Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMV0KW)

Drug Name

Ephedrine Drug Info

Synonyms

Biophedrin; Eciphin; Efedrin; Ephedral; Ephedremal; Ephedrin; Ephedrital; Ephedrol; Ephedrosan; Ephedrotal; Ephedsol; Ephendronal; Ephoxamin; Fedrin; Kratedyn; Lexofedrin; Manadrin; Mandrin; Nasol; Racephedrine; Sanedrine; Vencipon; Zephrol; CPDD 0049; D-Ephedrine; Ephedrine (TN); Ephedrine (USP); Ephedrine [USAN:BAN]; Ephedrine l-form; I-Sedrin; L-Ephedrine; L(-)-Ephedrine; L-(+)-Ephedrine; L-(-)-Ephedrine; (+)-Ephedrin; (1R,2R)-Ephedrine; (1S,2R)-Ephedrine; (L)-EPHEDRINE; 1-EPHEDRINE; 1-Sedrin

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Approved	[1]
Asthma	CA23	Approved	[2]
Bronchitis	CA20	Approved	[1]
Common cold	CA00	Approved	[1]
Headache	8A80-8A84	Approved	[1]
Rhinitis	FA20	Approved	[1]
Seasonal allergic rhinitis	CA08.01	Approved	[1]
Vasomotor/allergic rhinitis	CA08	Approved	[1]
Sinusitis	CA0A.Z	Investigative	[1]

Therapeutic Class

Central Nervous System Stimulants

Cross-matching ID

PubChem CID: 9294
ChEBI ID: CHEBI:15407
CAS Number: CAS 299-42-3
TTD Drug ID: DMMV0KW
INTEDE Drug ID: DR0586
ACDINA Drug ID: D00233

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Phase 4	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine D2 receptor (D2R)	DTT	DRD2	5.345	5.634	5.789	5.901
Sulfotransferase 1A1 (SULT1A1)	DME	SULT1A1	9.814	9.348	7.196	10.468

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Allergic rhinitis

ICD Disease Classification

CA08.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D2 receptor (D2R)	DTT	DRD2	2.50E-02	-0.08	-0.49
Sulfotransferase 1A1 (SULT1A1)	DME	SULT1A1	8.47E-01	3.57E-02	1.73E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Ephedrine FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 556).
3	The effect of alpha-2 adrenergic agonists on memory and cognitive flexibility. Cogn Behav Neurol. 2006 Dec;19(4):204-7.
4	Benzylic alcohols as stereospecific substrates and inhibitors for aryl sulfotransferase. Chirality. 1991;3(2):104-11.