Details of the Drug Combination

General Information of Drug Combination (ID: DCJCJEQ)

Drug Combination Name
Ethinyl Estradiol Quinine
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs Ethinyl Estradiol   DMODJ40 Quinine   DMSWYF5
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: KBM-7
Zero Interaction Potency (ZIP) Score: 33.17
Bliss Independence Score: 33.17
Loewe Additivity Score: 43.97
LHighest Single Agent (HSA) Score: 43.97

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Ethinyl Estradiol
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [2]
Female hypogonadism GA30.6 Approved [3]
Hot flushes GA30 Approved [2]
Obsolete atrophic vulva N.A. Approved [2]
Ethinyl Estradiol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Agonist [9]
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Ethinyl Estradiol Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]
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Ethinyl Estradiol Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [11]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [12]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Metabolism [13]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [14]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [13]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [15]
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⏷ Show the Full List of 6 DME(s)
Ethinyl Estradiol Interacts with 280 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Activity [14]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [16]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Hydroxylation [13]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Hydroxylation [13]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases Hydroxylation [13]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [10]
Sulfotransferase 1E1 (SULT1E1) OTGPJ517 ST1E1_HUMAN Decreases Activity [17]
Gamma-aminobutyric acid receptor subunit pi (GABRP) OTGKA8WS GBRP_HUMAN Decreases Expression [6]
Ectoderm-neural cortex protein 1 (ENC1) OTJEUB6U ENC1_HUMAN Decreases Expression [6]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) OTFK8KDP NHRF1_HUMAN Increases Expression [6]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Increases Expression [6]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Decreases Expression [6]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [6]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [6]
Band 4.1-like protein 2 (EPB41L2) OT6UABPM E41L2_HUMAN Increases Expression [6]
Tetraspanin-1 (TSPAN1) OTZQPIYK TSN1_HUMAN Decreases Expression [6]
Microfibrillar-associated protein 3-like (MFAP3L) OTNMHSAH MFA3L_HUMAN Increases Expression [6]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [6]
Dysferlin (DYSF) OTNSKJU0 DYSF_HUMAN Decreases Expression [6]
Gamma-butyrobetaine dioxygenase (BBOX1) OTKEX4RK BODG_HUMAN Decreases Expression [6]
Nebulette (NEBL) OT2WH1NC NEBL_HUMAN Decreases Expression [6]
ATP-dependent DNA helicase Q5 (RECQL5) OTVZMP1Q RECQ5_HUMAN Decreases Expression [6]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Decreases Expression [6]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Decreases Expression [6]
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) OTIXNT91 NDUB6_HUMAN Increases Expression [6]
Rap guanine nucleotide exchange factor 3 (RAPGEF3) OTMOW4Z4 RPGF3_HUMAN Decreases Expression [6]
Secretoglobin family 1D member 2 (SCGB1D2) OTSYWZAQ SG1D2_HUMAN Increases Expression [6]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [6]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Increases Expression [6]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [6]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [6]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Expression [6]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Decreases Expression [6]
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA) OTWJTCRK PCCA_HUMAN Increases Expression [6]
Alkaline phosphatase, placental type (ALPP) OTZU4G9W PPB1_HUMAN Increases Expression [6]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Expression [6]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Increases Expression [6]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [6]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [6]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Increases Expression [6]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [6]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [6]
Retinol-binding protein 1 (RBP1) OTRP1MFC RET1_HUMAN Decreases Expression [6]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Decreases Expression [6]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [6]
Alkaline phosphatase, germ cell type (ALPG) OTCIM29R PPBN_HUMAN Increases Expression [6]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Increases Expression [6]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Decreases Expression [6]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [6]
Endothelin-2 (EDN2) OTQ7RCPI EDN2_HUMAN Decreases Expression [6]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Increases Expression [6]
