Details of the Drug Combinations

General Information of This Drug (ID: DMZ1OO0)

Drug Name
AS-1949490   DMZ1OO0
Synonyms SH2 domain inositol phosphatase inhibitor (type 2 diabetes), Astellas
Indication
Disease Entry ICD 11 Status REF
Non-insulin dependent diabetes 5A11 Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

61 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + AS-1949490 DC2ICRK Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aciclovir + AS-1949490 DCYDNN0 Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + AS-1949490 DCRE89H Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Armodafinil + AS-1949490 DCJ5ES6 Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Aprepitant DCDAL3O Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Picoplatin DC0JYRI Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Gefitinib DCR4582 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Diethylcarbamazine DC005LI Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Citalopram DCKKIK6 Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Imipramine DCFR27V Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Vinblastine DCOMGZN Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Testosterone DCJ4K2Z Testosterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Triapine DC6ODF7 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Dexmedetomidine DCTQLWP Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Testosterone cypionate DC1PR6R Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Flavonoid derivative 1 DCBTOM8 Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Docetaxel DCVK66O Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Pentamidine DC4F7TP Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Isoproterenol DCLFKGC Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Ibutilide DCHCMTG Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Imatinib DC6ZR26 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Methylene blue DCZOTOM Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Cefmenoxime DCUF9RP Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Trimethobenzamide DCJM26F Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Maprotiline DCMV2ZN Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Teriflunomide DCCS77S Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole DCRNP9O 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Brincidofovir DCYM0V5 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Pomalidomide DC7084O Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Endoxifen DC4E37A Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Doxorubicin DCDQKGA Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + PMID28870136-Compound-43 DCWPG6I PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Vorinostat DCAIXDL Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Cerivastatin DCWD1M6 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + AS-1949490 DCPZ0XG Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Buspirone + AS-1949490 DCX5GO8 Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + AS-1949490 DCQNLXP Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clascoterone + AS-1949490 DCPATV2 Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clopidogrel + AS-1949490 DCDXZP0 Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + AS-1949490 DCOTM8H Cycloguanil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dantrolene + AS-1949490 DCBW8IR Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + AS-1949490 DCPHJUR Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + AS-1949490 DCSAUBN Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fenoprofen + AS-1949490 DCQQ5XS Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + AS-1949490 DCM8036 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GINKGOLIDE A + AS-1949490 DCTYS2W GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ginsenoside Rb1 + AS-1949490 DC85VNS Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + AS-1949490 DCJR4Y2 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Kanamycin + AS-1949490 DCHKC18 Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + AS-1949490 DC8V6YM Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + AS-1949490 DC3GP20 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + AS-1949490 DCOSQT0 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + AS-1949490 DC53YFO Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Naltrexone + AS-1949490 DC2614U Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pamidronate + AS-1949490 DC9LQVY Pamidronate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pentamidine + AS-1949490 DCAGB1B Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Phensuximide + AS-1949490 DC0OA7K Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + AS-1949490 DCCQ5CU Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + AS-1949490 DC72IK3 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + AS-1949490 DC8HE9M Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + AS-1949490 DC5THB3 Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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References

1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.