General Information of Drug (ID: DMGBKN7)

Drug Name
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info
Synonyms
CHEMBL511186; 4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide; 4-({[(4-fluorophenyl)sulfonyl]amino}methyl)benzenesulfonamide; 4-[[[(4-Fluorophenyl)sulfonyl]amino]methyl]benzenesulfonamide; BAS 02065178; AC1LG4NC; Cambridge id 6100956; Oprea1_631950; Oprea1_795607; MolPort-001-510-834; ZINC288074; STK396016; BDBM50247721; AKOS000644386; MCULE-1179145360; ST50706913; AB00102538-01; Z45537946; N-[4-(aminosulfonyl)benzyl]-4-fluoro-1-benzenesulfonamide; 4-[[(4-fluorophenyl)sulfonylamino]methyl]benzenesulfonamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
788811
TTD Drug ID
DMGBKN7

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Carbonic anhydrase IX (CA-IX) DTT CA9 5.04 6.156 4.609 6.756
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Carbonic anhydrase IX (CA-IX) DTT CA9 1.12E-10 -0.03 -0.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7.