Details of the Drug Combination

General Information of Drug Combination (ID: DCO82YN)

Drug Combination Name
Azathioprine Tacrolimus
Indication
Disease Entry Status REF
Uterine Factor Infertility Phase 2 [1]
Component Drugs Azathioprine   DMMZSXQ Tacrolimus   DMZ7XNQ
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Azathioprine
Disease Entry ICD 11 Status REF
Lupus nephritis 4A40.0Y Approved [2]
Organ transplant rejection NE84 Approved [3]
Azathioprine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Amidophosphoribosyltransferase (PPAT) TTZFTY4 PUR1_HUMAN Inhibitor [9]
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Azathioprine Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]
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Azathioprine Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [11]
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Metabolism [12]
Glutathione S-transferase alpha-2 (GSTA2) DEH49YS GSTA2_HUMAN Metabolism [13]
Glutathione S-transferase mu-1 (GSTM1) DEYZEJA GSTM1_HUMAN Metabolism [13]
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Azathioprine Interacts with 574 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Thiopurine S-methyltransferase (TPMT) OTFOX70W TPMT_HUMAN Increases ADR [14]
Glutathione S-transferase A2 (GSTA2) OTW7UB1H GSTA2_HUMAN Affects Response To Substance [15]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [16]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Affects Response To Substance [17]
Inosine triphosphate pyrophosphatase (ITPA) OTQ47WVR ITPA_HUMAN Affects Response To Substance [18]
Dipeptidyl peptidase 4 (DPP4) OT16MVL9 DPP4_HUMAN Decreases Expression [19]
Solute carrier family 15 member 1 (SLC15A1) OT1P16B5 S15A1_HUMAN Decreases Expression [19]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) OTPG0K7E IMDH2_HUMAN Increases Expression [20]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Increases Expression [20]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [20]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [20]
Glutathione synthetase (GSS) OTVSBEIW GSHB_HUMAN Increases Expression [20]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [6]
Phospholipid phosphatase 3 (PLPP3) OTSSF7BK PLPP3_HUMAN Decreases Expression [6]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Decreases Expression [6]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [6]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Decreases Expression [6]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Decreases Expression [6]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Decreases Expression [6]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Decreases Expression [6]
Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3) OTDA431Y ENTP3_HUMAN Increases Expression [6]
Antiviral innate immune response receptor RIG-I (RIGI) OTFIIC43 RIGI_HUMAN Decreases Expression [6]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [6]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [6]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [6]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Decreases Expression [6]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [6]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [6]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Expression [6]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Increases Expression [6]
Neuromedin-B (NMB) OT4NLN6H NMB_HUMAN Decreases Expression [6]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [6]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [6]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Decreases Expression [6]
Granulocyte colony-stimulating factor (CSF3) OT9GC6TP CSF3_HUMAN Decreases Expression [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [6]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Decreases Expression [6]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [6]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Increases Expression [6]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [6]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Expression [6]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Decreases Expression [6]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Decreases Expression [6]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [6]
Guanylate-binding protein 1 (GBP1) OTUM7RPJ GBP1_HUMAN Decreases Expression [6]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [6]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Increases Expression [6]
Macrophage metalloelastase (MMP12) OT9Z7LHM MMP12_HUMAN Decreases Expression [6]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Decreases Expression [6]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [6]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Increases Expression [6]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [6]
Spermine synthase (SMS) OT8JYKNH SPSY_HUMAN Decreases Expression [6]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [6]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Decreases Expression [6]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Decreases Expression [6]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [6]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) OTRZH80H TNAP2_HUMAN Decreases Expression [6]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Increases Expression [6]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Decreases Expression [6]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [6]
Probable ATP-dependent RNA helicase DDX10 (DDX10) OTH48438 DDX10_HUMAN Increases Expression [6]
Neuronal membrane glycoprotein M6-b (GPM6B) OT8Q1582 GPM6B_HUMAN Increases Expression [6]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Decreases Expression [6]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2) OTTUU92F ENPP2_HUMAN Increases Expression [6]
Nidogen-2 (NID2) OTHC33FF NID2_HUMAN Increases Expression [6]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Decreases Expression [6]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Decreases Expression [6]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Decreases Expression [6]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Increases Expression [6]
