Details of the Drug Combination

General Information of Drug Combination (ID: DCO7YLA)

• Drug Combination Name: Menthol + Diclofenac
• Indication: Pain; Status: Phase 1 [1]
• Component Drugs:
  Menthol (DMG2KW7): Small molecular drug
  Diclofenac (DMPIHLS): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Menthol

Disease Entry	ICD 11	Status	REF
Back pain	ME84.Z	Approved	[2]
Pityriasis simplex	N.A.	Approved	[2]
Throat irritation	CA0Y	Approved	[3]
Tinea versicolor	1F2D.0	Approved	[2]
Pruritus	EC90	Investigative	[2]

Menthol Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Activator	[9]
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[9]

Menthol Interacts with 341 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Transient receptor potential cation channel subfamily M member 8 (TRPM8)	OT7ACGYK	TRPM8_HUMAN	Decreases Response To Substance	[10]
Deoxyribonuclease-2-alpha (DNASE2)	OT6RC1BL	DNS2A_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[6]
E3 SUMO-protein ligase CBX4 (CBX4)	OT4XVRRF	CBX4_HUMAN	Increases Expression	[6]
DNA fragmentation factor subunit alpha (DFFA)	OTFPFMT8	DFFA_HUMAN	Increases Expression	[6]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Decreases Expression	[6]
Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4)	OTYAI1UO	CACB4_HUMAN	Decreases Expression	[6]
TNF receptor-associated factor 5 (TRAF5)	OTSBTLO0	TRAF5_HUMAN	Decreases Expression	[6]
Transcription factor E2F3 (E2F3)	OT5VQMWY	E2F3_HUMAN	Decreases Expression	[6]
Etoposide-induced protein 2.4 homolog (EI24)	OTD4NOYS	EI24_HUMAN	Decreases Expression	[6]
Prostaglandin E synthase (PTGES)	OTB7YQFU	PTGES_HUMAN	Decreases Expression	[6]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Increases Expression	[6]
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)	OT1Q40TZ	MP2K7_HUMAN	Decreases Expression	[6]
Programmed cell death protein 5 (PDCD5)	OT6T2DDL	PDCD5_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Decreases Expression	[6]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Increases Expression	[6]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)	OTVHOL9B	TR10C_HUMAN	Decreases Expression	[6]
Calpain-9 (CAPN9)	OTE4IU5U	CAN9_HUMAN	Decreases Expression	[6]
Protein Mdm4 (MDM4)	OTU10BSF	MDM4_HUMAN	Increases Expression	[6]
Phospholipid scramblase 1 (PLSCR1)	OTGY9B5T	PLS1_HUMAN	Decreases Expression	[6]
Tumor protein p73 (TP73)	OT0LUO47	P73_HUMAN	Decreases Expression	[6]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Increases Expression	[6]
Proline dehydrogenase 1, mitochondrial (PRODH)	OT7SQ1C7	PROD_HUMAN	Increases Expression	[6]
Death-associated protein kinase 3 (DAPK3)	OTLV7EKW	DAPK3_HUMAN	Decreases Expression	[6]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	OT0KMIYQ	RIPK2_HUMAN	Increases Expression	[6]
Glutamate receptor ionotropic, delta-2 (GRID2)	OTJ3R10R	GRID2_HUMAN	Increases Expression	[6]
Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G)	OTGKBRE4	CAC1G_HUMAN	Increases Expression	[6]
Tumor necrosis factor ligand superfamily member 12 (TNFSF12)	OT6FQ02V	TNF12_HUMAN	Decreases Expression	[6]
Tumor necrosis factor ligand superfamily member 14 (TNFSF14)	OT5QRF09	TNF14_HUMAN	Decreases Expression	[6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)	OTJKOMXE	BNI3L_HUMAN	Decreases Expression	[6]
Neuropilin-2 (NRP2)	OTZL256E	NRP2_HUMAN	Decreases Expression	[6]
Lipid transferase CIDEA (CIDEA)	OTDUTSOV	CIDEA_HUMAN	Increases Expression	[6]
Immunoglobulin mu Fc receptor (FCMR)	OTI7I47T	FCMR_HUMAN	Increases Expression	[6]
Polyglutamine-binding protein 1 (PQBP1)	OTXCBEAH	PQBP1_HUMAN	Increases Expression	[6]
Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F)	OTQTXNGF	CAC1F_HUMAN	Increases Expression	[6]
Nucleolar protein 3 (NOL3)	OT1K0L0D	NOL3_HUMAN	Increases Expression	[6]
Programmed cell death protein 6 (PDCD6)	OT2YA5M8	PDCD6_HUMAN	Decreases Expression	[6]
Nucleoside diphosphate kinase 6 (NME6)	OTJNKOFA	NDK6_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)	OT3EDGXO	TNR21_HUMAN	Decreases Expression	[6]
Syntaxin-11 (STX11)	OTHFRSFP	STX11_HUMAN	Decreases Expression	[6]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[6]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13)	OT90OWIO	TNF13_HUMAN	Decreases Expression	[6]
DNA fragmentation factor subunit beta (DFFB)	OTPBW5N5	DFFB_HUMAN	Increases Expression	[6]
Signal recognition particle subunit SRP72 (SRP72)	OTPV73W7	SRP72_HUMAN	Decreases Expression	[6]
Serine/threonine-protein kinase 17B (STK17B)	OT4NYNO8	ST17B_HUMAN	Decreases Expression	[6]
Pleckstrin homology domain-containing family G member 5 (PLEKHG5)	OTL0S21W	PKHG5_HUMAN	Increases Expression	[6]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15)	OTNGA2BW	TNF15_HUMAN	Decreases Expression	[6]
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)	OTM705TH	CAC1H_HUMAN	Decreases Expression	[6]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Increases Expression	[6]
CUGBP Elav-like family member 2 (CELF2)	OTLJJ4VT	CELF2_HUMAN	Increases Expression	[6]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)	OT1G9297	TFIP8_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)	OTKAN9G7	TNF6B_HUMAN	Decreases Expression	[6]
BAG family molecular chaperone regulator 4 (BAG4)	OTUPX3M2	BAG4_HUMAN	Increases Expression	[6]
Tyrosyl-DNA phosphodiesterase 2 (TDP2)	OT1K0UMV	TYDP2_HUMAN	Increases Expression	[6]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)	OT4TMERS	NFAC1_HUMAN	Increases Expression	[6]
BAG family molecular chaperone regulator 2 (BAG2)	OTI6LD27	BAG2_HUMAN	Decreases Expression	[6]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Increases Expression	[6]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Decreases Expression	[6]
B-cell lymphoma/leukemia 10 (BCL10)	OT47MCLI	BCL10_HUMAN	Decreases Expression	[6]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[6]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[6]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Expression	[6]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Expression	[6]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Decreases Expression	[6]
N-myc proto-oncogene protein (MYCN)	OTWD33K1	MYCN_HUMAN	Decreases Expression	[6]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Increases Expression	[6]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[6]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Decreases Expression	[6]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Decreases Expression	[6]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[6]
Gelsolin (GSN)	OT4KS2UU	GELS_HUMAN	Decreases Expression	[6]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Expression	[6]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Increases Expression	[6]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Increases Expression	[6]
Heat shock protein HSP 90-beta (HSP90AB1)	OTR69EG7	HS90B_HUMAN	Decreases Expression	[6]
Cytochrome c1, heme protein, mitochondrial (CYC1)	OT0962IM	CY1_HUMAN	Decreases Expression	[6]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Decreases Expression	[6]
Annexin A5 (ANXA5)	OTZS877V	ANXA5_HUMAN	Increases Expression	[6]
Granzyme B (GZMB)	OTPPVIRS	GRAB_HUMAN	Increases Expression	[6]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Decreases Expression	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[6]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Decreases Expression	[6]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Decreases Expression	[6]
Interferon regulatory factor 1 (IRF1)	OT43DI6J	IRF1_HUMAN	Decreases Expression	[6]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[6]
DNA topoisomerase 1 (TOP1)	OT51O0CF	TOP1_HUMAN	Decreases Expression	[6]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Increases Expression	[6]
Cation-independent mannose-6-phosphate receptor (IGF2R)	OTDXPQVX	MPRI_HUMAN	Increases Expression	[6]
ADP/ATP translocase 1 (SLC25A4)	OTKYLK2J	ADT1_HUMAN	Decreases Expression	[6]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[6]
Perforin-1 (PRF1)	OTFVXD7H	PERF_HUMAN	Decreases Expression	[6]
Endoplasmin (HSP90B1)	OT02XLBR	ENPL_HUMAN	Decreases Expression	[6]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Decreases Expression	[6]
Transcription factor JunD (JUND)	OTNKACJD	JUND_HUMAN	Increases Expression	[6]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Increases Expression	[6]
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)	OT1C8HQ4	ERCC2_HUMAN	Increases Expression	[6]
