Details of the Drug Combinations

General Information of This Drug (ID: DMNMW9R)

Drug Name
Pramipexole   DMNMW9R
Synonyms
Mirapex; Pramipexol; Pramipexolum; SUD919CL2Y; Mirapex (TN); Mirapexin (TN); Pramipexole [USAN:INN]; SND-919; Sifrol(TN); U-98528E; Pramipexole (USAN/INN); (-)-Pramipexole; (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole; 111GE001; 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole; 2-amino-6-propylaminotetrahydrobenzothiazole
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [1]
Therapeutic Class
Antiparkinson Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

111 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Pramipexole DCFMHW6 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aminosalicylic acid + Pramipexole DC5OZXL Aminosalicylic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Pramipexole DCQ3E1X Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Armodafinil + Pramipexole DCUP5O0 Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Benserazide + Pramipexole DC8BGNF Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Pramipexole DCUUMVA Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cefmenoxime + Pramipexole DC8TGWL Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Pramipexole DCB009B Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cilostazol + Pramipexole DCTR1QA Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ciprofibrate + Pramipexole DC0RET4 Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clopidogrel + Pramipexole DCINF0Z Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Pramipexole DC0E31A Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Daidzin + Pramipexole DCCBSL5 Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Darunavir + Pramipexole DCRZ5X6 Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dichlorphenamide + Pramipexole DCUJPKZ Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + Pramipexole DCDX8EM Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dopamine + Pramipexole DCS4F0L Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + Pramipexole DC1BG9Y Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Estramustine + Pramipexole DCVWJ03 Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethinyl estradiol + Pramipexole DCHJ6N4 Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ETHISTERONE + Pramipexole DC512CZ ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Pramipexole DCHFBYO Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Furazolidone + Pramipexole DCEMTX4 Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GS4071 + Pramipexole DCYR3BC GS4071 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Pramipexole DCWX3Y0 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imipramine + Pramipexole DCG962O Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Pramipexole DCBP123 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
L-165041 + Pramipexole DCYKOX6 L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Pramipexole DCVWVM2 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Pramipexole DCMJLSJ Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
LIAROZOLE + Pramipexole DC5HA4O LIAROZOLE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Linagliptin + Pramipexole DCZGNZ3 Linagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lithium Citrate + Pramipexole DCAIEW1 Lithium Citrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Pramipexole DCVYC8H Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
LY03004 + Pramipexole DC4L6HU LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maraviroc + Pramipexole DC554V1 Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + Pramipexole DCQDPEC Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Pramipexole DCRIPQX Mephenytoin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + Pramipexole DCPFKN0 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Pramipexole DC8FTYB ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Pramipexole DCD37YJ Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitrosoglutathione + Pramipexole DCG3OOV Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Olmesartan medoxomil + Pramipexole DCQCC8A Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxyphenbutazone + Pramipexole DCQ5CM8 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pentamidine + Pramipexole DCAYUOR Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Pramipexole DC5JEP4 Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Pramipexole DCQVYU2 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Pramipexole DC4O69F PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Ribavirin-TP DCRV691 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Lefaxin DCBD32P Lefaxin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Triiodothyronine DC8SA46 Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Gefitinib DCS0SS5 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Paromomycin DC8RNRM Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Dantrolene DCQJHWT Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Diethylcarbamazine DCJ7OXA Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Citalopram DCDM54V Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Epinephrine DC24W39 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + PMID28460551-Compound-2 DC64701 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Tacrine DCGXLFS Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Methotrexate DCEGQN0 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Miglustat DCE7L3V Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Triapine DCH8QJY Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Dronedarone DCB6JGH Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Metyrosine DC8EPRN Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Testosterone cypionate DCFK5W7 Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Emetine DCPLACB Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Ursodeoxycholic acid DCEND54 Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Chlorzoxazone DCUP86Z Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Memantine DC2Q96L Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Docetaxel DC6BSUC Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Methoxsalen DCTIAZN Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Fibrates DCP6CRD Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Clopidogrel DC9LG8E Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Pentamidine DCQ5FG4 Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + BIO-300 DC2R2FQ BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Norcisapride DC3IXEN Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Tiagabine DC5NL81 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Oseltamivir DC2BEJU Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Diazoxide DC3MMFG Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Tamoxifen DC7LCH4 Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Probenecid DCUC184 Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Atenolol DC2NXIZ Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Linagliptin DCNJ129 Linagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Moricizine DC688UN Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Trimethobenzamide DCV0V5O Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Maprotiline DCYO3SW Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Brincidofovir DCWIPYS Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Quinine DCXPS2P Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Loperamide DC1D2F1 Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Mycophenolic acid DCMT8L8 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Hydralazine DCC85K6 Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Mefloquine DCO21AF Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Lacosamide DC1MS8O Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Doxorubicin DCUJX0Q Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Zileuton DCQX7LA Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Nitisinone DCMTJM0 Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Auranofin DCYHAE7 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Rufinamide DCHZFSS Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Vorinostat DC6MLZY Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Hydroxychloroquine DCY7IDG Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + AS-1949490 DCCQ5CU AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Tacrolimus DCOV4V4 Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Pramipexole DCH1OXP Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Pramipexole DCQVEPH Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sumatriptan + Pramipexole DCR7AYS Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Pramipexole DCGISJ7 Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Pramipexole DC0E071 Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tranexamic acid + Pramipexole DC6WECI Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triamterene + Pramipexole DCUN0J6 Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Pramipexole DCVS5ZR Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Pramipexole DCTAJ1U Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 111 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Escitalopram + Pramipexole DCH0Z2Z Escitalopram Major Depression [4]
Pramipexole + Morphine DCAGSTX Morphine Renal Colic [5]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 953).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT00086307) Lexapro and Pramipexole and to Treat Major Depression
5 ClinicalTrials.gov (NCT04160520) Pramipexole and Morphine for Renal Colic