Olfactomedin-like protein 2B (OLFML2B) OTDNJFR4 OLM2B_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase RNF19B (RNF19B) OTYCWKBP RN19B_HUMAN Decreases Expression [6]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Decreases Expression [6]
Probable E3 ubiquitin-protein ligase HERC6 (HERC6) OT7G9PQE HERC6_HUMAN Decreases Expression [6]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Decreases Expression [6]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) OTCA9WCM RSAD2_HUMAN Decreases Expression [6]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Decreases Expression [6]
Interferon regulatory factor 7 (IRF7) OTC1A2PQ IRF7_HUMAN Decreases Expression [6]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Decreases Expression [6]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Increases Expression [6]
Interferon-induced helicase C domain-containing protein 1 (IFIH1) OTZA2AHA IFIH1_HUMAN Decreases Expression [6]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Increases Expression [6]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Increases Expression [6]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [6]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Increases Expression [6]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Decreases Expression [6]
Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) OT7FCZRM PP4R2_HUMAN Increases Expression [6]
E3 ISG15--protein ligase HERC5 (HERC5) OTZ5PR39 HERC5_HUMAN Decreases Expression [6]
Paired immunoglobulin-like type 2 receptor alpha (PILRA) OTBE0PLF PILRA_HUMAN Decreases Expression [6]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [6]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Decreases Expression [6]
2'-5'-oligoadenylate synthase 3 (OAS3) OT6E5FYS OAS3_HUMAN Decreases Expression [6]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Decreases Expression [7]
Odontogenic ameloblast-associated protein (ODAM) OTT666SJ ODAM_HUMAN Decreases Expression [7]
UPF0524 protein C3orf70 (C3ORF70) OTDWU4AC CC070_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Decreases Expression [7]
Cell division cycle 7-related protein kinase (CDC7) OT5133XY CDC7_HUMAN Decreases Expression [7]
Citron Rho-interacting kinase (CIT) OTOZDKPG CTRO_HUMAN Decreases Expression [7]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) OTB6YLFT ENPP3_HUMAN Decreases Expression [7]
Inositol monophosphatase 2 (IMPA2) OTNFB9YN IMPA2_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Decreases Expression [7]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [7]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [7]
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B) OT8JQ1F7 PI51B_HUMAN Decreases Expression [7]
Matrilin-3 (MATN3) OTH9H74J MATN3_HUMAN Decreases Expression [7]
Mitogen-activated protein kinase 13 (MAPK13) OT0W9GE7 MK13_HUMAN Increases Expression [7]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [7]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [7]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) OTIK337D TGFI1_HUMAN Increases Expression [7]
Protein Mis18-beta (OIP5) OTI5C2DE MS18B_HUMAN Decreases Expression [7]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [7]
Band 4.1-like protein 2 (EPB41L2) OT6UABPM E41L2_HUMAN Decreases Expression [7]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [7]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [7]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [7]
Periplakin (PPL) OTTM4WDO PEPL_HUMAN Increases Expression [7]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [7]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [7]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [7]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [7]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [7]
Geminin (GMNN) OTDYKNIY GEMI_HUMAN Decreases Expression [7]
Transcription elongation factor A protein 3 (TCEA3) OTLTRSK4 TCEA3_HUMAN Decreases Expression [7]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [7]
Isocitrate dehydrogenase cytoplasmic (IDH1) OT4DLHC8 IDHC_HUMAN Decreases Expression [7]
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) OT15HOJX AL1L1_HUMAN Increases Expression [7]
Rho-related BTB domain-containing protein 1 (RHOBTB1) OTGE8K45 RHBT1_HUMAN Decreases Expression [7]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Decreases Expression [7]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [7]
Centrosomal protein of 152 kDa (CEP152) OTOKZR9B CE152_HUMAN Decreases Expression [7]
Fibrinogen silencer-binding protein (RAD54B) OTMWB2P2 FSBP_HUMAN Decreases Expression [7]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [7]
Structural maintenance of chromosomes protein 2 (SMC2) OT5S0DV4 SMC2_HUMAN Decreases Expression [7]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) OTQ9ALTR GCNT3_HUMAN Increases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10) OTL32QH7 GTR10_HUMAN Decreases Expression [7]
Caveolae-associated protein 2 (CAVIN2) OTFHHDRU CAVN2_HUMAN Decreases Expression [7]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Decreases Expression [7]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [7]
Glutamate dehydrogenase 1, mitochondrial (GLUD1) OTXKOCUH DHE3_HUMAN Decreases Expression [7]
Phenylalanine-4-hydroxylase (PAH) OT6GT2K8 PH4H_HUMAN Decreases Expression [7]
Haptoglobin-related protein (HPR) OTXSC9UB HPTR_HUMAN Decreases Expression [7]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [7]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Increases Expression [7]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [7]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [7]
Apolipoprotein C-III (APOC3) OTW3520C APOC3_HUMAN Decreases Expression [7]
Fibrinogen alpha chain (FGA) OTMIHY80 FIBA_HUMAN Decreases Expression [7]
Angiogenin (ANG) OT3ECS6P ANGI_HUMAN Decreases Expression [7]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Decreases Expression [7]