Fibroblast growth factor receptor 2 (FGFR2) OTLOPACK FGFR2_HUMAN Decreases Expression [6]
Galanin peptides (GAL) OTB3VPTO GALA_HUMAN Increases Expression [6]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Decreases Expression [6]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Affects Expression [6]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Expression [6]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [6]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Expression [6]
Transcription factor HIVEP2 (HIVEP2) OTVOMCW4 ZEP2_HUMAN Decreases Expression [6]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Decreases Expression [6]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [6]
Activin receptor type-1B (ACVR1B) OT778HIQ ACV1B_HUMAN Decreases Expression [6]
Collagen alpha-1(XV) chain (COL15A1) OTTFKK18 COFA1_HUMAN Increases Expression [6]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Increases Expression [6]
Exosome RNA helicase MTR4 (MTREX) OTSQY30V MTREX_HUMAN Increases Expression [6]
G protein-activated inward rectifier potassium channel 1 (KCNJ3) OTHQG16J KCNJ3_HUMAN Decreases Expression [6]
Retinol-binding protein 2 (RBP2) OTR8QG5V RET2_HUMAN Decreases Expression [6]
LIM domain kinase 2 (LIMK2) OTRJD7VZ LIMK2_HUMAN Decreases Expression [6]
ADP-ribosylation factor 3 (ARF3) OTYYQX85 ARF3_HUMAN Decreases Expression [6]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Decreases Expression [6]
Phosphoserine phosphatase (PSPH) OTV1PVAX SERB_HUMAN Decreases Expression [6]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Decreases Expression [6]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Decreases Expression [6]
Low-density lipoprotein receptor-related protein 2 (LRP2) OTZ6W681 LRP2_HUMAN Decreases Expression [6]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [6]
Cyclic AMP-responsive element-binding protein 5 (CREB5) OTJDUJPI CREB5_HUMAN Increases Expression [6]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Decreases Expression [6]
Amino acid transporter heavy chain SLC3A1 (SLC3A1) OT56V01A SLC31_HUMAN Decreases Expression [6]
Cadherin-18 (CDH18) OTC06P9H CAD18_HUMAN Decreases Expression [6]
Calcyphosin (CAPS) OTC9GZ2M CAYP1_HUMAN Increases Expression [6]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [6]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Decreases Expression [6]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Decreases Expression [6]
Pericentriolar material 1 protein (PCM1) OTFM133C PCM1_HUMAN Decreases Expression [6]
Neutral amino acid transporter B(0) (SLC1A5) OTE2H26Q AAAT_HUMAN Increases Expression [6]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Decreases Expression [6]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [6]
Protein Dok-7 (DOK7) OTR2V7HO DOK7_HUMAN Increases Expression [6]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Increases Expression [6]
Piercer of microtubule wall 1 protein (PIERCE1) OTONT0CN PIRC1_HUMAN Decreases Expression [6]
Retrotransposon Gag-like protein 5 (RTL5) OT9ZJR3N RTL5_HUMAN Decreases Expression [6]
Protein phosphatase 1J (PPM1J) OTM6GDJJ PPM1J_HUMAN Increases Expression [6]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Increases Expression [6]
Disabled homolog 2-interacting protein (DAB2IP) OTF456VC DAB2P_HUMAN Affects Expression [6]
Muscleblind-like protein 2 (MBNL2) OTF7CF1F MBNL2_HUMAN Decreases Expression [6]
Anoctamin-1 (ANO1) OTSREUNI ANO1_HUMAN Increases Expression [6]
Proline-rich membrane anchor 1 (PRIMA1) OT9ITT3P PRIMA_HUMAN Decreases Expression [6]
Prolyl 3-hydroxylase 2 (P3H2) OTY84H6U P3H2_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase TRIM22 (TRIM22) OTJBLG5R TRI22_HUMAN Decreases Expression [6]
Solute carrier family 25 member 45 (SLC25A45) OTP7EAUM S2545_HUMAN Decreases Expression [6]
PACRG-like protein (PACRGL) OT5DEP0X PACRL_HUMAN Increases Expression [6]
N-acetylaspartate synthetase (NAT8L) OTA96AVN NAT8L_HUMAN Decreases Expression [6]
Retinoic acid-induced protein 3 (GPRC5A) OTPOCWR7 RAI3_HUMAN Decreases Expression [6]
Two pore channel protein 2 (TPCN2) OTLAF3ED TPC2_HUMAN Decreases Expression [6]
LIM domain only protein 3 (LMO3) OTR7AJHN LMO3_HUMAN Decreases Expression [6]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [6]
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) OT83O8WI ES8L1_HUMAN Decreases Expression [6]
Complexin-3 (CPLX3) OT0YTMN2 CPLX3_HUMAN Decreases Expression [6]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Decreases Expression [6]
Protein kinase C-binding protein NELL1 (NELL1) OTF3TX3N NELL1_HUMAN Decreases Expression [6]
LIM/homeobox protein Lhx4 (LHX4) OTVX3J6S LHX4_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase MIB2 (MIB2) OTJCC3HS MIB2_HUMAN Decreases Expression [6]
Dedicator of cytokinesis protein 10 (DOCK10) OTI3MBLV DOC10_HUMAN Decreases Expression [6]
Galactose mutarotase (GALM) OT7UPL4D GALM_HUMAN Decreases Expression [6]
Endoplasmic reticulum resident protein 27 (ERP27) OTVMGE2H ERP27_HUMAN Decreases Expression [6]
