Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHO0AR)

Drug Name

Ergocalciferol Drug Info

Synonyms

Calciferol; Calciferolum; Condacaps; Condocaps; Condol; Crtron; Crystallina; Daral; Davitin; Decaps; Deltalin; Deratol; Detalup; Diactol; Drisdol; Ercalciol; Ergocalciferolo; Ergocalciferols; Ergocalciferolum; Ergorone; Ertron; Fortodyl; Geltabs; Haliver; Hyperkil; Infron; Metadee; Mulsiferol; Mykostin; Ostelin; Radiostol; Radstein; Radsterin; Rodinec; Sterogyl; Vigantol; Viostdrol; Viosterol; CALCIFEROL IN A GELATIN MATRIX; Component of Geltabs Vitamin D; Davitamon D; Divit urto; Ergocalciferolo [DCIT]; Ergosterol activated; Ergosterol irradiated; Geltabs Vitamin D; Irradiated ergosterol; Oleovitamin D; Rodine C; Synthetic Vitamin D; Viosterol in Oil; Calciferon 2; Mina D2; Oleovitamin D2; VITAMIN D2; VITAMIN_D2; Vitamina D2; Buco-D; Calciferol (TN); Calciferol (vitamin D2); D-Arthin; D-Tracetten; De-rat concentrate; Dee-Osterol; Dee-Ron; Dee-Ronal; Dee-Roual; Deltalin (TN); Drisdol (TN); Ergocalciferol (D2); Ergocalciferol: Vitamin D; Ergocalciferolum [INN-Latin]; Ergosterol, irradiated; Hi-Deratol; Novovitamin-D; Oleovitamin D, Synthetic; Shock-ferol; Shock-ferol sterogyl; Sorex C.R; Uvesterol-D; Vio-D; Vitamin d-2; Vitamin-D2; Vitavel-D; Ergocalciferol (JP15/USP); Ergocalciferol [INN:BAN:JAN]; Sorex C.R.; VITAMIN D2 WATER DISPERSABLE U.S.P.; CALCIFEROL, U.S.P.; Irradiated ergosta-5,7,22-trien-3-beta-ol; Irradiated ergosta-5,7,22-trien-3.beta.-ol; (+)-Vitamin D2; (3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol; (3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol; (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol; (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol; (3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol; (5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol; (5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol; 7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87; 9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol;9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol; 9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol

Indication

Disease Entry	ICD 11	Status	REF
Hypoparathyroidism	5A50	Approved	[1]
Osteoporosis	FB83.0	Approved	[2]
Pleural tuberculosis		Approved	[2]
Rickets	5B57	Approved	[2]
Vitamin D deficiency	5B57	Approved	[2]
Vitamin D-dependent rickets		Approved	[2]
Vitamin deficiency	5B55-5B71	Approved	[2]
Autosomal dominant hypocalcemia	5A50.0Y	Investigative	[2]
X-linked dominant hypophosphatemic rickets		Investigative	[2]

Therapeutic Class

Vitamins

Cross-matching ID

PubChem CID: 5280793
ChEBI ID: CHEBI:28934
CAS Number: CAS 50-14-6
TTD Drug ID: DMHO0AR
INTEDE Drug ID: DR0596
ACDINA Drug ID: D00237

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vitamin D3 receptor (VDR)	TTK59TV	VDR_HUMAN	Antagonist	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Approved	[4]
Cholesterol desmolase (CYP11A1)	DE98XPV	CP11A_HUMAN	Approved	[5]
Cytochrome P450 2J2 (CYP2J2)	DERSX5P	CP2J2_HUMAN	Approved	[6]
Vitamin D 25-hydroxylase (CYP2R1)	DEBIHM3	CP2R1_HUMAN	Approved	[7]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Vitamin D3 receptor (VDR)	DTT	VDR	4.536	6.7	5.109	7.303
Cytochrome P450 2J2 (CYP2J2)	DME	CYP2J2	7.706	6.315	4.621	7.65
Vitamin D 25-hydroxylase (CYP2R1)	DME	CYP2R1	4.433	4.684	4.079	5.505
Cholesterol desmolase (CYP11A1)	DME	CYP11A1	5.409	4.385	5.19	5.6
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	11.692	6.58	4.984	9.089

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Hypoparathyroidism

ICD Disease Classification

5A50

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vitamin D3 receptor (VDR)	DTT	VDR	1.80E-03	-0.18	-0.42
Cytochrome P450 2J2 (CYP2J2)	DME	CYP2J2	3.14E-01	2.37E-02	8.44E-02
Vitamin D 25-hydroxylase (CYP2R1)	DME	CYP2R1	6.11E-08	9.96E-02	4.58E-01
Cholesterol desmolase (CYP11A1)	DME	CYP11A1	2.07E-01	2.50E-02	1.32E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	7.29E-03	-3.47E-02	-1.80E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040833.
2	Ergocalciferol FDA Label
3	Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41.
4	CYP3A4 is a human microsomal vitamin D 25-hydroxylase. J Bone Miner Res. 2004 Apr;19(4):680-8.
5	Vitamin D: mechanisms of action and clinical applications. Endocrinol Metab Clin North Am. 2017 Dec;46(4):xvii-xviii.
6	Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56.
7	CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev. 2007 Nov;23(8):631-6.