General Information of Drug (ID: DMXEUDM)

Drug Name
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide Drug Info
Synonyms
N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide; N-(4-sulfamoylphenyl)-2-sulfanylbenzamide; CHEMBL386049; reduced thio H5a; 2hd6; AC1LA75B; SCHEMBL6227210; BDBM11053; reduced monomeric thio of compound 5a; DB07476; BOS; N-(4-sulfamoylphenyl)-2-sulfanyl-benzamide; 4-(2-mercaptophenylcarboxamido)benzenesulfonamide; N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
462919
TTD Drug ID
DMXEUDM

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [2]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Carbonic anhydrase IX (CA-IX) DTT CA9 5.04 6.156 4.609 6.756
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Carbonic anhydrase IX (CA-IX) DTT CA9 1.12E-10 -0.03 -0.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2 Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem. 2008 Jun 12;51(11):3051-6.