Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIWGZS)

Drug Name

4-amino-6-chlorobenzene-1,3-disulfonamide Drug Info

Synonyms

121-30-2; 4-Amino-6-chlorobenzene-1,3-disulfonamide; 4-Amino-6-chloro-1,3-benzenedisulfonamide; Chloraminophenamide; Idorese; Salmid; Chloroaminophenamide; 1,3-Benzenedisulfonamide, 4-amino-6-chloro-; 5-Chloro-2,4-disulfamylaniline; 4-Amino-6-chloro-m-benzenedisulfonamide; 3-Chloro-4,6-disulfamoylaniline; 5-Chloro-2,4-disulfamoylaniline; UNII-3A52O8YREJ; Su 5683; 4-Amino-6-Chloro-1,3-Benzendisulfonamide; 3A52O8YREJ; CHEBI:3602; CHEMBL266240; 4-Amino-6-chlorobenzene-1,3-disulphonamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 67136
ChEBI ID: CHEBI:3602
CAS Number: CAS 121-30-2
TTD Drug ID: DMIWGZS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[2]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase VI (CA-VI)	DTT	CA6	3.678	5.784	5.19	5.717
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase VI (CA-VI)	DTT	CA6	3.64E-10	-0.17	-0.37
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
2	Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503.