Details of the Drug Combinations

General Information of This Drug (ID: DMTM2IK)

Drug Name
Mercaptopurine   DMTM2IK
Synonyms
6-mercaptopurine; Ismipur; Leukerin; Leupurin; Mercaleukim; Mercaleukin; Mercaptopurin; Mercaptopurina; Mercaptopurinum; Mercapurin; Merkaptopuryna; Mern; Purimethol; Purinethiol; Purinethol; Thiopurine; Leupu rin; Mercaptopurin [German]; Mercaptopurina Wellcome; Mercaptopurine anhydrous; Merkaptopuryna [Polish]; Puri Nethol; BW 57 323H; Glaxo Wellcome Brand of 6 Mercaptopurine; GlaxoSmithKline Brand of 6 Mercaptopurine; M0063; NCIMech_000025; PM6; Wellcome Brand of 6 Mercaptopurine; Glaxo Wellcome Brand of 6-Mercaptopurine; GlaxoSmithKline Brand of 6-Mercaptopurine; Mercaptopurina [INN-Spanish]; Mercaptopurine (INN); Mercaptopurine (VAN); Mercaptopurine (anhydrous); Mercaptopurinum [INN-Latin]; Puri-Nethol; Purineantimetabolite: inhibits nucleic acid replication; Purinethol (TN); U-4748; Wellcome Brand of 6-Mercaptopurine; AG-670/31547064; Purine-6-thiol; Leukerin, 99%-Carc; Purine-6(1H)-thione; Purinethol, 6-mercaptopurine, 6-MP, Mercaptopurine; 6 MP; 6 Mercaptopurine Monohydrate; 6 Thiohypoxanthine; 6 Thiopurine; 6-MERCAPTOPURINE MONOHYDRATE; 6-MP; 6-Mercaptopurin; 6-Merkaptopurin; 6-Merkaptopurin [Czech]; 6-Purinethiol; 6-Thiohypoxanthine; 6-Thiopurine; 6-Thioxopurine; Mercaptopurine (Purine analog)
Indication
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Approved [1]
Acute lymphocytic leukaemia 2B33.3 Approved [2]
Crohn disease DD70 Phase 4 [3]
Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [4]
Severe acute respiratory syndrome (SARS) 1D65 Preclinical [4]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

218 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
10-hydroxycamptothecin + Mercaptopurine DCLIU04 10-hydroxycamptothecin Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
10-hydroxycamptothecin + Mercaptopurine DCY012P 10-hydroxycamptothecin Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM) [5]
10-hydroxycamptothecin + Mercaptopurine DCUQKYP 10-hydroxycamptothecin Adenocarcinoma (Cell Line: HCT-15) [6]
10-hydroxycamptothecin + Mercaptopurine DC2OH6K 10-hydroxycamptothecin Melanoma (Cell Line: UACC-257) [6]
ABIRATERONE + Mercaptopurine DCBTLGS ABIRATERONE Renal cell carcinoma (Cell Line: UO-31) [5]
ABIRATERONE + Mercaptopurine DCIJJ5B ABIRATERONE Lung adenocarcinoma (Cell Line: NCI-H522) [6]
ABIRATERONE + Mercaptopurine DC3DT7I ABIRATERONE Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M) [6]
Amonafide + Mercaptopurine DC9UGZ1 Amonafide Adenocarcinoma (Cell Line: NCIH23) [5]
Amonafide + Mercaptopurine DCYHYUS Amonafide Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Amonafide + Mercaptopurine DCXZTCV Amonafide Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Amonafide + Mercaptopurine DCVUMK2 Amonafide Anaplastic large cell lymphoma (Cell Line: SR) [5]
Amonafide + Mercaptopurine DCLO539 Amonafide Astrocytoma (Cell Line: SNB-19) [5]
