11]
Transcription elongation factor A protein 3 (TCEA3) OTLTRSK4 TCEA3_HUMAN Decreases Expression [11]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [11]
Isocitrate dehydrogenase cytoplasmic (IDH1) OT4DLHC8 IDHC_HUMAN Decreases Expression [11]
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) OT15HOJX AL1L1_HUMAN Increases Expression [11]
Rho-related BTB domain-containing protein 1 (RHOBTB1) OTGE8K45 RHBT1_HUMAN Decreases Expression [11]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Decreases Expression [11]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [11]
Centrosomal protein of 152 kDa (CEP152) OTOKZR9B CE152_HUMAN Decreases Expression [11]
Fibrinogen silencer-binding protein (RAD54B) OTMWB2P2 FSBP_HUMAN Decreases Expression [11]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [11]
Structural maintenance of chromosomes protein 2 (SMC2) OT5S0DV4 SMC2_HUMAN Decreases Expression [11]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) OTQ9ALTR GCNT3_HUMAN Increases Expression [11]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10) OTL32QH7 GTR10_HUMAN Decreases Expression [11]
Caveolae-associated protein 2 (CAVIN2) OTFHHDRU CAVN2_HUMAN Decreases Expression [11]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Decreases Expression [11]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [11]
Glutamate dehydrogenase 1, mitochondrial (GLUD1) OTXKOCUH DHE3_HUMAN Decreases Expression [11]
Phenylalanine-4-hydroxylase (PAH) OT6GT2K8 PH4H_HUMAN Decreases Expression [11]
Haptoglobin-related protein (HPR) OTXSC9UB HPTR_HUMAN Decreases Expression [11]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [11]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Increases Expression [11]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [11]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [11]
Apolipoprotein C-III (APOC3) OTW3520C APOC3_HUMAN Decreases Expression [11]
Fibrinogen alpha chain (FGA) OTMIHY80 FIBA_HUMAN Decreases Expression [11]
Angiogenin (ANG) OT3ECS6P ANGI_HUMAN Decreases Expression [11]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Decreases Expression [11]
Platelet-derived growth factor subunit A (PDGFA) OTCMZ0W8 PDGFA_HUMAN Increases Expression [11]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [11]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [11]
Complement factor I (CFI) OTQYYX0P CFAI_HUMAN Decreases Expression [11]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [11]
Thyroxine-binding globulin (SERPINA7) OTUYVTSU THBG_HUMAN Decreases Expression [11]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [11]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases Expression [11]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Expression [11]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Decreases Expression [11]
Procathepsin L (CTSL) OTYTUW29 CATL1_HUMAN Increases Expression [11]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Expression [11]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Increases Expression [11]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Increases Expression [11]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [11]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [11]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Increases Expression [11]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Increases Expression [11]
Glycodelin (PAEP) OTQA0NV4 PAEP_HUMAN Increases Expression [11]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [11]
Histone H2A.Z (H2AZ1) OT3KJJNQ H2AZ_HUMAN Decreases Expression [11]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [11]
E3 SUMO-protein ligase EGR2 (EGR2) OTAVQ78J EGR2_HUMAN Increases Expression [11]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Decreases Expression [11]
Mannose-binding protein C (MBL2) OTS63HG5 MBL2_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [11]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [11]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [11]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Decreases Expression [11]
Interleukin-7 (IL7) OTT6YSKM IL7_HUMAN Decreases Expression [11]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [11]
Leukemia inhibitory factor (LIF) OTO46S5S LIF_HUMAN Increases Expression [11]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Expression [11]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [11]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [11]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Expression [11]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [11]
Hexokinase-1 (HK1) OTMPHE8O HXK1_HUMAN Increases Expression [11]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [11]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [11]
Neutrophil cytosol factor 2 (NCF2) OTAUW7L2 NCF2_HUMAN Increases Expression [11]
