Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7JT24)

Drug Name
Acocantherin Drug Info
Synonyms
Ouabain; Ouabagenin L-Rhamnoside; Ouabagenin L-rhamnoside; Acocantherin; Acocantherine; Acolongifloroside K; Astrobain; G-Strophanthin; G-Strophanthin (JAN); G-Strophicor; Gratibain; Gratus strophanthin; Kombetin; O 3125; OBN; Ouabagenin-L-rhamnosid; Ouabagenin-L-rhamnosid [German]; Ouabain (anhydrous); Ouabain anhydrous; Ouabain octahydrate; Ouabain, Octahydrate; Ouabaine; Oubain; Purostrophan; Quabain; Rectobaina; Solufantina; Strodival; Strophalen; Strophanthin G; Strophanthin-G; Strophoperm; Strophosan; Uabaina; Uabanin
Indication
Disease Entry ICD 11 Status REF
Atrial fibrillation BC81.3 Approved [1]
Heart failure BD10-BD13 Approved [1]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [2]
Therapeutic Class
Cardiotonic Agents
Cross-matching ID
PubChem CID
439501
ChEBI ID
CHEBI:472805
CAS Number
CAS 630-60-4
TTD Drug ID
DM7JT24
VARIDT Drug ID
DR00155

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium pump subunit alpha-1 (ATP1A1) TTWK8D0 AT1A1_HUMAN Binder [3]
HUMAN sodium pump subunit alpha-1 (ATP1A1) TTWNK8B AT1A1_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Organic anion transporting polypeptide 4C1 (SLCO4C1) DTY0QMU SO4C1_HUMAN Approved [4]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Approved [5]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Approved [6]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Approved [7]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Sodium pump subunit alpha-1 (ATP1A1) DTT ATP1A1 7.891 11.257 11.348 10.906
Organic anion transporting polypeptide 4C1 (SLCO4C1) DTP OATP4C1 4.133 4.508 5.612 3.7
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTP OATP1A2 4.365 4.466 3.248 2.632
Organic anion transporting polypeptide 1B3 (SLCO1B3) DTP OATP1B3 8.873 2.17 2.485 3.322
Organic anion transporting polypeptide 1B1 (SLCO1B1) DTP OATP1B1 9.79 0.485 3.511 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Atrial fibrillation
ICD Disease Classification BC81.3
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Sodium pump subunit alpha-1 (ATP1A1) DTT ATP1A1 4.66E-01 1.00E-02 0.06
Sodium pump subunit alpha-1 (ATP1A1) DTT ATP1A1 3.31E-01 -0.03 -0.19
Organic anion transporting polypeptide 4C1 (SLCO4C1) DTP OATP4C1 4.06E-01 2.99E-02 7.03E-02
Organic anion transporting polypeptide 4C1 (SLCO4C1) DTP OATP4C1 1.84E-07 -3.88E-01 -1.02E+00
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTP OATP1A2 1.26E-02 1.81E-01 6.48E-01
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTP OATP1A2 8.14E-02 2.55E-02 2.32E-01
Organic anion transporting polypeptide 1B3 (SLCO1B3) DTP OATP1B3 3.20E-01 2.15E-02 1.15E-01
Organic anion transporting polypeptide 1B3 (SLCO1B3) DTP OATP1B3 1.40E-02 -4.58E-02 -1.12E-01
Organic anion transporting polypeptide 1B1 (SLCO1B1) DTP OATP1B1 2.41E-01 -2.63E-02 -8.50E-02
Organic anion transporting polypeptide 1B1 (SLCO1B1) DTP OATP1B1 5.54E-01 -1.65E-02 -1.24E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4826).
2 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4 Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74.
5 Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20.
6 Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855.
7 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33.