General Information of This Drug (ID: DMODJ40)

Drug Name
Ethinyl Estradiol   DMODJ40
Synonyms
Aethinyloestradiolum; Aethinyoestradiol; Amenoron; Amenorone; Anovlar; Certostat; Cyclosa; Dicromil; Diprol; Dyloform; Ertonyl; Esteed; Estigyn; Estinyl; Estopherol; Estoral; Estorals; Ethidol; Ethinoral; Ethinylestradiolum; Ethinylestriol; Ethinyloestradiol; Ethynylestradiol; Ethynyloestradiol; Eticyclin; Eticyclol; Eticylol; Etinestrol; Etinestryl; Etinilestradiol; Etinilestradiolo; Etinoestryl; Etistradiol; Etivex; Feminone; Follicoral; Ginestrene; Inestra; Kolpolyn; Linoral; Lynoral; Menolyn; Microfollin; Novestrol; Oradiol; Orestralyn; Orestrayln; Palonyl; Perovex; Primogyn; Prosexol; Spanestrin; Ylestrol; Aethinyoestradiol [German]; Component of Demulen; Component of Oracon; Component of Ortrel; Diogyn E; Effik Brand of Ethinyl Estradiol; Estoral [Orion]; Ethinyl Estradiol Hemihydrate; Ethinyl Estradiol [USP]; Ethinyl Oestradiol Effik; Ethinylestradiol Jenapharm; Ethinyloestradiol [Steroidal oestrogens]; Ethynyl estradiol; Etinilestradiolo [DCIT]; Jenapharm Brand of Ethinyl Estradiol; Microfollin Forte; Organon Brand of Ethinyl Estradiol; PUBERTAL ETHINYL ESTRADIOL STUDY; Primogyn C; Primogyn M; Progynon C; Progynon M; Schering Brand of Ethinyl Estradiol; EE2; Ethinyl E2; Ethy 11; Diognat-E; Diogyn-E; EE(sub 2); Estinyl (TN); Eston-E; Estoral (Orion); Estoral (VAN); Estradiol, Ethinyl; Estradiol, Ethynyl; Ethinyl estradiol (USP); Ethinyl-Oestradiol Effik; Ethinyl-oestranol; Ethinylestradiolum [INN-Latin]; Ethynylestradiol, Ethinyl Estradiol; Etinilestradiol [INN-Spanish]; Hemihydrate, Ethinyl Estradiol; Jenapharm, Ethinylestradiol; Neo-Estrone; Nogest-S; OVULEN-21; OVULEN-28; Ortho-Cyclen; Chee-O-Gen; Chee-O-Genf; Ethinylestradiol (JP15/INN); Ethinylestradiol [INN:BAN:JAN]; Ethinyl Estradiol, (8 alpha)-Isomer; 17 alpha-Ethinylestradiol; 17 alpha-Ethynylestradiol; 17 alpha-Ethynyloestradiol; 17 alpha-ethinyestradiol; 17-Ethinyl-3,17-estradiol; 17-Ethinyl-3,17-oestradiol; 17-Ethinylestradiol; 17-Ethynylestradiol; 17-Ethynyloestradiol; 17-alpha-Ethinyl-17-beta-estradiol; 17-alpha-Ethynyl-17-beta-oestradiol; 17-alpha-Ethynylestradiol; 17-alpha-Ethynylestradiol-17-beta; 17-alpha-Ethynylestradiol-l7-beta; 17-alpha-Ethynyloestradiol-17-beta; 17-alpha-ethynyl estradiol; 17.alpha.-Ethinyl-17.beta.-estradiol; 17.alpha.-Ethinylestradiol; 17.alpha.-Ethynyl-17.beta.-oestradiol; 17.alpha.-Ethynylestradiol; 17.alpha.-Ethynyloestradiol; 17a-Ethynylestradiol; 17alpha-Ethinyl estradiol; 17alpha-Ethinylestradiol; 17alpha-Ethinylestradiol-17beta; 17alpha-Ethynylestradiol; 17alpha-Ethynyloestradiol; 17alpha-Ethynyloestradiol-17beta
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Female hypogonadism GA30.6 Approved [2]
Hot flushes GA30 Approved [1]
Obsolete atrophic vulva N.A. Approved [1]
Therapeutic Class
Estrogens
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

