Details of the Drug Combinations

General Information of This Drug (ID: DMPIHLS)

• Drug Name: Diclofenac (DMPIHLS)
• Synonyms: Diclofenac (sodium matrix patch, pain)

Indication

Chronic renal failure; ICD 11: GB61.Z; Status: Approved [1]; Dysmenorrhea; ICD 11: GA34.3; Status: Approved [1]; Knee osteoarthritis; ICD 11: FA01; Status: Approved [1]; Osteoarthritis; ICD 11: FA00-FA05; Status: Approved [2]; Pain; ICD 11: MG30-MG3Z; Status: Approved [1]

• Therapeutic Class: Neurology Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

14 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Diclofenac + Morphine	DC4EXXO	Morphine	Trauma	[3]
Diclofenac + Nepafenac	DC2F0WT	Nepafenac	Post Surgical Management	[4]
Etoricoxib + Diclofenac	DCTJTEV	Etoricoxib	Achilles Tendinopathy	[5]
Levobupivacaine + Diclofenac	DC2EF2A	Levobupivacaine	Pain, Postoperative	[6]
Menthol + Diclofenac	DCO7YLA	Menthol	Pain	[7]
Diclofenac + Acetaminophen	DCJMBGB	Acetaminophen	Pain	[8]
Diclofenac + Magnesium Sulfate	DCXDC8F	Magnesium Sulfate	Renal Colic	[9]
Lidocaine + Diclofenac	DCWQL5E	Lidocaine	Renal Colic	[9]
Capsaicin + Diclofenac	DCSLTQB	Capsaicin	Acute Pain	[10]
Diclofenac + Lacosamide	DCDMX1S	Lacosamide	Sciatica Acute	[11]
Caffeine + Diclofenac	DCGCCUJ	Caffeine	Post-Dural Puncture Headache	[12]
Diclofenac + Midazolam	DCYXQ29	Midazolam	Postcraniotomy Headache	[13]
Ibuprofen + Diclofenac	DCWJXT4	Ibuprofen	Low Back Pain	[14]
Tamsulosin + Diclofenac	DCX0L9Q	Tamsulosin	Renal Stone	[15]

References

• [1] Diclofenac FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] ClinicalTrials.gov (NCT02094807) Pain as Indication for Operative Treatment of Traumatic Rib Fractures
• [4] ClinicalTrials.gov (NCT02506348) Comparison of Diclofenac vs. Nepafenac Ophthalmic Drops: Patient Comfort
• [5] ClinicalTrials.gov (NCT00792376) "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes"
• [6] ClinicalTrials.gov (NCT02556970) A Study Investigating Pain Following Single-port or Multi-port Video Assisted Thoracoscopic Surgery
• [7] ClinicalTrials.gov (NCT02201238) Pharmacokinetics Study Comparing Topical Diclofenac/Menthol Gels With Voltaren Gel and Oral Diclofenac Sodium
• [8] ClinicalTrials.gov (NCT02417337) Efficacy of Different Drugs to Control Post Root Canal Treatment Pain
• [9] ClinicalTrials.gov (NCT03199924) Treatment of Renal Colic in the Emergency Departement (ED).
• [10] ClinicalTrials.gov (NCT02700815) Capsaicin + Diclofenac Gel in Acute Back Pain or Neck Pain
• [11] ClinicalTrials.gov (NCT05626140) COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
• [12] ClinicalTrials.gov (NCT03910088) Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean
• [13] ClinicalTrials.gov (NCT01907984) Diclofenac Administered Before Skull Operations Reduces the Severity of Headache After the Intervention
• [14] ClinicalTrials.gov (NCT04611529) Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.
• [15] ClinicalTrials.gov (NCT04819828) Tamsulosin as Adjunctive Therapy After Extracorporeal Shock Wave Lithotripsy for Renal Stones