Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN6EZY)

Drug Name
Vitamin K Drug Info
Synonyms 12001-79-5; MBWXNTAXLNYFJB-LKUDQCMESA-N; 81818-54-4
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5280483
ChEBI ID
CHEBI:94399
CAS Number
CAS 12001-79-5
TTD Drug ID
DMN6EZY
INTEDE Drug ID
DR1702

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor IIa (F2) TT6L509 THRB_HUMAN Cofactor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DEVRYQN VKOR1_HUMAN Investigative [2]
VKORC1-like protein 1 (VKORC1L1) DERQV72 VKORL_HUMAN Investigative [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Coagulation factor IIa (F2) DTT F2 11.608 4.285 4.453 5.174
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DME VKORC1 9.227 8.054 8.182 8.368
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DME VKORC1 4.41E-01 -3.62E-01 -6.10E-01
VKORC1-like protein 1 (VKORC1L1) DME VKORC1L1 6.04E-01 -2.18E-01 -5.46E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Plasma levels of protein C and vitamin K-dependent coagulation factors in patients on long-term oral anticoagulant therapy. Tohoku J Exp Med. 1986 Aug;149(4):351-7.
2 VKORC1L1, an enzyme mediating the effect of vitamin K in liver and extrahepatic tissues. Nutrients. 2018 Jul 26;10(8). pii: E970.
3 VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. J Biol Chem. 2013 Oct 4;288(40):28733-42.