Platelet-derived growth factor subunit A (PDGFA) OTCMZ0W8 PDGFA_HUMAN Increases Expression [7]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [7]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [7]
Complement factor I (CFI) OTQYYX0P CFAI_HUMAN Decreases Expression [7]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [7]
Thyroxine-binding globulin (SERPINA7) OTUYVTSU THBG_HUMAN Decreases Expression [7]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [7]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases Expression [7]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Expression [7]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Decreases Expression [7]
Procathepsin L (CTSL) OTYTUW29 CATL1_HUMAN Increases Expression [7]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Expression [7]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Increases Expression [7]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Increases Expression [7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [7]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [7]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Increases Expression [7]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Increases Expression [7]
Glycodelin (PAEP) OTQA0NV4 PAEP_HUMAN Increases Expression [7]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [7]
Histone H2A.Z (H2AZ1) OT3KJJNQ H2AZ_HUMAN Decreases Expression [7]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [7]
E3 SUMO-protein ligase EGR2 (EGR2) OTAVQ78J EGR2_HUMAN Increases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Decreases Expression [7]
Mannose-binding protein C (MBL2) OTS63HG5 MBL2_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [7]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [7]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [7]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Decreases Expression [7]
Interleukin-7 (IL7) OTT6YSKM IL7_HUMAN Decreases Expression [7]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [7]
Leukemia inhibitory factor (LIF) OTO46S5S LIF_HUMAN Increases Expression [7]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Expression [7]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [7]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [7]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Expression [7]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [7]
Hexokinase-1 (HK1) OTMPHE8O HXK1_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [7]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [7]
Neutrophil cytosol factor 2 (NCF2) OTAUW7L2 NCF2_HUMAN Increases Expression [7]
Follistatin (FST) OTRIVK9Y FST_HUMAN Increases Expression [7]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [7]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [7]
Aromatic-L-amino-acid decarboxylase (DDC) OT0TSW09 DDC_HUMAN Decreases Expression [7]
Interleukin-11 (IL11) OTXHN86R IL11_HUMAN Increases Expression [7]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Decreases Expression [7]
COUP transcription factor 2 (NR2F2) OTJFS67N COT2_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [7]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Decreases Expression [7]
Deoxycytidine kinase (DCK) OTW8HLZC DCK_HUMAN Decreases Expression [7]
Proteasome subunit beta type-9 (PSMB9) OTFV57T8 PSB9_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [7]
Grancalcin (GCA) OTAJ7ZHG GRAN_HUMAN Decreases Expression [7]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [7]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [7]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [7]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Increases Expression [7]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [7]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Increases Expression [7]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM5 (MCM5) OTAHLB62 MCM5_HUMAN Decreases Expression [7]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Decreases Expression [7]
Serine hydroxymethyltransferase, cytosolic (SHMT1) OTIINA3J GLYC_HUMAN Decreases Expression [7]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [7]
Sodium channel protein type 1 subunit alpha (SCN1A) OTJ9ZTYI SCN1A_HUMAN Decreases Expression [7]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Decreases Expression [7]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [7]
Glutaredoxin-1 (GLRX) OT0QHTAR GLRX1_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [7]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [7]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Decreases Expression [7]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [7]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [7]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [7]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Increases Expression [7]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [7]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Decreases Expression [7]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [7]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [7]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Increases Expression [7]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [7]
Nuclear autoantigenic sperm protein (NASP) OTNE4THC NASP_HUMAN Decreases Expression [7]
Flavin-containing monooxygenase 5 (FMO5) OTTILF8T FMO5_HUMAN Decreases Expression [7]
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) OTV57BZD AL7A1_HUMAN Decreases Expression [7]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [7]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [7]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Decreases Expression [7]
Type I iodothyronine deiodinase (DIO1) OTFYLYJ0 IOD1_HUMAN Decreases Expression [7]
Kinetochore-associated protein 1 (KNTC1) OTI2OOFN KNTC1_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase RNF144A (RNF144A) OTCG27CT R144A_HUMAN Decreases Expression [7]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Decreases Expression [7]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [7]
