Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDKSZ0)

Drug Name

2-oxo-N-m-tolyl-2H-chromene-3-carboxamide Drug Info

Synonyms

1846-99-7; 2-oxo-N-(m-tolyl)-2H-chromene-3-carboxamide; 2-Oxo-2H-chromene-3-carboxylic acid m-tolylamide; N-(3-Methylphenyl)-2-oxo-2H-chromene-3-carboxamide; AC1LCCPQ; BAS 00837918; AC1Q2NKJ; 3-carboxamido coumarin, 8; TimTec1_006709; Oprea1_808053; Oprea1_256730; CBDivE_000076; MLS001209245; CHEMBL445184; SCHEMBL6228552; BDBM29158; 2h-1-benzopyran-3-carboxamide,n-(3-methylphenyl)-2-oxo-; MolPort-000-375-220; XUNAVIWFCXQWCJ-UHFFFAOYSA-N; HMS2825F09; HMS1553A21; ZINC130233; N-(m-Tolyl)-3-coumarincarboxamide; STK408207

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 599289
TTD Drug ID: DMDKSZ0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42.