Follistatin (FST) OTRIVK9Y FST_HUMAN Increases Expression [11]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [11]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [11]
Aromatic-L-amino-acid decarboxylase (DDC) OT0TSW09 DDC_HUMAN Decreases Expression [11]
Interleukin-11 (IL11) OTXHN86R IL11_HUMAN Increases Expression [11]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Decreases Expression [11]
COUP transcription factor 2 (NR2F2) OTJFS67N COT2_HUMAN Decreases Expression [11]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [11]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Decreases Expression [11]
Deoxycytidine kinase (DCK) OTW8HLZC DCK_HUMAN Decreases Expression [11]
Proteasome subunit beta type-9 (PSMB9) OTFV57T8 PSB9_HUMAN Decreases Expression [11]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [11]
Grancalcin (GCA) OTAJ7ZHG GRAN_HUMAN Decreases Expression [11]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [11]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [11]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [11]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Increases Expression [11]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [11]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Increases Expression [11]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [11]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [11]
DNA replication licensing factor MCM5 (MCM5) OTAHLB62 MCM5_HUMAN Decreases Expression [11]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Decreases Expression [11]
Serine hydroxymethyltransferase, cytosolic (SHMT1) OTIINA3J GLYC_HUMAN Decreases Expression [11]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [11]
Sodium channel protein type 1 subunit alpha (SCN1A) OTJ9ZTYI SCN1A_HUMAN Decreases Expression [11]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Decreases Expression [11]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [11]
Glutaredoxin-1 (GLRX) OT0QHTAR GLRX1_HUMAN Increases Expression [11]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [11]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [11]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Decreases Expression [11]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [11]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [11]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [11]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Increases Expression [11]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [11]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Decreases Expression [11]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [11]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [11]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Increases Expression [11]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [11]
Nuclear autoantigenic sperm protein (NASP) OTNE4THC NASP_HUMAN Decreases Expression [11]
Flavin-containing monooxygenase 5 (FMO5) OTTILF8T FMO5_HUMAN Decreases Expression [11]
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) OTV57BZD AL7A1_HUMAN Decreases Expression [11]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [11]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [11]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [11]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Decreases Expression [11]
Type I iodothyronine deiodinase (DIO1) OTFYLYJ0 IOD1_HUMAN Decreases Expression [11]
Kinetochore-associated protein 1 (KNTC1) OTI2OOFN KNTC1_HUMAN Decreases Expression [11]
E3 ubiquitin-protein ligase RNF144A (RNF144A) OTCG27CT R144A_HUMAN Decreases Expression [11]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Decreases Expression [11]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [11]
Aldo-keto reductase family 1 member D1 (AKR1D1) OTBDJ6RL AK1D1_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [11]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [11]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [11]
Kinesin-like protein KIF11 (KIF11) OTHRGLCQ KIF11_HUMAN Decreases Expression [11]
2-iminobutanoate/2-iminopropanoate deaminase (RIDA) OTW4098I RIDA_HUMAN Decreases Expression [11]
Hexokinase-2 (HK2) OTC0GCQO HXK2_HUMAN Decreases Expression [11]
Thimet oligopeptidase (THOP1) OT9E148D THOP1_HUMAN Increases Expression [11]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Increases Expression [11]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [11]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) OT6W40XU P5CS_HUMAN Decreases Expression [11]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Decreases Expression [11]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [11]
Breast cancer anti-estrogen resistance protein 1 (BCAR1) OTKT2C2N BCAR1_HUMAN Increases Expression [11]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [11]
Anthrax toxin receptor 2 (ANTXR2) OTOGFGOJ ANTR2_HUMAN Increases Expression [11]