Large ribosomal subunit protein uL30 (RPL7)	OT4WCQBE	RL7_HUMAN	Increases Expression	[6]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)	OTVAW3P1	ERCC3_HUMAN	Increases Expression	[6]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Increases Expression	[6]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Increases Expression	[6]
B-cell lymphoma 3 protein (BCL3)	OT1M5B95	BCL3_HUMAN	Increases Expression	[6]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Decreases Expression	[6]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Decreases Expression	[6]
Cadherin-3 (CDH3)	OTKNLQU7	CADH3_HUMAN	Increases Expression	[6]
E3 ubiquitin-protein ligase CBL (CBL)	OTTKELCU	CBL_HUMAN	Decreases Expression	[6]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Decreases Expression	[6]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4)	OTOCBX7P	TNFL4_HUMAN	Increases Expression	[6]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[6]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Decreases Expression	[6]
Insulin-like growth factor-binding protein 6 (IGFBP6)	OTW878VI	IBP6_HUMAN	Increases Expression	[6]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[6]
Deoxyribonuclease-1 (DNASE1)	OTM4KWB3	DNAS1_HUMAN	Decreases Expression	[6]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Decreases Expression	[6]
Proteasome subunit alpha type-3 (PSMA3)	OT52M10V	PSA3_HUMAN	Increases Expression	[6]
Tumor necrosis factor receptor superfamily member 5 (CD40)	OT5YU2XB	TNR5_HUMAN	Decreases Expression	[6]
Elongation factor 1-gamma (EEF1G)	OTW7DH2F	EF1G_HUMAN	Decreases Expression	[6]
CD27 antigen (CD27)	OTH7NA58	CD27_HUMAN	Increases Expression	[6]
Proteasome subunit alpha type-5 (PSMA5)	OT38E6Y1	PSA5_HUMAN	Increases Expression	[6]
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)	OTJ8UM8O	TNR8_HUMAN	Decreases Expression	[6]
DNA-3-methyladenine glycosylase (MPG)	OTAHW80B	3MG_HUMAN	Decreases Expression	[6]
AT-rich interactive domain-containing protein 4A (ARID4A)	OT1XKBZ0	ARI4A_HUMAN	Increases Expression	[6]
Lysine-specific demethylase 5A (KDM5A)	OTLYFX8A	KDM5A_HUMAN	Decreases Expression	[6]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Decreases Expression	[6]
Nitric oxide synthase 1 (NOS1)	OT7M8XVG	NOS1_HUMAN	Increases Expression	[6]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Decreases Expression	[6]
CD40 ligand (CD40LG)	OT75Z6A6	CD40L_HUMAN	Decreases Expression	[6]
Peroxiredoxin-5, mitochondrial (PRDX5)	OTUEKZ18	PRDX5_HUMAN	Decreases Expression	[6]
Translocator protein (TSPO)	OTSU7ESK	TSPO_HUMAN	Decreases Expression	[6]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Expression	[6]
RAC-beta serine/threonine-protein kinase (AKT2)	OTBB632K	AKT2_HUMAN	Decreases Expression	[6]
Caspase-14 (CASP14)	OTKY93H9	CASPE_HUMAN	Increases Expression	[6]
CD70 antigen (CD70)	OTHB2AL1	CD70_HUMAN	Increases Expression	[6]
Tumor necrosis factor ligand superfamily member 8 (TNFSF8)	OTDYGDJ3	TNFL8_HUMAN	Decreases Expression	[6]
Cannabinoid receptor 2 (CNR2)	OTYP9P43	CNR2_HUMAN	Decreases Expression	[6]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Decreases Expression	[6]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)	OTTWCZYM	ALS_HUMAN	Increases Expression	[6]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Increases Expression	[6]
Tumor necrosis factor receptor superfamily member 3 (LTBR)	OT2HVZGV	TNR3_HUMAN	Increases Expression	[6]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Decreases Expression	[6]
Nuclear pore glycoprotein p62 (NUP62)	OTMN63DH	NUP62_HUMAN	Decreases Expression	[6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[6]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9)	OTV9L89D	TNFL9_HUMAN	Increases Expression	[6]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[6]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Decreases Expression	[6]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Increases Expression	[6]
Huntingtin (HTT)	OTKN8P85	HD_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)	OTDK74C0	TNR4_HUMAN	Decreases Expression	[6]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)	OTZPZX11	MP2K4_HUMAN	Increases Expression	[6]
Small ribosomal subunit protein uS4 (RPS9)	OTPV69Q0	RS9_HUMAN	Decreases Expression	[6]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[6]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Increases Expression	[6]
Presenilin-1 (PSEN1)	OTKL39RT	PSN1_HUMAN	Decreases Expression	[6]
Type-2 angiotensin II receptor (AGTR2)	OTU8GU9M	AGTR2_HUMAN	Decreases Expression	[6]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Increases Expression	[6]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Decreases Expression	[6]
Death-associated protein 1 (DAP)	OT5YLL7E	DAP1_HUMAN	Decreases Expression	[6]
Small ribosomal subunit protein mS29 (DAP3)	OTNPEZYM	RT29_HUMAN	Decreases Expression	[6]
Tyrosine-protein kinase Blk (BLK)	OT1EB8MT	BLK_HUMAN	Decreases Expression	[6]
Caspase-5 (CASP5)	OT0F2THD	CASP5_HUMAN	Decreases Expression	[6]
Cyclin-G1 (CCNG1)	OT17IA9L	CCNG1_HUMAN	Decreases Expression	[6]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Decreases Expression	[6]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Decreases Expression	[6]
Mitogen-activated protein kinase 10 (MAPK10)	OTC46VX1	MK10_HUMAN	Decreases Expression	[6]
UV excision repair protein RAD23 homolog B (RAD23B)	OT0PGOG3	RD23B_HUMAN	Decreases Expression	[6]
Epithelial membrane protein 3 (EMP3)	OTODMJ1D	EMP3_HUMAN	Increases Expression	[6]
Allograft inflammatory factor 1 (AIF1)	OTGES18F	AIF1_HUMAN	Increases Expression	[6]
Exportin-2 (CSE1L)	OTV2X99A	XPO2_HUMAN	Increases Expression	[6]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Expression	[6]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[6]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Decreases Expression	[6]
Cyclin-dependent kinase 4 inhibitor D (CDKN2D)	OT2TTZPZ	CDN2D_HUMAN	Decreases Expression	[6]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Expression	[6]
Nucleoside diphosphate kinase homolog 5 (NME5)	OTE8OLFN	NDK5_HUMAN	Decreases Expression	[6]
Caspase recruitment domain-containing protein 18 (CARD18)	OTBMLB80	CAR18_HUMAN	Decreases Expression	[6]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Increases Expression	[6]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Increases Expression	[6]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Decreases Expression	[6]
Small ribosomal subunit protein uS10 (RPS20)	OTI8052R	RS20_HUMAN	Increases Expression	[6]
Small ribosomal subunit protein eS1 (RPS3A)	OTUEP7CL	RS3A_HUMAN	Increases Expression	[6]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Decreases Expression	[6]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1)	OTUUNQBT	DAD1_HUMAN	Decreases Expression	[6]
Large ribosomal subunit protein eL31 (RPL31)	OTV9E1OE	RL31_HUMAN	Decreases Expression	[6]
Growth factor receptor-bound protein 2 (GRB2)	OTOP7LTE	GRB2_HUMAN	Decreases Expression	[6]
Elongation factor 1-alpha 1 (EEF1A1)	OT00THXS	EF1A1_HUMAN	Decreases Expression	[6]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)	OTEO98CR	IF4G2_HUMAN	Decreases Expression	[6]
T-complex protein 1 subunit beta (CCT2)	OTW1VV4E	TCPB_HUMAN	Decreases Expression	[6]
Glutathione S-transferase omega-1 (GSTO1)	OTUJ93MN	GSTO1_HUMAN	Increases Expression	[6]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)	OTTM6KRB	ADA17_HUMAN	Increases Expression	[6]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Decreases Expression	[6]
Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B)	OTRM0XDW	CAC1B_HUMAN	Decreases Expression	[6]
Protein BEX3 (BEX3)	OTW1V1L5	BEX3_HUMAN	Increases Expression	[6]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B)	OT9NPJCR	PDE1B_HUMAN	Decreases Expression	[6]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1)	OTOVM4D4	SPTB2_HUMAN	Increases Expression	[6]
Nucleolysin TIAR (TIAL1)	OTV2KFZH	TIAR_HUMAN	Decreases Expression	[6]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Increases Expression	[6]
Forkhead box protein K2 (FOXK2)	OTFXDZ3R	FOXK2_HUMAN	Increases Expression	[6]
Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)	OTQFH2ZD	CAC1D_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)	OT1YFEP1	TNR17_HUMAN	Increases Expression	[6]
Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1)	OTV42SIT	CACB1_HUMAN	Decreases Expression	[6]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Decreases Expression	[6]
DNA topoisomerase 2-beta (TOP2B)	OTDHKQZ8	TOP2B_HUMAN	Increases Expression	[6]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Expression	[6]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)	OTRZH80H	TNAP2_HUMAN	Increases Expression	[6]
