Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVOJ7K)

Drug Name

1-(3,4-dichlorophenyl)-3-hydroxyurea Drug Info

Synonyms

1-(3,4-Dichlorophenyl)-3-hydroxyurea; N-(3,4-Dichlorophenyl)-N'-hydroxyurea; 31225-17-9; Dichlorphenyloxyurea; Urea, N-(3,4-dichlorophenyl)-N'-hydroxy-; Urea, 1-(3,4-dichlorophenyl)-3-hydroxy-; EINECS 250-519-3; NSC125191; NSC 125191; BRN 2806578; AI3-63029; CHEMBL213348; AC1L3YKI; AC1Q3OJ7; SCHEMBL6791055; DTXSID8067602; CTK4G6577; Urea,4-dichlorophenyl)-3-hydroxy-; ZINC4809416; Urea,4-dichlorophenyl)-N'-hydroxy-; BDBM50188774; AKOS024368418; NSC-125191; MCULE-3584918333; 1-(3,4-dichlorophenyl)-3-hydroxy-urea; LS-159754

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 97463
CAS Number: CAS 31225-17-9
TTD Drug ID: DMVOJ7K

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase IV (CA-IV)	DTT	CA4	1.58E-77	-2.02	-1.77
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20.