70 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abacavir + Ethinyl estradiol DCZ0AXB Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acamprosate + Ethinyl estradiol DCJC2L5 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bortezomib + Ethinyl estradiol DCN6ELX Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Ethinyl estradiol DC3Y71O Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Ethinyl estradiol DCG8O61 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Ethinyl estradiol DCZFW3G Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Clindamycin + Ethinyl estradiol DCY4OEG Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diethylcarbamazine + Ethinyl estradiol DCD00GA Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Doxorubicin + Ethinyl estradiol DCH1LWA Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Ribavirin-TP DCVNUO2 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Gefitinib DCLEIB1 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Clindamycin DCVRH80 Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Dantrolene DC1P2H0 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Diethylcarbamazine DCOKBVR Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Kanamycin DCVHM1T Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + PMID28460551-Compound-2 DC5XGJJ PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Panobinostat DC13MZ1 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Ethinyl estradiol + Methotrexate DCG2CY5 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Vinblastine DC9TWI1 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Pazopanib HCl DCPKS22 Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Triapine DCO5YI9 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Dexmedetomidine DCP8XDA Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Tranexamic acid DCIPS6D Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Pepstatin DC3LRDX Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + IT-141 DCTG8V3 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Metyrosine DCNEBTA Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Terameprocol DCHGAXG Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Chlorzoxazone DCBOK2P Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + GS4071 DCX7Z41 GS4071 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Dichlorphenamide DCQKRBR Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + BIO-300 DCPAUXA BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Niclosamide DCWOYPJ Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Diazoxide DCX9AXM Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Idarubicin DCQQYTQ Idarubicin Glioblastoma? (Cell Line: T98G) [3]
Ethinyl estradiol + Imatinib DC1EEK3 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Darunavir DC17C6R Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Atenolol DCN59FV Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Pramipexole DCHJ6N4 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Bortezomib DC1TX2T Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Methylene blue DC12E4K Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Clascoterone DCAQ3T8 Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Trimethobenzamide DC2ZO0W Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Leflunomide DCSWO2R Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Brincidofovir DCYOG2K Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Hyodeoxycholic acid DCEBT2R Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Quinine DCJCJEQ Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Mycophenolic acid DC8PVF1 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Mefloquine DCNN96L Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + PMID28870136-Compound-43 DCP9R1D PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Vorinostat DC8PG55 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Estramustine DCTLXAV Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Cerivastatin DCM3ZUF Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Aciclovir DCJY9F3 Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ethinyl estradiol + Acetohydroxamic Acid DCX946R Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fomepizole + Ethinyl estradiol DCGMX4K Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
GINKGOLIDE A + Ethinyl estradiol DC6J3TT GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
GYKI-52466 + Ethinyl estradiol DCQ8O8G GYKI-52466 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Ethinyl estradiol DCEDVR4 Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
IT-141 + Ethinyl estradiol DC31Q7L IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Ethinyl estradiol DC79ITT Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Ethinyl estradiol DCEW30V Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Ethinyl estradiol DC6P447 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Nitisinone + Ethinyl estradiol DCG4HTI Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PF-02545920 + Ethinyl estradiol DCS4KHR PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tiagabine + Ethinyl estradiol DCKK9CP Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Ethinyl estradiol DCLQK1X Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Topotecan + Ethinyl estradiol DCJVT2J Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tranexamic acid + Ethinyl estradiol DC6YAV9 Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trihexyphenidyl + Ethinyl estradiol DCIA5FG Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Vinblastine + Ethinyl estradiol DCDFRJK Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 70 DrugCom(s)
3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Cyproterone acetate + Ethinyl estradiol DCXXKRR Cyproterone acetate Hyperandrogenism [5]
Levonorgestrel + Ethinyl estradiol DC4WBB7 Levonorgestrel Hepatitis C, Chronic [6]
Trimegestone + Ethinyl estradiol DCJN49L Trimegestone Contraception [7]
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References

1 Ethinyl estradiol FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7071).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5 ClinicalTrials.gov (NCT02460445) Phlebotomy and Polycystic Ovary Syndrome
6 ClinicalTrials.gov (NCT01570244) Drug-drug Interaction of BI 201335 and Microgynon
7 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016303)