Hedgehog-interacting protein (HHIP) OT77RQYS HHIP_HUMAN Decreases Expression [6]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Decreases Expression [6]
Neurturin (NRTN) OT4PAKUY NRTN_HUMAN Increases Expression [6]
Ras-like protein family member 11B (RASL11B) OTHEVZS6 RSLBB_HUMAN Decreases Expression [6]
Mitochondrial ribosome-associated GTPase 1 (MTG1) OTC9U1LI MTG1_HUMAN Decreases Expression [6]
Melanophilin (MLPH) OT7ADCXL MELPH_HUMAN Increases Expression [6]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [6]
Keratin-associated protein 2-1 (KRTAP2-1) OTV1SGF2 KRA21_HUMAN Decreases Expression [6]
Keratin, type I cytoskeletal 23 (KRT23) OTQW6UAG K1C23_HUMAN Decreases Expression [6]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) OT38HXJP CRLD1_HUMAN Increases Expression [6]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) OTAQD3YV ARNT2_HUMAN Decreases Expression [6]
Plexin-A4 (PLXNA4) OT5XKB3Q PLXA4_HUMAN Decreases Expression [6]
Palmdelphin (PALMD) OTRLOZ4Y PALMD_HUMAN Decreases Expression [6]
Transcription and mRNA export factor ENY2 (ENY2) OTTNU8RK ENY2_HUMAN Decreases Expression [6]
Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2) OT661S7D SCUB2_HUMAN Decreases Expression [6]
Cytochrome P450 26B1 (CYP26B1) OT92XA92 CP26B_HUMAN Decreases Expression [6]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Increases Expression [6]
Cytokine-inducible SH2-containing protein (CISH) OT8T5NYL CISH_HUMAN Increases Expression [6]
ATPase family AAA domain-containing protein 3A (ATAD3A) OTWF6HBP ATD3A_HUMAN Decreases Expression [6]
Kv channel-interacting protein 1 (KCNIP1) OTGLGK1R KCIP1_HUMAN Decreases Expression [6]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Increases Expression [6]
Peroxisomal sarcosine oxidase (PIPOX) OTWTCOTN SOX_HUMAN Increases Expression [6]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) OTV3Q0DS ATS9_HUMAN Increases Expression [6]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Decreases Expression [6]
Dickkopf-related protein 3 (DKK3) OTDU94EY DKK3_HUMAN Decreases Expression [6]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Decreases Expression [6]
Rho family-interacting cell polarization regulator 2 (RIPOR2) OTXB6LIR RIPR2_HUMAN Decreases Expression [6]
Transcription factor HES-2 (HES2) OTMWY2KV HES2_HUMAN Increases Expression [6]
Tolloid-like protein 2 (TLL2) OTHZ4TBL TLL2_HUMAN Increases Expression [6]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [16]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Affects Activity [16]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) OTX8L3M5 SAHH2_HUMAN Affects Expression [7]
Putative hydrolase DDAH2 (DDAH2) OT8Q40G2 DDAH2_HUMAN Affects Expression [7]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Affects Expression [7]
Small integral membrane protein 6 (SMIM6) OTRGL3O1 SMIM6_HUMAN Affects Expression [7]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Affects Expression [7]
Integrin beta-6 (ITGB6) OTI3DJ7U ITB6_HUMAN Affects Expression [7]
Deoxyribonuclease-1 (DNASE1) OTM4KWB3 DNAS1_HUMAN Affects Expression [7]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Affects Expression [7]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Affects Expression [7]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Affects Expression [7]
Diacylglycerol kinase epsilon (DGKE) OTWS86AS DGKE_HUMAN Affects Expression [7]
Cadherin-6 (CDH6) OT81Y80S CADH6_HUMAN Affects Expression [7]
Phospholipid-transporting ATPase ID (ATP8B2) OTH5WJ09 AT8B2_HUMAN Affects Expression [7]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Affects Expression [7]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Affects Expression [7]
Sclerostin domain-containing protein 1 (SOSTDC1) OTAKDNSM SOSD1_HUMAN Affects Expression [7]
Transmembrane protein 64 (TMEM64) OTO9IDFD TMM64_HUMAN Affects Expression [7]
Echinoderm microtubule-associated protein-like 6 (EML6) OTE1MUQS EMAL6_HUMAN Affects Expression [7]
PX domain-containing protein kinase-like protein (PXK) OTSP1WLK PXK_HUMAN Affects Expression [7]
Protein limb expression 1 homolog (LIX1) OT1CPNCC LIX1_HUMAN Affects Expression [7]
Uncharacterized protein FAM241A (FAM241A) OTC12ETA F241A_HUMAN Affects Expression [7]
RalBP1-associated Eps domain-containing protein 2 (REPS2) OTSE3TRP REPS2_HUMAN Affects Expression [7]
Syntaxin-binding protein 6 (STXBP6) OTUEKTIP STXB6_HUMAN Affects Expression [7]
POC1 centriolar protein homolog B (POC1B) OTDIMIRZ POC1B_HUMAN Affects Expression [7]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12) OT0EDNV9 GTR12_HUMAN Affects Expression [7]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Affects Expression [7]
Peroxidasin homolog (PXDN) OTFGGM9R PXDN_HUMAN Affects Expression [7]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Affects Expression [7]
DNA endonuclease RBBP8 (RBBP8) OTRHJ3GI CTIP_HUMAN Affects Expression [7]
Transmembrane protease serine 4 (TMPRSS4) OTCCGY2K TMPS4_HUMAN Affects Expression [7]
Cdc42 effector protein 3 (CDC42EP3) OTUZ3U9Z BORG2_HUMAN Affects Expression [7]
Teneurin-1 (TENM1) OTSKSU4V TEN1_HUMAN Affects Expression [7]
RNA polymerase II elongation factor ELL2 (ELL2) OTZJRTFM ELL2_HUMAN Affects Expression [8]