Aldo-keto reductase family 1 member D1 (AKR1D1) OTBDJ6RL AK1D1_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [7]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [7]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [7]
Kinesin-like protein KIF11 (KIF11) OTHRGLCQ KIF11_HUMAN Decreases Expression [7]
2-iminobutanoate/2-iminopropanoate deaminase (RIDA) OTW4098I RIDA_HUMAN Decreases Expression [7]
Hexokinase-2 (HK2) OTC0GCQO HXK2_HUMAN Decreases Expression [7]
Thimet oligopeptidase (THOP1) OT9E148D THOP1_HUMAN Increases Expression [7]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Increases Expression [7]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [7]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) OT6W40XU P5CS_HUMAN Decreases Expression [7]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Decreases Expression [7]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [7]
Breast cancer anti-estrogen resistance protein 1 (BCAR1) OTKT2C2N BCAR1_HUMAN Increases Expression [7]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [7]
Anthrax toxin receptor 2 (ANTXR2) OTOGFGOJ ANTR2_HUMAN Increases Expression [7]
Protein FAM3B (FAM3B) OTC2S91N FAM3B_HUMAN Decreases Expression [7]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Increases Expression [7]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Decreases Expression [7]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Increases Expression [7]
Gamma-aminobutyric acid receptor subunit epsilon (GABRE) OTXF5ICU GBRE_HUMAN Increases Expression [7]
Iroquois-class homeodomain protein IRX-3 (IRX3) OTLJ48FG IRX3_HUMAN Decreases Expression [7]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [7]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Decreases Expression [7]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [7]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [7]
Cyclic AMP-responsive element-binding protein 5 (CREB5) OTJDUJPI CREB5_HUMAN Increases Expression [7]
Hematopoietically-expressed homeobox protein HHEX (HHEX) OTLIUVYX HHEX_HUMAN Decreases Expression [7]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Decreases Expression [7]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [7]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Increases Expression [7]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [7]
Peroxisomal bifunctional enzyme (EHHADH) OTBAAHL5 ECHP_HUMAN Decreases Expression [7]
Putative sodium-coupled neutral amino acid transporter 11 (SLC38A11) OTFXRU35 S38AB_HUMAN Decreases Expression [7]
TBC1 domain family member 8B (TBC1D8B) OTSYGOXH TBC8B_HUMAN Decreases Expression [7]
Coiled-coil domain-containing protein 15 (CCDC15) OT1NZX84 CCD15_HUMAN Decreases Expression [7]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [7]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Decreases Expression [7]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [7]
Syntaxin-3 (STX3) OT4CIWLJ STX3_HUMAN Increases Expression [7]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [7]
Growth factor receptor-bound protein 10 (GRB10) OTCKXGRC GRB10_HUMAN Increases Expression [7]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [7]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [7]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Decreases Expression [7]
Four and a half LIM domains protein 3 (FHL3) OTMPRLZ5 FHL3_HUMAN Increases Expression [7]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Increases Expression [7]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Decreases Expression [7]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [7]
Glucokinase regulatory protein (GCKR) OTSIWXGG GCKR_HUMAN Increases Expression [7]
Growth factor receptor-bound protein 14 (GRB14) OTFET2YM GRB14_HUMAN Decreases Expression [7]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Decreases Expression [7]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [7]
Separin (ESPL1) OTMGEVOK ESPL1_HUMAN Decreases Expression [7]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Decreases Expression [7]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [7]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Increases Expression [7]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [7]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [7]
DNA polymerase delta subunit 3 (POLD3) OTEQEFQ2 DPOD3_HUMAN Decreases Expression [7]
Transcription elongation factor A protein-like 1 (TCEAL1) OTAPG2L5 TCAL1_HUMAN Decreases Expression [7]
Transcription factor E2F5 (E2F5) OT1XWING E2F5_HUMAN Decreases Expression [7]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Decreases Expression [7]
SH2 domain-containing adapter protein B (SHB) OTF2HSC0 SHB_HUMAN Increases Expression [7]
SCL-interrupting locus protein (STIL) OT9799VN STIL_HUMAN Decreases Expression [7]
Pachytene checkpoint protein 2 homolog (TRIP13) OTFM3TI9 PCH2_HUMAN Decreases Expression [7]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3) OTA2TBWS HMGN3_HUMAN Decreases Expression [7]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Decreases Expression [7]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [7]
C-C motif chemokine 15 (CCL15) OTOGZ85M CCL15_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [7]
Kynureninase (KYNU) OTINL2RE KYNU_HUMAN Increases Expression [7]
Histone H2B type 2-E (H2BC21) OT0FDCUC H2B2E_HUMAN Increases Expression [7]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Decreases Expression [7]
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) OTW1SCZW CPEB4_HUMAN Increases Expression [7]
Sodium/glucose cotransporter 4 (SLC5A9) OTWQBZ5Q SC5A9_HUMAN Decreases Expression [7]
Autophagy-related protein 2 homolog A (ATG2A) OTGYDDSV ATG2A_HUMAN Increases Expression [7]
Protein FAM161A (FAM161A) OTF5ZRYJ F161A_HUMAN Decreases Expression [7]
Renal cancer differentiation gene 1 protein (C4ORF46) OTXL7SLI CD046_HUMAN Decreases Expression [7]
Centrosomal protein of 55 kDa (CEP55) OTGSG2PA CEP55_HUMAN Decreases Expression [7]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [7]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [7]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [7]
Spindlin-4 (SPIN4) OT09ZWHM SPIN4_HUMAN Decreases Expression [7]
