Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYX31S)

Drug Name

MPDT Drug Info

Synonyms

BGC 20-761; 17375-63-2; UNII-6G5F6ESV5I; 6G5F6ESV5I; CHEMBL7318; BGC-20-761; 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine; 2-(5-methoxy-2-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine; MPDT; AC1OCFJ3; GTPL71; SCHEMBL5763578; N,N-Dimethyl-2-(5-methoxy-2-phenylindol-3-yl)ethylamine; Indole, 3-(2-(dimethylamino)ethyl)-5-methoxy-2-phenyl-; 1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-2-phenyl-; MolPort-023-276-754; PDSP2_001402; BDBM50085970; PDSP1_001418; ZINC13805807; AKOS024457555; NCGC00370860-01

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6918515
CAS Number: CAS 17375-63-2
TTD Drug ID: DMYX31S

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Antagonist	[2]
5-HT 1D receptor (HTR1D)	TT6MSOK	5HT1D_HUMAN	Antagonist	[2]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Antagonist	[2]
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Antagonist	[2]
5-HT 5A receptor (HTR5A)	TTRUFDT	5HT5A_HUMAN	Antagonist	[2]
5-HT 6 receptor (HTR6)	TTJS8PY	5HT6R_HUMAN	Antagonist	[2]
5-HT 7 receptor (HTR7)	TTO9X1H	5HT7R_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2C receptor (HTR2C)	DTT	HTR2C	4.233	3.329	3.843	3.888
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
5-HT 7 receptor (HTR7)	DTT	HTR7	1.561	1.233	0.848	1.485
5-HT 6 receptor (HTR6)	DTT	HTR6	5.594	5.781	5.271	3.963
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129
5-HT 1D receptor (HTR1D)	DTT	HTR1D	3.307	1.263	2.585	5.833

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 71).
2	2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8.