Amonafide + Mercaptopurine DCC3PHH Amonafide Large cell lung carcinoma (Cell Line: NCI-H460) [5]
Amonafide + Mercaptopurine DCMUWBC Amonafide Plasma cell myeloma (Cell Line: RPMI-8226) [5]
Amonafide + Mercaptopurine DCW3RNH Amonafide Colon adenocarcinoma (Cell Line: COLO 205) [7]
Anastrozole + Mercaptopurine DCYDNS8 Anastrozole Adenocarcinoma (Cell Line: HT29) [5]
Anastrozole + Mercaptopurine DCLEURE Anastrozole Amelanotic melanoma (Cell Line: M14) [5]
Anastrozole + Mercaptopurine DCUNF41 Anastrozole Chronic myelogenous leukemia (Cell Line: K-562) [5]
Anastrozole + Mercaptopurine DCQFN5O Anastrozole Cutaneous melanoma (Cell Line: SK-MEL-28) [5]
Anastrozole + Mercaptopurine DCJHLG9 Anastrozole Cutaneous melanoma (Cell Line: SK-MEL-5) [5]
Anastrozole + Mercaptopurine DCGPJ9J Anastrozole Malignant melanoma (Cell Line: LOX IMVI) [5]
Anastrozole + Mercaptopurine DCJ4T9R Anastrozole Melanoma (Cell Line: SK-MEL-2) [5]
Anastrozole + Mercaptopurine DC2FREV Anastrozole Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [5]
Anastrozole + Mercaptopurine DCL5SVN Anastrozole Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3) [5]
Anastrozole + Mercaptopurine DC0QMDX Anastrozole Renal cell carcinoma (Cell Line: UO-31) [5]
Anastrozole + Mercaptopurine DCKHSF7 Anastrozole Colon adenocarcinoma (Cell Line: COLO 205) [7]
Arfolitixorin + Mercaptopurine DC3ZZEY Arfolitixorin Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [6]
Azacitidine + Mercaptopurine DCCPGG6 Azacitidine Adenocarcinoma (Cell Line: HT29) [5]
Azacitidine + Mercaptopurine DCZTD9P Azacitidine Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM) [5]
Azacitidine + Mercaptopurine DCAAA2G Azacitidine Large cell lung carcinoma (Cell Line: NCI-H460) [5]
Azacitidine + Mercaptopurine DCJ4K0I Azacitidine Plasma cell myeloma (Cell Line: RPMI-8226) [5]
BIO-300 + Mercaptopurine DC0CHQO BIO-300 Chronic myelogenous leukemia (Cell Line: K-562) [5]
BIO-300 + Mercaptopurine DC9IXGX BIO-300 Glioma (Cell Line: SF-539) [5]
BIO-300 + Mercaptopurine DC4HJO5 BIO-300 Colon adenocarcinoma (Cell Line: COLO 205) [7]
BIO-300 + Mercaptopurine DC2XE67 BIO-300 Adenocarcinoma (Cell Line: HT29) [6]
BIO-300 + Mercaptopurine DC66OAN BIO-300 Adenocarcinoma (Cell Line: SW-620) [6]
Bleomycin + Mercaptopurine DCWYO7E Bleomycin Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Bleomycin + Mercaptopurine DCK8GEJ Bleomycin High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES) [6]
Bleomycin + Mercaptopurine DCWRKWX Bleomycin Large cell lung carcinoma (Cell Line: NCI-H460) [6]
Cabazitaxel + Mercaptopurine DCDVBEU Cabazitaxel Astrocytoma (Cell Line: SNB-19) [5]
Cabazitaxel + Mercaptopurine DCRH15E Cabazitaxel Clear cell renal cell carcinoma (Cell Line: 786-0) [5]
Cabazitaxel + Mercaptopurine DCNMWM5 Cabazitaxel Clear cell renal cell carcinoma (Cell Line: CAKI-1) [5]
Cabazitaxel + Mercaptopurine DCQEY27 Cabazitaxel Glioma (Cell Line: SF-295) [5]
Cabazitaxel + Mercaptopurine DCB4MT3 Cabazitaxel Glioma (Cell Line: SF-539) [5]
