General Information of Drug (ID: DMVOJ7K)

Drug Name
1-(3,4-dichlorophenyl)-3-hydroxyurea
Synonyms
1-(3,4-Dichlorophenyl)-3-hydroxyurea; N-(3,4-Dichlorophenyl)-N'-hydroxyurea; 31225-17-9; Dichlorphenyloxyurea; Urea, N-(3,4-dichlorophenyl)-N'-hydroxy-; Urea, 1-(3,4-dichlorophenyl)-3-hydroxy-; EINECS 250-519-3; NSC125191; NSC 125191; BRN 2806578; AI3-63029; CHEMBL213348; AC1L3YKI; AC1Q3OJ7; SCHEMBL6791055; DTXSID8067602; CTK4G6577; Urea,4-dichlorophenyl)-3-hydroxy-; ZINC4809416; Urea,4-dichlorophenyl)-N'-hydroxy-; BDBM50188774; AKOS024368418; NSC-125191; MCULE-3584918333; 1-(3,4-dichlorophenyl)-3-hydroxy-urea; LS-159754
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 221.04
Logarithm of the Partition Coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C7H6Cl2N2O2
IUPAC Name
1-(3,4-dichlorophenyl)-3-hydroxyurea
Canonical SMILES
C1=CC(=C(C=C1NC(=O)NO)Cl)Cl
InChI
InChI=1S/C7H6Cl2N2O2/c8-5-2-1-4(3-6(5)9)10-7(12)11-13/h1-3,13H,(H2,10,11,12)
InChIKey
VKYZMAVGJARVPE-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
97463
CAS Number
31225-17-9
TTD ID
D09UQM

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase IV (CA-IV) TTZHA0O CAH4_HUMAN Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase IV (CA-IV) DTT CA4 1.58E-77 -2.02 -1.77
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Carbonic anhydrase IX (CA-IX) DTT CA9 1.12E-10 -0.03 -0.09
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20.