Lactoylglutathione lyase (GLO1)	OTXFS5B3	LGUL_HUMAN	Increases Expression	[6]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Expression	[6]
Peroxiredoxin-1 (PRDX1)	OTZ3BEC4	PRDX1_HUMAN	Increases Expression	[6]
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)	OTNOM26L	TNR9_HUMAN	Increases Expression	[6]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Decreases Expression	[6]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Increases Expression	[6]
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2)	OT53K8W2	CACB2_HUMAN	Decreases Expression	[6]
Lactadherin (MFGE8)	OTQKE41R	MFGM_HUMAN	Increases Expression	[6]
Retinoblastoma-like protein 2 (RBL2)	OTBQSOE6	RBL2_HUMAN	Decreases Expression	[6]
Histone acetyltransferase p300 (EP300)	OTL8QJDX	EP300_HUMAN	Decreases Expression	[6]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Decreases Expression	[6]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)	OTESFZSO	PTN13_HUMAN	Increases Expression	[6]
TNF receptor-associated factor 2 (TRAF2)	OT1MEZZN	TRAF2_HUMAN	Decreases Expression	[6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)	OTVZD4H6	BNIP2_HUMAN	Increases Expression	[6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Decreases Expression	[6]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Decreases Expression	[6]
Baculoviral IAP repeat-containing protein 1 (NAIP)	OTLA925F	BIRC1_HUMAN	Increases Expression	[6]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Decreases Expression	[6]
TNF receptor-associated factor 3 (TRAF3)	OT5TQBGV	TRAF3_HUMAN	Increases Expression	[6]
FAS-associated death domain protein (FADD)	OTV7GFHH	FADD_HUMAN	Decreases Expression	[6]
Serine/threonine-protein kinase PAK 2 (PAK2)	OTLUNCIH	PAK2_HUMAN	Increases Expression	[6]
E3 ubiquitin-protein ligase CBL-B (CBLB)	OTPLRER9	CBLB_HUMAN	Decreases Expression	[6]
Nucleoside diphosphate kinase 3 (NME3)	OT0CA0GF	NDK3_HUMAN	Decreases Expression	[6]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)	OTS3FVTY	M3K1_HUMAN	Increases Expression	[6]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Decreases Expression	[6]
Cyclin-dependent kinase 5 activator 2 (CDK5R2)	OTNUTLPU	CD5R2_HUMAN	Increases Expression	[6]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Increases Expression	[6]
Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2)	OTK5T6HZ	NFAC2_HUMAN	Increases Expression	[6]
GRB2-associated-binding protein 1 (GAB1)	OTQKE6V4	GAB1_HUMAN	Increases Expression	[6]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[6]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	OTC41R1E	RIPK1_HUMAN	Increases Expression	[6]
Deoxyribonuclease gamma (DNASE1L3)	OTEUIMC2	DNSL3_HUMAN	Increases Expression	[6]
Apoptosis-stimulating of p53 protein 2 (TP53BP2)	OTOWJ2Y4	ASPP2_HUMAN	Increases Expression	[6]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)	OT6VY3A3	SPTN1_HUMAN	Decreases Expression	[6]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)	OT37EWR0	BACD2_HUMAN	Decreases Expression	[6]
Cyclin-dependent kinase 13 (CDK13)	OT3P7JF1	CDK13_HUMAN	Increases Expression	[6]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Decreases Expression	[6]
Dedicator of cytokinesis protein 1 (DOCK1)	OTCFV3ON	DOCK1_HUMAN	Decreases Expression	[6]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[6]
Transcription factor Dp-2 (TFDP2)	OTKQFX5H	TFDP2_HUMAN	Decreases Expression	[6]
Fas-activated serine/threonine kinase (FASTK)	OTTHFZMP	FASTK_HUMAN	Decreases Expression	[6]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Increases Expression	[6]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Decreases Expression	[6]
Glutamate receptor ionotropic, NMDA 2C (GRIN2C)	OTV7ZA9O	NMDE3_HUMAN	Decreases Expression	[6]
Nuclear mitotic apparatus protein 1 (NUMA1)	OTTKAVG4	NUMA1_HUMAN	Increases Expression	[6]
Protein disulfide-isomerase A6 (PDIA6)	OT8YBR17	PDIA6_HUMAN	Increases Expression	[6]
Retinoblastoma-binding protein 5 (RBBP5)	OT12W2MK	RBBP5_HUMAN	Decreases Expression	[6]
Transcription factor E2F5 (E2F5)	OT1XWING	E2F5_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)	OTBOSJHO	TRADD_HUMAN	Increases Expression	[6]
Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)	OTHATMLU	CAC1E_HUMAN	Decreases Expression	[6]
Programmed cell death protein 2 (PDCD2)	OTUOGSDJ	PDCD2_HUMAN	Decreases Expression	[6]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[6]
Quinone oxidoreductase PIG3 (TP53I3)	OTSCM68G	QORX_HUMAN	Increases Expression	[6]
Serine/threonine-protein kinase LMTK1 (AATK)	OTVHAX5N	LMTK1_HUMAN	Decreases Expression	[6]
E3 ubiquitin-protein ligase RBBP6 (RBBP6)	OTTVG4HU	RBBP6_HUMAN	Increases Expression	[6]
E3 ubiquitin-protein ligase SIAH1 (SIAH1)	OT29A838	SIAH1_HUMAN	Decreases Expression	[6]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[6]
TRAF3-interacting protein 1 (TRAF3IP1)	OTLCC64B	MIPT3_HUMAN	Decreases Expression	[6]
MAP kinase-activating death domain protein (MADD)	OTUFYVGG	MADD_HUMAN	Increases Expression	[6]
Unconventional myosin-XVIIIa (MYO18A)	OT2YPT7O	MY18A_HUMAN	Increases Expression	[6]
Protein FAN (NSMAF)	OTYNVZ23	FAN_HUMAN	Increases Expression	[6]
Zinc finger protein ubi-d4 (DPF2)	OTL0JH2C	REQU_HUMAN	Decreases Expression	[6]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Increases Expression	[6]
TRAF family member-associated NF-kappa-B activator (TANK)	OTZSGFIK	TANK_HUMAN	Decreases Expression	[6]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Expression	[6]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Increases Expression	[6]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)	OTB82PFO	TNR14_HUMAN	Increases Expression	[6]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)	OTVZ7I3A	TNR25_HUMAN	Decreases Expression	[6]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)	OTFYDEES	AT2A3_HUMAN	Increases Expression	[6]
Modulator of apoptosis 1 (MOAP1)	OTVF3LUG	MOAP1_HUMAN	Decreases Expression	[6]
PRKC apoptosis WT1 regulator protein (PAWR)	OTKY7W52	PAWR_HUMAN	Increases Expression	[6]
Bcl-2-modifying factor (BMF)	OT90NSLI	BMF_HUMAN	Decreases Expression	[6]
Parkinson disease protein 7 (PARK7)	OT0SKNTG	PARK7_HUMAN	Decreases Expression	[6]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)	OTT3DOOL	M3K14_HUMAN	Increases Expression	[6]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Increases Expression	[6]
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)	OT53LJGW	M3K3_HUMAN	Decreases Expression	[6]
BAG family molecular chaperone regulator 1 (BAG1)	OTRQNIA4	BAG1_HUMAN	Decreases Expression	[6]
B-cell CLL/lymphoma 7 protein family member B (BCL7B)	OT8DQQRD	BCL7B_HUMAN	Increases Expression	[6]
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1)	OTJP4U7K	HNRL1_HUMAN	Increases Expression	[6]
Oxidoreductase HTATIP2 (HTATIP2)	OT9MZ4QO	HTAI2_HUMAN	Increases Expression	[6]
TNF receptor-associated factor 4 (TRAF4)	OTJLRVMC	TRAF4_HUMAN	Decreases Expression	[6]
E3 ubiquitin-protein ligase TRAIP (TRAIP)	OTMPT9Y2	TRAIP_HUMAN	Decreases Expression	[6]
Caspase recruitment domain-containing protein 10 (CARD10)	OT2RPM4I	CAR10_HUMAN	Decreases Expression	[6]
Caspase recruitment domain-containing protein 6 (CARD6)	OTEI1PJ1	CARD6_HUMAN	Decreases Expression	[6]
Caspase recruitment domain-containing protein 14 (CARD14)	OTADQHOV	CAR14_HUMAN	Decreases Expression	[6]
Caspase recruitment domain-containing protein 11 (CARD11)	OTRCTLYC	CAR11_HUMAN	Decreases Expression	[6]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)	OT87E7HW	B2L14_HUMAN	Increases Expression	[6]
NACHT, LRR and PYD domains-containing protein 1 (NLRP1)	OT4BNNOS	NLRP1_HUMAN	Increases Expression	[6]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Increases Expression	[6]
Caspase recruitment domain-containing protein 9 (CARD9)	OTJ81AWD	CARD9_HUMAN	Increases Expression	[6]
Bcl-2-like protein 12 (BCL2L12)	OTS6IFZY	B2L12_HUMAN	Decreases Expression	[6]
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2)	OTPGYWKC	NOD2_HUMAN	Increases Expression	[6]
p53-regulated apoptosis-inducing protein 1 (TP53AIP1)	OT1XVNDP	TPIP1_HUMAN	Decreases Expression	[6]
Bcl-2-like protein 10 (BCL2L10)	OTYXQJ3I	B2L10_HUMAN	Increases Expression	[6]
NLR family CARD domain-containing protein 4 (NLRC4)	OTAIA3NA	NLRC4_HUMAN	Decreases Expression	[6]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Increases Expression	[6]
Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2)	OTFJXVQQ	CA2D2_HUMAN	Decreases Expression	[6]
Bifunctional apoptosis regulator (BFAR)	OTTBG0V7	BFAR_HUMAN	Decreases Expression	[6]
Hematopoietic cell signal transducer (HCST)	OTILCB4K	HCST_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Decreases Expression	[6]