Cabazitaxel + Mercaptopurine DCB3TXQ Cabazitaxel Malignant melanoma (Cell Line: UACC62) [5]
Dacarbazine + Mercaptopurine DC7RRB2 Dacarbazine Anaplastic large cell lymphoma (Cell Line: SR) [5]
Dacarbazine + Mercaptopurine DCZN6XX Dacarbazine Large cell lung carcinoma (Cell Line: NCI-H460) [5]
Dacarbazine + Mercaptopurine DCDWL27 Dacarbazine Malignant melanoma (Cell Line: LOX IMVI) [5]
Dacarbazine + Mercaptopurine DCJPO9R Dacarbazine Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [5]
Dactinomycin + Mercaptopurine DCUQGB6 Dactinomycin Anaplastic large cell lymphoma (Cell Line: SR) [6]
Dactinomycin + Mercaptopurine DCQNU9D Dactinomycin Renal cell carcinoma (Cell Line: UO-31) [6]
Dasatinib + Mercaptopurine DC8BNE2 Dasatinib Amelanotic melanoma (Cell Line: MDA-MB-435) [5]
Dasatinib + Mercaptopurine DC789MI Dasatinib High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8) [5]
Dasatinib + Mercaptopurine DCCUKDN Dasatinib Large cell lung carcinoma (Cell Line: NCI-H460) [5]
Dasatinib + Mercaptopurine DCTBRSQ Dasatinib Lung adenocarcinoma (Cell Line: HOP-62) [5]
Dasatinib + Mercaptopurine DCKEQQR Dasatinib Papillary renal cell carcinoma (Cell Line: ACHN) [5]
Dasatinib + Mercaptopurine DC9RI75 Dasatinib Prostate carcinoma (Cell Line: PC-3) [5]
Dasatinib + Mercaptopurine DCM8827 Dasatinib Colon adenocarcinoma (Cell Line: COLO 205) [7]
Dexrazoxane + Mercaptopurine DCDWCHN Dexrazoxane Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Dexrazoxane + Mercaptopurine DCHEK5J Dexrazoxane Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Dexrazoxane + Mercaptopurine DCTYT1Y Dexrazoxane Anaplastic large cell lymphoma (Cell Line: SR) [5]
Dexrazoxane + Mercaptopurine DCWPZBL Dexrazoxane Colon carcinoma (Cell Line: KM12) [7]
Dexrazoxane + Mercaptopurine DCWK2SJ Dexrazoxane Large cell lung carcinoma (Cell Line: NCI-H460) [6]
Dexrazoxane + Mercaptopurine DCOW8SG Dexrazoxane Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [6]
Digitoxin + Mercaptopurine DCFC1UL Digitoxin High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES) [5]
Docetaxel + Mercaptopurine DC25QN0 Docetaxel Papillary renal cell carcinoma (Cell Line: ACHN) [5]
Docetaxel + Mercaptopurine DC7RR88 Docetaxel Renal cell carcinoma (Cell Line: UO-31) [5]
Epirubicin + Mercaptopurine DCEX5VS Epirubicin Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Epirubicin + Mercaptopurine DCT7E1L Epirubicin Lung adenocarcinoma (Cell Line: NCI-H522) [6]
Epirubicin + Mercaptopurine DC29B92 Epirubicin Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M) [6]
Estramustine + Mercaptopurine DCRXVAT Estramustine Melanoma (Cell Line: SK-MEL-2) [6]
Fludarabine + Mercaptopurine DCE0S9L Fludarabine Papillary renal cell carcinoma (Cell Line: ACHN) [5]
FORMESTANE + Mercaptopurine DCHYWJJ FORMESTANE Adenocarcinoma (Cell Line: HCC-2998) [5]
FORMESTANE + Mercaptopurine DCZIVWJ FORMESTANE Amelanotic melanoma (Cell Line: MDA-MB-435) [5]
FORMESTANE + Mercaptopurine DCOUFLI FORMESTANE High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES) [5]
