Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQKSGI)

Drug Name

Myo-inositol Drug Info

Synonyms

Scyllo-inositol; inositol; Muco-Inositol; epi-Inositol; i-Inositol; meso-Inositol; Allo-inositol; 87-89-8; 1D-Chiro-inositol; 1L-Chiro-inositol; 488-59-5; Scyllitol; 643-12-9; D-(+)-chiro-Inositol; cis-Inositol; mesoinositol; Quercinitol; Myoinosite; Dambose; Cyclohexane-1,2,3,4,5,6-hexaol; Neo-inositol; Meat sugar; 6917-35-7; Phaseomannite; Inositina; Cocositol; D-chiro-Inositol; Inositene; Inosital; Iso-inositol; cyclohexane-1,2,3,4,5,6-hexol; Phaseomannitol; Cyclohexitol; Mesoinosit; Scyllite; Mesoinosite; Inosite

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 2	[1]

Cross-matching ID

PubChem CID: 892
ChEBI ID: CHEBI:17268
CAS Number: CAS 551-72-4
TTD Drug ID: DMQKSGI
VARIDT Drug ID: DR00122
INTEDE Drug ID: DR2160

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Amyloid beta A4 protein (APP)	TTE4KHA	A4_HUMAN	Inhibitor	[1]
Mycobacterium CDP-diacylglycerol-inositol phosphatidyltransferase (MycB pssA)	TTI0TCK	PSS_MYCTU	Inhibitor	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
Sodium/myo-inositol cotransporter (SLC5A3)	DT8ACN1	SC5A3_HUMAN	Phase 4	[3]
Sodium/myo-inositol cotransporter 2 (SLC5A11)	DT2CAPQ	SC5AB_HUMAN	Phase 4	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Inositol dehydrogenase (idh)	DE0J45Y	A0A0J9X1Y2_LACCB	Phase 4	[5]
Inositol dehydrogenase (idh)	DEDUGWF	IOLG_LACCA	Phase 4	[5]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Amyloid beta A4 protein (APP)	DTT	APP	6.473	8.014	8.631	7.57
Sodium/myo-inositol cotransporter (SLC5A3)	DTP	SMIT	6.962	7.288	8.761	7.029

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Alzheimer disease

ICD Disease Classification

8A20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Amyloid beta A4 protein (APP)	DTT	APP	1.60E-02	-0.07	-0.31
Sodium/myo-inositol cotransporter (SLC5A3)	DTP	SMIT	6.58E-06	4.68E-01	9.02E-01
Sodium/myo-inositol cotransporter 2 (SLC5A11)	DTP	SMIT2	2.11E-04	2.65E-01	3.07E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Phosphatidylinositol synthesis in mycobacteria. Biochim Biophys Acta. 1999 Jan 4;1436(3):437-50.
3	Identification of a novel Na+/myo-inositol cotransporter. J Biol Chem. 2002 Sep 20;277(38):35219-24.
4	The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8.
5	Purification, crystallization and room-temperature X-ray diffraction of inositol dehydrogenase LcIDH2 from Lactobacillus casei BL23. Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):979-83.