Details of the Drug Combinations

General Information of This Drug (ID: DMPN5IH)

Drug Name
Guanfacine   DMPN5IH
Synonyms
GUANFACINE; Tenex; Guanfacinum [INN-Latin]; Guanfacina [INN-Spanish]; Estulic; Intuniv; N-amidino-2-(2,6-dichlorophenyl)acetamide; CHEBI:5558; INJOMKTZOLKMBF-UHFFFAOYSA-N; SPD 503; C9H9Cl2N3O; N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide; N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide; Guanfacine Monohydrochloride; NCGC00015469-05; Lon798; Guanfacine (INN); Estulic (TN); Tenex (Salt/Mix); Estulic (Salt/Mix); Tocris-1030; Prestwick1_000339; Prestwick3_000339; Prestwick2_000339; Prestwick0_000339; Lopac-G-1043
Indication
Disease Entry ICD 11 Status REF
Attention deficit hyperactivity disorder 6A05.Z Approved [1]
Alzheimer disease 8A20 Phase 3 [2]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

64 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acarbose + Guanfacine DC50G32 Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acetazolamide + Guanfacine DC0XVER Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acitretin + Guanfacine DCCXCZ2 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Arfolitixorin + Guanfacine DCWZ0A8 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Asenapine + Guanfacine DCT3K8S Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BIO-300 + Guanfacine DCPPZRR BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Guanfacine DCLDDU3 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bumetanide + Guanfacine DC3275Q Bumetanide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Guanfacine DCYEBUJ Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cevimeline + Guanfacine DCP9QQI Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Clopidogrel + Guanfacine DC1C7RV Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Guanfacine DCL0XRN Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diazoxide + Guanfacine DCFJART Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dichlorphenamide + Guanfacine DCXNA90 Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diphenidol + Guanfacine DCOKE53 Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Docetaxel + Guanfacine DCJ3V5J Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Emetine + Guanfacine DC0OLMB Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fenoprofen + Guanfacine DCMQICA Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Gefitinib + Guanfacine DC0SWCW Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
GINKGOLIDE A + Guanfacine DCW6K1T GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Mebutamate DCFBT02 Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Baclofen DCWRC0S Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Bepridil DCESPP2 Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Dantrolene DC5DKMD Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Epinephrine DCGXJU5 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Furazolidone DC5EFLU Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Fomepizole DCVCKH7 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Rifampin DC3TRRU Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Testosterone cypionate DCQS5DS Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Chlorzoxazone DCX9C16 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + ETHISTERONE DCGPHS1 ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Pazopanib DCUI0P2 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + PF-02545920 DCJ4SP5 PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Oseltamivir DC31SKZ Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Atenolol DCW3FD9 Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Bortezomib DCCANGB Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Olanzapine DCDXQJE Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Chlorambucil DC3P025 Chlorambucil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Endoxifen DC0UIYC Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Mycophenolic acid DC9MIPW Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + GSK2194069 DCRV70W GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hyodeoxycholic acid + Guanfacine DCHGMOM Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
IT-141 + Guanfacine DCIOOJF IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Leflunomide + Guanfacine DC5VGDR Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
LY03004 + Guanfacine DC1N6C6 LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mefloquine + Guanfacine DCSWHYJ Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Guanfacine DC4W5MZ Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Guanfacine DC0X0OC Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Niclosamide + Guanfacine DCTTQ10 Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Olmesartan medoxomil + Guanfacine DCJXN4O Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Oxyphenbutazone + Guanfacine DC0DKWV Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pinacidil + Guanfacine DCRLSZC Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PMID28460551-Compound-2 + Guanfacine DC1QB52 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pyrazinamide + Guanfacine DCB14WC Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Guanfacine DCT3PA3 Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
SCH 727965 + Guanfacine DC7RZCN SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Guanfacine DC4I5EV Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Guanfacine DCLLJ8O Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Testolactone + Guanfacine DCCMF15 Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Topotecan + Guanfacine DCO606O Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triapine + Guanfacine DCXKU4D Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trimethobenzamide + Guanfacine DCSL0UP Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tropisetron + Guanfacine DC8FOH8 Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Valproic Acid + Guanfacine DC8PZKM Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 64 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Guanfacine + Lidocaine DCFCPNK Lidocaine Trigeminal Neuralgia [5]
Guanfacine + Hydrochlorothiazide DC1BR0M Hydrochlorothiazide Obstructive Sleep Apnea [6]
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References

1 Guanfacine FDA Label
2 ClinicalTrials.gov (NCT03116126) Randomised Clinical Trial of Noradrenergic Add-on Therapy With Extended-Release Guanfacine in Alzheimer's Disease. U.S.National Institutes of Health.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5 ClinicalTrials.gov (NCT03865940) Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy
6 ClinicalTrials.gov (NCT02699125) Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic