Details of the Drug Combinations

General Information of This Drug (ID: DMY91A3)

Drug Name
ML323   DMY91A3
Synonyms ML 323; ML-323
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Preclinical [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

46 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Albendazole + ML323 DC85RDL Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Allopurinol + ML323 DCIH9QY Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Anamorelin + ML323 DCPW8RH Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + ML323 DC90GMX Atovaquone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bepridil + ML323 DC07MEV Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + ML323 DC62RI7 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cefmenoxime + ML323 DCGSZ8O Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + ML323 DCC4618 Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + ML323 DCX846F Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + ML323 DCWL9L8 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dopamine + ML323 DCVV3ZM Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + ML323 DCAIVR4 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fibrates + ML323 DCAI54M Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Galantamine + ML323 DC3YF55 Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GINKGOLIDE A + ML323 DCDBT59 GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + ML323 DCPVEX6 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Itraconazole + ML323 DCN9KN4 Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + ML323 DCA8G0K K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Loperamide + ML323 DC36P8M Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + ML323 DCC95JA Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + ML323 DC0FM0V Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + ML323 DCJ0VRM Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Kanamycin DCPMN1A Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Fomepizole DCWGYK2 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Tranexamic acid DCWO5KH Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + IT-141 DCCQL62 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Chlorzoxazone DCUDG2P Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Darunavir DCN7UEV Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Pramipexole DC8FTYB Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Artemisinin DC69Q2O Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Maprotiline DCZJUY5 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Novobiocin DCKWVMM Novobiocin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Hyodeoxycholic acid DCFFFGJ Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Maraviroc DCK3VFP Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Mycophenolic acid DCXCNHJ Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Mefloquine DCAI9KV Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Doxorubicin DCG0UCS Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Sumatriptan DCSM4DK Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Moricizine + ML323 DC8Y3W9 Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + ML323 DCRGWCF Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + ML323 DC0V93Q Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + ML323 DCSDCCT Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + ML323 DCFBYWS Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triapine + ML323 DCY9MHO Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trihexyphenidyl + ML323 DCEY768 Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + ML323 DCIL6PD Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 46 DrugCom(s)

References

1 Deubiquitylating enzymes and drug discovery: emerging opportunities. Nat Rev Drug Discov. 2018 Jan;17(1):57-78.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.