Mothers against decapentaplegic homolog 6 (SMAD6) OTUZZWUD SMAD6_HUMAN Affects Expression [8]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [18]
RAS guanyl-releasing protein 1 (RASGRP1) OTX9WN2E GRP1_HUMAN Affects Expression [8]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Expression [19]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Increases Expression [20]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Increases Expression [21]
Plasminogen (PLG) OTWWIPPY PLMN_HUMAN Increases Expression [22]
Renin (REN) OT52GZR2 RENI_HUMAN Increases Activity [23]
ATP synthase subunit a (ATP6) OTPHOGLX ATP6_HUMAN Increases Expression [20]
Antithrombin-III (SERPINC1) OTDFATG0 ANT3_HUMAN Decreases Activity [22]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Increases Expression [23]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [24]
Follitropin subunit beta (FSHB) OTGLS283 FSHB_HUMAN Decreases Expression [25]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Decreases Activity [26]
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Increases Expression [25]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Increases Expression [27]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Increases Expression [28]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Expression [29]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Increases Expression [30]
Histidine-rich glycoprotein (HRG) OTPLUFOG HRG_HUMAN Decreases Expression [31]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Increases Expression [32]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [33]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [25]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Affects Expression [8]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Affects Expression [34]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Decreases Expression [21]
Vitamin K-dependent protein S (PROS1) OTXQWNOI PROS_HUMAN Decreases Expression [22]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Increases Activity [35]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Affects Expression [8]
Coagulation factor VII (F7) OTGNJ97M FA7_HUMAN Increases Expression [21]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Affects Expression [8]
Chromogranin-A (CHGA) OTXYX5JH CMGA_HUMAN Affects Expression [8]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Affects Expression [8]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Affects Expression [8]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Increases Expression [36]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Affects Expression [8]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Increases Expression [37]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Decreases Expression [27]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [38]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Affects Expression [8]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [27]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Activity [39]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) OTTWCZYM ALS_HUMAN Decreases Expression [25]
ETS translocation variant 5 (ETV5) OTE2OBM4 ETV5_HUMAN Affects Expression [8]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Affects Expression [8]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Decreases Expression [19]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Increases Expression [40]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Affects Expression [8]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Affects Expression [8]
Cysteine--tRNA ligase, cytoplasmic (CARS1) OTOUZF6O SYCC_HUMAN Affects Expression [8]
Serine--tRNA ligase, cytoplasmic (SARS1) OTFKXQ1O SYSC_HUMAN Affects Expression [8]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Affects Expression [8]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Affects Expression [8]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Affects Expression [8]
Transformer-2 protein homolog beta (TRA2B) OTZYQW52 TRA2B_HUMAN Increases Expression [41]
Small ribosomal subunit protein RACK1 (RACK1) OTZBCQ1U RACK1_HUMAN Increases Expression [42]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [43]
Schlafen family member 5 (SLFN5) OTT1AESL SLFN5_HUMAN Affects Expression [8]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Affects Expression [8]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Expression [8]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Decreases Expression [19]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [44]
Advanced glycosylation end product-specific receptor (AGER) OTPY0IH7 RAGE_HUMAN Increases Expression [35]
Erythroferrone (ERFE) OTSES1HA ERFE_HUMAN Affects Expression [8]
FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) OTIH6283 FGD3_HUMAN Affects Expression [8]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) OTGFK4MH NHRF3_HUMAN Increases Expression [36]
Early estrogen-induced gene 1 protein (EEIG1) OT2BMEAE EEIG1_HUMAN Increases Expression [36]