FORMESTANE + Mercaptopurine DCU78Z2 FORMESTANE Large cell lung carcinoma (Cell Line: NCI-H460) [5]
FORMESTANE + Mercaptopurine DCJ8UP5 FORMESTANE Melanoma (Cell Line: SK-MEL-2) [5]
FORMESTANE + Mercaptopurine DC89HTK FORMESTANE Papillary renal cell carcinoma (Cell Line: ACHN) [5]
FORMESTANE + Mercaptopurine DCYI37F FORMESTANE Pleural epithelioid mesothelioma (Cell Line: NCI-H226) [5]
FORMESTANE + Mercaptopurine DCI5HF2 FORMESTANE Carcinoma (Cell Line: RXF 393) [7]
Gefitinib + Mercaptopurine DCD5NRO Gefitinib Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [5]
Gefitinib + Mercaptopurine DCIWSJB Gefitinib Colon carcinoma (Cell Line: KM12) [7]
Idarubicin + Mercaptopurine DC42BZO Idarubicin Melanoma (Cell Line: SK-MEL-2) [6]
Indazole derivative 5 + Mercaptopurine DCBBAI9 Indazole derivative 5 Cutaneous melanoma (Cell Line: SK-MEL-28) [6]
JNK-IN-8 + Mercaptopurine DCR8W35 JNK-IN-8 Lung adenocarcinoma (Cell Line: EKVX) [6]
Lenalidomide + Mercaptopurine DCPB867 Lenalidomide Invasive ductal carcinoma (Cell Line: HS 578T) [7]
Lenalidomide + Mercaptopurine DCT0CIN Lenalidomide Amelanotic melanoma (Cell Line: M14) [6]
Lenalidomide + Mercaptopurine DCBHU29 Lenalidomide Melanoma (Cell Line: SK-MEL-2) [6]
Lenalidomide + Mercaptopurine DCVQ6ID Lenalidomide Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M) [6]
Lenalidomide + Mercaptopurine DCSV8YA Lenalidomide Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [6]
Letrozole + Mercaptopurine DCCJJFI Letrozole Adenocarcinoma (Cell Line: HCC-2998) [5]
Letrozole + Mercaptopurine DCLPI78 Letrozole Glioma (Cell Line: SF-268) [5]
Letrozole + Mercaptopurine DCQKOND Letrozole Lung adenocarcinoma (Cell Line: HOP-62) [5]
Letrozole + Mercaptopurine DCKSS77 Letrozole Plasma cell myeloma (Cell Line: RPMI-8226) [5]
Letrozole + Mercaptopurine DCJH8G2 Letrozole Pleural epithelioid mesothelioma (Cell Line: NCI-H226) [5]
Mechlorethamine + Mercaptopurine DCOPLJL Mechlorethamine Invasive ductal carcinoma (Cell Line: HS 578T) [7]
Mercaptopurine + Pentostatin DCC9VHM Pentostatin Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Mercaptopurine + Pentostatin DC25TB9 Pentostatin Chronic myelogenous leukemia (Cell Line: K-562) [5]
Mercaptopurine + Pentostatin DCTSZZ4 Pentostatin Renal cell carcinoma (Cell Line: UO-31) [5]
Mercaptopurine + Arsenic trioxide DCN60AQ Arsenic trioxide Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Mercaptopurine + Arsenic trioxide DCMMAC1 Arsenic trioxide Plasma cell myeloma (Cell Line: RPMI-8226) [5]
Mercaptopurine + Topetecan DC1438Y Topetecan Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Mercaptopurine + Topetecan DCXJ3R5 Topetecan Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Mercaptopurine + Topetecan DC2DKE7 Topetecan Anaplastic large cell lymphoma (Cell Line: SR) [5]
Mercaptopurine + Topetecan DCVDB7M Topetecan Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM) [5]