Peflin (PEF1)	OTY24CUW	PEF1_HUMAN	Increases Expression	[6]
Serine/threonine-protein kinase 17A (STK17A)	OTS87MOT	ST17A_HUMAN	Decreases Expression	[6]
Death domain-associated protein 6 (DAXX)	OTX6O7PL	DAXX_HUMAN	Decreases Expression	[6]
Lipid transferase CIDEB (CIDEB)	OT873IYM	CIDEB_HUMAN	Increases Expression	[6]
NADH dehydrogenase 1 alpha subcomplex subunit 12 (NDUFA12)	OTCD6I5M	NDUAC_HUMAN	Increases Expression	[6]
Death-associated protein kinase 2 (DAPK2)	OTWODUQG	DAPK2_HUMAN	Decreases Expression	[6]
Inhibitor of growth protein 1 (ING1)	OTEZBRKW	ING1_HUMAN	Increases Expression	[6]
CASP8-associated protein 2 (CASP8AP2)	OTTWT68S	C8AP2_HUMAN	Decreases Expression	[6]
BAG family molecular chaperone regulator 5 (BAG5)	OT0J97C6	BAG5_HUMAN	Increases Expression	[6]
Apoptosis-associated speck-like protein containing a CARD (PYCARD)	OT67RON3	ASC_HUMAN	Decreases Expression	[6]
Calpain-11 (CAPN11)	OTEHK57V	CAN11_HUMAN	Decreases Expression	[6]
Bcl-2-related ovarian killer protein (BOK)	OTDQPDIX	BOK_HUMAN	Decreases Expression	[6]
Tumor necrosis factor ligand superfamily member 18 (TNFSF18)	OT3ANRX1	TNF18_HUMAN	Increases Expression	[6]
FAS-associated factor 1 (FAF1)	OTGAMLM4	FAF1_HUMAN	Decreases Expression	[6]
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1)	OTUN9GUS	NOD1_HUMAN	Decreases Expression	[6]
RAC-gamma serine/threonine-protein kinase (AKT3)	OT5M2LFI	AKT3_HUMAN	Increases Expression	[6]
Caspase recruitment domain-containing protein 8 (CARD8)	OTXXZYWU	CARD8_HUMAN	Increases Expression	[6]
TNF receptor-associated factor 6 (TRAF6)	OTA5GO5K	TRAF6_HUMAN	Decreases Expression	[6]
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)	OTL1D484	RIPK3_HUMAN	Increases Expression	[6]
NF-kappa-B essential modulator (IKBKG)	OTNWJWSD	NEMO_HUMAN	Decreases Expression	[6]
Calpain-6 (CAPN6)	OT8K5PR5	CAN6_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)	OT1FISGN	TNR11_HUMAN	Decreases Expression	[6]
NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8)	OTW4A4Q0	NDUB8_HUMAN	Decreases Expression	[11]
Cytochrome c oxidase subunit 2 (COX2)	OTTMVBJJ	COX2_HUMAN	Decreases Expression	[11]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Secretion	[12]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[13]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Secretion	[12]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Increases Expression	[13]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)	OTRE1M1T	SDHB_HUMAN	Decreases Expression	[11]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[14]
Transforming protein RhoA (RHOA)	OT6YOJ9N	RHOA_HUMAN	Increases Expression	[15]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Increases Expression	[15]
Ras-related protein Rap-1A (RAP1A)	OT5RH6TI	RAP1A_HUMAN	Increases Expression	[15]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Phosphorylation	[12]
Transient receptor potential cation channel subfamily V member 1 (TRPV1)	OTHHDR03	TRPV1_HUMAN	Increases Activity	[10]

Indication(s) of Diclofenac

Disease Entry	ICD 11	Status	REF
Chronic renal failure	GB61.Z	Approved	[4]
Dysmenorrhea	GA34.3	Approved	[4]
Knee osteoarthritis	FA01	Approved	[4]
Osteoarthritis	FA00-FA05	Approved	[5]
Pain	MG30-MG3Z	Approved	[4]

Diclofenac Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Prostaglandin G/H synthase (COX)	TTK0943	PGH1_HUMAN; PGH2_HUMAN	Modulator	[26]

Diclofenac Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[27]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[28]

Diclofenac Interacts with 14 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[29]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[30]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[31]
Cytochrome P450 2C18 (CYP2C18)	DEZMWRE	CP2CI_HUMAN	Metabolism	[31]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[32]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[33]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Metabolism	[34]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[31]
Cholesterol 24-hydroxylase (CYP46A1)	DEKP5HX	CP46A_HUMAN	Metabolism	[35]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Metabolism	[36]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Metabolism	[24]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DE85D2P	UD19_HUMAN	Metabolism	[24]
Cytochrome P450 102A1 (cyp102)	DE4OGUF	CPXB_BACMB	Metabolism	[37]
Cytochrome P450 105D7 (cyp105)	DECV2ME	CYP28_STRAW	Metabolism	[38]

Diclofenac Interacts with 470 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[20]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[39]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Increases Expression	[39]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Hydroxylation	[40]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Increases Hydroxylation	[41]
Cholesterol 24-hydroxylase (CYP46A1)	OTJ27FOX	CP46A_HUMAN	Increases Hydroxylation	[35]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Activity	[42]
Solute carrier family 22 member 1 (SLC22A1)	OT7817I4	S22A1_HUMAN	Decreases Activity	[43]
Solute carrier family 22 member 6 (SLC22A6)	OTKRCBVM	S22A6_HUMAN	Decreases Activity	[43]
Organic anion transporter 7 (SLC22A9)	OTO4BJCC	S22A9_HUMAN	Decreases Activity	[43]
Solute carrier family 22 member 11 (SLC22A11)	OTAJLNJZ	S22AB_HUMAN	Decreases Activity	[43]
Solute carrier family 22 member 7 (SLC22A7)	OTKTNH1W	S22A7_HUMAN	Decreases Activity	[43]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Decreases Activity	[44]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[19]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Expression	[20]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Increases Expression	[20]
Protransforming growth factor alpha (TGFA)	OTPD1LL9	TGFA_HUMAN	Increases Expression	[20]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[20]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Increases Expression	[20]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[20]
Fatty acid-binding protein, liver (FABP1)	OTR34ETM	FABPL_HUMAN	Decreases Expression	[20]
Transcription factor JunD (JUND)	OTNKACJD	JUND_HUMAN	Increases Expression	[20]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[20]
Phosphatidylcholine translocator ABCB4 (ABCB4)	OTE6PY83	MDR3_HUMAN	Decreases Expression	[20]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Increases Expression	[20]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[20]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[20]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Increases Expression	[20]
Adenosine kinase (ADK)	OTXR6VDI	ADK_HUMAN	Increases Expression	[20]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Affects Expression	[20]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[20]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Increases Expression	[21]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Decreases Expression	[21]
Toll-like receptor 2 (TLR2)	OTGO5P4R	TLR2_HUMAN	Decreases Expression	[21]
Antiviral innate immune response receptor RIG-I (RIGI)	OTFIIC43	RIGI_HUMAN	Decreases Expression	[21]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Decreases Expression	[21]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Decreases Expression	[21]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Expression	[21]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[21]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Decreases Expression	[21]
Steryl-sulfatase (STS)	OTXTJQPC	STS_HUMAN	Increases Expression	[21]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Decreases Expression	[21]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Decreases Expression	[21]
Interferon-induced GTP-binding protein Mx1 (MX1)	OT6X8G5T	MX1_HUMAN	Decreases Expression	[21]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Decreases Expression	[21]
Guanylate-binding protein 1 (GBP1)	OTUM7RPJ	GBP1_HUMAN	Decreases Expression	[21]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[21]
Macrophage metalloelastase (MMP12)	OT9Z7LHM	MMP12_HUMAN	Decreases Expression	[21]
Interferon alpha-inducible protein 27, mitochondrial (IFI27)	OTI2XGIT	IFI27_HUMAN	Decreases Expression	[21]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Decreases Expression	[21]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Decreases Expression	[21]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Decreases Expression	[21]
Interferon-induced 35 kDa protein (IFI35)	OTV9RZ53	IN35_HUMAN	Decreases Expression	[21]