N-acetyltransferase ESCO2 (ESCO2) OTJEMAQU ESCO2_HUMAN Decreases Expression [7]
Transmembrane protein 170B (TMEM170B) OT4AS8RJ T170B_HUMAN Decreases Expression [7]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) OT5WC0Q8 KANK4_HUMAN Decreases Expression [7]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Increases Expression [7]
Coiled-coil domain-containing protein 18 (CCDC18) OT0S9DA2 CCD18_HUMAN Decreases Expression [7]
DEP domain-containing protein 1A (DEPDC1) OT0JWE1B DEP1A_HUMAN Decreases Expression [7]
PX domain-containing protein 1 (PXDC1) OTQUA3TG PXDC1_HUMAN Increases Expression [7]
Mitochondrial amidoxime-reducing component 1 (MTARC1) OTNBE033 MARC1_HUMAN Decreases Expression [7]
Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1) OTRSC1CD IKBP1_HUMAN Decreases Expression [7]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [7]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Increases Expression [7]
Protein sel-1 homolog 3 (SEL1L3) OT10N6Z2 SE1L3_HUMAN Increases Expression [7]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [7]
Transcription factor Sp5 (SP5) OT4HUP9B SP5_HUMAN Decreases Expression [7]
Phostensin (PPP1R18) OT0JVGOZ PPR18_HUMAN Increases Expression [7]
Mis18-binding protein 1 (MIS18BP1) OT41T0FB M18BP_HUMAN Decreases Expression [7]
Mitochondrial fission regulator 2 (MTFR2) OTLOR68D MTFR2_HUMAN Decreases Expression [7]
Rho GTPase-activating protein 11A (ARHGAP11A) OTVQCFVP RHGBA_HUMAN Decreases Expression [7]
Proline/serine-rich coiled-coil protein 1 (PSRC1) OT7MDJMN PSRC1_HUMAN Decreases Expression [7]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [7]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Decreases Expression [7]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [7]
HHIP-like protein 2 (HHIPL2) OTB7P4GV HIPL2_HUMAN Increases Expression [7]
Nephronectin (NPNT) OTFZAO1G NPNT_HUMAN Decreases Expression [7]
Calcium/manganese antiporter SLC30A10 (SLC30A10) OTXM5JW4 ZNT10_HUMAN Decreases Expression [7]
Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) OT4IN0MV HSDL2_HUMAN Decreases Expression [7]
Lysosomal amino acid transporter 1 homolog (SLC66A1) OTUM63MK LAAT1_HUMAN Increases Expression [7]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1) OTVILUUN SO4C1_HUMAN Decreases Expression [7]
RNA-binding protein with multiple splicing 2 (RBPMS2) OTY24L1F RBPS2_HUMAN Increases Expression [7]
Rho GTPase-activating protein 27 (ARHGAP27) OT8BSRPC RHG27_HUMAN Increases Expression [7]
SH2 domain-containing protein 5 (SH2D5) OTJDS1NN SH2D5_HUMAN Increases Expression [7]
Vesicle transport protein GOT1A (GOLT1A) OTY8H2OF GOT1A_HUMAN Increases Expression [7]
Membrane progestin receptor epsilon (PAQR9) OTLY2CZM PAQR9_HUMAN Decreases Expression [7]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [7]
Histone H2A.V (H2AZ2) OT0I5H2P H2AV_HUMAN Decreases Expression [7]
Carbohydrate sulfotransferase 9 (CHST9) OT1DEZRM CHST9_HUMAN Decreases Expression [7]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [7]
Transmembrane channel-like protein 7 (TMC7) OT9RUFN8 TMC7_HUMAN Increases Expression [7]
Transmembrane channel-like protein 6 (TMC6) OTKH50J4 TMC6_HUMAN Increases Expression [7]
Low-density lipoprotein receptor-related protein 10 (LRP10) OT8490HT LRP10_HUMAN Increases Expression [7]
HAUS augmin-like complex subunit 6 (HAUS6) OT7ZVR57 HAUS6_HUMAN Decreases Expression [7]
Protein O-glucosyltransferase 3 (POGLUT3) OTBTJI73 PLGT3_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase SH3RF1 (SH3RF1) OT7MYGYO SH3R1_HUMAN Increases Expression [7]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Expression [7]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Decreases Expression [7]
Suppressor APC domain-containing protein 2 (SAPCD2) OTXS0EXM SAPC2_HUMAN Decreases Expression [7]
Condensin-2 complex subunit G2 (NCAPG2) OTZYENKO CNDG2_HUMAN Decreases Expression [7]
GAS2-like protein 3 (GAS2L3) OTWPVI29 GA2L3_HUMAN Decreases Expression [7]
Cilium assembly protein DZIP1 (DZIP1) OTBVPO66 DZIP1_HUMAN Decreases Expression [7]
Rab11 family-interacting protein 4 (RAB11FIP4) OTIGHER7 RFIP4_HUMAN Decreases Expression [7]
Inactive tyrosine-protein kinase PRAG1 (PRAG1) OTV83SGI PRAG1_HUMAN Increases Expression [7]
Transmembrane channel-like protein 8 (TMC8) OTUAD95X TMC8_HUMAN Increases Expression [7]
Leucine rich adaptor protein 1-like (LURAP1L) OTSJ29M5 LUR1L_HUMAN Increases Expression [7]
Immunoglobulin superfamily DCC subclass member 3 (IGDCC3) OTGR1KA4 IGDC3_HUMAN Decreases Expression [7]
Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) OT9YEJXS IPRI_HUMAN Increases Expression [7]
Volume-regulated anion channel subunit LRRC8A (LRRC8A) OT23OE7H LRC8A_HUMAN Increases Expression [7]
Protein FAM200C (FAM200C) OTZOXUEK F200C_HUMAN Decreases Expression [7]
Solute carrier family 22 member 15 (SLC22A15) OT60WAAI S22AF_HUMAN Increases Expression [7]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [7]
EP300-interacting inhibitor of differentiation 3 (EID3) OTAND0C7 EID3_HUMAN Increases Expression [7]
N-acetylglutamate synthase, mitochondrial (NAGS) OTITB7DO NAGS_HUMAN Increases Expression [7]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [7]
Mucin-20 (MUC20) OTYYE1GK MUC20_HUMAN Increases Expression [7]
Choline transporter-like protein 3 (SLC44A3) OTL0FT8L CTL3_HUMAN Decreases Expression [7]
Testis-expressed protein 9 (TEX9) OTMYCDCW TEX9_HUMAN Decreases Expression [7]
Mixed lineage kinase domain-like protein (MLKL) OTDSLC81 MLKL_HUMAN Decreases Expression [7]
Golgi membrane protein 1 (GOLM1) OTOZSV6O GOLM1_HUMAN Increases Expression [7]
Aquaporin-11 (AQP11) OT1IQMHV AQP11_HUMAN Decreases Expression [7]
Uncharacterized protein C1orf131 (C1ORF131) OTTFSELE CA131_HUMAN Decreases Expression [7]
Meiosis-specific nuclear structural protein 1 (MNS1) OT67F3JQ MNS1_HUMAN Decreases Expression [7]
SHC SH2 domain-binding protein 1 (SHCBP1) OT3A21CM SHCBP_HUMAN Decreases Expression [7]
Methylcytosine dioxygenase TET1 (TET1) OTZDHT1D TET1_HUMAN Decreases Expression [7]
V-type proton ATPase subunit e 2 (ATP6V0E2) OTFU678I VA0E2_HUMAN Decreases Expression [7]