Protein FAM3B (FAM3B) OTC2S91N FAM3B_HUMAN Decreases Expression [11]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Increases Expression [11]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Decreases Expression [11]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Increases Expression [11]
Gamma-aminobutyric acid receptor subunit epsilon (GABRE) OTXF5ICU GBRE_HUMAN Increases Expression [11]
Iroquois-class homeodomain protein IRX-3 (IRX3) OTLJ48FG IRX3_HUMAN Decreases Expression [11]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [11]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Decreases Expression [11]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [11]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [11]
Cyclic AMP-responsive element-binding protein 5 (CREB5) OTJDUJPI CREB5_HUMAN Increases Expression [11]
Hematopoietically-expressed homeobox protein HHEX (HHEX) OTLIUVYX HHEX_HUMAN Decreases Expression [11]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Decreases Expression [11]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [11]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Increases Expression [11]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [11]
Peroxisomal bifunctional enzyme (EHHADH) OTBAAHL5 ECHP_HUMAN Decreases Expression [11]
Putative sodium-coupled neutral amino acid transporter 11 (SLC38A11) OTFXRU35 S38AB_HUMAN Decreases Expression [11]
TBC1 domain family member 8B (TBC1D8B) OTSYGOXH TBC8B_HUMAN Decreases Expression [11]
Coiled-coil domain-containing protein 15 (CCDC15) OT1NZX84 CCD15_HUMAN Decreases Expression [11]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [11]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Decreases Expression [11]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [11]
Syntaxin-3 (STX3) OT4CIWLJ STX3_HUMAN Increases Expression [11]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [11]
Growth factor receptor-bound protein 10 (GRB10) OTCKXGRC GRB10_HUMAN Increases Expression [11]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [11]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [11]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Decreases Expression [11]
Four and a half LIM domains protein 3 (FHL3) OTMPRLZ5 FHL3_HUMAN Increases Expression [11]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Increases Expression [11]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Decreases Expression [11]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [11]
Glucokinase regulatory protein (GCKR) OTSIWXGG GCKR_HUMAN Increases Expression [11]
Growth factor receptor-bound protein 14 (GRB14) OTFET2YM GRB14_HUMAN Decreases Expression [11]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Decreases Expression [11]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Decreases Expression [11]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [11]
Separin (ESPL1) OTMGEVOK ESPL1_HUMAN Decreases Expression [11]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Decreases Expression [11]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [11]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Increases Expression [11]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [11]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [11]
DNA polymerase delta subunit 3 (POLD3) OTEQEFQ2 DPOD3_HUMAN Decreases Expression [11]
Transcription elongation factor A protein-like 1 (TCEAL1) OTAPG2L5 TCAL1_HUMAN Decreases Expression [11]
Transcription factor E2F5 (E2F5) OT1XWING E2F5_HUMAN Decreases Expression [11]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Decreases Expression [11]
SH2 domain-containing adapter protein B (SHB) OTF2HSC0 SHB_HUMAN Increases Expression [11]
SCL-interrupting locus protein (STIL) OT9799VN STIL_HUMAN Decreases Expression [11]
Pachytene checkpoint protein 2 homolog (TRIP13) OTFM3TI9 PCH2_HUMAN Decreases Expression [11]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3) OTA2TBWS HMGN3_HUMAN Decreases Expression [11]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Decreases Expression [11]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [11]
C-C motif chemokine 15 (CCL15) OTOGZ85M CCL15_HUMAN Increases Expression [11]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [11]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [11]
Kynureninase (KYNU) OTINL2RE KYNU_HUMAN Increases Expression [11]
Histone H2B type 2-E (H2BC21) OT0FDCUC H2B2E_HUMAN Increases Expression [11]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Decreases Expression [11]
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) OTW1SCZW CPEB4_HUMAN Increases Expression [11]
Sodium/glucose cotransporter 4 (SLC5A9) OTWQBZ5Q SC5A9_HUMAN Decreases Expression [11]
Autophagy-related protein 2 homolog A (ATG2A) OTGYDDSV ATG2A_HUMAN Increases Expression [11]
Protein FAM161A (FAM161A) OTF5ZRYJ F161A_HUMAN Decreases Expression [11]
Renal cancer differentiation gene 1 protein (C4ORF46) OTXL7SLI CD046_HUMAN Decreases Expression [11]
