Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDTRZ2)

Drug Name

2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide Drug Info

Synonyms

91533-01-6; 2-morpholin-4-yl-N-(4-sulfamoylphenyl)acetamide; CHEMBL180943; Sulfanilamide, N4-(alpha-morpholinoacetyl)-; 2-(morpholin-4-yl)-N-(4-sulfamoylphenyl)acetamide; N4-(alpha-Morpholinoacetyl)sulfanilamide; AE-848/36321029; 2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide; AC1L47H0; SCHEMBL15798186; DTXSID70238616; MolPort-000-225-319; BDBM50157946; ZINC19901027; STL294445; AKOS001028531; MCULE-6306887577; ST086382; SR-01000467406; SR-01000467406-1; Z46180370; 4-Morpholineacetamide, N-(4-(aminosulfonyl)phenyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 180598
CAS Number: CAS 91533-01-6
TTD Drug ID: DMDTRZ2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic... Bioorg Med Chem Lett. 2005 Jan 17;15(2):367-72.