Kinesin-like protein KIF18A (KIF18A) OTSMBJ24 KI18A_HUMAN Decreases Expression [7]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [7]
Arrestin domain-containing protein 2 (ARRDC2) OTVEOXAG ARRD2_HUMAN Increases Expression [7]
Nuclear protein MDM1 (MDM1) OTI9JUWA MDM1_HUMAN Decreases Expression [7]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Decreases Expression [7]
2-phosphoxylose phosphatase 1 (PXYLP1) OTX8T7F6 PXYP1_HUMAN Decreases Expression [7]
Rhomboid-related protein 4 (RHBDD1) OTL5J132 RHBL4_HUMAN Increases Expression [7]
Centrosomal protein of 192 kDa (CEP192) OTBLFV7T CE192_HUMAN Decreases Expression [7]
PDZ domain-containing protein GIPC2 (GIPC2) OT68YFO1 GIPC2_HUMAN Decreases Expression [7]
Monocarboxylate transporter 10 (SLC16A10) OTH70529 MOT10_HUMAN Decreases Expression [7]
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5) OTUM65JL GDPD5_HUMAN Decreases Expression [7]
Sodium-dependent phosphate transporter 1 (SLC20A1) OTC3D894 S20A1_HUMAN Increases Expression [7]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [7]
Kelch repeat and BTB domain-containing protein 7 (KBTBD7) OT1NIRLK KBTB7_HUMAN Decreases Expression [7]
Cytoskeleton-associated protein 2 (CKAP2) OTCLTC0J CKAP2_HUMAN Decreases Expression [7]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [7]
Ras and Rab interactor 2 (RIN2) OTCY73U9 RIN2_HUMAN Increases Expression [7]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2) OTBXYFRH ARAP2_HUMAN Increases Expression [7]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Increases Expression [7]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [7]
Gamma-glutamyl hydrolase (GGH) OTL71J7T GGH_HUMAN Decreases Expression [7]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [7]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Increases Expression [7]
Liver-expressed antimicrobial peptide 2 (LEAP2) OTUOPIS5 LEAP2_HUMAN Decreases Expression [7]
Protein MAL2 (MAL2) OTVPEI80 MAL2_HUMAN Decreases Expression [7]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [7]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Decreases Expression [7]
RAD51-associated protein 1 (RAD51AP1) OTXM7UTD R51A1_HUMAN Decreases Expression [7]
SPRY domain-containing SOCS box protein 1 (SPSB1) OTGY26U4 SPSB1_HUMAN Increases Expression [7]
Spindle and kinetochore-associated protein 1 (SKA1) OTDYJ12A SKA1_HUMAN Decreases Expression [7]
Solute carrier family 22 member 18 (SLC22A18) OT9C3KR4 S22AI_HUMAN Increases Expression [7]
Endoplasmic reticulum resident protein 27 (ERP27) OTVMGE2H ERP27_HUMAN Decreases Expression [7]
Ankyrin repeat and SOCS box protein 9 (ASB9) OT3AA61T ASB9_HUMAN Decreases Expression [7]
RecQ-mediated genome instability protein 2 (RMI2) OTA0HP4S RMI2_HUMAN Decreases Expression [7]
Protein Spindly (SPDL1) OTI0JNTM SPDLY_HUMAN Decreases Expression [7]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [7]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [7]
Cell division cycle-associated 7-like protein (CDCA7L) OT1FFWKC CDA7L_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase greatwall (MASTL) OTQ7YKK5 GWL_HUMAN Decreases Expression [7]
Coiled-coil domain-containing protein 34 (CCDC34) OTZ3AGSQ CCD34_HUMAN Decreases Expression [7]
Carboxypeptidase B2 (CPB2) OTPIL8IE CBPB2_HUMAN Decreases Expression [7]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [7]
Leucine-rich repeat protein 1 (LRR1) OTSWDXVY LLR1_HUMAN Decreases Expression [7]
Coiled-coil domain-containing protein 138 (CCDC138) OTT1TXO8 CC138_HUMAN Decreases Expression [7]
Uncharacterized protein C5orf34 (C5ORF34) OTT2ESR4 CE034_HUMAN Decreases Expression [7]
Transmembrane protein 237 (TMEM237) OTQEVL7L TM237_HUMAN Decreases Expression [7]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [7]
Sperm-associated antigen 5 (SPAG5) OTCLJ56M SPAG5_HUMAN Decreases Expression [7]
PAS domain-containing serine/threonine-protein kinase (PASK) OT4MOQZ8 PASK_HUMAN Decreases Expression [7]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [7]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [7]
Serine incorporator 2 (SERINC2) OTZ039U0 SERC2_HUMAN Increases Expression [7]
Cytochrome P450 2S1 (CYP2S1) OTKHX4RF CP2S1_HUMAN Increases Expression [7]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [7]
Cell division cycle-associated protein 3 (CDCA3) OTUI8QK3 CDCA3_HUMAN Decreases Expression [7]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [7]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Decreases Expression [7]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [7]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [7]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Decreases Expression [7]
SMC5-SMC6 complex localization factor protein 1 (SLF1) OT6ZA2K9 SLF1_HUMAN Decreases Expression [7]
Coiled-coil domain-containing protein 77 (CCDC77) OTQQT2IC CCD77_HUMAN Decreases Expression [7]
DNA replication complex GINS protein PSF3 (GINS3) OT8NVXTD PSF3_HUMAN Decreases Expression [7]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [7]
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1) OTYKRRGE RHNO1_HUMAN Decreases Expression [7]
Protein PIMREG (PIMREG) OTKC8T3E PIMRE_HUMAN Decreases Expression [7]
Immediate early response gene 2 protein (IER2) OT5OY8BO IER2_HUMAN Increases Expression [7]
EF-hand calcium-binding domain-containing protein 11 (EFCAB11) OTXDJ9R8 EFC11_HUMAN Decreases Expression [7]
Sister chromatid cohesion protein DCC1 (DSCC1) OTPUVLZT DCC1_HUMAN Decreases Expression [7]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Decreases Expression [7]
Cell division cycle-associated protein 7 (CDCA7) OT12HDZY CDCA7_HUMAN Decreases Expression [7]
Meiotic nuclear division protein 1 homolog (MND1) OTS87F3H MND1_HUMAN Decreases Expression [7]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [7]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [7]
Cell adhesion molecule 1 (CADM1) OTRWG9QS CADM1_HUMAN Decreases Expression [7]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [7]
Kinetochore protein Nuf2 (NUF2) OTOOQL35 NUF2_HUMAN Decreases Expression [7]
Protein sprouty homolog 4 (SPRY4) OT2VK9N0 SPY4_HUMAN Increases Expression [7]