Signal transducer and activator of transcription 4 (STAT4)	OTAK3VFR	STAT4_HUMAN	Decreases Expression	[21]
Bcl-2-related protein A1 (BCL2A1)	OTWRYSNA	B2LA1_HUMAN	Decreases Expression	[21]
Lymphocyte antigen 6E (LY6E)	OTMG16BZ	LY6E_HUMAN	Decreases Expression	[21]
Interferon-induced protein 44-like (IFI44L)	OTXKORJP	IF44L_HUMAN	Decreases Expression	[21]
Olfactomedin-like protein 2B (OLFML2B)	OTDNJFR4	OLM2B_HUMAN	Increases Expression	[21]
E3 ubiquitin-protein ligase RNF19B (RNF19B)	OTYCWKBP	RN19B_HUMAN	Decreases Expression	[21]
Probable E3 ubiquitin-protein ligase HERC6 (HERC6)	OT7G9PQE	HERC6_HUMAN	Decreases Expression	[21]
Interferon-induced protein 44 (IFI44)	OTOKSZVA	IFI44_HUMAN	Decreases Expression	[21]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)	OTCA9WCM	RSAD2_HUMAN	Decreases Expression	[21]
Interferon regulatory factor 7 (IRF7)	OTC1A2PQ	IRF7_HUMAN	Decreases Expression	[21]
Interferon-stimulated gene 20 kDa protein (ISG20)	OTCWRJJW	ISG20_HUMAN	Decreases Expression	[21]
Latexin (LXN)	OTZQ2M6Y	LXN_HUMAN	Increases Expression	[21]
Interferon-induced helicase C domain-containing protein 1 (IFIH1)	OTZA2AHA	IFIH1_HUMAN	Decreases Expression	[21]
Interleukin-23 subunit alpha (IL23A)	OTYO99HC	IL23A_HUMAN	Decreases Expression	[21]
Large neutral amino acids transporter small subunit 2 (SLC7A8)	OT8XXVO8	LAT2_HUMAN	Increases Expression	[21]
E3 ISG15--protein ligase HERC5 (HERC5)	OTZ5PR39	HERC5_HUMAN	Decreases Expression	[21]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Decreases Expression	[21]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[45]
Prostaglandin reductase 1 (PTGR1)	OTMAR351	PTGR1_HUMAN	Decreases Activity	[46]
Glutathione S-transferase A4 (GSTA4)	OTZ1USIA	GSTA4_HUMAN	Decreases Activity	[47]
Glutathione S-transferase A1 (GSTA1)	OTA7K5XA	GSTA1_HUMAN	Decreases Activity	[47]
Glutathione S-transferase P (GSTP1)	OTLP0A0Y	GSTP1_HUMAN	Affects Activity	[47]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Decreases Activity	[47]
Glutathione S-transferase Mu 2 (GSTM2)	OTG4WT05	GSTM2_HUMAN	Decreases Activity	[47]
Glutathione S-transferase Mu 4 (GSTM4)	OTOTF8DU	GSTM4_HUMAN	Affects Activity	[47]
Glutathione S-transferase A3 (GSTA3)	OTJ3REE3	GSTA3_HUMAN	Decreases Activity	[47]
Cytochrome P450 2E1 (CYP2E1)	OTHQ17JG	CP2E1_HUMAN	Decreases Activity	[48]
Thymidine kinase 2, mitochondrial (TK2)	OTS1V4XB	KITM_HUMAN	Affects Expression	[23]
DNA fragmentation factor subunit alpha (DFFA)	OTFPFMT8	DFFA_HUMAN	Affects Expression	[23]
Cell division cycle 7-related protein kinase (CDC7)	OT5133XY	CDC7_HUMAN	Affects Expression	[23]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)	OTOMP6TH	PK3CD_HUMAN	Affects Expression	[23]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)	OTFBU4GD	P3C2A_HUMAN	Affects Expression	[23]
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2)	OTZSUQK5	P85B_HUMAN	Affects Expression	[23]
Suppressor of cytokine signaling 7 (SOCS7)	OT503VJG	SOCS7_HUMAN	Affects Expression	[23]
Suppressor of cytokine signaling 6 (SOCS6)	OT2O5ZBK	SOCS6_HUMAN	Affects Expression	[23]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Affects Expression	[23]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Affects Expression	[23]
Guanine nucleotide-binding protein subunit beta-5 (GNB5)	OT3ZSAXH	GNB5_HUMAN	Affects Expression	[23]
DNA-directed RNA polymerase III subunit RPC1 (POLR3A)	OT5MSK10	RPC1_HUMAN	Affects Expression	[23]
Ras-related protein M-Ras (MRAS)	OTNCVCQW	RASM_HUMAN	Affects Expression	[23]
Transcription regulator protein BACH1 (BACH1)	OTY8004K	BACH1_HUMAN	Affects Expression	[23]
Histone acetyltransferase type B catalytic subunit (HAT1)	OT307KEN	HAT1_HUMAN	Affects Expression	[23]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Increases Expression	[49]
Antizyme inhibitor 1 (AZIN1)	OTX5W77I	AZIN1_HUMAN	Affects Expression	[23]
Mitogen-activated protein kinase 13 (MAPK13)	OT0W9GE7	MK13_HUMAN	Affects Expression	[23]
Fanconi anemia group G protein (FANCG)	OT7MC8TZ	FANCG_HUMAN	Affects Expression	[23]
Transmembrane protease serine 2 (TMPRSS2)	OTN44YQ5	TMPS2_HUMAN	Increases Expression	[50]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Affects Expression	[23]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	OTP45YKX	P4HA2_HUMAN	Increases Expression	[51]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Affects Expression	[23]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Affects Expression	[23]
Adenylate cyclase type 6 (ADCY6)	OTFOY4WW	ADCY6_HUMAN	Affects Expression	[23]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)	OTUXEASC	M3K7_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3)	OTZCRXLJ	IF4G3_HUMAN	Affects Expression	[23]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)	OTDTF5BU	SUV91_HUMAN	Affects Expression	[23]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Affects Expression	[23]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Affects Expression	[23]
Integral membrane protein 2A (ITM2A)	OT590V63	ITM2A_HUMAN	Increases Expression	[51]
Mediator of RNA polymerase II transcription subunit 14 (MED14)	OTMD20XN	MED14_HUMAN	Affects Expression	[23]
RNA helicase aquarius (AQR)	OTMNDXM1	AQR_HUMAN	Affects Expression	[23]
Frizzled-6 (FZD6)	OTBCPII8	FZD6_HUMAN	Affects Expression	[23]
Adenylate cyclase type 9 (ADCY9)	OT1IZT5K	ADCY9_HUMAN	Affects Expression	[23]
DNA polymerase zeta catalytic subunit (REV3L)	OT0OP8EJ	REV3L_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily A member 2 (DNAJA2)	OTKF1VBT	DNJA2_HUMAN	Affects Expression	[23]
Auxilin (DNAJC6)	OT1P6ZIE	AUXI_HUMAN	Affects Expression	[23]
Frizzled-7 (FZD7)	OTTK3F6E	FZD7_HUMAN	Affects Expression	[23]
Rho-associated protein kinase 2 (ROCK2)	OTVYN14T	ROCK2_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily B member 6 (DNAJB6)	OTMHIIAN	DNJB6_HUMAN	Affects Expression	[23]
Nucleoside diphosphate phosphatase ENTPD5 (ENTPD5)	OTFH05B9	ENTP5_HUMAN	Affects Expression	[23]
DNA polymerase theta (POLQ)	OTBHK0E6	DPOLQ_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Affects Expression	[23]
Mediator of RNA polymerase II transcription subunit 6 (MED6)	OT4GF4RM	MED6_HUMAN	Affects Expression	[23]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 8 (DNAJC8)	OTBE4I4X	DNJC8_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase D3 (PRKD3)	OT987HJI	KPCD3_HUMAN	Affects Expression	[23]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Affects Expression	[23]
Epsin-2 (EPN2)	OTH5BHUN	EPN2_HUMAN	Affects Expression	[23]
Neuroendocrine secretory protein 55 (GNAS)	OTMH8BKJ	GNAS3_HUMAN	Affects Expression	[23]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)	OTBMJUOC	M4K4_HUMAN	Affects Expression	[23]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Affects Expression	[23]
Formimidoyltransferase-cyclodeaminase (FTCD)	OTX9HZT5	FTCD_HUMAN	Affects Expression	[23]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Affects Expression	[23]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Affects Expression	[23]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[52]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[53]
GTPase NRas (NRAS)	OTVQ1DG3	RASN_HUMAN	Affects Expression	[23]
GTPase HRas (HRAS)	OTWQN0DP	RASH_HUMAN	Affects Expression	[23]
GTPase KRas (KRAS)	OT78QCN8	RASK_HUMAN	Affects Expression	[23]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Increases Expression	[49]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[54]
Erythropoietin (EPO)	OTZ90CN4	EPO_HUMAN	Affects Expression	[23]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)	OTRGGIFP	DRB1_HUMAN	Affects Expression	[55]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Affects Activity	[56]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Increases Expression	[49]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Affects Expression	[23]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Affects Expression	[23]
Argininosuccinate lyase (ASL)	OTI2NGQR	ARLY_HUMAN	Affects Expression	[23]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[52]
Protein S100-A8 (S100A8)	OTVMOB3F	S10A8_HUMAN	Increases Expression	[57]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Affects Expression	[23]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Affects Expression	[23]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Affects Expression	[23]
DNA-directed RNA polymerase III subunit RPC4 (POLR3D)	OTXQTBS0	RPC4_HUMAN	Affects Expression	[23]
Integrin beta-1 (ITGB1)	OT6G1IAR	ITB1_HUMAN	Affects Expression	[23]
