Details of the Drug Combinations

General Information of This Drug (ID: DMVYXR8)

Drug Name
Sumatriptan   DMVYXR8
Synonyms
Sumatran; Sumatriptanum; Sumax; GR 43175; GR 43175X; NP101; GR-43175; Imigran (TN); Imitrex (TN); KS-1116; Sumatriptanum [INN-Latin]; Sumatriptan (JAN/USP/INN); (3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide; 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide; 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methylmethanesulfonamide; 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide; 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide; 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide; 3-[2-(Dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide
Indication
Disease Entry ICD 11 Status REF
Cluster headache 8A81.0 Approved [1]
Migraine 8A80 Approved [2]
Migraine disorder N.A. Approved [1]
Therapeutic Class
Vasoconstrictor Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

97 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
10-hydroxycamptothecin + Sumatriptan DCK50XM 10-hydroxycamptothecin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acamprosate + Sumatriptan DCSBLTM Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acetohydroxamic Acid + Sumatriptan DCNT82Y Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Arfolitixorin + Sumatriptan DCC1IIS Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Atenolol + Sumatriptan DCT7Y6H Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Auranofin + Sumatriptan DCHP6LW Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Azatadine + Sumatriptan DC5EGEL Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BIO-300 + Sumatriptan DCMIDE8 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bortezomib + Sumatriptan DC2X710 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Sumatriptan DC99WYR Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Sumatriptan DCCY7KE Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Sumatriptan DCZ7Z2J Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dantrolene + Sumatriptan DCRHS3J Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dichlorphenamide + Sumatriptan DCT4WUL Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Doxapram + Sumatriptan DC9WW1Z Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Doxorubicin + Sumatriptan DCUQ93N Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eflornithine + Sumatriptan DCPG96E Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Emetine + Sumatriptan DC5UFS3 Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Epinephrine + Sumatriptan DCMV1NF Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Etonogestrel + Sumatriptan DCBIMK0 Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fluspirilene + Sumatriptan DCP7UQ6 Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fomepizole + Sumatriptan DCSYXZO Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Sumatriptan DC6O1GN Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
K-134 + Sumatriptan DC9173E K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Sumatriptan DCT8T0Q Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Linagliptin + Sumatriptan DCP1IMR Linagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Lubiprostone + Sumatriptan DCM5VQ2 Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Sumatriptan DCLG2XC Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mephenytoin + Sumatriptan DCBJSDU Mephenytoin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mesalazine + Sumatriptan DCK4DH6 Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metaxalone + Sumatriptan DC2PCMW Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methotrexate + Sumatriptan DC0FXBF Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metyrosine + Sumatriptan DCG28BF Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
ML323 + Sumatriptan DCSM4DK ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Naltrexone + Sumatriptan DCQ80AN Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Olmesartan medoxomil + Sumatriptan DCU43KZ Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pentamidine + Sumatriptan DCSF2PU Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PF-02545920 + Sumatriptan DC6Q06J PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PHA-739358 + Sumatriptan DCMXNXG PHA-739358 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sulfapyridine + Sumatriptan DC7IU13 Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Pentostatin DCKK0Y3 Pentostatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Gefitinib DC0ZRF8 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Diethylcarbamazine DCQ4Q2A Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Ruxolitinib DCE3ANI Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Sumatriptan + Lumefantrine DCXG4E9 Lumefantrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Crotamiton DCYT9YI Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Epinephrine DC2XFVH Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Repaglinide DCOSUO4 Repaglinide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Vinblastine DCXTOMD Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Sivelestat DCC2YGG Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Ramelteon DC0U5FT Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Triapine DCH2JSR Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Acitretin DCGUA00 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Everolimus DCY1KGE Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Pepstatin DCMYXSC Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + IT-141 DCRRV7Z IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Palonosetron DCNGMWW Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Efavirenz DC2H6PR Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Guanfacine DC4I5EV Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + SCH 727965 DCA4INZ SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Emetine DCF5URD Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Memantine DC60J3Q Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Docetaxel DC878AZ Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + ETHISTERONE DC53FC5 ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Pazopanib DC0WI4R Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Armodafinil DCQEPDX Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Mecamylamine DCLTIXP Mecamylamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Clopidogrel DC30EH3 Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Procarbazine DCW7NX8 Procarbazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + BIO-300 DC4RC5D BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Tiagabine DCVI75V Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Benserazide DCK8TRH Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Probenecid DCTDVEH Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Pramipexole DCR7AYS Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Methylene blue DC8G8BG Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Moricizine DCQMEHG Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Enalaprilat DCQ8895 Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Maprotiline DCUFSPK Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Acetohexamide DCQXX7E Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Leflunomide DCUVF4F Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Bumetanide DCN5632 Bumetanide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Hyodeoxycholic acid DCFRQVI Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Naltrexone DC5QZMU Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Quinine DCLSMFV Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Mycophenolic acid DCGKEW5 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Hydralazine DCD3TJ1 Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Mefloquine DCAPLWU Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Nabilone DC444TD Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Vorinostat DCVY2BI Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Cerivastatin DCMRSYO Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Tetracycline DC0EKW6 Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Cilostazol DCY92KC Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Sumatriptan DCT91GX Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Topotecan + Sumatriptan DCPR78O Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triapine + Sumatriptan DCWGWLM Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triflupromazine + Sumatriptan DCUVCNK Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triiodothyronine + Sumatriptan DCQBDDG Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 97 DrugCom(s)
4 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Sumatriptan + Naproxen DCDCR0L Naproxen Migraine [5]
Sumatriptan + Isosorbide mononitrate DCYSQX2 Isosorbide mononitrate Migraine [6]
Sumatriptan + Promethazine DCR6XGR Promethazine Migraine [7]
Sumatriptan + Lasmiditan DCD3Q5E Lasmiditan Migraine [8]
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References

1 Sumatriptan FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 54).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5 ClinicalTrials.gov (NCT01071317) Trial of Comprehensive Migraine Intervention
6 ClinicalTrials.gov (NCT02485340) The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 ClinicalTrials.gov (NCT03076970) Effect of Single Oral Doses of Lasmiditan When Coadministered With Single Oral Doses of Sumatriptan in Healthy Participants