Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMAS3K)

Drug Name
SULFAMIDE Drug Info
Synonyms
Sulfuric diamide; 7803-58-9; Sulfamamide; Sulfuryl amide; Sulfuryl diamide; Sulfonyl diamide; sulfamoylamine; sulphamide; Sulphuric diamide; UNII-VS7TZW634V; Imidosulfamic acid; H4N2O2S; H2NSO2NH2; VS7TZW634V; CHEMBL355001; CHEBI:29368; NVBFHJWHLNUMCV-UHFFFAOYSA-N; MFCD00011606; Sulfamide, 98+%; Imidosulfamic acid (VAN); aminosulfonamide; NSC 252; diamidodioxidosulfur; EINECS 232-262-9; Sulfamide, 99%; AI3-30237; NH2SO2NH2; AC1Q55HN; KSC377O7F; NSC252; AC1L332P; DTXSID5064885; CTK2H7772; BDBM26995; NSC-252; MolPort-000-146-081
Cross-matching ID
PubChem CID
82267
ChEBI ID
CHEBI:29368
CAS Number
CAS 7803-58-9
TTD Drug ID
DMMAS3K

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [2]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [2]
Carbonic anhydrase IV (CA-IV) TTZHA0O CAH4_HUMAN Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Carbonic anhydrase IX (CA-IX) DTT CA9 5.04 6.156 4.609 6.756
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase IV (CA-IV) DTT CA4 1.58E-77 -2.02 -1.77
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Carbonic anhydrase IX (CA-IX) DTT CA9 1.12E-10 -0.03 -0.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
2 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.
3 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbo... Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71.