Mercaptopurine + Topetecan DCGWRGX Topetecan Glioma (Cell Line: SF-539) [5]
Mercaptopurine + Topetecan DCGI2B8 Topetecan Plasma cell myeloma (Cell Line: RPMI-8226) [5]
Mercaptopurine + Mitomycin DCJ1NQL Mitomycin Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Mercaptopurine + Mitomycin DC72IXI Mitomycin Glioma (Cell Line: SF-539) [5]
Mercaptopurine + Mitomycin DCSYAPN Mitomycin Plasma cell myeloma (Cell Line: RPMI-8226) [5]
Mercaptopurine + Cisplatin DCN55QN Cisplatin Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Mercaptopurine + Cisplatin DC884RG Cisplatin Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM) [5]
Mercaptopurine + Chlorambucil DCJE8LT Chlorambucil Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Mercaptopurine + Chlorambucil DCYXOWY Chlorambucil Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM) [5]
Mercaptopurine + ER819762 DCJEHB7 ER819762 Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Mercaptopurine + ER819762 DCODJN4 ER819762 Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Mercaptopurine + ER819762 DC0BC0V ER819762 Anaplastic large cell lymphoma (Cell Line: SR) [5]
Mercaptopurine + ER819762 DCWCADL ER819762 Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM) [5]
Mercaptopurine + PMID28870136-Compound-43 DC7F1L5 PMID28870136-Compound-43 Glioblastoma (Cell Line: SNB-75) [5]
Mercaptopurine + Aminolevulinic Acid Hydrochloride DCODK40 Aminolevulinic Acid Hydrochloride Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Mercaptopurine + Aminolevulinic Acid Hydrochloride DCOHXK2 Aminolevulinic Acid Hydrochloride Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM) [5]
Mercaptopurine + Busulfan DCDMS5W Busulfan Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Mercaptopurine + Busulfan DCTVBKH Busulfan Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Mercaptopurine + Busulfan DCRAEMU Busulfan Glioma (Cell Line: SF-539) [5]
Mercaptopurine + Arsenic trioxide DCBMHXA Arsenic trioxide Invasive ductal carcinoma (Cell Line: T-47D) [7]
Mercaptopurine + Topetecan DCB13CI Topetecan Invasive ductal carcinoma (Cell Line: T-47D) [7]
Mercaptopurine + Ifosfamide DCQNSFW Ifosfamide Invasive ductal carcinoma (Cell Line: HS 578T) [7]
Mercaptopurine + Cisplatin DCGD0QL Cisplatin Invasive ductal carcinoma (Cell Line: T-47D) [7]
Mercaptopurine + Chlorambucil DCDPIIM Chlorambucil Colon adenocarcinoma (Cell Line: COLO 205) [7]
Mercaptopurine + ER819762 DCD3CP3 ER819762 Breast adenocarcinoma (Cell Line: MDA-MB-468) [7]
Mercaptopurine + ER819762 DCZ1FYY ER819762 Colon adenocarcinoma (Cell Line: COLO 205) [7]
Mercaptopurine + Aminolevulinic Acid Hydrochloride DCGMMFG Aminolevulinic Acid Hydrochloride Carcinoma (Cell Line: RXF 393) [7]
Mercaptopurine + Arsenic trioxide DC857Z3 Arsenic trioxide Melanoma (Cell Line: MALME-3M) [6]
Mercaptopurine + Topetecan DCRW7VZ Topetecan Adenocarcinoma (Cell Line: NCIH23) [6]
Mercaptopurine + Topetecan DCGMD2D Topetecan Adenocarcinoma (Cell Line: HCT116) [6]