Very-long-chain (HACD2) OTAZO9F6 HACD2_HUMAN Affects Expression [8]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Affects Expression [8]
Ly6/PLAUR domain-containing protein 1 (LYPD1) OT0HSGML LYPD1_HUMAN Affects Expression [8]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Affects Splicing [41]
Stonin-2 (STON2) OT01JHHE STON2_HUMAN Affects Expression [8]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Affects Expression [8]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Activity [45]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Expression [19]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Affects Expression [8]
Mediator of RNA polymerase II transcription subunit 8 (MED8) OTSIZ1I7 MED8_HUMAN Affects Expression [8]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Expression [19]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Affects Expression [8]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Increases Expression [29]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [46]
Protein associated with UVRAG as autophagy enhancer (RUBCNL) OTMQIDOI PACER_HUMAN Affects Expression [8]
Tetratricopeptide repeat protein 12 (TTC12) OTDB24YV TTC12_HUMAN Affects Expression [8]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Affects Expression [8]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Affects Expression [8]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Affects Expression [8]
Kelch-like protein 14 (KLHL14) OTYOS55H KLH14_HUMAN Affects Expression [8]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Affects Expression [8]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Affects Expression [8]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Affects Expression [8]
SET-binding protein (SETBP1) OTKGCOSR SETBP_HUMAN Affects Expression [8]
Sulfotransferase 2A1 (SULT2A1) OT0ISKQ4 ST2A1_HUMAN Increases Metabolism [47]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Increases Metabolism [47]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Uptake [48]
Cytochrome P450 (CYP2B) OTDDG81I Q14097_HUMAN Increases ADR [49]
Sulfotransferase 1B1 (SULT1B1) OTH0RQYA ST1B1_HUMAN Increases Metabolism [47]
Sulfotransferase 1A3 (SULT1A4) OTHJ8WWV ST1A3_HUMAN Increases Sulfation [50]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Hydroxylation [13]
Fibroblast growth factor 4 (FGF4) OTNVV3ZG FGF4_HUMAN Increases ADR [49]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Affects Metabolism [51]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Increases Hydroxylation [13]
------------------------------------------------------------------------------------
⏷ Show the Full List of 280 DOT(s)
Indication(s) of Quinine
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [4]
Quinine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
E3 ubiquitin-protein ligase COP1 (RFWD2) TT05DLS COP1_HUMAN Modulator [52]
------------------------------------------------------------------------------------
Quinine Interacts with 6 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [53]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [54]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [55]
Organic cation/carnitine transporter 2 (SLC22A5) DT3HUVD S22A5_HUMAN Substrate [56]
Organic cation/carnitine transporter 1 (SLC22A4) DT2EG60 S22A4_HUMAN Substrate [57]
Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DTBPTJF S6A12_HUMAN Substrate [58]
------------------------------------------------------------------------------------
⏷ Show the Full List of 6 DTP(s)
Quinine Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [59]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [60]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [61]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [62]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [62]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [63]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [64]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [65]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 DME(s)
Quinine Interacts with 13 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Activity [66]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Activity [66]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Decreases Activity [66]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Expression [67]
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Decreases Activity [68]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Decreases Activity [68]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Affects Uptake [69]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Decreases Activity [70]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Decreases Activity [70]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [67]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [71]
Sodium/hydrogen exchanger 7 (SLC9A7) OTVDLTYA SL9A7_HUMAN Decreases Activity [72]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Increases Uptake [73]
------------------------------------------------------------------------------------
⏷ Show the Full List of 13 DOT(s)

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