Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAKZ43)

Drug Name

2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one Drug Info

Synonyms

2,8-dimethyl-1-oxa-8-azaspiro[4.5]decan-3-one; CHEMBL40121; 123319-03-9; ARL-14995; 2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one; SCHEMBL1326512; 1-Oxa-8-azaspiro[4.5]decan-3-one, 2,8-dimethyl-; MolPort-039-242-339; OODDNJQTVFMGCF-UHFFFAOYSA-N; BDBM50034651; AKOS033633463; 2,8-dimethyl-1-oxa-8-azaspiro[4,5]decan-3-one; L010200; 2,8-dimethyl-1-oxa-8-azaspiro[4.5]-decan-3-one; 2,8-dimethyl-1-oxa-8-azaspiro[4,5]-decan-3-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10176401
TTD Drug ID: DMAKZ43

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M2 (CHRM2)	TTYEG6Q	ACM2_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M4 (CHRM4)	TTQ3JTF	ACM4_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M5 (CHRM5)	TTH18TF	ACM5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Muscarinic acetylcholine receptor M4 (CHRM4)	DTT	CHRM4	6.227	5.863	5.776	5.567

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M1 (CHRM1)	DTT	CHRM1	5.59E-01	0.19	0.41
Muscarinic acetylcholine receptor M2 (CHRM2)	DTT	CHRM2	5.59E-01	0.19	0.41

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. J Med Chem. 1998 Oct 22;41(22):4181-5.