General Information of Drug (ID: DMO32HN)

Drug Name
HYDROSULFIDE Drug Info
Synonyms
hydrosulfide; sulfanide; HS anion; CHEMBL38703; CHEBI:29919; 15035-72-0; hydrosulphide; bisulfide; thiolate; Hydridesulfuranion; Hydrosulfide Anion; Hydrogensulfide Ion; hydrogen sulfide ion; sulfur(1-); Sulfide (HS1-); hydrogen(sulfide)(-1); hydrogen(sulfide)(1-); AC1NUTG4; AC1NNM8X; BDBM26990; RWSOTUBLDIXVET-UHFFFAOYSA-M; HS(-); HS(-1)
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5047209
ChEBI ID
CHEBI:29919
CAS Number
CAS 15035-72-0
TTD Drug ID
DMO32HN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [2]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Carbonic anhydrase IX (CA-IX) DTT CA9 5.04 6.156 4.609 6.756
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Carbonic anhydrase IX (CA-IX) DTT CA9 1.12E-10 -0.03 -0.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.
2 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.