Details of the Drug Combinations

General Information of This Drug (ID: DMU8JGH)

Drug Name
Hydralazine   DMU8JGH
Synonyms
Apresolin; Apresoline; Apressin; Apressoline; Aprezolin; HLZ; Hidral; Hidralazin; Hidralazina; Hipoftalin; Hydralazin; Hydralazinum; Hydrallazin; Hydrallazine; Hydrazinophthalazine; Hypophthalin; Idralazina; Hidralazina [Spanish]; Idralazina [DCIT]; Idralazina [Italian]; BA 5968; C 5968; Ciba 5968; Praparat 5968; Apresoline (TN); Apressin (pharmaceutical); C-5068; C-5968; Hidral (TN); Hidralazina [INN-Spanish]; Hydralazine (INN); Hydralazine [INN:BAN]; Hydralazinum [INN-Latin]; Hydrazone 1(2H)-phthalazinone; Phthalazin-1-ylhydrazine; [2H-Phthalazin-(1Z)-Ylidene]-Hydrazine Hydrochloride; (1Z)-1(2H)-Phthalazinone hydrazone; (2H)-Phthalazinone hydrazone; 1(2H)-Phthalazinone hydrazone; 1(2H)-Phthalazinone, hydrazone; 1-Hydrazinophthalazine; 1-Phthalazinylhydrazine; 6-Hydralazine
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Therapeutic Class
Antihypertensive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

100 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Hydralazine DCC09UG Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acarbose + Hydralazine DC7CU2Z Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acetohexamide + Hydralazine DCZFXTU Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acetohydroxamic Acid + Hydralazine DCH0BCW Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Allopurinol + Hydralazine DC47BD2 Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Auranofin + Hydralazine DCP6VJX Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Azatadine + Hydralazine DCKWUMM Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BHV-0223 + Hydralazine DC1I72Y BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Hydralazine DCLDOOD Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BRL-15572 + Hydralazine DC9USZD BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cefmenoxime + Hydralazine DCWXH0N Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Hydralazine DCZP4LV Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chloroquine + Hydralazine DCNVADH Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Hydralazine DCUYFFN Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cilostazol + Hydralazine DCVNYJM Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Hydralazine DCVJ6TL Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diazoxide + Hydralazine DCG0CO4 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diethylcarbamazine + Hydralazine DCTE3WK Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Docetaxel + Hydralazine DCE8N7A Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dopamine + Hydralazine DCKJ102 Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Doxorubicin + Hydralazine DC4Q8HB Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dronedarone + Hydralazine DCIUEUI Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Etonogestrel + Hydralazine DC7NIAI Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Everolimus + Hydralazine DCHKUDN Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fibrates + Hydralazine DCGVI7S Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ginsenoside Rb1 + Hydralazine DCDZYQY Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Ribavirin-TP DC6IW1Y Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Sertraline DC11I9L Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Mebutamate DCPJ9SN Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Picoplatin DCO1UEO Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Gefitinib DCPWJI0 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Dantrolene DCF7027 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Diethylcarbamazine DCO8O73 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Epinephrine DCMFUCL Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + PMID28460551-Compound-2 DC0ND1V PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Vinblastine DCP166S Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Anamorelin DCGIY3A Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Fomepizole DC0XZPS Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Triapine DCKNRBS Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + IT-141 DCN4QV7 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Palonosetron DC7KRVI Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Isosorbide dinitrate DCONH4P Isosorbide dinitrate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + BHV-0223 DCMQDGQ BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Metyrosine DCBH233 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Testosterone cypionate DCG7UPE Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Flavonoid derivative 1 DC25ZRJ Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Carglumic acid DCY9J0G Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Doxapram DCITVR0 Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + K-134 DCHQOZ7 K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Docetaxel DCNDUC8 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Sulfinpyrazone DCTJY5N Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Pazopanib DCAMJ4C Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Ciprofibrate DCIP8UK Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Sulfapyridine DCUI27J Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Eflornithine DC03FDS Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Tiagabine DCXPLZQ Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Diazoxide DC5OJ60 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Tamoxifen DCZ4RZC Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Imatinib DCT34XI Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Probenecid DCNSS0E Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Methylene blue DCON1MF Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Ethinyl estradiol DCEDVR4 Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Artemisinin DCFDC5T Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Maprotiline DC1LHRE Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Leflunomide DCXQEYT Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Brincidofovir DCIB6LT Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Endoxifen DCZ1SOC Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Mycophenolic acid DCESPA5 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Mefloquine DCLYWF4 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Pizotyline DCPPXJ3 Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Doxorubicin DCGVU7C Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Vorinostat DCKDT4X Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Metaxalone DCFAN62 Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Albendazole DC76SZ3 Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Tacrolimus DCMTSJQ Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imatinib + Hydralazine DCYXFJT Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isoproterenol + Hydralazine DCEB38Z Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
IT-141 + Hydralazine DC6R5DG IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Hydralazine DC6VDWG Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Loperamide + Hydralazine DC5DLFJ Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methoxsalen + Hydralazine DCNOOTI Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Nabilone + Hydralazine DCQ0TCJ Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Olanzapine + Hydralazine DCZFQ85 Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Oseltamivir + Hydralazine DCJB4CG Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Oxyphenbutazone + Hydralazine DC2C6GI Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Paromomycin + Hydralazine DCV1Q7L Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pinacidil + Hydralazine DCBOC33 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PMID28460551-Compound-2 + Hydralazine DCWXINU PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pramipexole + Hydralazine DCC85K6 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Quinine + Hydralazine DCR0IFL Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ribavirin-TP + Hydralazine DCK4EON Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rifampin + Hydralazine DCPL6GD Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Hydralazine DCSQP4U Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sulfinpyrazone + Hydralazine DCBUD2X Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Hydralazine DCD3TJ1 Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Terameprocol + Hydralazine DCLPLYY Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tiagabine + Hydralazine DCVAW4Y Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Hydralazine DC48CEZ Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Topotecan + Hydralazine DCWCWLX Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
VR-776 + Hydralazine DCAGL6X VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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References

1 Hydralazine FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7326).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.