Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1I8LU)

Drug Name
Coenzyme A Drug Info
Synonyms
coenzyme A; CoASH; CoA-SH; Zeel; 85-61-0; Depot-Zeel; CoA; HSCoA; Coenzym A; Coenzyme ASH; co-enzyme-A; UNII-SAA04E81UX; HS-CoA; SAA04E81UX; CHEBI:15346; 3'-phosphoadenosine-(5')diphospho(4')pantatheine; Coenzyme A hydrate; co-A; Co-A-SH; Reduced CoA; 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] dihydrogen diphosphate}
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
87642
ChEBI ID
CHEBI:15346
CAS Number
CAS 85-61-0
TTD Drug ID
DM1I8LU
VARIDT Drug ID
DR00302

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Pantothenate kinase (Bact coaA) TTSEOPJ COAA_ECOLI Inhibitor [2]
Carnitine acyltransferase (CRAT) TTC8M31 CACP_HUMAN Inhibitor [2]
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [2]
Phosphopantetheine adenylyltransferase (PPAT) TT4YO0Z COASY_HUMAN Inhibitor [2]
Staphylococcus DHNA-CoA synthase (Stap-coc menB) TT8HWCD MENB_STAAC Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Graves disease carrier protein (SLC25A16) DTNU9EW GDC_HUMAN Phase 3 [3]
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) DTU4HKJ S2542_HUMAN Phase 3 [4]
Peroxisomal membrane protein PMP34 (SLC25A17) DTYR5U7 PM34_HUMAN Phase 3 [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
HMG-CoA reductase (HMGCR) DTT HMGCR 6.357 6.256 5.17 6.85
Peroxisomal membrane protein PMP34 (SLC25A17) DTP PMP34 5.15 5.397 5.19 4.498
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) DTP SLC25A42 2.202 0.678 1.888 1.888
Graves disease carrier protein (SLC25A16) DTP GDC 6.387 4.555 5.252 5.511
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
HMG-CoA reductase (HMGCR) DTT HMGCR 1.01E-05 0.65 1.53
Peroxisomal membrane protein PMP34 (SLC25A17) DTP PMP34 7.38E-02 -8.98E-02 -7.93E-01
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) DTP SLC25A42 3.36E-02 -1.22E-01 -8.00E-01
Graves disease carrier protein (SLC25A16) DTP GDC 5.07E-03 2.87E-01 1.23E+00
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3044).
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster. Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):137-146.
4 A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. J Biol Chem. 2009 Jul 3;284(27):18152-9.
5 The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+. Biochem J. 2012 Apr 1;443(1):241-7.