Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIF1D6)

Drug Name

4-ethynyl benzene sulfonamide Drug Info

Synonyms

4-ethynylbenzenesulfonamide; 1788-08-5; 4-Ethynylbenzene-1-sulfonamide; 4-Ethynybenzenesulfonamide; 4-ethynyl benzene sulfonamide; Benzenesulfonamide, 4-ethynyl-; CHEMBL272881; benzenesulfonamide, 4-ethynyl- (9ci); P-Ethynylbenzenesulfonamide; 4-ethvnylbenzenesulfonamide; 4-ethynylbenzene sulfonamide; 4-ethynyl-benzenesulfonamide; Benzenesulfonamide,4-ethynyl-; SCHEMBL1066580; CTK4D6902; DTXSID80659176; OQPUCENNUFNCQO-UHFFFAOYSA-N; MolPort-004-759-802; KS-00000L2U; ANW-45086; BDBM50236140; ZINC29134554; FC0779; AKOS006308323

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44457221
CAS Number: CAS 1788-08-5
TTD Drug ID: DMIF1D6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. J Med Chem. 2008 Mar 27;51(6):1945-53.