Insulin receptor (INSR)	OTTY341H	INSR_HUMAN	Affects Expression	[23]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Affects Expression	[23]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Increases Expression	[57]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Increases Expression	[52]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Affects Expression	[23]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Affects Expression	[23]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Affects Expression	[23]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Affects Expression	[23]
Calmodulin-1 (CALM2)	OTNYA92F	CALM1_HUMAN	Affects Expression	[23]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[58]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Affects Activity	[56]
Serine/threonine-protein kinase A-Raf (ARAF)	OTZJ0FNO	ARAF_HUMAN	Affects Expression	[23]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Increases Expression	[52]
Nuclear receptor subfamily 2 group F member 6 (NR2F6)	OTNVO2B6	NR2F6_HUMAN	Affects Expression	[23]
COUP transcription factor 1 (NR2F1)	OTGWZWYL	COT1_HUMAN	Affects Expression	[23]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[59]
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT)	OT4KZ5R9	ODB2_HUMAN	Affects Expression	[23]
Fibroblast growth factor receptor 1 (FGFR1)	OT4GLCXW	FGFR1_HUMAN	Affects Expression	[23]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Affects Expression	[60]
Bone morphogenetic protein 4 (BMP4)	OTPZMDFH	BMP4_HUMAN	Affects Expression	[23]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[22]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Affects Expression	[23]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[58]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)	OT1LQSGX	MTDC_HUMAN	Affects Expression	[23]
L-selectin (SELL)	OT6RAJZR	LYAM1_HUMAN	Decreases Expression	[61]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Affects Expression	[23]
POU domain, class 2, transcription factor 1 (POU2F1)	OTK7ELJ0	PO2F1_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase B-raf (BRAF)	OT7S81XQ	BRAF_HUMAN	Affects Expression	[23]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2)	OTNIZPEA	ATF2_HUMAN	Affects Expression	[23]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Increases Expression	[62]
Transcription factor E2-alpha (TCF3)	OTW6FR32	TFE2_HUMAN	Affects Expression	[23]
Replication protein A 32 kDa subunit (RPA2)	OTZ54WAF	RFA2_HUMAN	Affects Expression	[23]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[63]
Carbonyl reductase 1 (CBR1)	OTQ3A541	CBR1_HUMAN	Affects Expression	[23]
Tyrosine-protein kinase Fer (FER)	OT9JR7AE	FER_HUMAN	Affects Expression	[23]
Stathmin (STMN1)	OTDJ4RV0	STMN1_HUMAN	Affects Expression	[23]
Rho-related GTP-binding protein RhoQ (RHOQ)	OTUBTU57	RHOQ_HUMAN	Affects Expression	[23]
Aspartate aminotransferase, cytoplasmic (GOT1)	OTZLM5UB	AATC_HUMAN	Increases Secretion	[64]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Affects Expression	[23]
Integrin alpha-2 (ITGA2)	OTPFL017	ITA2_HUMAN	Affects Expression	[23]
CTP synthase 1 (CTPS1)	OTZ9J6ZG	PYRG1_HUMAN	Affects Expression	[23]
Probable ATP-dependent RNA helicase DDX5 (DDX5)	OTLS124U	DDX5_HUMAN	Affects Expression	[23]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Affects Expression	[23]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[65]
Glutathione peroxidase 2 (GPX2)	OTXI2NTI	GPX2_HUMAN	Affects Expression	[23]
Interleukin-1 receptor antagonist protein (IL1RN)	OT308CBE	IL1RA_HUMAN	Increases Expression	[66]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[23]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)	OTSBQR6D	PLCG1_HUMAN	Affects Expression	[23]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Affects Expression	[23]
Casein kinase II subunit alpha' (CSNK2A2)	OT7MA2LV	CSK22_HUMAN	Affects Expression	[23]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Decreases Expression	[52]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2)	OTXF0B09	IF2B_HUMAN	Affects Expression	[23]
Hepatocyte nuclear factor 1-alpha (HNF1A)	OT9DOUKL	HNF1A_HUMAN	Affects Expression	[23]
Ras GTPase-activating protein 1 (RASA1)	OTZJ3LP4	RASA1_HUMAN	Affects Expression	[23]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Affects Expression	[23]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Decreases Expression	[67]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Affects Expression	[23]
Bone morphogenetic protein 6 (BMP6)	OT9WN536	BMP6_HUMAN	Increases Expression	[49]
Trifunctional purine biosynthetic protein adenosine-3 (GART)	OT01JWJB	PUR2_HUMAN	Affects Expression	[23]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)	OT3MPPYX	ENPP1_HUMAN	Affects Expression	[23]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)	OTJXOUCL	HEM0_HUMAN	Affects Expression	[23]
E3 ubiquitin-protein ligase CBL (CBL)	OTTKELCU	CBL_HUMAN	Affects Expression	[23]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)	OT6RMDCE	KAPCB_HUMAN	Affects Expression	[23]
Glycine dehydrogenase (GLDC)	OTVVDNW0	GCSP_HUMAN	Affects Expression	[23]
Thymidylate kinase (DTYMK)	OTJXYQYK	KTHY_HUMAN	Affects Expression	[23]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Increases Secretion	[64]
COUP transcription factor 2 (NR2F2)	OTJFS67N	COT2_HUMAN	Affects Expression	[23]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Affects Expression	[23]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Affects Expression	[23]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily B member 1 (DNAJB1)	OTCOSEVH	DNJB1_HUMAN	Affects Expression	[23]
Amine oxidase B (MAOB)	OTTDFM1O	AOFB_HUMAN	Affects Expression	[23]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[58]
Aryl hydrocarbon receptor nuclear translocator (ARNT)	OTMSIEZY	ARNT_HUMAN	Affects Expression	[23]
Replication protein A 70 kDa DNA-binding subunit (RPA1)	OT76POLP	RFA1_HUMAN	Affects Expression	[23]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Affects Expression	[23]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[58]
Dual specificity protein phosphatase 1 (DUSP1)	OTN6BR75	DUS1_HUMAN	Affects Expression	[23]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)	OTFIHQGD	2AAB_HUMAN	Affects Expression	[23]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Affects Expression	[23]
Glutathione S-transferase theta-1 (GSTT1)	OTRFMWBK	GSTT1_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily A member 1 (DNAJA1)	OT38BZQQ	DNJA1_HUMAN	Affects Expression	[23]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Affects Expression	[23]
RAC-beta serine/threonine-protein kinase (AKT2)	OTBB632K	AKT2_HUMAN	Affects Expression	[23]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[51]
Cystathionine gamma-lyase (CTH)	OTC90LA0	CGL_HUMAN	Affects Expression	[23]
Cleavage stimulation factor subunit 2 (CSTF2)	OTR6G4II	CSTF2_HUMAN	Affects Expression	[23]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)	OT0THBVA	DUT_HUMAN	Affects Expression	[23]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Affects Expression	[23]
Serine hydroxymethyltransferase, cytosolic (SHMT1)	OTIINA3J	GLYC_HUMAN	Affects Expression	[23]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Affects Expression	[23]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Decreases Expression	[52]
Cystathionine beta-synthase (CBS)	OT46FSKD	CBS_HUMAN	Affects Expression	[23]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)	OTNWEJ5Y	PCKGC_HUMAN	Affects Expression	[23]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Affects Expression	[23]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[23]
Choline kinase alpha (CHKA)	OT7FVO3Z	CHKA_HUMAN	Affects Expression	[23]
Activin receptor type-1B (ACVR1B)	OT778HIQ	ACV1B_HUMAN	Affects Expression	[23]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Increases Activity	[68]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Increases Expression	[60]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Affects Expression	[23]
Glycine--tRNA ligase (GARS1)	OT5B6R9Y	GARS_HUMAN	Affects Expression	[23]
Reduced folate transporter (SLC19A1)	OTWB0BTO	S19A1_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 1 (EIF1)	OTB4GZ0V	EIF1_HUMAN	Affects Expression	[23]
Protein kinase C iota type (PRKCI)	OTKBAVT3	KPCI_HUMAN	Affects Expression	[23]
Signal transducer and activator of transcription 6 (STAT6)	OTCKMP49	STAT6_HUMAN	Affects Expression	[23]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Affects Expression	[23]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[69]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Affects Expression	[23]
Tyrosine-protein kinase ABL2 (ABL2)	OTS8F4GD	ABL2_HUMAN	Affects Expression	[23]