Mercaptopurine + Bendamustine hydrochloride DC54BUW Bendamustine hydrochloride Adenocarcinoma (Cell Line: HCT-15) [6]
Mercaptopurine + Mitomycin DCM38J6 Mitomycin High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES) [6]
Mercaptopurine + Mitomycin DCSGSU8 Mitomycin Large cell lung carcinoma (Cell Line: NCI-H460) [6]
Mercaptopurine + Altretamine DCUA7LH Altretamine Lung adenocarcinoma (Cell Line: EKVX) [6]
Mercaptopurine + Cisplatin DCEHB8H Cisplatin Adenocarcinoma (Cell Line: DU-145) [6]
Mercaptopurine + Cisplatin DCPDKUE Cisplatin Adenocarcinoma (Cell Line: HCT-15) [6]
Mercaptopurine + Cisplatin DCULB34 Cisplatin Adenocarcinoma (Cell Line: HCT116) [6]
Mercaptopurine + Cisplatin DCG4EKR Cisplatin Lung adenocarcinoma (Cell Line: EKVX) [6]
Mercaptopurine + Cisplatin DCIDVYV Cisplatin Malignant melanoma (Cell Line: LOX IMVI) [6]
Mercaptopurine + Chlorambucil DCXKF4S Chlorambucil Adenocarcinoma (Cell Line: HCT116) [6]
Mercaptopurine + Chlorambucil DCBIVCH Chlorambucil Large cell lung carcinoma (Cell Line: NCI-H460) [6]
Mercaptopurine + Chlorambucil DCVB0AJ Chlorambucil Malignant melanoma (Cell Line: LOX IMVI) [6]
Mercaptopurine + Chlorambucil DC2VELU Chlorambucil Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3) [6]
Mercaptopurine + ER819762 DC38UUK ER819762 Adenocarcinoma (Cell Line: A549) [6]
Mercaptopurine + ER819762 DCD00RK ER819762 Amelanotic melanoma (Cell Line: MDA-MB-435) [6]
Mercaptopurine + ER819762 DC1DVOQ ER819762 Large cell lung carcinoma (Cell Line: NCI-H460) [6]
Mercaptopurine + PMID28870136-Compound-43 DC3X2EI PMID28870136-Compound-43 Adenocarcinoma (Cell Line: HCC-2998) [6]
Mercaptopurine + Aminolevulinic Acid Hydrochloride DCF1M7W Aminolevulinic Acid Hydrochloride Large cell lung carcinoma (Cell Line: NCI-H460) [6]
Methotrexate + Mercaptopurine DCUBR59 Methotrexate Adenocarcinoma (Cell Line: DU-145) [5]
Picoplatin + Mercaptopurine DCQ0HJ6 Picoplatin Glioblastoma (Cell Line: SNB-75) [5]
Picoplatin + Mercaptopurine DCBV4IS Picoplatin Invasive ductal carcinoma (Cell Line: HS 578T) [7]
Picoplatin + Mercaptopurine DCP1F07 Picoplatin Amelanotic melanoma (Cell Line: M14) [6]
Picoplatin + Mercaptopurine DCIDCIW Picoplatin Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [6]
PMID28460551-Compound-2 + Mercaptopurine DCJITA6 PMID28460551-Compound-2 Anaplastic large cell lymphoma (Cell Line: SR) [5]
PMID28460551-Compound-2 + Mercaptopurine DC0FW2Z PMID28460551-Compound-2 Glioma (Cell Line: SF-268) [5]
PMID28460551-Compound-2 + Mercaptopurine DCISRN5 PMID28460551-Compound-2 Lung adenocarcinoma (Cell Line: HOP-62) [6]
PMID28460551-Compound-2 + Mercaptopurine DCJVK5C PMID28460551-Compound-2 Malignant melanoma (Cell Line: LOX IMVI) [6]
Romidepsin + Mercaptopurine DC9HW13 Romidepsin Glioma (Cell Line: SF-295) [5]
Romidepsin + Mercaptopurine DCQGRD4 Romidepsin Papillary renal cell carcinoma (Cell Line: ACHN) [5]
Romidepsin + Mercaptopurine DC5NNKO Romidepsin Plasma cell myeloma (Cell Line: RPMI-8226) [5]
