Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXK8FQ)

Drug Name
VP004 Drug Info
Indication
Disease Entry ICD 11 Status REF
Substance use disorder 6C4Z Discontinued in Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMXK8FQ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor delta (OPRD1) TT27RFC OPRD_HUMAN Not Available [2]
Opioid receptor kappa (OPRK1) TTQW87Y OPRK_HUMAN Not Available [2]
Opioid receptor mu (MOP) TTKWM86 OPRM_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Opioid receptor kappa (OPRK1) DTT OPRK1 5.533 5.372 5.703 5.632
Opioid receptor mu (MOP) DTT OPRM1 4.548 5.062 4.652 4.776
Opioid receptor delta (OPRD1) DTT OPRD1 2.848 2.263 1.536 2
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Substance use disorder
ICD Disease Classification 6C4Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Opioid receptor mu (MOP) DTT OPRM1 5.94E-01 -0.02 -0.17
Opioid receptor delta (OPRD1) DTT OPRD1 5.52E-01 0.03 0.23
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025668)
2 WO patent application no. 2007,0677,14, Treatment of sequelae of psychiatric disorders.