Homeobox protein Hox-D1 (HOXD1) OTN4V9ZF HXD1_HUMAN Decreases Expression [7]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [7]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Decreases Expression [7]
Homeobox protein MIXL1 (MIXL1) OT584VOQ MIXL1_HUMAN Decreases Expression [7]
Centromere protein H (CENPH) OTPOO9LK CENPH_HUMAN Decreases Expression [7]
Kinetochore-associated protein DSN1 homolog (DSN1) OTHROI0H DSN1_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [7]
Protein FAM83D (FAM83D) OTQWZ1UO FA83D_HUMAN Decreases Expression [7]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Increases Expression [7]
ATP-dependent DNA helicase PIF1 (PIF1) OTUHKKVP PIF1_HUMAN Decreases Expression [7]
Syncoilin (SYNC) OTEFLG59 SYNCI_HUMAN Decreases Expression [7]
Thiol S-methyltransferase TMT1A (TMT1A) OT4IAAZP TMT1A_HUMAN Decreases Expression [7]
Cytochrome P450 4F11 (CYP4F11) OTHZ2GG2 CP4FB_HUMAN Increases Expression [7]
Kinetochore protein Spc25 (SPC25) OTCAS0OH SPC25_HUMAN Decreases Expression [7]
DNA polymerase delta subunit 4 (POLD4) OTG578YH DPOD4_HUMAN Increases Expression [7]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Increases Expression [7]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [7]
Unconventional myosin-Vc (MYO5C) OTKLOCWZ MYO5C_HUMAN Decreases Expression [7]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [7]
Kinesin-like protein KIF15 (KIF15) OTJRJEXL KIF15_HUMAN Decreases Expression [7]
Sal-like protein 1 (SALL1) OTYYZGLH SALL1_HUMAN Decreases Expression [7]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) OTALLHT1 FIRRM_HUMAN Decreases Expression [7]
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) OTR4990X PLPL3_HUMAN Decreases Expression [7]
Protein diaphanous homolog 3 (DIAPH3) OTPOT23F DIAP3_HUMAN Decreases Expression [7]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [7]
Serine palmitoyltransferase 3 (SPTLC3) OTZDX6PT SPTC3_HUMAN Decreases Expression [7]
Transmembrane protein 140 (TMEM140) OTQCEGEO TM140_HUMAN Increases Expression [7]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [7]
Spermine oxidase (SMOX) OT11E62Y SMOX_HUMAN Increases Expression [7]
PCNA-interacting partner (PARPBP) OTPZDGW7 PARI_HUMAN Decreases Expression [7]
Membrane progestin receptor gamma (PAQR5) OTGGWXQE PAQR5_HUMAN Increases Expression [7]
Protein Mis18-alpha (MIS18A) OTD80K5X MS18A_HUMAN Decreases Expression [7]
G2 and S phase-expressed protein 1 (GTSE1) OTPP742Z GTSE1_HUMAN Decreases Expression [7]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [7]
Kelch-like protein 14 (KLHL14) OTYOS55H KLH14_HUMAN Decreases Expression [7]
DNA (DNMT3B) OTZ0JCNP DNM3B_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Increases Expression [7]
CAP-Gly domain-containing linker protein 2 (CLIP2) OTSCIQIY CLIP2_HUMAN Increases Expression [7]
Doublecortin domain-containing protein 2 (DCDC2) OTSUFH1H DCDC2_HUMAN Decreases Expression [7]
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) OTZ71SK9 BI2L1_HUMAN Increases Expression [7]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [7]
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OT9KIVZW OSGI1_HUMAN Increases Expression [7]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [7]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Increases Expression [7]
Protein phosphatase 1H (PPM1H) OTKSVU7S PPM1H_HUMAN Decreases Expression [7]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [7]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [7]
Sex comb on midleg-like protein 1 (SCML1) OT7V5DAR SCML1_HUMAN Decreases Expression [7]
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) OTN51IPT S6A14_HUMAN Decreases Expression [7]
Exonuclease 1 (EXO1) OTI87RS5 EXO1_HUMAN Decreases Expression [7]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Decreases Expression [7]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [7]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [7]
Dexamethasone-induced Ras-related protein 1 (RASD1) OT2BAJHK RASD1_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase DTX4 (DTX4) OTGX30AO DTX4_HUMAN Decreases Expression [7]
Nuclear factor erythroid 2-related factor 3 (NFE2L3) OT1MGXT0 NF2L3_HUMAN Decreases Expression [7]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1) OTIPDI15 CRBG1_HUMAN Decreases Expression [7]
BTB/POZ domain-containing protein KCTD3 (KCTD3) OT6EGR42 KCTD3_HUMAN Decreases Expression [7]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Increases Expression [7]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [7]
Mitochondrial pyruvate carrier 1 (MPC1) OT6DYFUO MPC1_HUMAN Decreases Expression [7]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Decreases Expression [7]
Lymphocyte antigen 96 (LY96) OTN4HXA2 LY96_HUMAN Increases Expression [7]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [21]
Rap1 GTPase-activating protein 1 (RAP1GAP) OTC31ONQ RPGP1_HUMAN Increases Expression [21]
Ras-related protein R-Ras2 (RRAS2) OT83NCEB RRAS2_HUMAN Increases Expression [21]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [21]
F-box only protein 30 (FBXO30) OTD1P6LA FBX30_HUMAN Increases Expression [21]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [22]
Serine protease inhibitor Kazal-type 1 (SPINK1) OTSUVAL2 ISK1_HUMAN Increases Expression [23]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [24]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [25]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Mutagenesis [26]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [24]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [27]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Increases Phosphorylation [27]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [27]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [27]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Increases Phosphorylation [27]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Decreases Activity [8]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [28]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Decreases Phosphorylation [8]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [8]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Affects Mutagenesis [29]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Increases Expression [22]