Centrosomal protein of 55 kDa (CEP55) OTGSG2PA CEP55_HUMAN Decreases Expression [11]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [11]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [11]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [11]
Spindlin-4 (SPIN4) OT09ZWHM SPIN4_HUMAN Decreases Expression [11]
N-acetyltransferase ESCO2 (ESCO2) OTJEMAQU ESCO2_HUMAN Decreases Expression [11]
Transmembrane protein 170B (TMEM170B) OT4AS8RJ T170B_HUMAN Decreases Expression [11]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) OT5WC0Q8 KANK4_HUMAN Decreases Expression [11]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Increases Expression [11]
Coiled-coil domain-containing protein 18 (CCDC18) OT0S9DA2 CCD18_HUMAN Decreases Expression [11]
DEP domain-containing protein 1A (DEPDC1) OT0JWE1B DEP1A_HUMAN Decreases Expression [11]
PX domain-containing protein 1 (PXDC1) OTQUA3TG PXDC1_HUMAN Increases Expression [11]
Mitochondrial amidoxime-reducing component 1 (MTARC1) OTNBE033 MARC1_HUMAN Decreases Expression [11]
Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1) OTRSC1CD IKBP1_HUMAN Decreases Expression [11]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [11]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Increases Expression [11]
Protein sel-1 homolog 3 (SEL1L3) OT10N6Z2 SE1L3_HUMAN Increases Expression [11]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [11]
Transcription factor Sp5 (SP5) OT4HUP9B SP5_HUMAN Decreases Expression [11]
Phostensin (PPP1R18) OT0JVGOZ PPR18_HUMAN Increases Expression [11]
Mis18-binding protein 1 (MIS18BP1) OT41T0FB M18BP_HUMAN Decreases Expression [11]
Mitochondrial fission regulator 2 (MTFR2) OTLOR68D MTFR2_HUMAN Decreases Expression [11]
Rho GTPase-activating protein 11A (ARHGAP11A) OTVQCFVP RHGBA_HUMAN Decreases Expression [11]
Proline/serine-rich coiled-coil protein 1 (PSRC1) OT7MDJMN PSRC1_HUMAN Decreases Expression [11]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [11]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Decreases Expression [11]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [11]
HHIP-like protein 2 (HHIPL2) OTB7P4GV HIPL2_HUMAN Increases Expression [11]
Nephronectin (NPNT) OTFZAO1G NPNT_HUMAN Decreases Expression [11]
Calcium/manganese antiporter SLC30A10 (SLC30A10) OTXM5JW4 ZNT10_HUMAN Decreases Expression [11]
Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) OT4IN0MV HSDL2_HUMAN Decreases Expression [11]
Lysosomal amino acid transporter 1 homolog (SLC66A1) OTUM63MK LAAT1_HUMAN Increases Expression [11]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1) OTVILUUN SO4C1_HUMAN Decreases Expression [11]
RNA-binding protein with multiple splicing 2 (RBPMS2) OTY24L1F RBPS2_HUMAN Increases Expression [11]
Rho GTPase-activating protein 27 (ARHGAP27) OT8BSRPC RHG27_HUMAN Increases Expression [11]
SH2 domain-containing protein 5 (SH2D5) OTJDS1NN SH2D5_HUMAN Increases Expression [11]
Vesicle transport protein GOT1A (GOLT1A) OTY8H2OF GOT1A_HUMAN Increases Expression [11]
Membrane progestin receptor epsilon (PAQR9) OTLY2CZM PAQR9_HUMAN Decreases Expression [11]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [11]
Histone H2A.V (H2AZ2) OT0I5H2P H2AV_HUMAN Decreases Expression [11]
Carbohydrate sulfotransferase 9 (CHST9) OT1DEZRM CHST9_HUMAN Decreases Expression [11]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [11]
Transmembrane channel-like protein 7 (TMC7) OT9RUFN8 TMC7_HUMAN Increases Expression [11]
Transmembrane channel-like protein 6 (TMC6) OTKH50J4 TMC6_HUMAN Increases Expression [11]
Low-density lipoprotein receptor-related protein 10 (LRP10) OT8490HT LRP10_HUMAN Increases Expression [11]
HAUS augmin-like complex subunit 6 (HAUS6) OT7ZVR57 HAUS6_HUMAN Decreases Expression [11]
Protein O-glucosyltransferase 3 (POGLUT3) OTBTJI73 PLGT3_HUMAN Decreases Expression [11]
E3 ubiquitin-protein ligase SH3RF1 (SH3RF1) OT7MYGYO SH3R1_HUMAN Increases Expression [11]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Expression [11]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Decreases Expression [11]
Suppressor APC domain-containing protein 2 (SAPCD2) OTXS0EXM SAPC2_HUMAN Decreases Expression [11]
Condensin-2 complex subunit G2 (NCAPG2) OTZYENKO CNDG2_HUMAN Decreases Expression [11]
GAS2-like protein 3 (GAS2L3) OTWPVI29 GA2L3_HUMAN Decreases Expression [11]
Cilium assembly protein DZIP1 (DZIP1) OTBVPO66 DZIP1_HUMAN Decreases Expression [11]
Rab11 family-interacting protein 4 (RAB11FIP4) OTIGHER7 RFIP4_HUMAN Decreases Expression [11]
Inactive tyrosine-protein kinase PRAG1 (PRAG1) OTV83SGI PRAG1_HUMAN Increases Expression [11]
Transmembrane channel-like protein 8 (TMC8) OTUAD95X TMC8_HUMAN Increases Expression [11]
Leucine rich adaptor protein 1-like (LURAP1L) OTSJ29M5 LUR1L_HUMAN Increases Expression [11]
Immunoglobulin superfamily DCC subclass member 3 (IGDCC3) OTGR1KA4 IGDC3_HUMAN Decreases Expression [11]
Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) OT9YEJXS IPRI_HUMAN Increases Expression [11]
Volume-regulated anion channel subunit LRRC8A (LRRC8A) OT23OE7H LRC8A_HUMAN Increases Expression [11]
Protein FAM200C (FAM200C) OTZOXUEK F200C_HUMAN Decreases Expression [11]
Solute carrier family 22 member 15 (SLC22A15) OT60WAAI S22AF_HUMAN Increases Expression [11]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [11]
EP300-interacting inhibitor of differentiation 3 (EID3) OTAND0C7 EID3_HUMAN Increases Expression [11]
N-acetylglutamate synthase, mitochondrial (NAGS) OTITB7DO NAGS_HUMAN Increases Expression [11]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [11]
Mucin-20 (MUC20) OTYYE1GK MUC20_HUMAN Increases Expression [11]
Choline transporter-like protein 3 (SLC44A3) OTL0FT8L CTL3_HUMAN Decreases Expression [11]
Testis-expressed protein 9 (TEX9) OTMYCDCW TEX9_HUMAN Decreases Expression [11]
Mixed lineage kinase domain-like protein (MLKL) OTDSLC81 MLKL_HUMAN Decreases Expression [11]
Golgi membrane protein 1 (GOLM1) OTOZSV6O GOLM1_HUMAN Increases Expression [11]
Aquaporin-11 (AQP11) OT1IQMHV AQP11_HUMAN Decreases Expression [11]
Uncharacterized protein C1orf131 (C1ORF131) OTTFSELE CA131_HUMAN Decreases Expression [11]
Meiosis-specific nuclear structural protein 1 (MNS1) OT67F3JQ MNS1_HUMAN Decreases Expression [11]
SHC SH2 domain-binding protein 1 (SHCBP1) OT3A21CM SHCBP_HUMAN Decreases Expression [11]
Methylcytosine dioxygenase TET1 (TET1) OTZDHT1D TET1_HUMAN Decreases Expression [11]
V-type proton ATPase subunit e 2 (ATP6V0E2) OTFU678I VA0E2_HUMAN Decreases Expression [11]
Kinesin-like protein KIF18A (KIF18A) OTSMBJ24 KI18A_HUMAN Decreases Expression [11]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [11]
Arrestin domain-containing protein 2 (ARRDC2) OTVEOXAG ARRD2_HUMAN Increases Expression [11]
Nuclear protein MDM1 (MDM1) OTI9JUWA MDM1_HUMAN Decreases Expression [11]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Decreases Expression [11]
2-phosphoxylose phosphatase 1 (PXYLP1) OTX8T7F6 PXYP1_HUMAN Decreases Expression [11]
Rhomboid-related protein 4 (RHBDD1) OTL5J132 RHBL4_HUMAN Increases Expression [11]
Centrosomal protein of 192 kDa (CEP192) OTBLFV7T CE192_HUMAN Decreases Expression [11]
PDZ domain-containing protein GIPC2 (GIPC2) OT68YFO1 GIPC2_HUMAN Decreases Expression [11]
Monocarboxylate transporter 10 (SLC16A10) OTH70529 MOT10_HUMAN Decreases Expression [11]
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5) OTUM65JL GDPD5_HUMAN Decreases Expression [11]
Sodium-dependent phosphate transporter 1 (SLC20A1) OTC3D894 S20A1_HUMAN Increases Expression [11]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [11]
Kelch repeat and BTB domain-containing protein 7 (KBTBD7) OT1NIRLK KBTB7_HUMAN Decreases Expression [11]
Cytoskeleton-associated protein 2 (CKAP2) OTCLTC0J CKAP2_HUMAN Decreases Expression [11]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [11]
Ras and Rab interactor 2 (RIN2) OTCY73U9 RIN2_HUMAN Increases Expression [11]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2) OTBXYFRH ARAP2_HUMAN Increases Expression [11]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Increases Expression [11]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [11]
Gamma-glutamyl hydrolase (GGH) OTL71J7T GGH_HUMAN Decreases Expression [11]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [11]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Increases Expression [11]
Liver-expressed antimicrobial peptide 2 (LEAP2) OTUOPIS5 LEAP2_HUMAN Decreases Expression [11]
Protein MAL2 (MAL2) OTVPEI80 MAL2_HUMAN Decreases Expression [11]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [11]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Decreases Expression [11]
RAD51-associated protein 1 (RAD51AP1) OTXM7UTD R51A1_HUMAN Decreases Expression [11]
SPRY domain-containing SOCS box protein 1 (SPSB1) OTGY26U4 SPSB1_HUMAN Increases Expression [11]
Spindle and kinetochore-associated protein 1 (SKA1) OTDYJ12A SKA1_HUMAN Decreases Expression [11]
Solute carrier family 22 member 18 (SLC22A18) OT9C3KR4 S22AI_HUMAN Increases Expression [11]
Endoplasmic reticulum resident protein 27 (ERP27) OTVMGE2H ERP27_HUMAN Decreases Expression [11]
Ankyrin repeat and SOCS box protein 9 (ASB9) OT3AA61T ASB9_HUMAN Decreases Expression [11]
RecQ-mediated genome instability protein 2 (RMI2) OTA0HP4S RMI2_HUMAN Decreases Expression [11]
Protein Spindly (SPDL1) OTI0JNTM SPDLY_HUMAN Decreases Expression [11]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [11]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [11]
Cell division cycle-associated 7-like protein (CDCA7L) OT1FFWKC CDA7L_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase greatwall (MASTL) OTQ7YKK5 GWL_HUMAN Decreases Expression [11]
Coiled-coil domain-containing protein 34 (CCDC34) OTZ3AGSQ CCD34_HUMAN Decreases Expression [11]
