Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSA367)

Drug Name

6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info

Synonyms

20315-68-8; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; 6-methoxytryptoline; 6-Methoxy-1,2,3,4-tetrahydro-beta-carboline; pinoline; 6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole; 6-MeOthbc; 6-methoxy-2,3,4,9-tetrahydro-1H-beta-carboline; 6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4b] indole; 6-Methoxytetrahydro-beta-carboline; 2,3,4,9-Tetrahydro-6-methoxy-1H-pyrido(3,4-b)indole; BRN 0172873; CHEMBL266084; 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-6-methoxy-; QYMDEOQLJUUNOF-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1868
CAS Number: CAS 20315-68-8
TTD Drug ID: DMSA367

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[2]
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.
2	Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5.