Romidepsin + Mercaptopurine DCQUP06 Romidepsin Large cell lung carcinoma (Cell Line: NCI-H460) [6]
Romidepsin + Mercaptopurine DCOB3UN Romidepsin Malignant melanoma (Cell Line: UACC62) [6]
Romidepsin + Mercaptopurine DC4PV12 Romidepsin Non-small cell lung carcinoma (Cell Line: HOP-92) [6]
Ruxolitinib + Mercaptopurine DCBK5YD Ruxolitinib Anaplastic large cell lymphoma (Cell Line: SR) [5]
Ruxolitinib + Mercaptopurine DCZAKE6 Ruxolitinib Papillary renal cell carcinoma (Cell Line: ACHN) [5]
Ruxolitinib + Mercaptopurine DC5N5QF Ruxolitinib Lung adenocarcinoma (Cell Line: NCI-H522) [6]
SCH 727965 + Mercaptopurine DCLTBV5 SCH 727965 Glioma (Cell Line: SF-295) [5]
SCH 727965 + Mercaptopurine DCC66B5 SCH 727965 Melanoma (Cell Line: SK-MEL-2) [6]
Sirolimus + Mercaptopurine DC38MZJ Sirolimus Large cell lung carcinoma (Cell Line: NCI-H460) [6]
TEM + Mercaptopurine DCMR5OX TEM Glioma (Cell Line: SF-268) [5]
TEM + Mercaptopurine DCEBWX7 TEM Carcinoma (Cell Line: RXF 393) [7]
TEM + Mercaptopurine DCJ3DLT TEM Cutaneous melanoma (Cell Line: SK-MEL-28) [6]
TEM + Mercaptopurine DCT7BAC TEM Lung adenocarcinoma (Cell Line: MDA-MB-231) [6]
Thioguanine + Mercaptopurine DC5VWHV Thioguanine Anaplastic large cell lymphoma (Cell Line: SR) [5]
Thioguanine + Mercaptopurine DC7CYMZ Thioguanine Adenocarcinoma (Cell Line: NCIH23) [6]
Thioguanine + Mercaptopurine DCE81J7 Thioguanine Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [6]
Topotecan + Mercaptopurine DCB2ET0 Topotecan Invasive ductal carcinoma (Cell Line: HS 578T) [7]
Topotecan + Mercaptopurine DCGCVGN Topotecan Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [6]
Topotecan + Mercaptopurine DC8KV7I Topotecan Cutaneous melanoma (Cell Line: SK-MEL-28) [6]
Topotecan + Mercaptopurine DCTF9JG Topotecan Glioblastoma (Cell Line: SNB-75) [6]
Topotecan + Mercaptopurine DCGDNB9 Topotecan Glioma (Cell Line: SF-268) [6]
Topotecan + Mercaptopurine DC7OOVN Topotecan Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [6]
Topotecan + Mercaptopurine DCJ21PM Topotecan Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3) [6]
Topotecan + Mercaptopurine DC0H5Z0 Topotecan Pleural epithelioid mesothelioma (Cell Line: NCI-H226) [6]
Trifluridine + Mercaptopurine DCIGPG9 Trifluridine Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Trifluridine + Mercaptopurine DC11KOG Trifluridine Astrocytoma (Cell Line: SNB-19) [5]
Trifluridine + Mercaptopurine DCSCJV3 Trifluridine Lung adenocarcinoma (Cell Line: EKVX) [6]
Trifluridine + Mercaptopurine DCOYKAI Trifluridine Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [6]
Valrubicin + Mercaptopurine DCE07FB Valrubicin Adult acute myeloid leukemia (Cell Line: HL-60(TB)) [5]
Valrubicin + Mercaptopurine DC02EAY Valrubicin Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Valrubicin + Mercaptopurine DCX81CX Valrubicin Astrocytoma (Cell Line: U251) [5]
Valrubicin + Mercaptopurine DC15RGP Valrubicin Glioblastoma (Cell Line: SNB-75) [5]
Valrubicin + Mercaptopurine DCADVZJ Valrubicin Plasma cell myeloma (Cell Line: RPMI-8226) [5]