Carboxypeptidase B2 (CPB2) OTPIL8IE CBPB2_HUMAN Decreases Expression [11]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [11]
Leucine-rich repeat protein 1 (LRR1) OTSWDXVY LLR1_HUMAN Decreases Expression [11]
Coiled-coil domain-containing protein 138 (CCDC138) OTT1TXO8 CC138_HUMAN Decreases Expression [11]
Uncharacterized protein C5orf34 (C5ORF34) OTT2ESR4 CE034_HUMAN Decreases Expression [11]
Transmembrane protein 237 (TMEM237) OTQEVL7L TM237_HUMAN Decreases Expression [11]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [11]
Sperm-associated antigen 5 (SPAG5) OTCLJ56M SPAG5_HUMAN Decreases Expression [11]
PAS domain-containing serine/threonine-protein kinase (PASK) OT4MOQZ8 PASK_HUMAN Decreases Expression [11]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [11]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [11]
Serine incorporator 2 (SERINC2) OTZ039U0 SERC2_HUMAN Increases Expression [11]
Cytochrome P450 2S1 (CYP2S1) OTKHX4RF CP2S1_HUMAN Increases Expression [11]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [11]
Cell division cycle-associated protein 3 (CDCA3) OTUI8QK3 CDCA3_HUMAN Decreases Expression [11]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [11]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Decreases Expression [11]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [11]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [11]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Decreases Expression [11]
SMC5-SMC6 complex localization factor protein 1 (SLF1) OT6ZA2K9 SLF1_HUMAN Decreases Expression [11]
Coiled-coil domain-containing protein 77 (CCDC77) OTQQT2IC CCD77_HUMAN Decreases Expression [11]
DNA replication complex GINS protein PSF3 (GINS3) OT8NVXTD PSF3_HUMAN Decreases Expression [11]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [11]
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1) OTYKRRGE RHNO1_HUMAN Decreases Expression [11]
Protein PIMREG (PIMREG) OTKC8T3E PIMRE_HUMAN Decreases Expression [11]
Immediate early response gene 2 protein (IER2) OT5OY8BO IER2_HUMAN Increases Expression [11]
EF-hand calcium-binding domain-containing protein 11 (EFCAB11) OTXDJ9R8 EFC11_HUMAN Decreases Expression [11]
Sister chromatid cohesion protein DCC1 (DSCC1) OTPUVLZT DCC1_HUMAN Decreases Expression [11]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Decreases Expression [11]
Cell division cycle-associated protein 7 (CDCA7) OT12HDZY CDCA7_HUMAN Decreases Expression [11]
Meiotic nuclear division protein 1 homolog (MND1) OTS87F3H MND1_HUMAN Decreases Expression [11]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [11]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [11]
Cell adhesion molecule 1 (CADM1) OTRWG9QS CADM1_HUMAN Decreases Expression [11]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [11]
Kinetochore protein Nuf2 (NUF2) OTOOQL35 NUF2_HUMAN Decreases Expression [11]
Protein sprouty homolog 4 (SPRY4) OT2VK9N0 SPY4_HUMAN Increases Expression [11]
Homeobox protein Hox-D1 (HOXD1) OTN4V9ZF HXD1_HUMAN Decreases Expression [11]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [11]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Decreases Expression [11]
Homeobox protein MIXL1 (MIXL1) OT584VOQ MIXL1_HUMAN Decreases Expression [11]
Centromere protein H (CENPH) OTPOO9LK CENPH_HUMAN Decreases Expression [11]
Kinetochore-associated protein DSN1 homolog (DSN1) OTHROI0H DSN1_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [11]
Protein FAM83D (FAM83D) OTQWZ1UO FA83D_HUMAN Decreases Expression [11]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Increases Expression [11]
ATP-dependent DNA helicase PIF1 (PIF1) OTUHKKVP PIF1_HUMAN Decreases Expression [11]
Syncoilin (SYNC) OTEFLG59 SYNCI_HUMAN Decreases Expression [11]
Thiol S-methyltransferase TMT1A (TMT1A) OT4IAAZP TMT1A_HUMAN Decreases Expression [11]
Cytochrome P450 4F11 (CYP4F11) OTHZ2GG2 CP4FB_HUMAN Increases Expression [11]
Kinetochore protein Spc25 (SPC25) OTCAS0OH SPC25_HUMAN Decreases Expression [11]
DNA polymerase delta subunit 4 (POLD4) OTG578YH DPOD4_HUMAN Increases Expression [11]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Increases Expression [11]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Increases Expression [11]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [11]
Unconventional myosin-Vc (MYO5C) OTKLOCWZ MYO5C_HUMAN Decreases Expression [11]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [11]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [11]
Kinesin-like protein KIF15 (KIF15) OTJRJEXL KIF15_HUMAN Decreases Expression [11]
Sal-like protein 1 (SALL1) OTYYZGLH SALL1_HUMAN Decreases Expression [11]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) OTALLHT1 FIRRM_HUMAN Decreases Expression [11]
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) OTR4990X PLPL3_HUMAN Decreases Expression [11]
Protein diaphanous homolog 3 (DIAPH3) OTPOT23F DIAP3_HUMAN Decreases Expression [11]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [11]
