Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSQEXP)

Drug Name

N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide Drug Info

Synonyms

32873-56-6; 2-Acetylamino-5-mercapto-1,3,4-thiadiazole; N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)acetamide; 2-Acetamido-5-mercapto-1,3,4-Thiadiazole; UNII-6B8475348K; MLS002703417; CHEMBL382111; DWSMAMSVZRCQMP-UHFFFAOYSA-N; N-(5-mercapto-1,3,4-thiadiazol-2-yl)acetamide; N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide; 6B8475348K; {N}-(5-mercapto-1,3,4-thiadiazol-2-yl)acetamide; N-(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)acetamide; Acetamide,N-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-; C4H5N3OS2; NSC97893

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2723687
CAS Number: CAS 32873-56-6
TTD Drug ID: DMSQEXP

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.