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) OT6QGM5Y IMDH1_HUMAN Affects Response To Substance [30]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Affects Metabolism [31]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Affects Response To Substance [32]
Purine nucleoside phosphorylase (PNP) OTO5NIJ2 PNPH_HUMAN Increases ADR [33]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Affects Response To Substance [32]
Cytosolic 5'-nucleotidase 1A (NT5C1A) OTS7UF36 5NT1A_HUMAN Increases ADR [33]
------------------------------------------------------------------------------------
⏷ Show the Full List of 574 DOT(s)
Indication(s) of Tacrolimus
Disease Entry ICD 11 Status REF
Graft-versus-host disease 4B24 Approved [4]
Hepatosplenic T-cell lymphoma N.A. Approved [4]
Kidney transplant rejection NE84 Approved [4]
Large granular lymphocytic leukemia 2A90.1 Approved [4]
Leukemia N.A. Approved [4]
Lupus nephritis 4A40.0Y Approved [4]
MALT lymphoma N.A. Approved [4]
Myeloproliferative neoplasm 2A20 Approved [4]
Nodal marginal zone lymphoma 2A85.0 Approved [4]
Organ transplant rejection NE84 Approved [5]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified N.A. Approved [4]
Recurrent adult burkitt lymphoma 2A85.6 Approved [4]
Small intestine lymphoma N.A. Approved [4]
Splenic marginal zone lymphoma N.A. Approved [4]
Testicular lymphoma N.A. Approved [4]
Ocular allergy 4A81 Phase 3 [5]
Classic Hodgkin lymphoma N.A. Investigative [4]
Tacrolimus Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Calcineurin (PPP3CA) TTA4LDE PP2BA_HUMAN Inhibitor [36]
------------------------------------------------------------------------------------
Tacrolimus Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [37]
------------------------------------------------------------------------------------
Tacrolimus Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [38]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [39]
NADPH-cytochrome P450 reductase (CPR) DE3N2FM NCPR_HUMAN Metabolism [40]
Ribosomal 23S RNA methyltransferase Erm (erm) DEW6V07 A0A5N1AHF6_CORAY Metabolism [41]
Ribosomal 23S RNA methyltransferase Erm (erm) DEA65D8 A0A381KDL2_CORJE Metabolism [41]
------------------------------------------------------------------------------------
Tacrolimus Interacts with 49 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Methylation [42]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Decreases Methylation [42]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Affects Response To Substance [43]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Response To Substance [44]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [45]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Increases Expression [45]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Expression [45]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [46]
Natural cytotoxicity triggering receptor 3 (NCR3) OT20M764 NCTR3_HUMAN Increases Expression [47]
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) OTCYYCAC HGS_HUMAN Increases Expression [35]
Rho guanine nucleotide exchange factor 11 (ARHGEF11) OTDOMEH6 ARHGB_HUMAN Increases Expression [35]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [48]
Actin-related protein 2/3 complex subunit 5 (ARPC5) OTFNMMDL ARPC5_HUMAN Increases Expression [35]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [48]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Increases Expression [34]
Insulin (INS) OTZ85PDU INS_HUMAN Decreases Expression [49]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Secretion [50]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [51]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [25]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [52]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Increases Expression [52]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Expression [51]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [51]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Decreases Expression [53]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Decreases Expression [51]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [54]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [34]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [53]
Ras-related protein Rab-4A (RAB4A) OT7BL9WW RAB4A_HUMAN Increases Expression [35]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Degradation [50]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Decreases Expression [55]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Decreases Expression [55]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [56]
Troponin T, cardiac muscle (TNNT2) OT80NN7R TNNT2_HUMAN Increases Expression [57]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Decreases Secretion [58]
Glycogen synthase kinase-3 alpha (GSK3A) OT0F6DWV GSK3A_HUMAN Increases Phosphorylation [34]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [34]
Eotaxin (CCL11) OT3BIFPK CCL11_HUMAN Decreases Expression [53]
C-C chemokine receptor type 3 (CCR3) OT6GBUFA CCR3_HUMAN Decreases Expression [53]
LIM domain kinase 1 (LIMK1) OTFZ8MZ0 LIMK1_HUMAN Increases Expression [35]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Decreases Expression [51]
Neutrophil gelatinase-associated lipocalin (LCN2) OTSB42BR NGAL_HUMAN Increases Expression [52]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [56]
Lethal(2) giant larvae protein homolog 1 (LLGL1) OTAIQSXZ L2GL1_HUMAN Increases Expression [35]
Calcineurin subunit B type 1 (PPP3R1) OTGQNFJQ CANB1_HUMAN Increases ADR [33]
Catalase (CAT) OTHEBX9R CATA_HUMAN Decreases Response To Substance [59]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Response To Substance [59]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Affects Response To Substance [43]
Cytochrome P450 3A7 (CYP3A7) OTTCDHHM CP3A7_HUMAN Decreases Methylation [42]
------------------------------------------------------------------------------------
⏷ Show the Full List of 49 DOT(s)

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