Serine palmitoyltransferase 3 (SPTLC3) OTZDX6PT SPTC3_HUMAN Decreases Expression [11]
Transmembrane protein 140 (TMEM140) OTQCEGEO TM140_HUMAN Increases Expression [11]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [11]
Spermine oxidase (SMOX) OT11E62Y SMOX_HUMAN Increases Expression [11]
PCNA-interacting partner (PARPBP) OTPZDGW7 PARI_HUMAN Decreases Expression [11]
Membrane progestin receptor gamma (PAQR5) OTGGWXQE PAQR5_HUMAN Increases Expression [11]
Protein Mis18-alpha (MIS18A) OTD80K5X MS18A_HUMAN Decreases Expression [11]
G2 and S phase-expressed protein 1 (GTSE1) OTPP742Z GTSE1_HUMAN Decreases Expression [11]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [11]
Kelch-like protein 14 (KLHL14) OTYOS55H KLH14_HUMAN Decreases Expression [11]
DNA (DNMT3B) OTZ0JCNP DNM3B_HUMAN Decreases Expression [11]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Increases Expression [11]
CAP-Gly domain-containing linker protein 2 (CLIP2) OTSCIQIY CLIP2_HUMAN Increases Expression [11]
Doublecortin domain-containing protein 2 (DCDC2) OTSUFH1H DCDC2_HUMAN Decreases Expression [11]
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) OTZ71SK9 BI2L1_HUMAN Increases Expression [11]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [11]
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OT9KIVZW OSGI1_HUMAN Increases Expression [11]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [11]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Increases Expression [11]
Protein phosphatase 1H (PPM1H) OTKSVU7S PPM1H_HUMAN Decreases Expression [11]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [11]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [11]
Sex comb on midleg-like protein 1 (SCML1) OT7V5DAR SCML1_HUMAN Decreases Expression [11]
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) OTN51IPT S6A14_HUMAN Decreases Expression [11]
Exonuclease 1 (EXO1) OTI87RS5 EXO1_HUMAN Decreases Expression [11]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Decreases Expression [11]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [11]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [11]
Dexamethasone-induced Ras-related protein 1 (RASD1) OT2BAJHK RASD1_HUMAN Increases Expression [11]
E3 ubiquitin-protein ligase DTX4 (DTX4) OTGX30AO DTX4_HUMAN Decreases Expression [11]
Nuclear factor erythroid 2-related factor 3 (NFE2L3) OT1MGXT0 NF2L3_HUMAN Decreases Expression [11]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1) OTIPDI15 CRBG1_HUMAN Decreases Expression [11]
BTB/POZ domain-containing protein KCTD3 (KCTD3) OT6EGR42 KCTD3_HUMAN Decreases Expression [11]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Increases Expression [11]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [11]
Mitochondrial pyruvate carrier 1 (MPC1) OT6DYFUO MPC1_HUMAN Decreases Expression [11]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Decreases Expression [11]
Lymphocyte antigen 96 (LY96) OTN4HXA2 LY96_HUMAN Increases Expression [11]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [25]
Rap1 GTPase-activating protein 1 (RAP1GAP) OTC31ONQ RPGP1_HUMAN Increases Expression [25]
Ras-related protein R-Ras2 (RRAS2) OT83NCEB RRAS2_HUMAN Increases Expression [25]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [25]
F-box only protein 30 (FBXO30) OTD1P6LA FBX30_HUMAN Increases Expression [25]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [26]
Serine protease inhibitor Kazal-type 1 (SPINK1) OTSUVAL2 ISK1_HUMAN Increases Expression [27]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [28]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [29]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Mutagenesis [30]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [28]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [31]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Increases Phosphorylation [31]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [31]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [31]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Increases Phosphorylation [31]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Decreases Activity [12]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [32]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Decreases Phosphorylation [12]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [12]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Affects Mutagenesis [33]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Increases Expression [26]
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) OT6QGM5Y IMDH1_HUMAN Affects Response To Substance [34]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Affects Metabolism [35]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Affects Response To Substance [36]
Purine nucleoside phosphorylase (PNP) OTO5NIJ2 PNPH_HUMAN Increases ADR [37]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Affects Response To Substance [36]