Transcription factor GATA-4 (GATA4)	OTQHWAZG	GATA4_HUMAN	Affects Expression	[23]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Affects Expression	[23]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Affects Expression	[23]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	OTI2OREX	MP2K3_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX)	OTWG2LAB	IF1AX_HUMAN	Affects Expression	[23]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Affects Expression	[23]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Affects Expression	[23]
Serine--tRNA ligase, cytoplasmic (SARS1)	OTFKXQ1O	SYSC_HUMAN	Affects Expression	[23]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Affects Expression	[23]
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)	OTOODWTU	GNAQ_HUMAN	Affects Expression	[23]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4)	OTOXNDI9	GBG4_HUMAN	Affects Expression	[23]
Cyclin-dependent kinase 7 (CDK7)	OTAO19PQ	CDK7_HUMAN	Affects Expression	[23]
Signal transducer and activator of transcription 5B (STAT5B)	OTZVPEBT	STA5B_HUMAN	Affects Expression	[23]
Cyclin-H (CCNH)	OTKDU3SR	CCNH_HUMAN	Affects Expression	[23]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Affects Expression	[23]
DNA polymerase subunit gamma-1 (POLG)	OTDUCT04	DPOG1_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 5 (EIF5)	OT79PQUN	IF5_HUMAN	Affects Expression	[23]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[52]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Affects Expression	[23]
Hepatocyte nuclear factor 3-alpha (FOXA1)	OTEBY0TD	FOXA1_HUMAN	Affects Expression	[23]
Tumor protein D52 (TPD52)	OTPKSK43	TPD52_HUMAN	Increases Expression	[67]
Eukaryotic translation initiation factor 3 subunit B (EIF3B)	OTF67VPH	EIF3B_HUMAN	Affects Expression	[23]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Activity	[70]
C-terminal-binding protein 2 (CTBP2)	OTGZGT87	CTBP2_HUMAN	Affects Expression	[23]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Affects Expression	[23]
Eukaryotic initiation factor 4A-I (EIF4A1)	OTMTBX6N	IF4A1_HUMAN	Affects Expression	[23]
DNA-directed RNA polymerases I, II, and III subunit RPABC2 (POLR2F)	OTF9T8I2	RPAB2_HUMAN	Affects Expression	[23]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Decreases Expression	[51]
Ras-related protein R-Ras2 (RRAS2)	OT83NCEB	RRAS2_HUMAN	Affects Expression	[23]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)	OTYFTYFR	PP1B_HUMAN	Affects Expression	[23]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Affects Expression	[23]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)	OT9297OG	2ABA_HUMAN	Affects Expression	[23]
Small ribosomal subunit protein RACK1 (RACK1)	OTZBCQ1U	RACK1_HUMAN	Affects Expression	[23]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Affects Expression	[23]
Casein kinase II subunit alpha (CSNK2A1)	OT9T8WQM	CSK21_HUMAN	Affects Expression	[23]
ETS-related transcription factor Elf-3 (ELF3)	OTUTLEQO	ELF3_HUMAN	Affects Expression	[23]
Phosphatidylinositol-glycan-specific phospholipase D (GPLD1)	OTUUQOVY	PHLD_HUMAN	Affects Expression	[23]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Affects Expression	[23]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Affects Expression	[23]
Cyclin-dependent kinase 5 (CDK5)	OT1YAK9F	CDK5_HUMAN	Affects Expression	[23]
Fanconi anemia group C protein (FANCC)	OTTIDM3P	FANCC_HUMAN	Affects Expression	[23]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Activity	[71]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Affects Expression	[23]
Myocyte-specific enhancer factor 2A (MEF2A)	OTV2SF6E	MEF2A_HUMAN	Affects Expression	[23]
Cytochrome P450 4A11 (CYP4A11)	OTPU5J0S	CP4AB_HUMAN	Affects Activity	[72]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)	OT2CF1E6	IF4G1_HUMAN	Affects Expression	[23]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Affects Expression	[23]
Max dimerization protein 1 (MXD1)	OTS5CTHX	MAD1_HUMAN	Affects Expression	[23]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Affects Expression	[23]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Affects Expression	[23]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Affects Expression	[23]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[52]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Increases Expression	[73]
Son of sevenless homolog 1 (SOS1)	OTTCWXC3	SOS1_HUMAN	Affects Expression	[23]
Son of sevenless homolog 2 (SOS2)	OTV3XRE5	SOS2_HUMAN	Affects Expression	[23]
Epithelial discoidin domain-containing receptor 1 (DDR1)	OTYW1SH8	DDR1_HUMAN	Affects Expression	[23]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Affects Expression	[23]
Cleavage stimulation factor subunit 3 (CSTF3)	OT1Y7B5U	CSTF3_HUMAN	Affects Expression	[23]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Increases Expression	[49]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)	OT6T408U	MP2K5_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase PAK 2 (PAK2)	OTLUNCIH	PAK2_HUMAN	Affects Expression	[23]
Growth factor receptor-bound protein 10 (GRB10)	OTCKXGRC	GRB10_HUMAN	Affects Expression	[23]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)	OTF7CGO2	2A5G_HUMAN	Affects Expression	[23]
Rho-associated protein kinase 1 (ROCK1)	OTSXYVW1	ROCK1_HUMAN	Affects Expression	[23]
Frizzled-5 (FZD5)	OTXFFY56	FZD5_HUMAN	Affects Expression	[23]
GRB2-associated-binding protein 1 (GAB1)	OTQKE6V4	GAB1_HUMAN	Affects Expression	[23]
Mothers against decapentaplegic homolog 4 (SMAD4)	OTWQWCKG	SMAD4_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)	OTHBQVD5	4EBP1_HUMAN	Affects Expression	[23]
Cullin-3 (CUL3)	OTDNOAPM	CUL3_HUMAN	Affects Expression	[23]
Activin receptor type-2B (ACVR2B)	OT209XLA	AVR2B_HUMAN	Affects Expression	[23]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)	OT5UO1FA	HNRPD_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 3 subunit A (EIF3A)	OTFABY9G	EIF3A_HUMAN	Affects Expression	[23]
Rho guanine nucleotide exchange factor 7 (ARHGEF7)	OT9BPJCL	ARHG7_HUMAN	Affects Expression	[23]
ARF GTPase-activating protein GIT2 (GIT2)	OTQ2EQJ1	GIT2_HUMAN	Affects Expression	[23]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Affects Expression	[23]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Affects Expression	[23]
Translation initiation factor eIF2B subunit alpha (EIF2B1)	OT4NCVY1	EI2BA_HUMAN	Affects Expression	[23]
Eukaryotic initiation factor 4A-II (EIF4A2)	OT08H03R	IF4A2_HUMAN	Affects Expression	[23]
Endonuclease G, mitochondrial (ENDOG)	OT5IM7B3	NUCG_HUMAN	Affects Expression	[23]
Guanine nucleotide-binding protein subunit alpha-13 (GNA13)	OTVDL515	GNA13_HUMAN	Affects Expression	[23]
Sodium channel protein type 5 subunit alpha (SCN5A)	OTGYZWR6	SCN5A_HUMAN	Decreases Activity	[74]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[59]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)	OT9EROL6	HERP1_HUMAN	Affects Expression	[23]
Advanced glycosylation end product-specific receptor (AGER)	OTPY0IH7	RAGE_HUMAN	Increases Expression	[57]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A)	OTZBCRGI	2A5A_HUMAN	Affects Expression	[23]
Pregnancy-specific beta-1-glycoprotein 5 (PSG5)	OTHTU98X	PSG5_HUMAN	Increases Expression	[51]
Transcription factor E2F5 (E2F5)	OT1XWING	E2F5_HUMAN	Affects Expression	[23]
Nuclear receptor subfamily 6 group A member 1 (NR6A1)	OTFZOOQ9	NR6A1_HUMAN	Affects Expression	[23]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1)	OTDOTWU4	KS6A1_HUMAN	Affects Expression	[23]
Protein phosphatase 1 regulatory subunit 7 (PPP1R7)	OTY5IE69	PP1R7_HUMAN	Affects Expression	[23]
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Affects Expression	[23]
ETS-related transcription factor Elf-2 (ELF2)	OTEI347F	ELF2_HUMAN	Affects Expression	[23]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Stability	[23]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Affects Expression	[23]
Dihydropyrimidinase-related protein 2 (DPYSL2)	OTWNQ74H	DPYL2_HUMAN	Affects Expression	[23]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Activity	[70]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Decreases Expression	[52]
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6)	OTM6QYNQ	CPSF6_HUMAN	Affects Expression	[23]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[75]
Programmed cell death protein 4 (PDCD4)	OTZ6NXUX	PDCD4_HUMAN	Decreases Expression	[67]
UMP-CMP kinase 2, mitochondrial (CMPK2)	OTOG90R0	CMPK2_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 21 (DNAJC21)	OT8C14QA	DJC21_HUMAN	Affects Expression	[23]