Valrubicin + Mercaptopurine DCUU13L Valrubicin Colon adenocarcinoma (Cell Line: COLO 205) [7]
Valrubicin + Mercaptopurine DCE1K9D Valrubicin Invasive ductal carcinoma (Cell Line: T-47D) [7]
Valrubicin + Mercaptopurine DC0CP77 Valrubicin Adenocarcinoma (Cell Line: HCT116) [6]
Valrubicin + Mercaptopurine DCS5OY9 Valrubicin High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8) [6]
Valrubicin + Mercaptopurine DCQLUHJ Valrubicin Lung adenocarcinoma (Cell Line: NCI-H522) [6]
Valrubicin + Mercaptopurine DCNKDTJ Valrubicin Melanoma (Cell Line: SK-MEL-2) [6]
Valrubicin + Mercaptopurine DCI8R7J Valrubicin Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1) [6]
Vandetanib + Mercaptopurine DCQJZ2Q Vandetanib Amelanotic melanoma (Cell Line: M14) [6]
Vemurafenib + Mercaptopurine DCNWZ09 Vemurafenib Invasive ductal carcinoma (Cell Line: HS 578T) [7]
Vemurafenib + Mercaptopurine DCDXEZB Vemurafenib Anaplastic large cell lymphoma (Cell Line: SR) [6]
Vemurafenib + Mercaptopurine DCFLPWD Vemurafenib Glioblastoma (Cell Line: SNB-75) [6]
Vemurafenib + Mercaptopurine DCR5Y1F Vemurafenib Malignant melanoma (Cell Line: UACC62) [6]
Vemurafenib + Mercaptopurine DCHLJYT Vemurafenib Malignant melanoma (Cell Line: LOX IMVI) [6]
Vemurafenib + Mercaptopurine DCDEKE4 Vemurafenib Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M) [6]
Vemurafenib + Mercaptopurine DC7QOZ8 Vemurafenib Papillary renal cell carcinoma (Cell Line: ACHN) [6]
Vincristine + Mercaptopurine DCYJZJZ Vincristine Clear cell renal cell carcinoma (Cell Line: 786-0) [5]
Vincristine + Mercaptopurine DCSA5T9 Vincristine Glioma (Cell Line: SF-295) [5]
Vinflunine + Mercaptopurine DCODB6P Vinflunine Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4) [5]
Vinflunine + Mercaptopurine DC3L96A Vinflunine Anaplastic large cell lymphoma (Cell Line: SR) [5]
Vismodegib + Mercaptopurine DCY7Q91 Vismodegib Clear cell renal cell carcinoma (Cell Line: 786-0) [6]
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⏷ Show the Full List of 218 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Methotrexate + Mercaptopurine DC0YH58 Methotrexate Recurrent Childhood Acute Lymphoblastic Leukemia [8]
Venetoclax + Mercaptopurine DC7PHD5 Venetoclax Acute Myeloid Leukemia, in Relapse [9]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7226).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 ClinicalTrials.gov (NCT00846703) The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia. U.S. National Institutes of Health.
4 Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16.
5 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
7 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
8 ClinicalTrials.gov (NCT00089349) Alemtuzumab With or Without Methotrexate and Mercaptopurine in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia
9 ClinicalTrials.gov (NCT05506332) Treatment With ABT-199 (Venetoclax) and Purine Analogues in Relapsed/Refractory Acute Myeloid Leukemia