General Information of Drug (ID: DM0U7CK)

Drug Name
NSC-637992 Drug Info
Synonyms
CCRIS 7539; UNII-3S0283Z6W9; C 1310; NSC-637992; CHEMBL125082; 3S0283Z6W9; 138154-40-2; 5-((2-(Diethylamino)ethyl)amino)-8-hydroxy-1-methyl-6H-imidazo(4,5,1-de)acidin-6-one; 6H-Imidazo(4,5,1-de)acridin-6-one, 5-((2-(diethylamino)ethyl)amino)-8-hydroxy-1-methyl-; AC1L30G5; SCHEMBL13526631; DTXSID70160509; ZINC3825293; BDBM50008344; NCI60_012641; LS-183332; 5-(2-(diethylamino)ethylamino)-8-hydroxy-1-methyl-6H-imidazo[4,5,1-de]acridin-6-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
132128
CAS Number
CAS 138154-40-2
TTD Drug ID
DM0U7CK
VARIDT Drug ID
DR01477

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Quinone reductase 2 (NQO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [2]
NSC-645809 DMPJQZG Breast cancer 2C60-2C65 Phase 2 [1]
Prolarix DMZIQ8G Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
CB1954 DMVP4YK Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [4]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [4]
2-iodo-melatonin DMSEIUP Discovery agent N.A. Investigative [5]
3,4,5-Trimethoxy-4'-amino-trans-stilbene DMDBOJ5 Discovery agent N.A. Investigative [6]
NSC-645808 DMMBAR3 Discovery agent N.A. Investigative [1]
decynium 22 DMWCTZ7 Discovery agent N.A. Investigative [7]
NSC-106080 DMR6P9S Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Quinone reductase 2 (NQO2) TTJLP0R NQO2_HUMAN Inhibitor [1]

References

1 Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6.
2 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84.
6 Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66.
7 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.