Transcription initiation factor TFIID subunit 3 (TAF3)	OTVMULE9	TAF3_HUMAN	Affects Expression	[23]
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD)	OTJI1XF3	NAPEP_HUMAN	Affects Expression	[23]
General transcription factor IIH subunit 5 (GTF2H5)	OTRL219S	TF2H5_HUMAN	Affects Expression	[23]
Mediator of RNA polymerase II transcription subunit 13-like (MED13L)	OTSP1W0F	MD13L_HUMAN	Affects Expression	[23]
PTB-containing, cubilin and LRP1-interacting protein (PID1)	OT5YJ7FI	PCLI1_HUMAN	Increases Expression	[49]
Glycerate kinase (GLYCTK)	OTVTBNSM	GLCTK_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 10 (DNAJC10)	OTD2EG0R	DJC10_HUMAN	Affects Expression	[23]
Mitochondrial Rho GTPase 2 (RHOT2)	OTV8WT2L	MIRO2_HUMAN	Affects Expression	[23]
Fanconi anemia group M protein (FANCM)	OTNJG99Z	FANCM_HUMAN	Affects Expression	[23]
Angiogenic factor with G patch and FHA domains 1 (AGGF1)	OTA7U2T8	AGGF1_HUMAN	Affects Expression	[23]
Fanconi anemia group B protein (FANCB)	OTMZTXB5	FANCB_HUMAN	Affects Expression	[23]
Choline dehydrogenase, mitochondrial (CHDH)	OTO2DPGL	CHDH_HUMAN	Affects Expression	[23]
Tudor domain-containing protein 7 (TDRD7)	OTK639ET	TDRD7_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily B member 14 (DNAJB14)	OTAC2K95	DJB14_HUMAN	Affects Expression	[23]
Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4)	OTSGQGT2	CR3L4_HUMAN	Affects Expression	[23]
Fibroblast growth factor receptor substrate 2 (FRS2)	OTDMD800	FRS2_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 9 (DNAJC9)	OTDBQBNZ	DNJC9_HUMAN	Affects Expression	[23]
Histone acetyltransferase KAT6B (KAT6B)	OTMUDTAH	KAT6B_HUMAN	Affects Expression	[23]
Proteasome inhibitor PI31 subunit (PSMF1)	OTX84WLQ	PSMF1_HUMAN	Affects Expression	[23]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)	OTXGJ8N1	P55G_HUMAN	Affects Expression	[23]
Hamartin (TSC1)	OTFF4YZ7	TSC1_HUMAN	Affects Expression	[23]
General transcription factor IIH subunit 4 (GTF2H4)	OTPD1DIU	TF2H4_HUMAN	Affects Expression	[23]
TRAF family member-associated NF-kappa-B activator (TANK)	OTZSGFIK	TANK_HUMAN	Affects Expression	[23]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Affects Expression	[23]
DNA repair protein RAD50 (RAD50)	OTYMU9G1	RAD50_HUMAN	Affects Expression	[23]
Rho guanine nucleotide exchange factor 2 (ARHGEF2)	OTBQTFRT	ARHG2_HUMAN	Affects Expression	[23]
Major histocompatibility complex class I-related gene protein (MR1)	OTZU3XX7	HMR1_HUMAN	Affects Expression	[55]
Protein phosphatase 1 regulatory subunit 14B (PPP1R14B)	OT9PTWAX	PP14B_HUMAN	Affects Expression	[23]
Hepatitis A virus cellular receptor 1 (HAVCR1)	OT184CRZ	HAVR1_HUMAN	Increases Expression	[60]
DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3)	OT61924T	DNJA3_HUMAN	Affects Expression	[23]
Thialysine N-epsilon-acetyltransferase (SAT2)	OT28QL7H	SAT2_HUMAN	Affects Expression	[23]
Mediator of RNA polymerase II transcription subunit 30 (MED30)	OTM3INJN	MED30_HUMAN	Affects Expression	[23]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Increases Expression	[57]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)	OTMV4ASV	MAGI1_HUMAN	Affects Expression	[23]
Formin-binding protein 1 (FNBP1)	OTSJ5KKA	FNBP1_HUMAN	Affects Expression	[23]
Paired amphipathic helix protein Sin3a (SIN3A)	OTM8OZWV	SIN3A_HUMAN	Affects Expression	[23]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 3 subunit C (EIF3C)	OTR8RF9X	EIF3C_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 7 (DNAJC7)	OTQ5AL3F	DNJC7_HUMAN	Affects Expression	[23]
BRCA1-associated RING domain protein 1 (BARD1)	OTTC0Z9Y	BARD1_HUMAN	Affects Expression	[23]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Affects Expression	[23]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Decreases Expression	[75]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[76]
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)	OTN0NXX2	E2AK1_HUMAN	Affects Expression	[23]
Mediator of RNA polymerase II transcription subunit 10 (MED10)	OTCQ3ZRR	MED10_HUMAN	Affects Expression	[23]
Fanconi anemia group J protein (BRIP1)	OT38QBD4	FANCJ_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 2A (EIF2A)	OTWXELQP	EIF2A_HUMAN	Affects Expression	[23]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Decreases Expression	[50]
Sulfiredoxin-1 (SRXN1)	OTYDBO4L	SRXN1_HUMAN	Increases Expression	[23]
Group XIIA secretory phospholipase A2 (PLA2G12A)	OTHHCQ17	PG12A_HUMAN	Affects Expression	[23]
Epsin-3 (EPN3)	OTNNYDT6	EPN3_HUMAN	Affects Expression	[23]
DNA replication factor Cdt1 (CDT1)	OTVY53VG	CDT1_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 5 (DNAJC5)	OTCZDXAL	DNJC5_HUMAN	Affects Expression	[23]
dCTP pyrophosphatase 1 (DCTPP1)	OTP1GZYF	DCTP1_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 18 (DNAJC18)	OTCQNEO7	DJC18_HUMAN	Affects Expression	[23]
Protein argonaute-3 (AGO3)	OTNQGROH	AGO3_HUMAN	Affects Expression	[23]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)	OTNA9G8V	MKNK2_HUMAN	Affects Expression	[23]
Transcription initiation factor TFIID subunit 9B (TAF9B)	OTORBI4I	TAF9B_HUMAN	Affects Expression	[23]
Calpain-10 (CAPN10)	OTS9LJW4	CAN10_HUMAN	Affects Expression	[23]
Protein argonaute-4 (AGO4)	OTKXQD70	AGO4_HUMAN	Affects Expression	[23]
Frizzled-3 (FZD3)	OTIWDN78	FZD3_HUMAN	Affects Expression	[23]
Fanconi anemia group F protein (FANCF)	OT3WA9N1	FANCF_HUMAN	Affects Expression	[23]
Transcription factor 7-like 2 (TCF7L2)	OTVWPZ8B	TF7L2_HUMAN	Affects Expression	[23]
Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7)	OT3QER33	ENTP7_HUMAN	Affects Expression	[23]
DNA polymerase epsilon subunit 4 (POLE4)	OTCMWUT6	DPOE4_HUMAN	Affects Expression	[23]
Rho guanine nucleotide exchange factor 3 (ARHGEF3)	OTHGNC0A	ARHG3_HUMAN	Affects Expression	[23]
CTP synthase 2 (CTPS2)	OT2X9YO1	PYRG2_HUMAN	Affects Expression	[23]
DNA polymerase epsilon subunit 3 (POLE3)	OTOELRF6	DPOE3_HUMAN	Affects Expression	[23]
Mediator of RNA polymerase II transcription subunit 17 (MED17)	OTEZR5GC	MED17_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 11 (DNAJC11)	OTYLMZWW	DJC11_HUMAN	Affects Expression	[23]
E3 ubiquitin-protein ligase FANCL (FANCL)	OTJC7QPQ	FANCL_HUMAN	Affects Expression	[23]
Very long chain fatty acid elongase 2 (ELOVL2)	OTDAF6U3	ELOV2_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Activity	[23]
eIF-2-alpha kinase GCN2 (EIF2AK4)	OTLE1JY8	E2AK4_HUMAN	Affects Expression	[23]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Affects Expression	[23]
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L)	OT3HG324	ASH2L_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily B member 9 (DNAJB9)	OT38EQT6	DNJB9_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily B member 4 (DNAJB4)	OTUD01BK	DNJB4_HUMAN	Affects Expression	[23]
Mediator of RNA polymerase II transcription subunit 13 (MED13)	OTP5LEJE	MED13_HUMAN	Affects Expression	[23]
Protein TASOR (TASOR)	OTEAMOON	TASOR_HUMAN	Affects Expression	[23]
Apoptotic chromatin condensation inducer in the nucleus (ACIN1)	OTK81F92	ACINU_HUMAN	Affects Expression	[23]
Protein argonaute-2 (AGO2)	OT4JY32Q	AGO2_HUMAN	Affects Expression	[23]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1)	OT4DLRYY	ASAP1_HUMAN	Affects Expression	[23]
Frizzled-4 (FZD4)	OTGLZIE0	FZD4_HUMAN	Affects Expression	[23]
Rho GTPase-activating protein 26 (ARHGAP26)	OTNGQU7A	RHG26_HUMAN	Affects Expression	[23]
GRB2-associated-binding protein 2 (GAB2)	OTBFN705	GAB2_HUMAN	Affects Expression	[23]
Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4)	OTJ2O8BW	ENTP4_HUMAN	Affects Expression	[23]
DNA polymerase eta (POLH)	OTN07WXU	POLH_HUMAN	Affects Expression	[23]
Choline/ethanolamine kinase (CHKB)	OTNX5LPF	CHKB_HUMAN	Affects Expression	[23]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)	OTXK0SDM	2ABG_HUMAN	Affects Expression	[23]
Endophilin-B1 (SH3GLB1)	OTAZ5OP8	SHLB1_HUMAN	Affects Expression	[23]
Mediator of RNA polymerase II transcription subunit 31 (MED31)	OTFVKXJE	MED31_HUMAN	Affects Expression	[23]
DnaJ homolog subfamily C member 15 (DNAJC15)	OTNDUKAA	DJC15_HUMAN	Affects Expression	[23]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Affects Expression	[23]
NF-kappa-B essential modulator (IKBKG)	OTNWJWSD	NEMO_HUMAN	Affects Expression	[23]
Nuclear receptor coactivator 3 (NCOA3)	OTBX300Z	NCOA3_HUMAN	Affects Expression	[23]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Increases Response To Substance	[77]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Increases Response To Substance	[77]

References

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• [2] methyl salicylate FDA Label
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