Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM17NYA)

• Drug Name: CYC-103 Drug Info
• Synonyms: Cyclin groove inhibitors, Cyclacel; CYC-103 (Pimetics series); CYC-103 cyclin groove inhibitors, Cyclacel; CYC-103 program, Cyclacel

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Terminated	[1]

• Cross-matching ID: TTD Drug ID: DM17NYA

Molecule-Related Drug Atlas

Drug(s) Targeting Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[4]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[5]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[6]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[7]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[8]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[9]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[11]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[2]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[12]

Drug(s) Targeting Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[4]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[5]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[6]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[7]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[8]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[9]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[12]
GLR2007	DM7DWLY	Glioblastoma of brain	2A00.00	Phase 1/2	[13]
FCN-437	DMQ8VUW	Breast cancer	2C60-2C65	Phase 1/2	[14]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[15]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 4 (CDK4)	TT0PG8F	CDK4_HUMAN	Inhibitor	[2]
Cyclin-dependent kinase 6 (CDK6)	TTO0FDJ	CDK6_HUMAN	Inhibitor	[3]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015455)
• [2] Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154.
• [3] WO patent application no. 2007,0898,78, Sutures and anti-scarring agents.
• [4] Agreement signed with Prostagenics to develop prostate cancer treatment. Innovate Oncology, Inc. 2005.
• [5] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2017
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
• [9] Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.
• [10] A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
• [11] Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
• [12] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [13] Clinical pipeline report, company report or official report of Gan & Lee Pharmaceuticals.
• [14] Clinical pipeline report, company report or official report of Fochon Pharmaceuticals.
• [15] ClinicalTrials.gov (NCT04541225) Phase 1/2 Dose Escalation, Safety, Pharmacokinetics, and Efficacy Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors. U.S.National Institutes of Health.