Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7EQ06)

Drug Name

4-azidobenzenesulfonamide Drug Info

Synonyms

4-azidobenzenesulfonamide; 4-azidobenzene-1-sulfonamide; CHEMBL222837; 36326-86-0; diazosulfanilamide; azide 1; AC1MSFSV; 4-azidophenylsulfonamide; 4-azido-benzenesulfonamide; SCHEMBL15155897; BDBM15222; MolPort-023-499-930; NSC80928; ZINC12410597; NSC-80928

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3558590
CAS Number: CAS 36326-86-0
TTD Drug ID: DM7EQ06

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[2]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[2]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2273-6.
2	Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7.