Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLG69R)

Drug Name

3-Fluoro-4-hydrazino-benzenesulfonamide Drug Info

Synonyms

3-Fluoro-4-hydrazino-benzenesulfonamide; 606126-17-4; 3-fluoro-4-hydrazinobenzenesulfonamide; hydrazide deriv. 15; SCHEMBL1244816; CHEMBL176180; CTK2E9801; BDBM12160; DTXSID90448811; IDSRHQBHQWPDNY-UHFFFAOYSA-N; AKOS013645919; 4-Hydrazino-3-fluorobenzenesulfonamide; Benzenesulfonamide, 3-fluoro-4-hydrazino-; TC-063144; 3-fluoro-4-hydrazinylbenzene-1-sulfonamide; 144147-EP2287165A2; 144147-EP2292620A2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10932611
CAS Number: CAS 606126-17-4
TTD Drug ID: DMLG69R

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5.