Cytosolic 5'-nucleotidase 1A (NT5C1A) OTS7UF36 5NT1A_HUMAN Increases ADR [37]
------------------------------------------------------------------------------------
⏷ Show the Full List of 574 DOT(s)
Indication(s) of Ruxolitinib
Disease Entry ICD 11 Status REF
Essential thrombocythemia 3B63.1Z Approved [4]
High-risk myelofibrosis 2A20.2 Approved [5]
Myelofibrosis 2A22 Approved [6]
Myeloproliferative neoplasm 2A20 Approved [7]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [8]
Pancreatic cancer 2C10 Phase 3 [5]
Atopic dermatitis EA80 Phase 1/2 [9]
Vitiligo ED63.0 Phase 1/2 [9]
Ruxolitinib Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Modulator [38]
Janus kinase 1 (JAK-1) TT6DM01 JAK1_HUMAN Modulator [38]
Urokinase plasminogen activator surface receptor (PLAUR) TTPRL03 UPAR_HUMAN Inhibitor [39]
HUMAN janus kinase 1 (JAK-1) TTWKB01 JAK1_HUMAN Inhibitor [40]
HUMAN janus kinase 2 (JAK-2) TT0F5HE JAK2_HUMAN Inhibitor [40]
------------------------------------------------------------------------------------
Ruxolitinib Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases ADR [37]
------------------------------------------------------------------------------------

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Azathioprine FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7120).
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5688).
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
7 Ruxolitinib FDA Label
8 Incyte begins Phase III trial of ruxolitinib to treat Covid-19. 20.April.2020.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
11 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
12 CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest. 2003 Apr;111(8):1133-45. doi: 10.1172/JCI16432.
13 IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br J Clin Pharmacol. 2008 Jan;65(1):69-77.
14 Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22.
15 Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis. 2000 Jun;21(6):1157-62.
16 Nodular regenerative liver hyperplasia as a complication of azathioprine-containing immunosuppressive treatment for Crohn's disease. Immunopharmacol Immunotoxicol. 2011 Jun;33(2):398-402.
17 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
18 PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity. Hum Mol Genet. 2012 Nov 1;21(21):4793-804.
19 Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine. Chem Biol Interact. 2010 Jul 30;186(2):110-7. doi: 10.1016/j.cbi.2010.04.028. Epub 2010 Apr 29.
20 Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm Bowel Dis. 2007 Jan;13(1):57-64. doi: 10.1002/ibd.20004.
21 MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease. Inflamm Bowel Dis. 2007 May;13(5):585-90. doi: 10.1002/ibd.20044.
22 Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics. 2004 Mar;14(3):181-7. doi: 10.1097/00008571-200403000-00006.
23 Severe villus atrophy and chronic malabsorption induced by azathioprine. Gastroenterology. 2003 Jun;124(7):1950-7.
24 Petit E, Langouet S, Akhdar H, Nicolas-Nicolaz C, Guillouzo A, Morel F. Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes. Toxicol In Vitro. 2008;22(3):632-642. [PMID: 18222062]
25 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
26 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
27 Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
28 Immune responses in autoimmune hepatitis: effect of prednisone and azathioprine treatment: case report. Int J Med Sci. 2009 Jun 30;6(4):177-83. doi: 10.7150/ijms.6.177.
29 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
30 More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine. Exp Dermatol. 2008 Apr;17(4):349-55. doi: 10.1111/j.1600-0625.2007.00651.x. Epub 2007 Nov 2.
31 Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):568-78. doi: 10.1016/j.taap.2013.07.024. Epub 2013 Aug 16.
32 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
33 PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients. Br J Cancer. 2008 Oct 21;99(8):1276-84. doi: 10.1038/sj.bjc.6604665.
34 IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance. Pharmacogenomics J. 2007 Oct;7(5):312-7. doi: 10.1038/sj.tpj.6500421. Epub 2006 Oct 17.
35 Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members. J Mol Biol. 2008 Feb 1;375(5):1365-79. doi: 10.1016/j.jmb.2007.11.034. Epub 2007 Nov 19.
36 HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nat Genet. 2014 Oct;46(10):1131-4. doi: 10.1038/ng.3093. Epub 2014 Sep 14.
37 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
38 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
39 Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis.Cell Cycle. 2014;13(12):1958-69.
40 The Use of Anti-Inflammatory Drugs in the Treatment of People With Severe Coronavirus Disease 2019 (COVID-19): The Perspectives of Clinical Immunologists From China. Clin Immunol. 2020 May;214:108393.